The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.
Submissions from 2002
Psychopharmacological treatment, Agnieszka Popiel, Lynn Montgomery, and Robert A. DiTomasso
Sepsis-induced depressed contractile function of isolated ventricular myocytes is due to altered calcium transient properties, J. Ren, B. H. Ren, and Avadhesh C. Sharma
Decompensation characterized by decreased perfusion of the heart and brain during hemorrhagic shock: Role of endothelin-1, Avadhesh C. Sharma, G. Singh, and A. Gulati
Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution, Rangaiah Shashidharamurthy, D. K. Jagadeesha, K. S. Girish, and K. Kemparaju
Osteoporosis screening in an outpatient liver transplant clinic: Impact of primary immunosuppression, Gregory A. Smallwood, Julie M. Wickman, E. Martinez, A. C. Stieber, and T. G. Heffron
Hepatitis C treatment outcomes of African Americans following liver transplantation, Gregory Smallwood, G. Coffey, L. Davis, Enrique Martinez, A. C. Stieber, and Thomas Heffron
Can patients awaiting liver transplantation elicit an immune response to the hepatitis A vaccine?, Gregory Smallwood, C. T. Coloura, Enrique Martinez, A. C. Stieber, and Thomas Heffron
Mycophenolate's influence in the treatment of recurrent hepatitis C following liver transplantation, Gregory Smallwood, L. Davis, Enrique Martinez, A. C. Stieber, and Thomas Heffron
Renal sparing effects of mycophenolate when used in long-term liver transplant receipients, Gregory Smallwood, A. C. Stieber, L. Davis, Enrique Martinez, and Thomas Heffron
The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification, Liesbeth Van Wesenbeeck, Paul R. Odgren, Carole A. MacKay, Marina D'Angelo, Fayez F. Safadi, Steven N. Popoff, Wim Van Hul, and Sandy C. Marks Jr.
Functional group interactions of a 5-HT3R antagonist, Padmavati Venkataraman, Prasad Joshi, Srinivasan P. Venkatachalan, Mani Mathalagi, Harish S. Parihar, Karen S. Kirschbaum, and Marvin K. Schulte
Medical Professionalism and the Role of State Medical Boards, Matthew Weinberg
The Right-to-Die Movement, Matthew D. Weinberg
Estrogen and vascular function, Richard E. White
Endothelium-independent effect of estrogen on Ca2+-activated K+ channels in human coronary artery smooth muscle cells, Richard E. White, Guichun Han, Melissa Maunz, Christiana Dimitropoulou, Abdalla M. El-Mowafy, Robert S. Barlow, John D. Catravas, Connie Snead, Gerald O. Carrier, and Shu Zhu
Managed care gatekeeping, emergency medicine coding, and insurance reimbursement outcomes for 980 emergency department visits from four states nationwide, G. O. Young, J. Ellis, John W. Becher Jr., C. Yeh, J. Kovar, and M. A. Levitt
Mg2+ efflux from the isolated perfused rabbit heart is mediated by two states of the ß1-adrenergic receptor, Lindon Young, Andrea Bercute-Dammann, and Margaret T. Weiss
Cloning and molecular characterization of two mosquito iron regulatory proteins, Dianzheng Zhang, G. Dimopoulos, A. Wolf, B. Minana, F. Kafatos, and Joy J. Winzerling
PGE2 action in human coronary artery smooth muscle: Role of potassium channels and signaling cross-talk, Shu Zhu, Guichun Han, and Richard E. White
Submissions from 2001
Sezary T Cell Activating Factor is a Chlamydia pneumoniae Associated Protein, J. Todd Abrams, Brian J. Balin, and Eric C. Vonderheid
Apoptosis and bone disease, Christopher S. Adams and W. E. Horton Jr.
Apoptosis and Bone Disease, Christopher S. Adams and W. E. Horton
A novel mechanism of body mass regulation, Christopher S. Adams, A. I. Korytko, and J. L. Blank
Matrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ions, Christopher S. Adams, K. Mansfield, R. L. Perlot, and I. M. Shapiro
Steroid withdrawal in liver transplant recipients, Rebecca Adams, Robin Chapman, and Gregory Smallwood
An in vivo model for investigating bilateral synaptic plasticity across CA3/CA1 synapses in guinea pig dorsal hippocampus, S. Chirwa, J. Mack, R. Park, K. Dennis, and Adwoa Aduonum
Authentic matrix vesicles contain active metalloproteases (MMP): A role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-ß, Marina D'Angelo, Paul C. Billings, Maurizio Pacifici, Phoebe S. Leboy, and Thorsten Kirsch
Activation of transforming growth factor ß in chondrocytes undergoing endochondral ossification, Marina D'Angelo, David P. Sarment, Paul Billings, and Maurizio Pacifici
Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis, Jayasri Das Sarma, Li Fu, and Susan T. Hingley
Mouse hepatitis virus type-2 infection in mice: An experimental model system of acute meningitis and hepatitis, Jayasri Das Sarma, Li Fu, Susan T. Hingley, and Ehud Lavi
Continuous Integration of Skill, Attitude, and Knowledge Assessment across the Curriculum, Michael J. Deimling, William B. French, Christy Cox, David Ralph, Dennis Thompson, and Virgil Van Dusen
Interferon-α and ribavirin for the treatment of recurrent hepatitis C after liver transplantation, Michael de Vera, Gregory Smallwood, Kathia Rosado, Laurel Davis, Enrique Martinez, Shobha Sharma, Andrei Stieber, and Thomas Heffron
Angiotensin II relaxes microvessels via the AT2 receptor and Ca2+-activated K+ (BKCa) channels, Christiana Dimitropoulou, Richard E. White, Leslie Fuchs, Hanfang Zhang, John D. Catravas, and Gerald O. Carrier
Human cytosolic iron regulatory protein 1 contains a linear iron-sulfur cluster [12], Jurgen Gailer, Graham N. George, Ingrid J. Pickering, Roger C. Prince, Peter Koelhepp, Dianzheng Zhang, F. Ann Walker, and Joy J. Winzerling
The Journal of the American Osteopathic Association: Editorial, Katherine Galluzzi
Myod-positive Myoblasts Are Present in Mature Fetal Organs Lacking Skeletal Muscle, Jacquelyn Gerhart, Brian Bast, Christine Neely, Stephanie Iem, Paula Amegbe, Robert Niewenhuis, Steven Miklasz, Pei Feng Cheng, and Mindy George-Weinstein
Rx for pain control: OMT, Frederick J. Goldstein
Insulin-like Growth Factor-I Induces Renal Cell Hypertrophy via a Calcineurin-dependent Mechanism, Jennifer L. Gooch, Y. Tang, J. M. Ricono, and H. E. Abboud
The role of Notch and Rho GTPase signaling in the control of dendritic development, Lori Redmond Hardy and Anirvan Ghosh
Getting the T-box dose right, Cathy J. Hatcher and Craig T. Basson
TBX5 transcription factor regulates cell proliferation during cardiogenesis, Cathy J. Hatcher, Minsu Kim, Caroline S. Maha, Marsha M. Goldstein, Benjamin Wong, Takashi Mikawa, and Craig T. Basson
Single-dose induction with daclizumab immediately after liver transplantation in pediatric patients, Thomas Heffron, Todd Pillen, Gregory Smallwood, E. Martinez, M. E. de Vera, and Rene Romero
Daclizumab induction in liver transplant recipients, Thomas Heffron, Gregory Smallwood, M. E. de Vera, Laurel Davis, Enrique Martinez, and A. C. Stieber
CAKß/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus, Yueqiao Huang, Wei-Yang Lu, Declan W. Ali, Kenneth A. Pelkey, Graham M. Pitcher, You Ming Lu, Hiroshi Aoto, John C. Roder, Terukatsu Sasaki, and Michael W. Salter
PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia-reperfusion, Yasuhiko Ikeda, Lindon Young, Rosario Scalia, Christopher R. Ross, and Allan M. Lefer
Ureteral segment replacement using a circumferential small-intestinal submucosa xenogenic graft, Jamieson S. Jaffe, Phillip C. Ginsberg, Stephen J. Yanoshak, Louis E. Costa Jr., Francis N. Ogbolu, Christoper P. Moyer, Charlotte H. Greene, Leonard H. Finkelstein, and Richard C. Harkaway
Smad-Runx interactions during chondrocyte maturation., Phoebe S. Leboy, Giovi Grasso-Knight, Marina D'Angelo, Susan W. Volk, Jane V. Lian, Hitcham Drissi, Gary S. Stein, and Sherrill L. Adams
The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain, Michael Lee, Charles R. Breese, Maryann L. Strook, and Sherry Leonard
Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism, K. Mansfield, C. C. Teixeira, Christopher S. Adams, and I. M. Shapiro
Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance, Allison Miller, Christiana Dimitropoulou, Guichun Han, Richard E. White, D. W. Busija, and Gerald O. Carrier
Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis, Sonia Navas, Suhun Seo, Ming Chua, Jayasri Das Sarma, Ehud Lavi, Susan T. Hingley, and Susan R. Weiss
Pharmacoeconomic evaluation of a pharmacist-managed hypertension clinic, Mark P. Okamoto and Randy K. Nakahiro
5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions, Harish S. Parihar, Asha Suryanarayanan, Chun Ma, Prasad Joshi, Padma Venkataraman, Marvin K. Schulte, and Karen S. Kirschbaum
What is gross hematuria? Correlation of subjective and objective assessment, P. R. Peacock, H. L. Souto, G. E. Penner, W. C. Dalsey, John W. Becher Jr., and J. L. Kaplan
Innovative approaches to educating medical students for practice in a changing health care environment: The national UME-21 project, H. K. Rabinowitz, D. Babbott, S. Bastacky, J. M. Pascoe, K. K. Patel, K. L. Pye, J. Rodak Jr., Kenneth J. Veit, and D. L. Wood
Persistent hyperglycemia in pediatric liver transplant recipients, Rene Romero, K. Melde, Todd Pillen, Gregory Smallwood, and Thomas Heffron
Preemptive ganciclovir for CMV viremia in liver transplantation, Gregory Smallwood, M. E. de Vera, L. Davis, Enrique Martinez, A. C. Stieber, and Thomas Heffron
Considerations in children, Gregory Smallwood and Thomas Heffron
Correlates of employment: A cohort study, Robert C. Sterling, Edward Gottheil, Scott D. Glassman, S. P. Weinstein, Ronald D. Serota, and Alan Lundy
Medical ethics : applying theories and principles to the patient encounter, Matthew D. Weinberg
Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism, Lindon Young, Yasuhiko Ikeda, and Allan M. Lefer
Protein kinase inhibition exerts cardioprotective effects in myocardial ischemia/reperfusion via inhibition of superoxide release, Lindon Young, Yasuhiko Ikeda, and Allan M. Lefer
Structural basis for thermostability in aporubredoxins from Pyrococcus furiosus and Clostridium pasteurianum, E. R. Zartler, Francis E. Jenney Jr., M. Terrell, M. K. Eidsness, Michael W. Adams, and J. H. Prestegard
Repression of Manduca sexta ferritin synthesis by IRP1/ire interaction, Dianzheng Zhang, D. W. Albert, Paul Kohlhepp, Daphne Pham, and Joy J. Winzerling
Manduca sexta IRP1: molecular characterization and in vivo response to iron, Dianzheng Zhang, Cara Ferris, Jurgen Gailer, Pete Kohlhepp, and Joy J. Winzerling
Submissions from 2000
Antibodies to HIV-1 gp41 recognize synthetic peptides of human IFN-a and IFN-ß, Yun Bai, Y. Zhao, Tianwei Yu, and Manfred P. Dierich
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia, Charles R. Breese, Michael Lee, Cathy E. Adams, Bernadette Sullivan, Judy Logel, Kieron M. Gillen, Michael J. Marks, Allan C. Collins, and Sherry Leonard
Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex, Mairead Casy, Carl J. Vaughan, Jie He, Cathy J. Hatcher, Jordan M. Winter, Stanislawa Weremowicz, Kate Montgomery, Raju Kucherlapati, Cynthia C. Morton, and Craig T. Bassoni
MMP-13 is induced during chondrocyte hypertrophy, Marina D'Angelo, Z. Yan, M. Nooreyazdan, Maurizio Pacifici, D. S. Sarment, Paul C. Billings, and Phoebe S. Leboy
Preparation of Chick Striated Muscle Cultures, Camille DiLullo, Jacquelyn Gerhart, and Mindy George-Weinstein
Medical patients in crisis, Robert A. DiTomasso, Donna M. Martin, and Karel D. Kovnat
DNA dendrimers localize MyoD mRNA in presomitic tissues of the chick embryo, Jacquelyn Gerhart, M. Baytion, S. Deluca, R. Getts, C. Lopez, R. Niewenhuis, T. Nilsen, S. Olex, H. Weintraub, and Mindy George-Weinstein
Clinical research: The process, Frederick J. Goldstein
Study underscores need to consider multiple factors in debate on physician-assisted suicide., Frederick J. Goldstein
The role of p21 in interferon-gamma-mediated growth inhibition of human breast cancer cells, Jennifer L. Gooch, R. E. Herrera, and D. Yee
Dopamine relaxes porcine coronary arteries and stimulates potassium channel activity in porcine coronary arterial smooth muscle cells, Guichun Han, J. P. McMillin, and Richard E. White
Nuclear Notch1 signaling and the regulation of dendritic development, Lori Redmond Hardy, Sang-rog Oh, Carol Hicks, Gerry Weinmaster, and Anirvan Ghosh
Identification and localization of TBX5 transcription factor during human cardiac morphogenesis, Cathy J. Hatcher, Marsha M. Goldstein, Caroline S. Mah, C. Susan Delia, and Craig T. Basson
Atrial form and function: Lessons from human molecular genetics, Cathy J. Hatcher, Minsu Kim, and Craig T. Basson
Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature, G. J. Hernandez, Francis E. Jenney Jr., M. W. Adams, and D. M. Lemaster
Cardioprotective effects of citrulline in ischemia/reperfusion injury via a non-nitric oxide-mediated mechanism, Yasuhiko Ikeda, Lindon Young, Rosario Scalia, and Allen M. Lefer
Diazepam, y-aminobutyric acid, and progesterone open K+ channels in myocytes from coronary arteries, Maryanne K. Jacob and Richard E. White
Caring for Low Back Pain, Evaluation and Management of Acute Low Back Pain, V. Jaeger, N. DiNubile, and Alexander S. Nicholas
Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition, A. V. Lee, J. L. Gooch, S. Oesterreich, R. L. Guler, and D. Yee
Ultrastructural analysis of beta-amyloid production in monocytes, epithelial, and endothelial cells infected with Chlamydia pneumoniae isolated from Alzheimer brains, Christopher S. Little, A. MacIntyre, Christine Hammond, E. Venuti, B. J. Bromke, Brian J. Balin, and Denah M. Appelt
An alternative to synthetic aortic grafts using Jejunum, S. E. Marshall, S. M. Tweedt, Charlotte H. Greene, and et al.
Inorganic phosphate induces apoptosis of osteoblast-like cells in culture, Z. Meleti, I. M. Shapiro, and Christopher S. Adams
Calcium-activated potassium channels and nitric oxide coregulate estrogen-induced vasodilation, Charles R. Rosenfeld, Richard E. White, Tim Roy, and Blair E. Cox
Adenosine and nitric oxide regulate regional vascular resistance via interdependent and independent mechanisms during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law
Interdependence of adenosine and nitric oxide in hepato-splanchnic circulation during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law
Central versus peripheral mediation of naloxone's perfusion effects in endotoxic rats, Avadhesh C. Sharma, A. D. Sam II, K. J. Alden, S. L. Moore, W. R. Law, and J. L. Ferguson
Loading of calcium and strontium into the sarcoplasmic reticulum in rat ventricular muscle, C. I. Spencer, Robert J. Barsotti, and J. R. Berlin
Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts, Ruth D. Thornton, P. Lane, Ruth C. Borghaei, E. A. Pease, J. Caro, and Eugene Mochan
Rational design of cytotoxic T-cell inhibitors, Anna P. Tretiakova, C. Scott Little, Kenneth J. Blank, and Bradford A. Jameson
Utilization of Bone Morphogenetic Protein Receptors during Chondrocyte Maturation., Susan W. Volk, Marina D'Angelo PhD, David Diefenderfer, and Phoebe S. Leboy
Tetraethylammonium potentiates the activity of muscarinic potassium channels in guinea-pig atrial myocytes., Desuo Wang and David L. Armstrong
Caring for Our Patients, Matthew D. Weinberg
Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia., Kristin Wijsanen Weitzel, Julie M. Wickman, Sara Grimsley Augustin, and J. Grady Strom
cAMP-dependent vasodilators cross-activate the cGMP-dependent protein kinase to stimulate Bk(Ca) channel activity in coronary artery smooth muscle cells, Richard E. White, Jonathan P. Kryman, Abdalla M. El-mowafy, Guichun Han, and Gerald O. Carrier
Recognizing and treating tardive dyskineseia, Julie M. Wickman and J. M. Cold