The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Works repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, book chapters, datasets, and unpublished works by faculty and staff at PCOM's Philadelphia, Georgia, and South Georgia campuses.
Submissions from 1994
Relaxation from rigor of skinned trabeculae of the guinea pig induced by laser photolysis of caged ATP, H. Martin and Robert J. Barsotti
Interactions between Sertoli cells and germ cells in the testis, Michael P. McGuinness and M. P. Griswold
Relationship of a mouse Sertoli cell line (MSC-1) to normal Sertoli cells, Michael P. McGuinness, C. C. Linder, C. R. Morales, L. L. Heckert, J. Pikus, and M. D. Griswold
Fibronectin inhibition of platelet thrombus formation in an in vivo porcine model of vascular injury., D G Moon, Brian Matayoshi, L K Weston, F L Minnear, and J E Kaplan
Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini, J. W. Regan, T. J. Bailey, J. E. Donello, K. L. Pierce, D. J. Pepperl, Dianzheng Zhang, K. M. Kedzie, C. E. Fairbairn, A. M. Bogardus, and D. F. Woodward
Effect of diaspirin cross-linked hemoglobin and norepinephrine on systemic hemodynamics and regional circulation in rats., Avadesh C. Sharma and A. Gulati
Dopamine receptor mediated antidepressant action of B-HT 920 in mice, Avadesh C. Sharma and S. K. Kulkarni
On the characterization of dopamine-induced contractile response of rat anococcygeus muscle preparation, Avadesh C. Sharma and S. K. Kulkarni
Regional circulatory and systemic hemodynamic effects of diaspirin cross-linked hemoglobin in the rat, Avadesh C. Sharma, S. K. Kulkarni, and A. Gulati
Renal endothelin mechanism in altered thyroid states, G. Singh, Avadhesh C. Sharma, E. B. Thompson, and A. Gulati
σ antagonist and k agonist activity of naltriben: Evidence for differential k interaction with the σ1 and σ2 opioid receptor subtypes, Peggy E. Stewart, E. M. Holper, and D. L. Hammond
Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes., Desuo Wang and Luiz Belardinelli
Submissions from 1993
PC-based multiparameter full-color display for tissue segmentation in MRI of adnexal masses, H. Keith Brown, T. R. Hazelton, A. K. Parsons, J. V. Fiorica, C. G. Berman, and M. L. Silbiger
Characteristics of DNA replication in isolated nuclei initiated by an aprotinin-binding protein, F. D. Coffman, Kerin L. Fresa, M. Hameed, and S. Cohen
In vitro replication of plasmids containing human ribosomal gene sequences: Origin localization and dependence on an aprotinin-binding cytosolic protein, F. D. Coffman, I. Georgoff, Kerin L. Fresa, J. Sylvester, I. Gonzalez, and S. Cohen
In Vitro and in Vivo Expression of Alpha 7 Integrin and Desmin Define the Primary and Secondary Myogenic Lineages, Mindy George-Weinstein, Rachel F. Foster, Jacquelyn Gerhart, and Stephen J. Kaufman
Fusion-defective mutants of mouse hepatitis virus A59 contain a mutation in the spike protein cleavage signal, James L. Gombold, Susan T. Hingley, and Susan R. Weiss
Basic fibroblast growth factor is a testicular germ cell product which may regulate sertoli cell function, I. S. Han, S. R. Sylvester, K. H. Kim, M. E. Schelling, S. Venkateswaran, V. D. Blanckaert, Michael P. McGuinness, and M. D. Griswold
A novel membrane-associated c-type cytochrome, cyt cy, can mediate the photosynthetic growth of Rhodobacter capsulatus and Rhodobacter sphaeroides, Francis E. Jenney Jr. and F. Daldal
GABA receptor mediated anticonvulsant action of Withania somnifera root extract, S. K. Kulkarni, Avadhesh C. Sharma, A. Verma, and M. K. Ticku
Fatal fulminant autoimmune haemolytic anaemia associated with tolmetin use and gastric carcinoma. Case report and literature review, J. R. Larsen and John W. Becher Jr.
Functional characterization of alpha adrenoceptors on rabbit intrarenal arteries in vitro, Mary P. Owen
(±)Baclofen sensitive scopolamine-induced short-term memory deficits in mice, Avadesh C. Sharma and S. K. Kulkarni
Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats, Avadesh C. Sharma and S. K. Kulkarni
Involvement of inhibitory dopamine-2 receptors in resting bradycardia in exercise-conditioned rats, Kenneth J. Slavik and J. LaPointe
Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia, Kenneth J. Slavik and J. E. Szilagyi
Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation, Richard E. White, A. B. Lee, A. D. Shcherbatko, T. M. Lincoln, A. Schonbrunn, and D. L. Armstrong
The Survivors Project, Bruce S. Zahn and Seran E. Schug
Submissions from 1992
Composite and classified color display in MR imaging of the female pelvis, H. Keith Brown, T. R. Hazelton, J. V. Fiorica, A. K. Parsons, L. P. Clarke, and M. L. Silbiger
Tomographic abdominal anatomy with magnetic resonance color composites, H. Keith Brown, T. R. Hazelton, L. M. Putnam, and M. L. Silbiger
Cognitive therapy of personality disorders., A. Freeman, D. D. Davis, and Robert A. DiTomasso
Factors Affecting Drug Response, Frederick J. Goldstein and R. F. Orzechowski
Pharmacodynamics, Frederick J. Goldstein and R. F. Orzechowski
Angiographic magnetic resonance color composites of the normal brain and its vasculature, T. R. Hazelton and H. Keith Brown
Autonomic surface potential analysis: Assessment of reproducibility and sensitivity, R. D. Hoeldtke, K. M. Davis, P. B. Hshieh, S. Gaspar, and Gerald E. Dworkin
Crystallization and oligomeric structure of rat liver arginase, Zoltan F. Kanyo, Cheau-Yun Chen, Farzaneh Daghigh, David E. Ash, and David W. Christianson
Cw holmium for medical applications: a preliminary study, Ronald A. Kirschner, Domenic DiBias, Charlotte H. Greene, Eric Brown, Corneliu Dimitriu, Alexander C. Keszeli, and Andrew Kirschner
Recent trends in information storage mechanisms, S. K. Kulkarni and Avadhesh C. Sharma
Benign Metastasizing Leiomyoma A Case Report and Review of the Literature, Daniel Parenti, T. F. Morley, and J. C. Giudice
Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice, Avadesh C. Sharma and S. K. Kulkarni
Naloxone-induced bradycardia in pithed rats: Evidence for an interaction with the peripheral sympathetic nervous system and alpha-2 adrenoceptors, Kenneth J. Slavik and J. E. Szilagyi
Therapeutic considerations: Lower respiratory tract infections in smokers, Michael A. Venditto
Differential Morphologic and Metabolic Alterations in Permissive Versus Nonpermissive Murine Macrophages Infected with Legionella Pneumophila, Yoshimasa Yamamoto, Thomas W. Klein, H. Keith Brown, and Herman Friedman
Submissions from 1991
Neurofilament Assembly in vitro: Biochemical, morphological and Immunoelectron Microscopic Studies Employing Monoclonal Antibodies to Defined Epitopes, Brian J. Balin, Edwin A. Clark, John Q. Trojanowski, and Virginia M.-Y. Lee
Individual Neurofilament Subunits Reassembled in vitro Exhibit Unique Biochemical, Morphological and Immunological Properties, Brian J. Balin and Virginia M.-Y. Lee
Uterine junctional zone: Correlation between histologic findings and MR imaging, H. Keith Brown
Generation of Color Composites for Enhanced Tissue Differentiation in Magnetic Resonance Imaging of the Brain, H. Keith Brown, T R Hazelton, and M L Silbiger
Initiation of lymphocyte DNA synthesis, F. D. Coffman, Kerin L. Fresa, and S. Cohen
Control of DNA replication in a transformed lymphoid cell line: Coexistence of activator and inhibitor activities, F. D. Coffman, Kerin L. Fresa, I. Oglesby, and S. Cohen
Transforming growth factor-ß modulation of glycosaminoglycan production by mesenchymal cells of the developing murine secondary palate, Marina D'Angelo and Robert M. Greene
Airway foreign bodies: A diagnostic challenge, C. J. Di Marco, Theodore P. Mauer, and R. N. Reinhard
The development of a patient satisfaction questionnaire in the ambulatory setting, Robert A. DiTomasso and M. A. Willard
Early detection of stage A prostate carcinoma: Combined use of prostate- specific antigen and transrectal ultrasonography, R. L. Fiorelli, R. L. Klaus, S. J. Manfrey, Laurence Belkoff, and Larry Finkelstein
Immunodetection of the transforming growth factors ß1 and ß2 in the developing murine palate, A. L. Gehris, Marina D'Angelo, and Robert M. Greene
In Vitro Development of Precursor Cells in the Myogenic Lineage, Stephen J. Kaufman, Mindy George-Weinstein, and Rachel F. Foster
Interferon-gamma Induced Resistance to Legionella Pneumophila in Susceptible A/J Mouse Macrophages., T W Klein, Y Yamamoto, H. Keith Brown, and H Friedman
Emergency intubation for paralysis of the uncooperative trauma patient, J. Kuchinski, G. Tinkoff, M. Rhodes, and John W. Becher Jr.
Elevated plus-maze: A novel psychobehavioral tool to measure anxiety in rodents, S. K. Kulkarni and Avadhesh C. Sharma
A method for maintaining and protecting chronic arterial and venous catheters in conscious rats, S. Z. Kurowski, Kenneth J. Slavik, and J. E. Szilagyi
Interaction of delta-9-tetrahydrocannabinol with herpesviruses and cultural conditions associated with drug-induced anti-cellular effects, G. Lancz, S. Specter, and H. Keith Brown
Suppressive effect of σ-9-tetrahydrocannabinol on herpes simplex virus infectivity in vitro, G. Lancz, S. Specter, and H. Keith Brown
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau, Virginia M. Lee, Brian J. Balin, L Otvos Jr., and John Q. Trojanowski
Transforming growth factor-ß receptor profiles of human and murine embryonic palate mesenchymal cells, Kersti K. Linask, Marina D'Angelo, Amy Gehris, and Robert M. Greene
Antibody Labling of Bovine Neurofilaments: Implications on the Structure of Neurofilament Sidearms, Lizanne Mulligan, Brian J. Balin, Virginia M.-Y. Lee, and Wallace Ip
Somatic component to myocardial infarction: Three year follow up, Alexander S. Nicholas, Domenic A. DiBias, and Charlotte H. Greene
Effects of MK-801 and ketamine on short-term memory deficits in passive avoidance step-down task paradigm in mice, Avadesh C. Sharma and S. K. Kulkarni
MK-801 produces antianxiety effect in elevated plus-maze in mice, Avadesh C. Sharma and S. K. Kulkarni
Effect of NMDA-receptor ligands on neocortical and hippocampal EEG activity of rat brain, Avadesh C. Sharma, S. K. Kulkarni, and U. Nayar
Dizocilpine, ketamine and ethanol reverse NMDA-induced EEG changes and convulsions in rats and mice, Avadesh C. Sharma, S. N. Thorat, U. Nayar, and S. K. Kulkarni
Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylation, Richard E. White, Agnes Schonbrunn, and David L. Armstrong
Submissions from 1990
Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase, M V. Autieri, Kerin L. Fresa, F. D. Coffman, M. E. Katz, and S. Cohen
Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase., M. V. Autieri, Kerin L. Fresa, F. D. Coffman, M. E. Katz, and S. Cohen
The behavioral treatment of essential hypertension: Implications for medical psychotherapy, Robert A. DiTomasso and Orlando F. Mills
Rehabilitation of the acutely injured hand, Gerald E. Dworkin and J. Spears
Priapism associated with intranasal cocaine abuse, R. L. Fiorelli, S. J. Manfrey, Laurence Belkoff, and Larry Finkelstein
Effect of Chronic Antidepressant Administration upon Opioid Analgesia, Frederick J. Goldstein
Effects of chronic clomipramine on central DADLE antinociception, Frederick J. Goldstein, R. T. Malseed, and J. F. Nutz
The effect of helium-neon laser and osteopathic manipulation on soft-tissue trigger points, Charlotte H. Greene, Domenic A. DiBias, D. Helig, Alexander S. Nicholas, K. England, W. Ehrenfeuchter, and Wanda L. Young
Selecting and using early childhood rating scales, George McCloskey
Pericardial effects on diastolic ventricular interaction during development, Bohdan M. Minczak, M. R. Wolfson, W. P. Santamore, and T. H. Shaffer
Methyldopa-induced hemolytic anemia in a 15 year old presenting as near-syncope, J. S. Naidorf, J. M. Kennedy, and John W. Becher Jr.
Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice, Avadesh C. Sharma and S. K. Kulkarni
A cytoplasmic activator of DNA replication is involved in signal transduction in antigen-specific T cell lines, R. L. Wong, R. B. Clark, J. Gutowski, M. E. Katz, Kerin L. Fresa, and S. Cohen
Submissions from 1989
Paradoxical intention: Its clarification and emergence as a conventional behavioral procedure, L. Michael Ascher
Triggering Terminal Myogenic Differentiation, D. Boettiger, Mindy George-Weinstein, and A. S. Menko
Coping styles, paradox, and the cold pressor task, J. S. Efran, R. L. Chorney, L. Michael Ascher, and M. D. Lukens
Intracellular mechanisms of lymphoid cell activation, Kerin L. Fresa, M. Hameed, and S. Cohen
In Vitro Assays of Cell Adhesion: Application To Teratogenicity Testing, Mindy George-Weinstein
School psychology applied to business, Patti L. Harrison and George McCloskey
Ciliostatic factors from Pseudomonas aeruginosa. Action on respiratory cilia, Susan T. Hingley, A. T. Hastie, Friedrich Kueppers, M. Higgins, and G. Weinbaum
Effect of the somatostatin analogue SMS-201-995 on the adrenergic response to glucose ingestion in patients with postprandial hypotension, R. D. Hoeldtke, Gerald E. Dworkin, S. Gaspar, and B. C. Israel
Sympathotonic orthostatic hypotension: A report of four cases, R. D. Hoeldtke, Gerald E. Dworkin, S. Gaspar, and B. C. Israel
Fibrosarcoma of the nose and the paranasal sinuses, J. Olekszyk, V. Siliunas, Theodore P. Mauer, and R. Biondi
Adrenergic control of intrarenal arteries of rabbits, Mary P. Owen, M. C. Taphorn, and J. G. Walmsley
Anomalous origin of the left coronary artery, E. Placentra, Bruce Kornberg, and A. D'Alonzo
Intraabdominal adhesions: Intraoperative US, F. J. Suslavitch, N. A. Turner, P. S. King, and H. Keith Brown
Diagnosis and management of ventricular dysphonia, C. P. Von Hake, I. Ganzman, and Theodore P. Mauer
Submissions from 1988
Transcytosis of Protein through the Mammalian Cerebral Epithelium and Endothelium. I. Chorioid Plexus and the Blood-cerebrospinal Fluid Barrier, Brian J. Balin and Richard D. Broadwell
Combined transurethral electroresection and neodymium:YAG laser therapy for obstructing prostatism, Laurence Belkoff and Larry Finkelstein