The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2003

Duct-to-duct biliary anastomosis for patients with sclerosing cholangitis undergoing liver transplantation, Thomas Heffron, Gregory Smallwood, T. Ramcharan, Laurel Davis, K. Connor, Enrique Martinez, and A. C. Stieber

Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats, Yasuhiko Ikeda, Lindon Young, and Allan M. Lefer

Adenosine A1 antagonism attenuates atropine-resistant hypoxic bradycardia in rats, J. L. Kaplan, E. Gao, L. De Garavilla, M. Victain, Bohdan M. Minczak, and W. C. Dalsey

Clinical relapses of multiple sclerosis are associated with 'novel' valleys in natural killer cell functional activity, L. F. Kastrukoff, A. Lau, R. Wee, D. Zecchini, Richard E. White, and D. W. Paty

Severity of menopausal symptoms and use of both conventional and complementary/alternative therapies, N. L. Keenan, S. Marks, A. Fugh-Berman, D. Browne, Joseph M. Kaczmarczyk, and C. Hunter

Developmental Biology and Human Evolution, C Owen Lovejoy, Melanie A. McCollum, Philip L. Reno, and Burt A. Rosenman

Cartilage viability after repetitive loading: A preliminary report, E. Luchinetti, Christopher S. Adams, W. E. Horton Jr., and P. A. Torzilli

Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells, Angela MacIntyre, R. Abramov, Christine J. Hammond, A. P. Hudson, E. J. Arking, C. Scott Little, Denah M. Appelt, and Brian J. Balin

Induction of apoptosis in skeletal tissues: Phosphate-mediated chick chondrocyte apoptosis is calcium dependent, K. Mansfield, B. Pucci, Christopher S. Adams, and I. M. Shapiro

Drug policy by popular referendum: This, too, shall pass, D. Marlowe, A. Elwork, David Festinger, and A. McLellan

Day treatment for cocaine dependence: Incremental utility over outpatient counseling and voucher incentives, D. Marlowe, K. Kirby, David Festinger, E. Merikle, G. Tran, and J. Platt

Carryover Effects of Free Reinforcement on Children's Work Completion, Brian K Martens, Alexandra M Hilt, Laura R Needham, James R Sutterer, Carlos J Panahon, and Amanda L. Lannie

Psychosocial oncology, Arthur M. Nezu, Christine M. Nezu, Stephanie H. Felgoise, and Marni L. Zwick

Project Genesis: Assessing the Efficacy of Problem-Solving Therapy for Distressed Adult Cancer Patients, Arthur M. Nezu, Christine M. Nezu, Kelly S. McClure, Stephanie H. Felgoise, and Peter S. Houts

Presence of Chapman Reflex Points in Hospitalized Patients with Pneumonia, Alexander S. Nicholas

Glycine binding primes NMDA receptor internalization, Yi Nong, Yueqiao Huang, William Ju, Lorraine V. Kalia, Gholamreza Ahmadian, Yu Tian Wang, and Michael W. Salter

Evaluation of propofol infusion syndrome in pediatric intensive care, Mark P. Okamoto, Debra L. Kawaguchi, and Alpesh N. Amin

Sexual Dimorphism in Australopithecus afarensis Was Similar to That of Modern Humans, Philip L. Reno, Richard S Meindl, Melanie A McCollum, and C Owen Lovejoy

An Organ Culture System for the Study of the Nucleus Pulposus: Description of the System and Evaluation of the Cells, M. V. Risbud, M. W. Izzo, Christopher S. Adams, W. W. Arnold, A. S. Hillibrand, E. J. Vresilovic, A. R. Vaccaro, T. J. Albert, and I. M. Shapiro

Peripheral eosinophilia and eosinophilic gastroenteritis after pediatric liver transplantation, Rene Romero, Carlos R. Abramowsky, Todd Pillen, Gregory Smallwood, and Thomas Heffron

The rational-experiential information processing system model: It's implication for cognitive therapy, J. A. Salas-Auvert and Stephanie H. Felgoise

A mediational study of computer attitudes, experience, and training interests among people with severe mental illnesses, M. S. Salzer and Virginia Burks Salzer

Nonresponders of interferon/ribavirin treatment for recurrent hepatitis C following liver transplantation, Gregory Smallwood, L. Davis, K. Connor, Enrique Martinez, A. C. Stieber, and Thomas Heffron

Gelatinase activity in synovial fluid and synovium obtained from healthy and osteoarthritic joints of dogs, Susan W. Volk, Amy S. Kapatkin, Mark E. Haskins, Raquel M. Walton, and Marina D'Angelo

Religiousness is related to quality of life in patients with ALS, Susan M. Walsh, Barbara Bremer, Stephanie S. Felgoise, and Zachary Simmons

Presence of Chapman Reflex Points in Hospitalized Patients With Pneumonia, K. Washington, R. Mosiello, Michael Venditto, John P. Simelaro, P. Coughlin, W. Crow, and Alexander Nicholas

The H4b Minor Histocompatibility Antigen Is Caused by a Combination of Genetically Determined and Posttranslational Modifications, Rajwardhan Yadav, Yoshitaka Yoshimura, Alina Boestenau, Gregory J. Christianson, Wilfred U. Ajayi, Rangaiah Shashidharamurthy, Aleksandar K. Stanic, Derry C. Roopenian, and Sebastian Joyce

Submissions from 2002

Components of extracellular matrix regulate chondrocyte apoptosis, Christopher S. Adams, K. D. Mansfield, R. Rajpurohit, H. Tachibana, C. M. Teixera, and I. M. Shapiro

The fate of the terminally differentiated chondrocyte: Evidence for microenvironmental regulation of chondrocyte apoptosis, Christopher S. Adams and I. M. Shapiro

Superoxide reductase: Fact or fiction?, M. W. Adams, Francis E. Jenney Jr., M. D. Clay, and M. K. Johnson

Paradoxical intention, L. Michael Ascher

Sequential extracts of human bone show differing collagen synthetic rates., J. Babraj, D. J. Cuthbertson, P. Rickhuss, W. Meier-Augenstein, K. Smith, J. Bo, R. R. Wolfe, J. N. Gibson, Christopher S. Adams, and M. J. Rennie


Polarized fluorescence depletion reports orientation distribution and rotational dynamics of muscle cross-bridges, Marcus G. Bell, Robert E. Dale, Uulke A. Van Der Heide, and Yale E. Goldman

The transforming growth factor-β-inducible matrix protein βig-h3 interacts with fibronectin, P. C. Billings, J. Charles Whitbeck, Christopher S. Adams, W. R. Adams, A. J. Cohen, B. N. Engelsberg, P. S. Howard, and J. Rosenbloom

RGD peptides immobilized on a mechanically deformable surface promote osteoblast differentiation, E. A. Cavalcanti-Adam, I. M. Shapiro, R. J. Composto, E. J. Macarak, and Christopher S. Adams

A neutron crystallographic analysis of a rubredoxin mutant, T. Chatake, K. Kurihara, I. Tanaka, M. W. Adams, Francis E. Jenney Jr., I. Tsyba, R. Bau, and N. Niimura

Spectroscopic studies of Pyrococcus furiosus superoxide reductase: Implications for active-site structures and the catalytic mechanism, M. D. Clay, Francis E. Jenney Jr., P. L. Hagedoorn, G. N. George, M. W. Adams, and M. K. Johnson

Resonance Raman characterization of the mononuclear iron active-site vibrations and putative electron transport pathways in Pyrococcus furiosus superoxide reductase, M. D. Clay, Francis E. Jenney Jr., H. J. Noh, P. L. Hagedoorn, M. W. Adams, and M. K. Johnson

Mismatch of School Desks and Chairs by Ethnicity and Grade Level in Middle School, Lance M Cotton, Dennis G O'Connell, Phillip B. Palmer, and Marsha D Rutland

Human gingival fibroblasts produce nitric oxide in response to proinflammatory cytokines, Farzaneh Daghigh, Ruth C. Borghaei, Ruth D. Thornton, and Joseph H. Bee

Anxiety disorders: An overview, Robert A. DiTomasso and Elizabeth A. Gosch

Anxiety disorders: An overview, Robert A. Ditomasso and Elizabeth A. Gosch

Clinical case presentation: The case of Sandra, Robert A. DiTomasso and Elizabeth A. Gosch

Comparative treatments for anxiety disorders, Robert A. DiTomasso and Elizabeth A. Gosch

Comparison of treatment approaches, Robert A. DiTomasso and Elizabeth A. Gosch

Advanced concepts in interventional spine care., Gerald E. Dworkin

Problem-solving approaches to treating anxiety disorders, Stephanie Felgoise, Arthur M. Nezu, and Christine Nezu

From telephone to office: Intake attendance as a function of appointment delay, David Festinger, R. Lamb, D. Marlowe, and K. Kirby

Status hearings in drug court: When more is less and less is more, David Festinger, D. Marlowe, P. Lee, K. Kirby, G. Bovasso, and A. McLellan

Response decision processes and externalizing behavior problems in adolescents, R. G. Fontaine, Virginia Burks Salzer, and K. A. Dodge

Modifying therapeutic homework for patients with personality disorders, A Freeman and Bradley M. Rosenfield

Dreams and the dream image: Using dreams in cognitive therapy, Arthur Freeman and Beverly White

Adjuncts to opioid therapy., Frederick J. Goldstein


STAT6 mediates interleukin-4 growth inhibition in human breast cancer cells, Jennifer L. Gooch, B. Christy, and D. Yee

Sirolimus-based immunosuppresive protocol for calcineurin sparing in liver transplantation, Thomas Heffron, Gregory Smallwood, L. Davis, E. Martinez, and A. C. Stieber

Autoimmune hepatitis following liver transplantation: Relationship to recurrent disease and steroid weaning, Thomas Heffron, Gregory Smallwood, B. Oakley, Todd Pillen, D. Welch, Enrique Martinez, Rene Romero, and A. C. Stieber

Liver transplant induction trial of daclizumab to spare calcineurin inhibition, Thomas Heffron, Gregory Smallwood, Todd Pillen, Laurel Davis, Enrique Martinez, Rene Romero, and A. C. Stieber

The virulence of mouse hepatitis virus strain A59 is not dependent on efficient spike protein cleavage and cell-to-cell fusion, Susan T. Hingley, Isabelle Leparc-Goffart, Suhun Seo, Jean C. Tsai, and Susan R. Weiss

Social adjustment of family members and significant others (FSOs) of drug users, C. Hudson, K. Kirby, M. Firely, David Festinger, and D. Marlowe

Attenuation of neutrophil-mediated myocardial ischemia-reperfusion injury by a calpain inhibitor, Yasuhiko Ikeda, Lindon Young, and Allan M. Lefer

Vascular effects of poly-N-acetylglucosamine in isolated rat aortic rings, Yasuhiko Ikeda, Lindon Young, John N. Vournakis, and Allen M. Lefer

Stretch-induced calcium release in smooth muscle, G. Ji, Robert J. Barsotti, M. E. Feldman, and M. I. Kotlikoff

Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells, Angela MacIntyre, Christine J. Hammond, C. Scott Little, Denah M. Appelt, and Brian J. Balin

Sensitivity of Children's Behavior to Probabilistic Reward: Effects of a Decreasing-Ratio Lottery System on Math Performance, Brian K Martens, Scott P Ardoin, Alexandra M Hilt, Amanda L. Lannie, Carlos J Panahon, and Laurie A Wolfe

Student Perceptions about Participation in Community Service in Rural Northern Georgia, Carol A. Miller

Advantages Osteopathic Family Physicians Have in the Treatment of Low Back Pain, Alexander S. Nicholas and N. Oleski

Osteopathic Manipulative Treatment for Postoperative Pain, Alexander S. Nicholas and N. Oleski

Prevalence of depressive symptoms in patients being evaluated for liver transplantation, E. R. Norris, Gregory Smallwood, K. Connor, K. McDonell, Enrique Martinez, A. C. Stieber, and Thomas Heffron

Induction of peritoneal sepsis increases the susceptibility of isolated hearts to a calcium paradox-mediated injury, A. Omachi, Avadhesh C. Sharma, K. J. Alden, A. D. Sam, and J. L. Ferguson

Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins, Thomas W. O'Rourke, Nicole A. Doudican, Melinda Maris, Paul W. Doetsch, and Gerald S. Shadel

Electrostatic potential surfaces of 5-HT3R agonists suggest accessory cation-p site adjacent to agonist binding domain, Harish S. Parihar and Karen S. Kirschbaum

Use of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 (COX-2) inhibitors: Indications and complications, Richard A. Pascucci

Matrix regulation of skeletal cell apoptosis II: Role of arg-gly-asp-containing peptides, R. L. Perlot Jr., I. M. Shapiro, K. Mansfield, and Christopher S. Adams

Psychopharmacological treatment, Agnieszka Popiel, Lynn Montgomery, and Robert A. DiTomasso

Sepsis-induced depressed contractile function of isolated ventricular myocytes is due to altered calcium transient properties, J. Ren, B. H. Ren, and Avadhesh C. Sharma

Decompensation characterized by decreased perfusion of the heart and brain during hemorrhagic shock: Role of endothelin-1, Avadhesh C. Sharma, G. Singh, and A. Gulati

Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution, Rangaiah Shashidharamurthy, D. K. Jagadeesha, K. S. Girish, and K. Kemparaju

Osteoporosis screening in an outpatient liver transplant clinic: Impact of primary immunosuppression, Gregory A. Smallwood, Julie M. Wickman, E. Martinez, A. C. Stieber, and T. G. Heffron

Hepatitis C treatment outcomes of African Americans following liver transplantation, Gregory Smallwood, G. Coffey, L. Davis, Enrique Martinez, A. C. Stieber, and Thomas Heffron

Can patients awaiting liver transplantation elicit an immune response to the hepatitis A vaccine?, Gregory Smallwood, C. T. Coloura, Enrique Martinez, A. C. Stieber, and Thomas Heffron

Mycophenolate's influence in the treatment of recurrent hepatitis C following liver transplantation, Gregory Smallwood, L. Davis, Enrique Martinez, A. C. Stieber, and Thomas Heffron

Renal sparing effects of mycophenolate when used in long-term liver transplant receipients, Gregory Smallwood, A. C. Stieber, L. Davis, Enrique Martinez, and Thomas Heffron


The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification, Liesbeth Van Wesenbeeck, Paul R. Odgren, Carole A. MacKay, Marina D'Angelo, Fayez F. Safadi, Steven N. Popoff, Wim Van Hul, and Sandy C. Marks Jr.


Functional group interactions of a 5-HT3R antagonist, Padmavati Venkataraman, Prasad Joshi, Srinivasan P. Venkatachalan, Mani Mathalagi, Harish S. Parihar, Karen S. Kirschbaum, and Marvin K. Schulte

Medical Professionalism and the Role of State Medical Boards, Matthew Weinberg

The Right-to-Die Movement, Matthew D. Weinberg

Estrogen and vascular function, Richard E. White

Endothelium-independent effect of estrogen on Ca2+-activated K+ channels in human coronary artery smooth muscle cells, Richard E. White, Guichun Han, Melissa Maunz, Christiana Dimitropoulou, Abdalla M. El-Mowafy, Robert S. Barlow, John D. Catravas, Connie Snead, Gerald O. Carrier, and Shu Zhu

Managed care gatekeeping, emergency medicine coding, and insurance reimbursement outcomes for 980 emergency department visits from four states nationwide, G. O. Young, J. Ellis, John W. Becher Jr., C. Yeh, J. Kovar, and M. A. Levitt

Mg2+ efflux from the isolated perfused rabbit heart is mediated by two states of the ß1-adrenergic receptor, Lindon Young, Andrea Bercute-Dammann, and Margaret T. Weiss

Cloning and molecular characterization of two mosquito iron regulatory proteins, Dianzheng Zhang, G. Dimopoulos, A. Wolf, B. Minana, F. Kafatos, and Joy J. Winzerling

PGE2 action in human coronary artery smooth muscle: Role of potassium channels and signaling cross-talk, Shu Zhu, Guichun Han, and Richard E. White

Submissions from 2001

Sezary T Cell Activating Factor is a Chlamydia pneumoniae Associated Protein, J. Todd Abrams, Brian J. Balin, and Eric C. Vonderheid

Apoptosis and Bone Disease, Christopher S. Adams and W. E. Horton

Apoptosis and bone disease, Christopher S. Adams and W. E. Horton Jr.

A novel mechanism of body mass regulation, Christopher S. Adams, A. I. Korytko, and J. L. Blank

Matrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ions, Christopher S. Adams, K. Mansfield, R. L. Perlot, and I. M. Shapiro

Steroid withdrawal in liver transplant recipients, Rebecca Adams, Robin Chapman, and Gregory Smallwood

An in vivo model for investigating bilateral synaptic plasticity across CA3/CA1 synapses in guinea pig dorsal hippocampus, S. Chirwa, J. Mack, R. Park, K. Dennis, and Adwoa Aduonum

Authentic matrix vesicles contain active metalloproteases (MMP): A role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-ß, Marina D'Angelo, Paul C. Billings, Maurizio Pacifici, Phoebe S. Leboy, and Thorsten Kirsch