The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Works repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, book chapters, datasets, and unpublished works by faculty and staff at PCOM's Philadelphia, Georgia, and South Georgia campuses.
Submissions from 2001
Correlates of employment: A cohort study, Robert C. Sterling, Edward Gottheil, Scott D. Glassman, S. P. Weinstein, Ronald D. Serota, and Alan Lundy
Medical ethics : applying theories and principles to the patient encounter, Matthew D. Weinberg
Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism, Lindon Young, Yasuhiko Ikeda, and Allan M. Lefer
Protein kinase inhibition exerts cardioprotective effects in myocardial ischemia/reperfusion via inhibition of superoxide release, Lindon Young, Yasuhiko Ikeda, and Allan M. Lefer
Structural basis for thermostability in aporubredoxins from Pyrococcus furiosus and Clostridium pasteurianum, E. R. Zartler, Francis E. Jenney Jr., M. Terrell, M. K. Eidsness, Michael W. Adams, and J. H. Prestegard
Repression of Manduca sexta ferritin synthesis by IRP1/ire interaction, Dianzheng Zhang, D. W. Albert, Paul Kohlhepp, Daphne Pham, and Joy J. Winzerling
Manduca sexta IRP1: molecular characterization and in vivo response to iron, Dianzheng Zhang, Cara Ferris, Jurgen Gailer, Pete Kohlhepp, and Joy J. Winzerling
Submissions from 2000
Antibodies to HIV-1 gp41 recognize synthetic peptides of human IFN-a and IFN-ß, Yun Bai, Y. Zhao, Tianwei Yu, and Manfred P. Dierich
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia, Charles R. Breese, Michael Lee, Cathy E. Adams, Bernadette Sullivan, Judy Logel, Kieron M. Gillen, Michael J. Marks, Allan C. Collins, and Sherry Leonard
Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex, Mairead Casy, Carl J. Vaughan, Jie He, Cathy J. Hatcher, Jordan M. Winter, Stanislawa Weremowicz, Kate Montgomery, Raju Kucherlapati, Cynthia C. Morton, and Craig T. Bassoni
MMP-13 is induced during chondrocyte hypertrophy, Marina D'Angelo, Z. Yan, M. Nooreyazdan, Maurizio Pacifici, D. S. Sarment, Paul C. Billings, and Phoebe S. Leboy
Preparation of Chick Striated Muscle Cultures, Camille DiLullo, Jacquelyn Gerhart, and Mindy George-Weinstein
Medical patients in crisis, Robert A. DiTomasso, Donna M. Martin, and Karel D. Kovnat
DNA dendrimers localize MyoD mRNA in presomitic tissues of the chick embryo, Jacquelyn Gerhart, M. Baytion, S. Deluca, R. Getts, C. Lopez, R. Niewenhuis, T. Nilsen, S. Olex, H. Weintraub, and Mindy George-Weinstein
Clinical research: The process, Frederick J. Goldstein
Study underscores need to consider multiple factors in debate on physician-assisted suicide., Frederick J. Goldstein
The role of p21 in interferon-gamma-mediated growth inhibition of human breast cancer cells, Jennifer L. Gooch, R. E. Herrera, and D. Yee
Dopamine relaxes porcine coronary arteries and stimulates potassium channel activity in porcine coronary arterial smooth muscle cells, Guichun Han, J. P. McMillin, and Richard E. White
Nuclear Notch1 signaling and the regulation of dendritic development, Lori Redmond Hardy, Sang-rog Oh, Carol Hicks, Gerry Weinmaster, and Anirvan Ghosh
Identification and localization of TBX5 transcription factor during human cardiac morphogenesis, Cathy J. Hatcher, Marsha M. Goldstein, Caroline S. Mah, C. Susan Delia, and Craig T. Basson
Atrial form and function: Lessons from human molecular genetics, Cathy J. Hatcher, Minsu Kim, and Craig T. Basson
Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature, G. J. Hernandez, Francis E. Jenney Jr., M. W. Adams, and D. M. Lemaster
Cardioprotective effects of citrulline in ischemia/reperfusion injury via a non-nitric oxide-mediated mechanism, Yasuhiko Ikeda, Lindon Young, Rosario Scalia, and Allen M. Lefer
Diazepam, y-aminobutyric acid, and progesterone open K+ channels in myocytes from coronary arteries, Maryanne K. Jacob and Richard E. White
Caring for Low Back Pain, Evaluation and Management of Acute Low Back Pain, V. Jaeger, N. DiNubile, and Alexander S. Nicholas
Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition, A. V. Lee, J. L. Gooch, S. Oesterreich, R. L. Guler, and D. Yee
Ultrastructural analysis of beta-amyloid production in monocytes, epithelial, and endothelial cells infected with Chlamydia pneumoniae isolated from Alzheimer brains, Christopher S. Little, A. MacIntyre, Christine Hammond, E. Venuti, B. J. Bromke, Brian J. Balin, and Denah M. Appelt
An alternative to synthetic aortic grafts using Jejunum, S. E. Marshall, S. M. Tweedt, Charlotte H. Greene, and et al.
Inorganic phosphate induces apoptosis of osteoblast-like cells in culture, Z. Meleti, I. M. Shapiro, and Christopher S. Adams
Calcium-activated potassium channels and nitric oxide coregulate estrogen-induced vasodilation, Charles R. Rosenfeld, Richard E. White, Tim Roy, and Blair E. Cox
Adenosine and nitric oxide regulate regional vascular resistance via interdependent and independent mechanisms during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law
Interdependence of adenosine and nitric oxide in hepato-splanchnic circulation during sepsis, A. D. Sam II, Avadhesh C. Sharma, A. N. Rice, J. L. Ferguson, and W. R. Law
Central versus peripheral mediation of naloxone's perfusion effects in endotoxic rats, Avadhesh C. Sharma, A. D. Sam II, K. J. Alden, S. L. Moore, W. R. Law, and J. L. Ferguson
Loading of calcium and strontium into the sarcoplasmic reticulum in rat ventricular muscle, C. I. Spencer, Robert J. Barsotti, and J. R. Berlin
Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts, Ruth D. Thornton, P. Lane, Ruth C. Borghaei, E. A. Pease, J. Caro, and Eugene Mochan
Rational design of cytotoxic T-cell inhibitors, Anna P. Tretiakova, C. Scott Little, Kenneth J. Blank, and Bradford A. Jameson
Utilization of Bone Morphogenetic Protein Receptors during Chondrocyte Maturation., Susan W. Volk, Marina D'Angelo PhD, David Diefenderfer, and Phoebe S. Leboy
Tetraethylammonium potentiates the activity of muscarinic potassium channels in guinea-pig atrial myocytes., Desuo Wang and David L. Armstrong
Caring for Our Patients, Matthew D. Weinberg
Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia., Kristin Wijsanen Weitzel, Julie M. Wickman, Sara Grimsley Augustin, and J. Grady Strom
cAMP-dependent vasodilators cross-activate the cGMP-dependent protein kinase to stimulate Bk(Ca) channel activity in coronary artery smooth muscle cells, Richard E. White, Jonathan P. Kryman, Abdalla M. El-mowafy, Guichun Han, and Gerald O. Carrier
Recognizing and treating tardive dyskineseia, Julie M. Wickman and J. M. Cold
Combinations of variations in multiple genes are associated with hypertension., S M Williams, J H Addy, J A Phillips, M Dai, J Kpodonu, J Afful, H Jackson, K Joseph, F Eason, M M Murray, P Epperson, Adwoa Aduonum, L J Wong, P A Jose, and R A Felder
Distinct subcellular localization and mRNA expression of neuronal nitric oxide synthase in the nucleus dorsalis and red nucleus and their correlation with inducible transcription factors after spinal cord hemisection, Mei Xu, Yee-Kong Ng, and Seng-Kee Leong
Neuroprotective and neurodestructive functions of nitric oxide after spinal cord hemisection, Mei Xu, Yee-Kong Ng, and Seng-Kee Leong
Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states, A. P. Yeh, Y. Hu, Francis E. Jenney Jr., Michael W. Adams, and D. C. Rees
C-peptide exerts cardioprotective effects in myocardial ischemia-reperfusion, Lindon Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer
Wortmannin, a potent antineutrophil agent, exerts cardioprotective effects in myocardial ischemia/reperfusion, Lindon Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer
Induction of high levels of epitope-specific antibodies by epitope/peptide candidate vaccines against human immunodeficiency virus type- 1 (HIV-1), Tianwei Yu, Yun Bai, Manfred P. Dierich, and Ying-Hua Chen
Human interferon-ß inhibits binding of HIV-1 gp41 to lymphocyte and monocyte cells and binds the potential receptor protein P50 for HIV-1 gp41, Tianwei Yu, Yi Xiao, Yun Bai, Qinhua Ru, Guoan Luo, Manfred P. Dierich, and Ying-Hua Chen
Submissions from 1999
Paradoxical intention and recursive anxiety, L. Michael Ascher and D. E. Schotte
Complementary and alternative medicine: herbal therapies for diabetes., B. M. Berman, J. P. Swyers, and Joseph M. Kaczmarczyk
Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3), Ruth C. Borghaei, C. Sullivan, and Eugene Mochan
Modulation of major histocompatibility complex antigen expression by human immunodeficiency virus-2 gp36, Ying-Hua Chen, Yun Bai, Tianwei Yu, and Manfred P. Dierich
Immunogenicity of the GPGRAFY epitope on synthetic peptides, Ying-Hua Chen, Tianwei Yu, Yun Bai, and M. P. Dierich
Two proteins share immunological epitopes on the tumor-associated antigen 17-1A, Ying-Hua Chen, Tianwei Yu, Yun Bai, and Nanming Zhao
The ADP release step of the smooth muscle cross-bridge cycle is not directly associated with force generation, J. A. Dantzig, Robert J. Barsotti, S. Manz, H. L. Sweeney, and Y. E. Goldman
Hepatocyte Growth Factor/Scatter Factor Promotes a Switch From E- to N-cadherin in Chick Embryo Epiblast Cells., Steven M. DeLuca, Jacquelyn Gerhart, Eric Cochran, Eileen Simak, Jennifer Blitz, Michelle Mattiacci-Paessler, Karen Knudsen, and Mindy George-Weinstein
Precept-assist: A computerized, data-based evaluation system, Robert A. DiTomasso, J. D. Gamble, and M. A. Willard
Caring for the caregivers., Katherine Galluzzi
Frequency of Apoliprotein E (APOE) Allele Types in Pateinets with Chlamydia-Associated Arthritis and other Arthridities, Hervé C. Gérard, Geng Feng Wang, Brian J. Balin, H. Ralph Schumacher, and Alan P. Hudson
DOs need more training in diagnosing and treating addiction, Frederick J. Goldstein
Kevorkian kills patients along with the clinical research to help them, Frederick J. Goldstein
Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death - Proliferative and anti-apoptotic effects, Jennifer L. Gooch, C. L. Van Den Berg, and D. Yee
Strain-specific differences in formation of apoptotic DNA ladders in MCF-7 breast cancer cells, Jennifer L. Gooch and D. Yee
Identification of IL-1 regulated genes in human synovial and gingival fibroblasts by differential display, G. K. Gorski, M. Paul, H. Soohoo, Ruth C. Borghaei, Eugene Mochan, Ruth D. Thornton, and E. A. Pease
Excessive microtubules are not responsible for depressed force per cross-bridge in cardiac neural-crest-ablated embryonic chick hearts, Cathy J. Hatcher, Robert E. Godt, and T. M. Nosek
Anaerobic microbes: Oxygen detoxification without superoxide dismutase, Francis E. Jenney Jr., M. F. Verhagen, X. Cui, and M. W. Adams
Community reinforcement training for family and significant others of drug abusers: A unilateral intervention to increase treatment entry of drug users, K. Kirby, D. Marlowe, David Festinger, K. Garvey, and V. Lamonaca
Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo, A. V. Lee, J. G. Jackson, J. L. Gooch, S. G. Hilsenbeck, E. Coronado-Heinsohn, C. K. Osborne, and D. Yee
Interobserver variability among faculty in evaluations of residents' clinical skills, J. Mantia, W. Rennie, D. Risucci, R. Cydulka, L. Spillane, L. Graff, John W. Becher Jr., and K. Kleinschmidt
Cardiopulmonary bypass increases coronary IL-8 in diabetic patients without evidence of reperfusion injury, S. I. Nawas, J. C. Doherty, W. T. Vigneswaran, B. G. Fogelson, M. A. McMillen, J. L. Ferguson, Avadhesh C. Sharma, and W. R. Law
Osteopathic Manipulation for Management of Pain, Alexander S. Nicholas, T. Bezilla, and R. Jones
COX-2-specific inhibition: implications for clinical practice., Richard A. Pascucci
Internal representational models of peers: implications for the development of problematic behavior., Virginia Burks Salzer, K. A. Dodge, J. M. Price, and R. D. Laird
Knowledge structures, social information processing, and children's aggressive behavior, Virginia Burks Salzer, R. D. Laird, K. A. Dodge, G. S. Pettit, and J. E. Bates
Sepsis produces depression of testosterone and steroidogenic acute regulatory (StAR) protein, A. D. Sam II, Avadhesh C. Sharma, L. Y. Lee, D. B. Hales, W. R. Law, J. L. Ferguson, and H. B. Bosmann
In situ localization and characterization of active proteases in chronically inflamed and healthy human gingival tissues, David P. Sarment, Jonathan Korostoff, Marina D'Angelo, Alan Polson, Ray Feldman, and Paul Billings
Elevated coronary endothelin-1 but not Nitric oxide in diabetics during CABG, Avadhesh C. Sharma, B. G. Fogelson, S. I. Nawas, W. T. Vigneswaran, A. D. Sam II, K. J. Alden, J. L. Ferguson, and W. R. Law
Secondary structure extensions in Pyrococcus furiosus ferredoxin destabilize the disulfide bond relative to that in other hyperthermostable ferredoxins. Global consequences for the disulfide orientational heterogeneity, P. L. Wang, L. Calzolai, K. L. Bren, Q. Teng, Francis E. Jenney Jr., P. S. Brereton, J. B. Howard, M. W. Adams, and G. N. La Mar
Suspected Medicine Theft by a Co-Worker: What Role Should a Nurse Play?, Matthew D. Weinberg
Molecular cloning and characterization of LKv1, a novel voltage-gated potassium channel in leech, Jamie L. Weiss, Jay Yang, Chunfa Jie, Diana L. Walker, Shawn Ahmed, Yunxia Zhu, Yueqiao Huang, Kristen M. Johansen, and Jørgen Johansen
Making cents out of caring for patients., Julie M. Wickman, R. Jackson, and J. Marquess
Submissions from 1998
Chondrocyte apoptosis increases with age in the articular cartilage of adult animals, Christopher S. Adams and W. E. Horton Jr.
Increased apoptosis of articular chondrocytes in a Bcl-2 knockout transgenic mouse line, Christopher S. Adams and W. E. Horton Jr.
Effect of aminoguanidine on plasma nitric oxide by-products and blood flow during chronic peritoneal sepsis, K. J. Alden, S. J. Motew, Avadhesh C. Sharma, and J. L. Ferguson
Interleukin-4 suppression of interleukin-1-induced transcription of collagenase (MMP-1) and stromelysin 1 (MMP-3) in human synovial fibroblasts, Ruth C. Borghaei, P. L. Rawlings Jr., and Eugene Mochan
Induction of mitogen-inducible nuclear orphan receptor by interleukin 1 in human synovial and gingival fibroblasts, Ruth C. Borghaei, R. S. Sinai, Eugene Mochan, and E. A. Pease
Idiopathic ulcerative colitis in patients with primary sclerosing colitis undergoing orthotopic liver transplantation (OLT) [2], Naga Chalasani and Gregory Smallwood
Is vaccination against hepatitis B infection indicated in patients waiting for or after orthotopic liver transplantation, Naga Chalasani, Gregory Smallwood, Joanne Halcomb, Michael W. Fried, and Thomas D. Boyer
Activation of TGFß2 accompanies chondrocyte maturation and is metalloprotease-mediated, Marina D'Angelo, D. Sarment, P. Billings, and Maurizio Pacifici
Diabetic patients produce an increase in coronary sinus endothelin 1 after coronary artery bypass grafting, B. G. Fogelson, S. I. Nawas, W. T. Vigneswaran, J. L. Ferguson, W. R. Law, and Avadhesh C. Sharma
Induction of bone morphogenetic protein-2 by interleukin-1 in human fibroblasts, M. J. Fowler Jr., M. S. Neff, Ruth C. Borghaei, E. A. Pease, and Eugene Mochan
Unexpected Effects of Wnt-1 on the Differentiation and Adhesion of Myogenic Cells., Mindy George-Weinstein, Jeffrey Dare, Jacquelyn Gerhart, Anthony M.C Brown, Ann Redfield, Heather Brown, and Karen A. Kmidsen
The Role of Stably Committed and Uncommitted Cells in Establishing Tissues of the Somite, Mindy George-Weinstein, Jacquelyn Gerhart, Michele Mattiacci-Paessler, Eileen Simak, Jennifer Blitz, Rebecca Reed, and Karen Knudsen
Sclerotherapists receive tips on managing addicts' pain., Frederick J. Goldstein
Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells, Jennifer L. Gooch, A. V. Lee, and D. Yee
Effect of exercise training on passive stiffness in locomotor skeletal muscle: Role of extracellular matrix, L. E. Gosselin; Christopher S. Adams; T. A. Cotter; R, J. Mccormick; and D. P. Thomas
The mouse hepatitis virus A59 spike protein is not cleaved in primary hepatocyte and glial cell cultures, Susan T. Hingley, Isabelle Leparc-Goffart, and Susan R. Weiss
The spike protein of murine coronavirus mouse hepatitis virus strain A59 is not cleaved in primary glial cells and primary hepatocytes, Susan T. Hingley, Isabelle Leparc-Goffart, and Susan R. Weiss