The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2001

Activation of transforming growth factor ß in chondrocytes undergoing endochondral ossification, Marina D'Angelo, David P. Sarment, Paul Billings, and Maurizio Pacifici

Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis, Jayasri Das Sarma, Li Fu, and Susan T. Hingley

Mouse hepatitis virus type-2 infection in mice: An experimental model system of acute meningitis and hepatitis, Jayasri Das Sarma, Li Fu, Susan T. Hingley, and Ehud Lavi

Continuous Integration of Skill, Attitude, and Knowledge Assessment across the Curriculum, Michael J. Deimling, William B. French, Christy Cox, David Ralph, Dennis Thompson, and Virgil Van Dusen

Interferon-α and ribavirin for the treatment of recurrent hepatitis C after liver transplantation, Michael de Vera, Gregory Smallwood, Kathia Rosado, Laurel Davis, Enrique Martinez, Shobha Sharma, Andrei Stieber, and Thomas Heffron

Angiotensin II relaxes microvessels via the AT2 receptor and Ca2+-activated K+ (BKCa) channels, Christiana Dimitropoulou, Richard E. White, Leslie Fuchs, Hanfang Zhang, John D. Catravas, and Gerald O. Carrier

Human cytosolic iron regulatory protein 1 contains a linear iron-sulfur cluster [12], Jurgen Gailer, Graham N. George, Ingrid J. Pickering, Roger C. Prince, Peter Koelhepp, Dianzheng Zhang, F. Ann Walker, and Joy J. Winzerling

The Journal of the American Osteopathic Association: Editorial, Katherine Galluzzi

Myod-positive Myoblasts Are Present in Mature Fetal Organs Lacking Skeletal Muscle, Jacquelyn Gerhart, Brian Bast, Christine Neely, Stephanie Iem, Paula Amegbe, Robert Niewenhuis, Steven Miklasz, Pei Feng Cheng, and Mindy George-Weinstein

Rx for pain control: OMT, Frederick J. Goldstein

Insulin-like Growth Factor-I Induces Renal Cell Hypertrophy via a Calcineurin-dependent Mechanism, Jennifer L. Gooch, Y. Tang, J. M. Ricono, and H. E. Abboud

The role of Notch and Rho GTPase signaling in the control of dendritic development, Lori Redmond Hardy and Anirvan Ghosh

Getting the T-box dose right, Cathy J. Hatcher and Craig T. Basson

TBX5 transcription factor regulates cell proliferation during cardiogenesis, Cathy J. Hatcher, Minsu Kim, Caroline S. Maha, Marsha M. Goldstein, Benjamin Wong, Takashi Mikawa, and Craig T. Basson

Single-dose induction with daclizumab immediately after liver transplantation in pediatric patients, Thomas Heffron, Todd Pillen, Gregory Smallwood, E. Martinez, M. E. de Vera, and Rene Romero

Daclizumab induction in liver transplant recipients, Thomas Heffron, Gregory Smallwood, M. E. de Vera, Laurel Davis, Enrique Martinez, and A. C. Stieber


CAKß/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus, Yueqiao Huang, Wei-Yang Lu, Declan W. Ali, Kenneth A. Pelkey, Graham M. Pitcher, You Ming Lu, Hiroshi Aoto, John C. Roder, Terukatsu Sasaki, and Michael W. Salter

PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia-reperfusion, Yasuhiko Ikeda, Lindon Young, Rosario Scalia, Christopher R. Ross, and Allan M. Lefer

Ureteral segment replacement using a circumferential small-intestinal submucosa xenogenic graft, Jamieson S. Jaffe, Phillip C. Ginsberg, Stephen J. Yanoshak, Louis E. Costa Jr., Francis N. Ogbolu, Christoper P. Moyer, Charlotte H. Greene, Leonard H. Finkelstein, and Richard C. Harkaway

Smad-Runx interactions during chondrocyte maturation., Phoebe S. Leboy, Giovi Grasso-Knight, Marina D'Angelo, Susan W. Volk, Jane V. Lian, Hitcham Drissi, Gary S. Stein, and Sherrill L. Adams

The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain, Michael Lee, Charles R. Breese, Maryann L. Strook, and Sherry Leonard

Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism, K. Mansfield, C. C. Teixeira, Christopher S. Adams, and I. M. Shapiro

Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance, Allison Miller, Christiana Dimitropoulou, Guichun Han, Richard E. White, D. W. Busija, and Gerald O. Carrier

Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis, Sonia Navas, Suhun Seo, Ming Chua, Jayasri Das Sarma, Ehud Lavi, Susan T. Hingley, and Susan R. Weiss

Pharmacoeconomic evaluation of a pharmacist-managed hypertension clinic, Mark P. Okamoto and Randy K. Nakahiro

5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions, Harish S. Parihar, Asha Suryanarayanan, Chun Ma, Prasad Joshi, Padma Venkataraman, Marvin K. Schulte, and Karen S. Kirschbaum

What is gross hematuria? Correlation of subjective and objective assessment, P. R. Peacock, H. L. Souto, G. E. Penner, W. C. Dalsey, John W. Becher Jr., and J. L. Kaplan

Innovative approaches to educating medical students for practice in a changing health care environment: The national UME-21 project, H. K. Rabinowitz, D. Babbott, S. Bastacky, J. M. Pascoe, K. K. Patel, K. L. Pye, J. Rodak Jr., Kenneth J. Veit, and D. L. Wood

Persistent hyperglycemia in pediatric liver transplant recipients, Rene Romero, K. Melde, Todd Pillen, Gregory Smallwood, and Thomas Heffron

Preemptive ganciclovir for CMV viremia in liver transplantation, Gregory Smallwood, M. E. de Vera, L. Davis, Enrique Martinez, A. C. Stieber, and Thomas Heffron

Considerations in children, Gregory Smallwood and Thomas Heffron

Correlates of employment: A cohort study, Robert C. Sterling, Edward Gottheil, Scott D. Glassman, S. P. Weinstein, Ronald D. Serota, and Alan Lundy

Medical ethics : applying theories and principles to the patient encounter, Matthew D. Weinberg

Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism, Lindon Young, Yasuhiko Ikeda, and Allan M. Lefer

Protein kinase inhibition exerts cardioprotective effects in myocardial ischemia/reperfusion via inhibition of superoxide release, Lindon Young, Yasuhiko Ikeda, and Allan M. Lefer

Structural basis for thermostability in aporubredoxins from Pyrococcus furiosus and Clostridium pasteurianum, E. R. Zartler, Francis E. Jenney Jr., M. Terrell, M. K. Eidsness, Michael W. Adams, and J. H. Prestegard

Repression of Manduca sexta ferritin synthesis by IRP1/ire interaction, Dianzheng Zhang, D. W. Albert, Paul Kohlhepp, Daphne Pham, and Joy J. Winzerling

Manduca sexta IRP1: molecular characterization and in vivo response to iron, Dianzheng Zhang, Cara Ferris, Jurgen Gailer, Pete Kohlhepp, and Joy J. Winzerling

Submissions from 2000

Antibodies to HIV-1 gp41 recognize synthetic peptides of human IFN-a and IFN-ß, Yun Bai, Y. Zhao, Tianwei Yu, and Manfred P. Dierich

Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia, Charles R. Breese, Michael Lee, Cathy E. Adams, Bernadette Sullivan, Judy Logel, Kieron M. Gillen, Michael J. Marks, Allan C. Collins, and Sherry Leonard


Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex, Mairead Casy, Carl J. Vaughan, Jie He, Cathy J. Hatcher, Jordan M. Winter, Stanislawa Weremowicz, Kate Montgomery, Raju Kucherlapati, Cynthia C. Morton, and Craig T. Bassoni

MMP-13 is induced during chondrocyte hypertrophy, Marina D'Angelo, Z. Yan, M. Nooreyazdan, Maurizio Pacifici, D. S. Sarment, Paul C. Billings, and Phoebe S. Leboy

Preparation of Chick Striated Muscle Cultures, Camille DiLullo, Jacquelyn Gerhart, and Mindy George-Weinstein

Medical patients in crisis, Robert A. DiTomasso, Donna M. Martin, and Karel D. Kovnat

DNA dendrimers localize MyoD mRNA in presomitic tissues of the chick embryo, Jacquelyn Gerhart, M. Baytion, S. Deluca, R. Getts, C. Lopez, R. Niewenhuis, T. Nilsen, S. Olex, H. Weintraub, and Mindy George-Weinstein

Clinical research: The process, Frederick J. Goldstein

Study underscores need to consider multiple factors in debate on physician-assisted suicide., Frederick J. Goldstein

The role of p21 in interferon-gamma-mediated growth inhibition of human breast cancer cells, Jennifer L. Gooch, R. E. Herrera, and D. Yee

Dopamine relaxes porcine coronary arteries and stimulates potassium channel activity in porcine coronary arterial smooth muscle cells, Guichun Han, J. P. McMillin, and Richard E. White

Nuclear Notch1 signaling and the regulation of dendritic development, Lori Redmond Hardy, Sang-rog Oh, Carol Hicks, Gerry Weinmaster, and Anirvan Ghosh

Identification and localization of TBX5 transcription factor during human cardiac morphogenesis, Cathy J. Hatcher, Marsha M. Goldstein, Caroline S. Mah, C. Susan Delia, and Craig T. Basson

Atrial form and function: Lessons from human molecular genetics, Cathy J. Hatcher, Minsu Kim, and Craig T. Basson

Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature, G. J. Hernandez, Francis E. Jenney Jr., M. W. Adams, and D. M. Lemaster

Cardioprotective effects of citrulline in ischemia/reperfusion injury via a non-nitric oxide-mediated mechanism, Yasuhiko Ikeda, Lindon Young, Rosario Scalia, and Allen M. Lefer

Diazepam, y-aminobutyric acid, and progesterone open K+ channels in myocytes from coronary arteries, Maryanne K. Jacob and Richard E. White

Caring for Low Back Pain, Evaluation and Management of Acute Low Back Pain, V. Jaeger, N. DiNubile, and Alexander S. Nicholas

Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition, A. V. Lee, J. L. Gooch, S. Oesterreich, R. L. Guler, and D. Yee

Ultrastructural analysis of beta-amyloid production in monocytes, epithelial, and endothelial cells infected with Chlamydia pneumoniae isolated from Alzheimer brains, Christopher S. Little, A. MacIntyre, Christine Hammond, E. Venuti, B. J. Bromke, Brian J. Balin, and Denah M. Appelt

An alternative to synthetic aortic grafts using Jejunum, S. E. Marshall, S. M. Tweedt, Charlotte H. Greene, and et al.

Inorganic phosphate induces apoptosis of osteoblast-like cells in culture, Z. Meleti, I. M. Shapiro, and Christopher S. Adams

Calcium-activated potassium channels and nitric oxide coregulate estrogen-induced vasodilation, Charles R. Rosenfeld, Richard E. White, Tim Roy, and Blair E. Cox

Adenosine and nitric oxide regulate regional vascular resistance via interdependent and independent mechanisms during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law

Interdependence of adenosine and nitric oxide in hepato-splanchnic circulation during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law

Central versus peripheral mediation of naloxone's perfusion effects in endotoxic rats, Avadhesh C. Sharma, A. D. Sam II, K. J. Alden, S. L. Moore, W. R. Law, and J. L. Ferguson

Loading of calcium and strontium into the sarcoplasmic reticulum in rat ventricular muscle, C. I. Spencer, Robert J. Barsotti, and J. R. Berlin

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts, Ruth D. Thornton, P. Lane, Ruth C. Borghaei, E. A. Pease, J. Caro, and Eugene Mochan

Rational design of cytotoxic T-cell inhibitors, Anna P. Tretiakova, C. Scott Little, Kenneth J. Blank, and Bradford A. Jameson

Utilization of Bone Morphogenetic Protein Receptors during Chondrocyte Maturation., Susan W. Volk, Marina D'Angelo PhD, David Diefenderfer, and Phoebe S. Leboy

Tetraethylammonium potentiates the activity of muscarinic potassium channels in guinea-pig atrial myocytes., Desuo Wang and David L. Armstrong

Caring for Our Patients, Matthew D. Weinberg

Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia., Kristin Wijsanen Weitzel, Julie M. Wickman, Sara Grimsley Augustin, and J. Grady Strom

cAMP-dependent vasodilators cross-activate the cGMP-dependent protein kinase to stimulate Bk(Ca) channel activity in coronary artery smooth muscle cells, Richard E. White, Jonathan P. Kryman, Abdalla M. El-mowafy, Guichun Han, and Gerald O. Carrier

Recognizing and treating tardive dyskineseia, Julie M. Wickman and J. M. Cold

Combinations of variations in multiple genes are associated with hypertension., S M Williams, J H Addy, J A Phillips, M Dai, J Kpodonu, J Afful, H Jackson, K Joseph, F Eason, M M Murray, P Epperson, Adwoa Aduonum, L J Wong, P A Jose, and R A Felder

Distinct subcellular localization and mRNA expression of neuronal nitric oxide synthase in the nucleus dorsalis and red nucleus and their correlation with inducible transcription factors after spinal cord hemisection, Mei Xu, Yee-Kong Ng, and Seng-Kee Leong

Neuroprotective and neurodestructive functions of nitric oxide after spinal cord hemisection, Mei Xu, Yee-Kong Ng, and Seng-Kee Leong

Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states, A. P. Yeh, Y. Hu, Francis E. Jenney Jr., Michael W. Adams, and D. C. Rees

C-peptide exerts cardioprotective effects in myocardial ischemia-reperfusion, Lindon Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer

Wortmannin, a potent antineutrophil agent, exerts cardioprotective effects in myocardial ischemia/reperfusion, Lindon Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer

Induction of high levels of epitope-specific antibodies by epitope/peptide candidate vaccines against human immunodeficiency virus type- 1 (HIV-1), Tianwei Yu, Yun Bai, Manfred P. Dierich, and Ying-Hua Chen

Human interferon-ß inhibits binding of HIV-1 gp41 to lymphocyte and monocyte cells and binds the potential receptor protein P50 for HIV-1 gp41, Tianwei Yu, Yi Xiao, Yun Bai, Qinhua Ru, Guoan Luo, Manfred P. Dierich, and Ying-Hua Chen

Submissions from 1999

Paradoxical intention and recursive anxiety, L. Michael Ascher and D. E. Schotte

Complementary and alternative medicine: herbal therapies for diabetes., B. M. Berman, J. P. Swyers, and Joseph M. Kaczmarczyk

Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3), Ruth C. Borghaei, C. Sullivan, and Eugene Mochan

Modulation of major histocompatibility complex antigen expression by human immunodeficiency virus-2 gp36, Ying-Hua Chen, Yun Bai, Tianwei Yu, and Manfred P. Dierich

Immunogenicity of the GPGRAFY epitope on synthetic peptides, Ying-Hua Chen, Tianwei Yu, Yun Bai, and M. P. Dierich

Two proteins share immunological epitopes on the tumor-associated antigen 17-1A, Ying-Hua Chen, Tianwei Yu, Yun Bai, and Nanming Zhao

The ADP release step of the smooth muscle cross-bridge cycle is not directly associated with force generation, J. A. Dantzig, Robert J. Barsotti, S. Manz, H. L. Sweeney, and Y. E. Goldman

Hepatocyte Growth Factor/Scatter Factor Promotes a Switch From E- to N-cadherin in Chick Embryo Epiblast Cells., Steven M. DeLuca, Jacquelyn Gerhart, Eric Cochran, Eileen Simak, Jennifer Blitz, Michelle Mattiacci-Paessler, Karen Knudsen, and Mindy George-Weinstein

Precept-assist: A computerized, data-based evaluation system, Robert A. DiTomasso, J. D. Gamble, and M. A. Willard

Caring for the caregivers., Katherine Galluzzi

Frequency of Apoliprotein E (APOE) Allele Types in Pateinets with Chlamydia-Associated Arthritis and other Arthridities, Hervé C. Gérard, Geng Feng Wang, Brian J. Balin, H. Ralph Schumacher, and Alan P. Hudson

DOs need more training in diagnosing and treating addiction, Frederick J. Goldstein

Kevorkian kills patients along with the clinical research to help them, Frederick J. Goldstein

Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death - Proliferative and anti-apoptotic effects, Jennifer L. Gooch, C. L. Van Den Berg, and D. Yee

Strain-specific differences in formation of apoptotic DNA ladders in MCF-7 breast cancer cells, Jennifer L. Gooch and D. Yee

Identification of IL-1 regulated genes in human synovial and gingival fibroblasts by differential display, G. K. Gorski, M. Paul, H. Soohoo, Ruth C. Borghaei, Eugene Mochan, Ruth D. Thornton, and E. A. Pease

Excessive microtubules are not responsible for depressed force per cross-bridge in cardiac neural-crest-ablated embryonic chick hearts, Cathy J. Hatcher, Robert E. Godt, and T. M. Nosek

Anaerobic microbes: Oxygen detoxification without superoxide dismutase, Francis E. Jenney Jr., M. F. Verhagen, X. Cui, and M. W. Adams

Community reinforcement training for family and significant others of drug abusers: A unilateral intervention to increase treatment entry of drug users, K. Kirby, D. Marlowe, David Festinger, K. Garvey, and V. Lamonaca