The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.

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Submissions from 2005

Novel approaches to using PDE4 inhibitors for antihypertensive therapy, Desuo Wang and Ting Wang

The expression of COX-2, PCNA and Cyclin D1 in the model of reflux esophagitis, T. Wang, J. Gong, Qian Chen, and J. Wang

Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle, Richard E. White, Guichun Han, Christiana Dimitropoulou, Shu Zhu, Katsuya Miyake, David Fulton, Shaylee Dave, and Scott A. Barman

Normal mode analysis of Pyrococcus furiosus rubredoxin via nuclear resonance vibrational spectroscopy (NRVS) and resonance Raman spectroscopy, Y. Xiao, H. Wang, S. J. George, M. C. Smith, Michael W. Adams, Francis E. Jenney Jr., W. Sturhahn, E. E. Alp, J. Zhao, and et al.

Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection, Mei Xu, George Wei-Cheong Yip, Le-Ting Gan, and Yee-Kong Ng

Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice, S. Yoshikawa, T. Miyahara, S. D. Reynolds, B. R. Stripp, Mircea Anghelescu, F. G. Eyal, and J. C. Parker

Gö 6983: A Fast Acting Protein Kinase C Inhibitor That Attenuates Myocardial Ischemia/Reperfusion Injury, Lindon H. Young, Brian J. Balin PhD, and Margaret T. Weis

Protein kinase C (PKC) isoform peptide activator/inhibitors exert cardioprotective effects in polymorphonuclear leukocyte (PMN) induced ischemia/reperfusion (I/R) injury, Lindon H. Young, A. Phillipson, D. Omiyi, N. Atkinson, M. Jivani, J. Adams, and E E. Peterman

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JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2), Dianzheng Zhang, Hoguen Yoon, and Jiemin Wong

Submissions from 2004

PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase, Scott A. Barman, Shu Zhu, and Richard E. White

NF-kB binds to a polymorphic repressor element in the MMP-3 promoter, Ruth C. Borghaei, P. L. Rawlings Jr., Masoud Javadi, and J. Woloshin

Photoreceptor Degeneration and Loss of Retinal Function in the C57BL/6-C2J Mouse, Arturo Bravo Nuevo, Natalie Walsh, and Jonathan Stone

Factors supporting quality of life over time for individuals with amyotrophic lateral sclerosis: The role of positive self-perception and religiosity, Barbara A. Bremer, Ann Louise Simone, Susan Walsh, Zachary Simmons, and Stephanie H. Felgoise

Bone cell survival in microgravity: Evidence that modeled microgravity increases osteoblast sensitivity to apoptogens, M. A. Bucaro, J. Fertala, Christopher S. Adams, M. Steinbeck, P. Ayyaswamy, K. Munkundakrishnan, I. M. Shapiro, and M. V. Risbud

Identifying United States substance abuse treatment programs: A test in one mid-sized city, D. Carise, A. McLellan, David Festinger, and H. Kleber

A neutron crystallographic analysis of a rubredoxin mutant at 1.6 Ã… resolution, T Chatake, K. Kurihara, I. Tanaka, I. Tsyba, R. Bau, Francis E. Jenney Jr., M. W. Adams, and N. Niimura

Cerebral ischemia and the unfolded protein response, Donald J. DeGracia and Heather L. Montie

Functionalized surfaces for bone cell adhesion, P. Ducheyne, G. Toworfe, M. H. Lee, R. J. Composto, Christopher S. Adams, and I. M. Shapiro

Model surfaces engineered with nanoscale roughness and RGD tripeptides promote osteoblast activity, A. R. El-Ghannam, P. Ducheyne, M. Risbud, Christopher S. Adams, I. M. Shapiro, D. Castner, S. Golledge, and R. J. Composto

Encyclopedia of cognitive behavior therapy, Arthur Freeman and Stephanie H. Felgoise

Dreams and the Dream Image: Using Dreams in Cognitive Therapy, Arthur Freeman and Beverly White

Professionalism: Orientation Exercises for Incoming Osteopathic Medical Students and Developing Class Vision Statements, Kerin L. Fresa-Dillon, Robert G. Cuzzolino, and Kenneth J. Veit

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Influence of age, gender, and race on depression in heart failure patients., Ronald Freudenberger, Stacey C. Cahn, and Christine Skotzko

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Visualizing the needle in the haystack: In situ hybridization with fluorescent dendrimers, Jacquelyn Gerhart, M. Baytion, J. Perlman, C. Neely, B. Hearon, T. Nilsen, R. Getts, J. Kadushin, and Mindy George-Weinstein

Epiblast cells that express MyoD recruit pluripotent cells to the skeletal muscle lineage, Jacquelyn Gerhart, C. Neely, B. Stewart, J. Perlman, D. Beckmann, M. Wallon, K. Knaudsen, and Mindy George-Weinstein

Emerging drug delivery systems: Scientific reality or media hype?, Naushad Ghilzai

Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2, Jeffrey R. Gingrich, Kenneth A. Pelkey, Sami R. Fam, Yueqiao Huang, Ronald S. Petralia, Robert J. Wenthold, and Michael W. Salter

Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom, K. S. Girish, Rangaiah Shashidharamurthy, T. V. Gowda, and K. Kemparaju

[contributions], Frederick J. Goldstein

Involvement of Calcineurin in Transforming Growth Factor-ß-mediated Regulation of Extracellular Matrix Accumulation, Jennifer L. Gooch, Y. Gorin, B. X. Zhang, and H. E. Abboud

Differential expression of calcineurin A isoforms in the diabetic kidney, Jennifer L. Gooch, P. E. Pargola, R. L. Guler, H. E. Abboud, and J. L. Barnes

Calcineurin A-α but not A-ß is required for normal kidney development and function, Jennifer L. Gooch, J. J. Toro, R. L. Guler, and J. L. Barnes

Left ventricular mitogen activated protein kinase signaling following polymicrobial sepsis during streptozotocin-induced hyperglycemia, A. Gupta, S. Brahmbhatt, and Avadhesh C. Sharma

Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases, A. Gupta and Avadhesh C. Sharma

Calcium signaling in dendrite development, Lori Redmond Hardy

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A role for Tbx5 in proepicardial cell migration during cardiogenesis, Cathy J. Hatcher, Nata Diman, Minsu Kim, David Pennisi, Yan Song, Marsha M. Goldstien, Takashi Mikawa, and Craig T. Basson

Interleukin-4 suppresses IL-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts, K. Jenkins and M. Javadi

Neutron crystallographic study on rubredoxin from Pyrococcus furiosus by BIX-3, a single-crystal diffractometer for biomacromolecules, K. Kurihara, I. Tanaka, T. Chatake, M. W. Adams, Francis E. Jenney Jr., N. Moiseeva, R. Bau, and N. Niimura

Effects of Task Difficulty and Type of Contingency on Students' Allocation of Responding to Math Worksheets, Amanda L. Lannie and Brian K Martens

Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice, C. Scott Little, Christine J. Hammond, Brian J. Balin, and Denah M. Appelt

W3Y single mutant of rubredoxin from Pyrococcus furiosus: a preliminary time-of-flight neutron study., X. Li, P. Langan, R. Bau, I. Tsyba, Francis E. Jenney Jr., Michael W. Adams, and B. P. Schoenborn

Activation Kinetics of Skinned Cardiac Muscle by Laser Photolysis of Nitrophenyl-EGTA, H. Martin, Marcus G. Bell, G. C. R. Ellis-Davies, and Robert J. Barsotti

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Activation Kinetics of Skinned Cardiac Muscle by Laser Photolysis of Nitrophenyl-EGTA, Hunter Martin, Marcus G. Bell, Graham C. Ellis-Davis, and Robert J. Barsotti

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Effects of sham air and cigarette smoke on A549 lung cells: Implications for iron-mediated oxidative damage, Jonathan J. Mayo, Pete Kohlhepp, Dianzheng Zhang, and Joy J. Winzerling

Functional Characterization of Na(+)/(H+) Exchangers in Primary Cultures of Prairie Dog Gallbladder, S.C. Narin, E.H. Park, R. Ramakrishnan, R. Garcia, J. N. Diven, Brian J. Balin, and Christine J. Hammond

NMDA receptors are movin' in, Yi Nong, Yueqiao Huang, and Michael W. Salter

Frank Stinchfield award: Titanium surface with biologic activity against infection, J. Parvizi, E. Wickstrom, A. R. Zeiger, Christopher S. Adams, I. M. Shapiro, J. J. Purtill, P. F. Sharkey, W. J. Hozack, R. H. Rothman, and N. J. Hickok

The UME-21 Project: Connecting Medical Education and Medical Practice, J. M. Pascoe, D. Babbott, K. L. Pye, H. V. Rabinowitz, Kenneth J. Veit, and D. L. Wood

Gö 6983 Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion, Ellen E. Peterman, Philip Taormina II, Margaret Harvey, and Lindon Young

Cross-bridge versus thin filament contributions to the level and rate of force development in cardiac muscle, M. Regnier, H. Martin, Robert J. Barsotti, A. J. Rivera, D. A. Martyn, and E. Clemmens

Role of small intestine submucosa (SIS) as a nerve conduit: preliminary report, Ryan M. Smith, Christina Wiedl, Paul Chubb, and Charlotte H. Greene

Ionizing radiation sensitizes bone cells to apoptosis, K. H. Szymczyk, I. M. Shapiro, and Christopher S. Adams

Regeneration of uterine horn using porcine small intestine submucosa grafts in rabbits, Jon W. Taveau, Michele Tartaglia, Dana Buchanan, Bret Smith, George Koenig, Kevin Thomfohrde, Bruce Stouch, Saul Jeck, and Charlotte H. Greene

Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin, W. Tempel, Z. Liu, F. D. Schubot, A. Shah, M. V. Weinberg, Francis E. Jenney Jr., W. B. Arendall III, M. W. Adams, J. S. Richardson, and J. P. Rose

Regulation of the p300 HAT domain via a novel activation loop, Paul R. Thompson, Dongxia Wang, Marcella Fulco, Natalia Pediconi, Dianzheng Zhang, Woojin An, Qingyuan Ge, Robert R. Roeder, Jiemin Wong, and Massimo Levrero

Effect of surface activated poly(dimethylsiloxane) on fibronectin adsorption and cell function, G. K. Toworfe, R. J. Composto, Christopher S. Adams, I. M. Shapiro, and P. Ducheyne

Fibronectin adsorption on surface-activated poly(dimethylsiloxane) and its effect on cellular function, G. K. Toworfe, R. J. Composto, Christopher S. Adams, I. M. Shapiro, and P. Ducheyne

Backbone solution structures of proteins using residual dipolar couplings: Application to a novel structural genomics target, H. Valafar, K. L. Mayer, C. M. Bougault, P. D. LeBlond, Francis E. Jenney Jr., P. S. Brereton, Michael W. Adams, and J. H. Prestegard

Osteopathic medical education - 2004, Kenneth J. Veit

Resistance of Photoreceptors in the C57BL/6-c2j, C57BL/6j, and BALB/CJ Mouse Strains to Oxygen Stress: Evidence of an Oxygen Phenotype, Natalie Walsh, Arturo Bravo Nuevo, Scott Geller, and Jonathan Stone

Rubrerythrin from the hyperthermophilic archaeon Pyrococcus furiosus is a rubredoxin-dependent, iron-containing peroxidase, M. V. Weinberg, Francis E. Jenney Jr., X. Cui, and Michael W. Adams

Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium, Margaret T. Weiss, Jason L. Crumley, Lindon Young, and John N. Stallone

The Transepithelial Transport of a G-CSF-Transferrin Conjugate in Caco-2 Cells and Its Myelopoietic Effect in BDF1 Mice, Adam Widera, Yun Bai, and Wei-Chiang Shen

Lessons Learned - UME-21 Project, D. L. Wood, D. Babbott, J. M. Pascoe, K. L. Pye, H. K. Rabinowitz, and Kenneth J. Veit

Submissions from 2003

Estradiol relaxes rat aorta via endothelium-dependent and -independent mechanisms, G. Abou-Mohamed, A. Elmorakby, G. O. Carrier, J. D. Catraval, R. W. Caldwell, and Richard E. White

Response to 'does weight gain lead to weight loss?', Christopher S. Adams and J. L. Blank

Mechanisms by which extracellular matrix components induce osteoblast apoptosis, Christopher S. Adams and I. M. Shapiro

Chlamydia pneumoniae in the Pathogenesis of Alzheimer's Disease, Brian J. Balin PhD, Christine J. Hammond, C. Scott Little PhD, Amanda McIntyre, and Denah M. Appelt

Observation of Fe - H/D modes by nuclear resonant vibrational spectroscopy, U. Bergman, W. Sturhahn, D. E. Linn Jr., Francis E. Jenney, M. W. Adams, K. Rupnik, B. J. Hales, E. E. Alp, A. Mayse, and S. P. Kramer

Mitochondrial Deletions in Normal and Degenerating Rat Retina, Arturo Bravo Nuevo, Neal Williams, Scott Geller, and Jonathan Stone

The Small Bovine Amelogenin LRAP Fails to Rescue the Amelogenin Null Phenotype, E. Chen, Z. Yuan, J. T. Wright, S. P. Hong, Y. Li, P. M. Collier, B. Hall, Marina D'Angelo, S. Decker, and R. Piddington

VEGF expression in forestomach cancer and precancerous lesions in mice and investigation of chemoprophylaxis trail, Qian Chen, X. Lian, W. Zheng, B. Zhou, and X. Wu

Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase, M. D. Clay, C. A. Cosper, Francis E. Jenney Jr., M. W. Adams, and M. K. Johnson

TBX5 nuclear localization is mediated by dual cooperative intramolecular signals, Anita Collavoli, Cathy J. Hacker, Jie He, Daniel Okin, Rahul Deo, and Craig T. Basson

A prospective trial of treating patients with nasopharyngeal carcinoma in late stage by combined hyperfractionated radiotherapy and concurrent chemotherapy, H. Deng, X. Zhang, Qian Chen, and S Han

Peer Rejection and Social Information-Processing Factors in the Development of Aggressive Behavior Problems in Children, K. A. Dodge, J. E. Lansford, Virginia Burks Salzer, J. E. Bates, G. S. Pettit, R. Fontaine, and J. M. Price

Soft tissue techniques, W. C. Ehrenfeuchter, D. Heilig, and Alexander S. Nicholas

Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism, D. V. Folden, A. Gupta, Avadhesh C. Sharma, S. Y. Li, J. T. Saari, and J. Ren

Training needed to dispel negative stereotype of elderly patients, Katherine Galluzzi

Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation, Jennifer L. Gooch, J. L. Barnes, S. Garcia, and H. E. Abboud

Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia., A. Gupta and Avadhesh C. Sharma

Modeling development of the epicardium and coronary vasculature: In vitro veritas?, Cathy J. Hatcher and Craig T. Basson

Transcription factor cascades in congenital heart malformation, Cathy J. Hatcher, Nata Diman, Deborah A. McDermott, and Craig T. Basson

Biliary complications after pediatric liver transplantation revisited, Thomas Heffron, Todd Pillen, Gregory Smallwood, D. Redd, and Rene Romero

Pediatric liver transplantation with daclizumab induction therapy, Thomas Heffron, Todd Pillen, Gregory Smallwood, David Welch, Brad Oakley, and Rene Romero

Hepatic artery thrombosis in pediatric liver transplantation, Thomas Heffron, Todd Pillen, David Welch, Gregory Smallwood, Dougg Redd, and Rene Romero

Adult and pediatric liver transplantation for autoimmune hepatitis, Thomas Heffron, Gregory Smallwood, B. Oakley, Todd Pillen, D. Welch, K. Connor, Enrique Martinez, Rene Romero, and A. C. Stieber

Duct-to-duct biliary anastomosis for patients with sclerosing cholangitis undergoing liver transplantation, Thomas Heffron, Gregory Smallwood, T. Ramcharan, Laurel Davis, K. Connor, Enrique Martinez, and A. C. Stieber

Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats, Yasuhiko Ikeda, Lindon Young, and Allan M. Lefer

Adenosine A1 antagonism attenuates atropine-resistant hypoxic bradycardia in rats, J. L. Kaplan, E. Gao, L. De Garavilla, M. Victain, Bohdan M. Minczak, and W. C. Dalsey

Clinical relapses of multiple sclerosis are associated with 'novel' valleys in natural killer cell functional activity, L. F. Kastrukoff, A. Lau, R. Wee, D. Zecchini, Richard E. White, and D. W. Paty

Severity of menopausal symptoms and use of both conventional and complementary/alternative therapies, N. L. Keenan, S. Marks, A. Fugh-Berman, D. Browne, Joseph M. Kaczmarczyk, and C. Hunter

Developmental Biology and Human Evolution, C Owen Lovejoy, Melanie A. McCollum, Philip L. Reno, and Burt A. Rosenman

Cartilage viability after repetitive loading: A preliminary report, E. Luchinetti, Christopher S. Adams, W. E. Horton Jr., and P. A. Torzilli

Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells, Angela MacIntyre, R. Abramov, Christine J. Hammond, A. P. Hudson, E. J. Arking, C. Scott Little, Denah M. Appelt, and Brian J. Balin

Induction of apoptosis in skeletal tissues: Phosphate-mediated chick chondrocyte apoptosis is calcium dependent, K. Mansfield, B. Pucci, Christopher S. Adams, and I. M. Shapiro

Drug policy by popular referendum: This, too, shall pass, D. Marlowe, A. Elwork, David Festinger, and A. McLellan

Day treatment for cocaine dependence: Incremental utility over outpatient counseling and voucher incentives, D. Marlowe, K. Kirby, David Festinger, E. Merikle, G. Tran, and J. Platt

Carryover Effects of Free Reinforcement on Children's Work Completion, Brian K Martens, Alexandra M Hilt, Laura R Needham, James R Sutterer, Carlos J Panahon, and Amanda L. Lannie

Psychosocial oncology, Arthur M. Nezu, Christine M. Nezu, Stephanie H. Felgoise, and Marni L. Zwick