The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.

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Submissions from 2000

Preparation of Chick Striated Muscle Cultures, Camille DiLullo, Jacquelyn Gerhart, and Mindy George-Weinstein

Medical patients in crisis, Robert A. DiTomasso, Donna M. Martin, and Karel D. Kovnat

DNA dendrimers localize MyoD mRNA in presomitic tissues of the chick embryo, Jacquelyn Gerhart, M. Baytion, S. Deluca, R. Getts, C. Lopez, R. Niewenhuis, T. Nilsen, S. Olex, H. Weintraub, and Mindy George-Weinstein

Clinical research: The process, Frederick J. Goldstein

Study underscores need to consider multiple factors in debate on physician-assisted suicide., Frederick J. Goldstein

The role of p21 in interferon-gamma-mediated growth inhibition of human breast cancer cells, Jennifer L. Gooch, R. E. Herrera, and D. Yee

Dopamine relaxes porcine coronary arteries and stimulates potassium channel activity in porcine coronary arterial smooth muscle cells, Guichun Han, J. P. McMillin, and Richard E. White

Nuclear Notch1 signaling and the regulation of dendritic development, Lori Redmond Hardy, Sang-rog Oh, Carol Hicks, Gerry Weinmaster, and Anirvan Ghosh

Identification and localization of TBX5 transcription factor during human cardiac morphogenesis, Cathy J. Hatcher, Marsha M. Goldstein, Caroline S. Mah, C. Susan Delia, and Craig T. Basson

Atrial form and function: Lessons from human molecular genetics, Cathy J. Hatcher, Minsu Kim, and Craig T. Basson

Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature, G. J. Hernandez, Francis E. Jenney Jr., M. W. Adams, and D. M. Lemaster

Cardioprotective effects of citrulline in ischemia/reperfusion injury via a non-nitric oxide-mediated mechanism, Yasuhiko Ikeda, Lindon Young, Rosario Scalia, and Allen M. Lefer

Diazepam, y-aminobutyric acid, and progesterone open K+ channels in myocytes from coronary arteries, Maryanne K. Jacob and Richard E. White

Caring for Low Back Pain, Evaluation and Management of Acute Low Back Pain, V. Jaeger, N. DiNubile, and Alexander S. Nicholas

Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition, A. V. Lee, J. L. Gooch, S. Oesterreich, R. L. Guler, and D. Yee

Ultrastructural analysis of beta-amyloid production in monocytes, epithelial, and endothelial cells infected with Chlamydia pneumoniae isolated from Alzheimer brains, Christopher S. Little, A. MacIntyre, Christine Hammond, E. Venuti, B. J. Bromke, Brian J. Balin, and Denah M. Appelt

An alternative to synthetic aortic grafts using Jejunum, S. E. Marshall, S. M. Tweedt, Charlotte H. Greene, and et al.

Inorganic phosphate induces apoptosis of osteoblast-like cells in culture, Z. Meleti, I. M. Shapiro, and Christopher S. Adams

Calcium-activated potassium channels and nitric oxide coregulate estrogen-induced vasodilation, Charles R. Rosenfeld, Richard E. White, Tim Roy, and Blair E. Cox

Adenosine and nitric oxide regulate regional vascular resistance via interdependent and independent mechanisms during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law

Interdependence of adenosine and nitric oxide in hepato-splanchnic circulation during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law

Central versus peripheral mediation of naloxone's perfusion effects in endotoxic rats, Avadhesh C. Sharma, A. D. Sam II, K. J. Alden, S. L. Moore, W. R. Law, and J. L. Ferguson

Loading of calcium and strontium into the sarcoplasmic reticulum in rat ventricular muscle, C. I. Spencer, Robert J. Barsotti, and J. R. Berlin

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts, Ruth D. Thornton, P. Lane, Ruth C. Borghaei, E. A. Pease, J. Caro, and Eugene Mochan

Rational design of cytotoxic T-cell inhibitors, Anna P. Tretiakova, C. Scott Little, Kenneth J. Blank, and Bradford A. Jameson

Utilization of Bone Morphogenetic Protein Receptors during Chondrocyte Maturation., Susan W. Volk, Marina D'Angelo PhD, David Diefenderfer, and Phoebe S. Leboy

Tetraethylammonium potentiates the activity of muscarinic potassium channels in guinea-pig atrial myocytes., Desuo Wang and David L. Armstrong

Caring for Our Patients, Matthew D. Weinberg

Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia., Kristin Wijsanen Weitzel, Julie M. Wickman, Sara Grimsley Augustin, and J. Grady Strom

cAMP-dependent vasodilators cross-activate the cGMP-dependent protein kinase to stimulate Bk(Ca) channel activity in coronary artery smooth muscle cells, Richard E. White, Jonathan P. Kryman, Abdalla M. El-mowafy, Guichun Han, and Gerald O. Carrier

Recognizing and treating tardive dyskineseia, Julie M. Wickman and J. M. Cold

Combinations of variations in multiple genes are associated with hypertension., S M Williams, J H Addy, J A Phillips, M Dai, J Kpodonu, J Afful, H Jackson, K Joseph, F Eason, M M Murray, P Epperson, Adwoa Aduonum, L J Wong, P A Jose, and R A Felder

Distinct subcellular localization and mRNA expression of neuronal nitric oxide synthase in the nucleus dorsalis and red nucleus and their correlation with inducible transcription factors after spinal cord hemisection, Mei Xu, Yee-Kong Ng, and Seng-Kee Leong

Neuroprotective and neurodestructive functions of nitric oxide after spinal cord hemisection, Mei Xu, Yee-Kong Ng, and Seng-Kee Leong

Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states, A. P. Yeh, Y. Hu, Francis E. Jenney Jr., Michael W. Adams, and D. C. Rees

C-peptide exerts cardioprotective effects in myocardial ischemia-reperfusion, Lindon Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer

Wortmannin, a potent antineutrophil agent, exerts cardioprotective effects in myocardial ischemia/reperfusion, Lindon Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer

Induction of high levels of epitope-specific antibodies by epitope/peptide candidate vaccines against human immunodeficiency virus type- 1 (HIV-1), Tianwei Yu, Yun Bai, Manfred P. Dierich, and Ying-Hua Chen

Human interferon-ß inhibits binding of HIV-1 gp41 to lymphocyte and monocyte cells and binds the potential receptor protein P50 for HIV-1 gp41, Tianwei Yu, Yi Xiao, Yun Bai, Qinhua Ru, Guoan Luo, Manfred P. Dierich, and Ying-Hua Chen

Submissions from 1999

Paradoxical intention and recursive anxiety, L. Michael Ascher and D. E. Schotte

Complementary and alternative medicine: herbal therapies for diabetes., B. M. Berman, J. P. Swyers, and Joseph M. Kaczmarczyk

Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3), Ruth C. Borghaei, C. Sullivan, and Eugene Mochan

Modulation of major histocompatibility complex antigen expression by human immunodeficiency virus-2 gp36, Ying-Hua Chen, Yun Bai, Tianwei Yu, and Manfred P. Dierich

Immunogenicity of the GPGRAFY epitope on synthetic peptides, Ying-Hua Chen, Tianwei Yu, Yun Bai, and M. P. Dierich

Two proteins share immunological epitopes on the tumor-associated antigen 17-1A, Ying-Hua Chen, Tianwei Yu, Yun Bai, and Nanming Zhao

The ADP release step of the smooth muscle cross-bridge cycle is not directly associated with force generation, J. A. Dantzig, Robert J. Barsotti, S. Manz, H. L. Sweeney, and Y. E. Goldman

Hepatocyte Growth Factor/Scatter Factor Promotes a Switch From E- to N-cadherin in Chick Embryo Epiblast Cells., Steven M. DeLuca, Jacquelyn Gerhart, Eric Cochran, Eileen Simak, Jennifer Blitz, Michelle Mattiacci-Paessler, Karen Knudsen, and Mindy George-Weinstein

Precept-assist: A computerized, data-based evaluation system, Robert A. DiTomasso, J. D. Gamble, and M. A. Willard

Caring for the caregivers., Katherine Galluzzi

Frequency of Apoliprotein E (APOE) Allele Types in Pateinets with Chlamydia-Associated Arthritis and other Arthridities, Hervé C. Gérard, Geng Feng Wang, Brian J. Balin, H. Ralph Schumacher, and Alan P. Hudson

DOs need more training in diagnosing and treating addiction, Frederick J. Goldstein

Kevorkian kills patients along with the clinical research to help them, Frederick J. Goldstein

Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death - Proliferative and anti-apoptotic effects, Jennifer L. Gooch, C. L. Van Den Berg, and D. Yee

Strain-specific differences in formation of apoptotic DNA ladders in MCF-7 breast cancer cells, Jennifer L. Gooch and D. Yee

Identification of IL-1 regulated genes in human synovial and gingival fibroblasts by differential display, G. K. Gorski, M. Paul, H. Soohoo, Ruth C. Borghaei, Eugene Mochan, Ruth D. Thornton, and E. A. Pease

Excessive microtubules are not responsible for depressed force per cross-bridge in cardiac neural-crest-ablated embryonic chick hearts, Cathy J. Hatcher, Robert E. Godt, and T. M. Nosek

Anaerobic microbes: Oxygen detoxification without superoxide dismutase, Francis E. Jenney Jr., M. F. Verhagen, X. Cui, and M. W. Adams

Community reinforcement training for family and significant others of drug abusers: A unilateral intervention to increase treatment entry of drug users, K. Kirby, D. Marlowe, David Festinger, K. Garvey, and V. Lamonaca

Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo, A. V. Lee, J. G. Jackson, J. L. Gooch, S. G. Hilsenbeck, E. Coronado-Heinsohn, C. K. Osborne, and D. Yee

Interobserver variability among faculty in evaluations of residents' clinical skills, J. Mantia, W. Rennie, D. Risucci, R. Cydulka, L. Spillane, L. Graff, John W. Becher Jr., and K. Kleinschmidt

Cardiopulmonary bypass increases coronary IL-8 in diabetic patients without evidence of reperfusion injury, S. I. Nawas, J. C. Doherty, W. T. Vigneswaran, B. G. Fogelson, M. A. McMillen, J. L. Ferguson, Avadhesh C. Sharma, and W. R. Law

Osteopathic Manipulation for Management of Pain, Alexander S. Nicholas, T. Bezilla, and R. Jones

COX-2-specific inhibition: implications for clinical practice., Richard A. Pascucci

Internal representational models of peers: implications for the development of problematic behavior., Virginia Burks Salzer, K. A. Dodge, J. M. Price, and R. D. Laird

Knowledge structures, social information processing, and children's aggressive behavior, Virginia Burks Salzer, R. D. Laird, K. A. Dodge, G. S. Pettit, and J. E. Bates

Sepsis produces depression of testosterone and steroidogenic acute regulatory (StAR) protein, A. D. Sam II, Avadhesh C. Sharma, L. Y. Lee, D. B. Hales, W. R. Law, J. L. Ferguson, and H. B. Bosmann

In situ localization and characterization of active proteases in chronically inflamed and healthy human gingival tissues, David P. Sarment, Jonathan Korostoff, Marina D'Angelo, Alan Polson, Ray Feldman, and Paul Billings

Elevated coronary endothelin-1 but not Nitric oxide in diabetics during CABG, Avadhesh C. Sharma, B. G. Fogelson, S. I. Nawas, W. T. Vigneswaran, A. D. Sam II, K. J. Alden, J. L. Ferguson, and W. R. Law

Secondary structure extensions in Pyrococcus furiosus ferredoxin destabilize the disulfide bond relative to that in other hyperthermostable ferredoxins. Global consequences for the disulfide orientational heterogeneity, P. L. Wang, L. Calzolai, K. L. Bren, Q. Teng, Francis E. Jenney Jr., P. S. Brereton, J. B. Howard, M. W. Adams, and G. N. La Mar

Suspected Medicine Theft by a Co-Worker: What Role Should a Nurse Play?, Matthew D. Weinberg

Molecular cloning and characterization of LKv1, a novel voltage-gated potassium channel in leech, Jamie L. Weiss, Jay Yang, Chunfa Jie, Diana L. Walker, Shawn Ahmed, Yunxia Zhu, Yueqiao Huang, Kristen M. Johansen, and Jørgen Johansen

Making cents out of caring for patients., Julie M. Wickman, R. Jackson, and J. Marquess

Submissions from 1998

Chondrocyte apoptosis increases with age in the articular cartilage of adult animals, Christopher S. Adams and W. E. Horton Jr.

Increased apoptosis of articular chondrocytes in a Bcl-2 knockout transgenic mouse line, Christopher S. Adams and W. E. Horton Jr.

Effect of aminoguanidine on plasma nitric oxide by-products and blood flow during chronic peritoneal sepsis, K. J. Alden, S. J. Motew, Avadhesh C. Sharma, and J. L. Ferguson

Interleukin-4 suppression of interleukin-1-induced transcription of collagenase (MMP-1) and stromelysin 1 (MMP-3) in human synovial fibroblasts, Ruth C. Borghaei, P. L. Rawlings Jr., and Eugene Mochan

Induction of mitogen-inducible nuclear orphan receptor by interleukin 1 in human synovial and gingival fibroblasts, Ruth C. Borghaei, R. S. Sinai, Eugene Mochan, and E. A. Pease

Idiopathic ulcerative colitis in patients with primary sclerosing colitis undergoing orthotopic liver transplantation (OLT) [2], Naga Chalasani and Gregory Smallwood

Is vaccination against hepatitis B infection indicated in patients waiting for or after orthotopic liver transplantation, Naga Chalasani, Gregory Smallwood, Joanne Halcomb, Michael W. Fried, and Thomas D. Boyer

Activation of TGFß2 accompanies chondrocyte maturation and is metalloprotease-mediated, Marina D'Angelo, D. Sarment, P. Billings, and Maurizio Pacifici

Diabetic patients produce an increase in coronary sinus endothelin 1 after coronary artery bypass grafting, B. G. Fogelson, S. I. Nawas, W. T. Vigneswaran, J. L. Ferguson, W. R. Law, and Avadhesh C. Sharma

Induction of bone morphogenetic protein-2 by interleukin-1 in human fibroblasts, M. J. Fowler Jr., M. S. Neff, Ruth C. Borghaei, E. A. Pease, and Eugene Mochan

Unexpected Effects of Wnt-1 on the Differentiation and Adhesion of Myogenic Cells., Mindy George-Weinstein, Jeffrey Dare, Jacquelyn Gerhart, Anthony M.C Brown, Ann Redfield, Heather Brown, and Karen A. Kmidsen

The Role of Stably Committed and Uncommitted Cells in Establishing Tissues of the Somite, Mindy George-Weinstein, Jacquelyn Gerhart, Michele Mattiacci-Paessler, Eileen Simak, Jennifer Blitz, Rebecca Reed, and Karen Knudsen

Sclerotherapists receive tips on managing addicts' pain., Frederick J. Goldstein

Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells, Jennifer L. Gooch, A. V. Lee, and D. Yee

Effect of exercise training on passive stiffness in locomotor skeletal muscle: Role of extracellular matrix, L. E. Gosselin; Christopher S. Adams; T. A. Cotter; R, J. Mccormick; and D. P. Thomas

The mouse hepatitis virus A59 spike protein is not cleaved in primary hepatocyte and glial cell cultures, Susan T. Hingley, Isabelle Leparc-Goffart, and Susan R. Weiss

The spike protein of murine coronavirus mouse hepatitis virus strain A59 is not cleaved in primary glial cells and primary hepatocytes, Susan T. Hingley, Isabelle Leparc-Goffart, and Susan R. Weiss

Chondrocyte apoptosis in development, aging and disease, W. E. Horton Jr., L. Feng, and Christopher S. Adams

Development and pathway formation of peripheral neurons during leech embryogenesis, Yueqiao Huang, John Jellies, Kristen M. Johansen, and Jørgen Johansen

Targeted recombination within the spike gene of murine coronavirus mouse hepatitis virus-A59: Q159 is a determinant of hepatotropism, Isabelle Leparc-Goffart, Susan T. Hingley, Ming Chua, J. Phillips, Ehud Lavi, and Susan R. Weiss

Cognitive, Neuroimaging, and Pathological Studies of Pick's Disease, Andrew P. Lieberman, John Q. Trojanowski, Virginia M.-Y. Lee, Brian J. Balin, Xin-Shen Ding, Joel Greenberg, and Donald Morrison

The role of feedforward and feedback inhibition on frequency-dependent information processing in a cerebellar granule cell, Huo Lu, F. W. Prior, and L. J. Larson-Prior

Adenosine receptor antagonism affects regional resting vascular resistance during rat peritoneal sepsis, S. J. Motew, A. D. Sam II, M. G. Mourelatos, Avadhesh C. Sharma, K. J. Alden, J. L. Ferguson, and W. R. Law

Helping cancer patients cope: A problem-solving approach, Arthur Nezu, Christine Nezu, Stephanie H. Felgoise (née Friedman), Shirley Faddis, and Peter Houts

Use of in vitro systems to study male germ cell development in neonatal rats, J. M. Orth, Michael P. McGuinness, J. Qiu, W. F. Jester Jr., and L. H. Li

Differences in the immune response during the acute phase of E-55+ murine leukemia virus infection in progressor BALB and long term nonprogressor C57BL mice., Vily Panoutsakopoulou, C. Scott Little PhD, Thomas G. Sieck, Elizabeth P. Blankenhorn, and Kenneth J. Blank

Cartilage formation in a hollow fiber bioreactor studied by proton magnetic resonance microscopy, K. Potter, J. J. Butler, Christopher S. Adams, K. W. Fishbein, E. W. Mcfarland, W. E. Horton, and R. G. Spencer

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The predictive validity of parent and teacher reports of ADHD symptoms, Thomas J. Power, Brian J. Doherty, Susan Panichelli-Mindel, James L. Karustis, Ricaro B. Eiraldi, Arthur D. Anastopoulos, and George J. DuPaul