The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.

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Submissions from 1994

Identification of peplomer cleavage site mutations arising during persistence of MHV-A59, James L. Gombold, Susan T. Hingley, and Susan R. Weiss

Healing of incisions in the tongue: A comparison of results with milliwatt carbon dioxide laser tissue welding versus suture repair, Charlotte H. Greene, Domenic A. DiBias, Maryanne J. Henderson, Rosemary Fair-Covely, Bryan Dorf, Alex L. Radin, and Wanda L. Young-Seidman

Prazosin blocks the pressor but not the regional circulatory effects of diaspirin crosslinked hemoglobin, A. Gulati and Avadhesh C. Sharma

Effect of stroma-free hemoglobin and diaspirin cross-linked hemoglogbin on the regional circulation and systematic hemodynamics, A. Gulati, Avadhesh C. Sharma, and K. E. Burhop

MHV-A59 fusion mutants are attenuated and display altered hepatotropism, Susan T. Hingley, James L. Gombold, Ehud Lavi, and Susan R. Weiss

Are there two types of diabetic foot ulcers?, R. D. Hoeldtke, K. M. Davis, P. B. Hshieh, S. Gaspar, and Gerald E. Dworkin

Roles of the soluble cytochrome c2 and membrane-associated cytochrome cy of rhodobacter capsulatus in photosynthetic electron transfer, Francis E. Jenney Jr.

Cognitive-behavioral interventions, Philip C. Kendall and Elizabeth A. Gosch

Gaba-B receptors and nociception, S. K. Kulkarni and Avadhesh C. Sharma

Rat anococcygeus: A dynamic smooth muscle preparation for experimental pharmacology, S. K. Kulkarni and Avadhesh C. Sharma

Reversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat(R)), a herbal preparation, S. K. Kulkarni and Avadhesh C. Sharma

Activation of skinned trabeculae of the guinea pig induced by laser photolysis of caged ATP, H. Martin and Robert J. Barsotti

Relaxation from rigor of skinned trabeculae of the guinea pig induced by laser photolysis of caged ATP, H. Martin and Robert J. Barsotti

Interactions between Sertoli cells and germ cells in the testis, Michael P. McGuinness and M. P. Griswold

Relationship of a mouse Sertoli cell line (MSC-1) to normal Sertoli cells, Michael P. McGuinness, C. C. Linder, C. R. Morales, L. L. Heckert, J. Pikus, and M. D. Griswold

Fibronectin inhibition of platelet thrombus formation in an in vivo porcine model of vascular injury., D G Moon, Brian Matayoshi, L K Weston, F L Minnear, and J E Kaplan

Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini, J. W. Regan, T. J. Bailey, J. E. Donello, K. L. Pierce, D. J. Pepperl, Dianzheng Zhang, K. M. Kedzie, C. E. Fairbairn, A. M. Bogardus, and D. F. Woodward

Effect of diaspirin cross-linked hemoglobin and norepinephrine on systemic hemodynamics and regional circulation in rats., Avadesh C. Sharma and A. Gulati

Dopamine receptor mediated antidepressant action of B-HT 920 in mice, Avadesh C. Sharma and S. K. Kulkarni

On the characterization of dopamine-induced contractile response of rat anococcygeus muscle preparation, Avadesh C. Sharma and S. K. Kulkarni

Regional circulatory and systemic hemodynamic effects of diaspirin cross-linked hemoglobin in the rat, Avadesh C. Sharma, S. K. Kulkarni, and A. Gulati

Renal endothelin mechanism in altered thyroid states, G. Singh, Avadhesh C. Sharma, E. B. Thompson, and A. Gulati

σ antagonist and k agonist activity of naltriben: Evidence for differential k interaction with the σ1 and σ2 opioid receptor subtypes, Peggy E. Stewart, E. M. Holper, and D. L. Hammond

Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes., Desuo Wang and Luiz Belardinelli

Submissions from 1993

PC-based multiparameter full-color display for tissue segmentation in MRI of adnexal masses, H. Keith Brown, T. R. Hazelton, A. K. Parsons, J. V. Fiorica, C. G. Berman, and M. L. Silbiger

Characteristics of DNA replication in isolated nuclei initiated by an aprotinin-binding protein, F. D. Coffman, Kerin L. Fresa, M. Hameed, and S. Cohen

In vitro replication of plasmids containing human ribosomal gene sequences: Origin localization and dependence on an aprotinin-binding cytosolic protein, F. D. Coffman, I. Georgoff, Kerin L. Fresa, J. Sylvester, I. Gonzalez, and S. Cohen

In Vitro and in Vivo Expression of Alpha 7 Integrin and Desmin Define the Primary and Secondary Myogenic Lineages, Mindy George-Weinstein, Rachel F. Foster, Jacquelyn Gerhart, and Stephen J. Kaufman

Fusion-defective mutants of mouse hepatitis virus A59 contain a mutation in the spike protein cleavage signal, James L. Gombold, Susan T. Hingley, and Susan R. Weiss

Basic fibroblast growth factor is a testicular germ cell product which may regulate sertoli cell function, I. S. Han, S. R. Sylvester, K. H. Kim, M. E. Schelling, S. Venkateswaran, V. D. Blanckaert, Michael P. McGuinness, and M. D. Griswold

A novel membrane-associated c-type cytochrome, cyt cy, can mediate the photosynthetic growth of Rhodobacter capsulatus and Rhodobacter sphaeroides, Francis E. Jenney Jr. and F. Daldal

GABA receptor mediated anticonvulsant action of Withania somnifera root extract, S. K. Kulkarni, Avadhesh C. Sharma, A. Verma, and M. K. Ticku

Fatal fulminant autoimmune haemolytic anaemia associated with tolmetin use and gastric carcinoma. Case report and literature review, J. R. Larsen and John W. Becher Jr.

Functional characterization of alpha adrenoceptors on rabbit intrarenal arteries in vitro, Mary P. Owen

Similarities and differences in the postjunctional role for neuropeptide Y in sympathetic vasomotor control of large vs. small arteries of rabbit renal and ear vasculature, Mary P. Owen

(±)Baclofen sensitive scopolamine-induced short-term memory deficits in mice, Avadesh C. Sharma and S. K. Kulkarni

Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats, Avadesh C. Sharma and S. K. Kulkarni

Involvement of inhibitory dopamine-2 receptors in resting bradycardia in exercise-conditioned rats, Kenneth J. Slavik and J. LaPointe

Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia, Kenneth J. Slavik and J. E. Szilagyi

Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation, Richard E. White, A. B. Lee, A. D. Shcherbatko, T. M. Lincoln, A. Schonbrunn, and D. L. Armstrong

The Survivors Project, Bruce S. Zahn and Seran E. Schug

Submissions from 1992

Composite and classified color display in MR imaging of the female pelvis, H. Keith Brown, T. R. Hazelton, J. V. Fiorica, A. K. Parsons, L. P. Clarke, and M. L. Silbiger

Tomographic abdominal anatomy with magnetic resonance color composites, H. Keith Brown, T. R. Hazelton, L. M. Putnam, and M. L. Silbiger

Cognitive therapy of personality disorders., A. Freeman, D. D. Davis, and Robert A. DiTomasso

Factors Affecting Drug Response, Frederick J. Goldstein and R. F. Orzechowski

Pharmacodynamics, Frederick J. Goldstein and R. F. Orzechowski

Angiographic magnetic resonance color composites of the normal brain and its vasculature, T. R. Hazelton and H. Keith Brown

Autonomic surface potential analysis: Assessment of reproducibility and sensitivity, R. D. Hoeldtke, K. M. Davis, P. B. Hshieh, S. Gaspar, and Gerald E. Dworkin

Crystallization and oligomeric structure of rat liver arginase, Zoltan F. Kanyo, Cheau-Yun Chen, Farzaneh Daghigh, David E. Ash, and David W. Christianson

Cw holmium for medical applications: a preliminary study, Ronald A. Kirschner, Domenic DiBias, Charlotte H. Greene, Eric Brown, Corneliu Dimitriu, Alexander C. Keszeli, and Andrew Kirschner

Recent trends in information storage mechanisms, S. K. Kulkarni and Avadhesh C. Sharma

Benign Metastasizing Leiomyoma A Case Report and Review of the Literature, Daniel Parenti, T. F. Morley, and J. C. Giudice

Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice, Avadesh C. Sharma and S. K. Kulkarni

Naloxone-induced bradycardia in pithed rats: Evidence for an interaction with the peripheral sympathetic nervous system and alpha-2 adrenoceptors, Kenneth J. Slavik and J. E. Szilagyi

Therapeutic considerations: Lower respiratory tract infections in smokers, Michael A. Venditto

Differential Morphologic and Metabolic Alterations in Permissive Versus Nonpermissive Murine Macrophages Infected with Legionella Pneumophila, Yoshimasa Yamamoto, Thomas W. Klein, H. Keith Brown, and Herman Friedman

Submissions from 1991

Neurofilament Assembly in vitro: Biochemical, morphological and Immunoelectron Microscopic Studies Employing Monoclonal Antibodies to Defined Epitopes, Brian J. Balin, Edwin A. Clark, John Q. Trojanowski, and Virginia M.-Y. Lee

Individual Neurofilament Subunits Reassembled in vitro Exhibit Unique Biochemical, Morphological and Immunological Properties, Brian J. Balin and Virginia M.-Y. Lee

Uterine junctional zone: Correlation between histologic findings and MR imaging, H. Keith Brown

Generation of Color Composites for Enhanced Tissue Differentiation in Magnetic Resonance Imaging of the Brain, H. Keith Brown, T R Hazelton, and M L Silbiger

Initiation of lymphocyte DNA synthesis, F. D. Coffman, Kerin L. Fresa, and S. Cohen

Control of DNA replication in a transformed lymphoid cell line: Coexistence of activator and inhibitor activities, F. D. Coffman, Kerin L. Fresa, I. Oglesby, and S. Cohen

Transforming growth factor-ß modulation of glycosaminoglycan production by mesenchymal cells of the developing murine secondary palate, Marina D'Angelo and Robert M. Greene

Airway foreign bodies: A diagnostic challenge, C. J. Di Marco, Theodore P. Mauer, and R. N. Reinhard

The development of a patient satisfaction questionnaire in the ambulatory setting, Robert A. DiTomasso and M. A. Willard

Early detection of stage A prostate carcinoma: Combined use of prostate- specific antigen and transrectal ultrasonography, R. L. Fiorelli, R. L. Klaus, S. J. Manfrey, Laurence Belkoff, and Larry Finkelstein

Immunodetection of the transforming growth factors ß1 and ß2 in the developing murine palate, A. L. Gehris, Marina D'Angelo, and Robert M. Greene

In Vitro Development of Precursor Cells in the Myogenic Lineage, Stephen J. Kaufman, Mindy George-Weinstein, and Rachel F. Foster

Interferon-gamma Induced Resistance to Legionella Pneumophila in Susceptible A/J Mouse Macrophages., T W Klein, Y Yamamoto, H. Keith Brown, and H Friedman

Emergency intubation for paralysis of the uncooperative trauma patient, J. Kuchinski, G. Tinkoff, M. Rhodes, and John W. Becher Jr.

Elevated plus-maze: A novel psychobehavioral tool to measure anxiety in rodents, S. K. Kulkarni and Avadhesh C. Sharma

A method for maintaining and protecting chronic arterial and venous catheters in conscious rats, S. Z. Kurowski, Kenneth J. Slavik, and J. E. Szilagyi

Interaction of delta-9-tetrahydrocannabinol with herpesviruses and cultural conditions associated with drug-induced anti-cellular effects, G. Lancz, S. Specter, and H. Keith Brown

Suppressive effect of σ-9-tetrahydrocannabinol on herpes simplex virus infectivity in vitro, G. Lancz, S. Specter, and H. Keith Brown

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau, Virginia M. Lee, Brian J. Balin, L Otvos Jr., and John Q. Trojanowski

Transforming growth factor-ß receptor profiles of human and murine embryonic palate mesenchymal cells, Kersti K. Linask, Marina D'Angelo, Amy Gehris, and Robert M. Greene

Antibody Labling of Bovine Neurofilaments: Implications on the Structure of Neurofilament Sidearms, Lizanne Mulligan, Brian J. Balin, Virginia M.-Y. Lee, and Wallace Ip

Somatic component to myocardial infarction: Three year follow up, Alexander S. Nicholas, Domenic A. DiBias, and Charlotte H. Greene

Effects of MK-801 and ketamine on short-term memory deficits in passive avoidance step-down task paradigm in mice, Avadesh C. Sharma and S. K. Kulkarni

MK-801 produces antianxiety effect in elevated plus-maze in mice, Avadesh C. Sharma and S. K. Kulkarni

Effect of NMDA-receptor ligands on neocortical and hippocampal EEG activity of rat brain, Avadesh C. Sharma, S. K. Kulkarni, and U. Nayar

Dizocilpine, ketamine and ethanol reverse NMDA-induced EEG changes and convulsions in rats and mice, Avadesh C. Sharma, S. N. Thorat, U. Nayar, and S. K. Kulkarni

Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylation, Richard E. White, Agnes Schonbrunn, and David L. Armstrong

Submissions from 1990

Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase, M V. Autieri, Kerin L. Fresa, F. D. Coffman, M. E. Katz, and S. Cohen

Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase., M. V. Autieri, Kerin L. Fresa, F. D. Coffman, M. E. Katz, and S. Cohen

The behavioral treatment of essential hypertension: Implications for medical psychotherapy, Robert A. DiTomasso and Orlando F. Mills

Rehabilitation of the acutely injured hand, Gerald E. Dworkin and J. Spears

Priapism associated with intranasal cocaine abuse, R. L. Fiorelli, S. J. Manfrey, Laurence Belkoff, and Larry Finkelstein

Effect of Chronic Antidepressant Administration upon Opioid Analgesia, Frederick J. Goldstein

Effects of chronic clomipramine on central DADLE antinociception, Frederick J. Goldstein, R. T. Malseed, and J. F. Nutz

The effect of helium-neon laser and osteopathic manipulation on soft-tissue trigger points, Charlotte H. Greene, Domenic A. DiBias, D. Helig, Alexander S. Nicholas, K. England, W. Ehrenfeuchter, and Wanda L. Young

Selecting and using early childhood rating scales, George McCloskey

Pericardial effects on diastolic ventricular interaction during development, Bohdan M. Minczak, M. R. Wolfson, W. P. Santamore, and T. H. Shaffer

Methyldopa-induced hemolytic anemia in a 15 year old presenting as near-syncope, J. S. Naidorf, J. M. Kennedy, and John W. Becher Jr.

Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice, Avadesh C. Sharma and S. K. Kulkarni

A cytoplasmic activator of DNA replication is involved in signal transduction in antigen-specific T cell lines, R. L. Wong, R. B. Clark, J. Gutowski, M. E. Katz, Kerin L. Fresa, and S. Cohen

Submissions from 1989

Paradoxical intention: Its clarification and emergence as a conventional behavioral procedure, L. Michael Ascher

Triggering Terminal Myogenic Differentiation, D. Boettiger, Mindy George-Weinstein, and A. S. Menko

Coping styles, paradox, and the cold pressor task, J. S. Efran, R. L. Chorney, L. Michael Ascher, and M. D. Lukens

Intracellular mechanisms of lymphoid cell activation, Kerin L. Fresa, M. Hameed, and S. Cohen