The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 1999

Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo, A. V. Lee, J. G. Jackson, J. L. Gooch, S. G. Hilsenbeck, E. Coronado-Heinsohn, C. K. Osborne, and D. Yee

Interobserver variability among faculty in evaluations of residents' clinical skills, J. Mantia, W. Rennie, D. Risucci, R. Cydulka, L. Spillane, L. Graff, John W. Becher Jr., and K. Kleinschmidt

Cardiopulmonary bypass increases coronary IL-8 in diabetic patients without evidence of reperfusion injury, S. I. Nawas, J. C. Doherty, W. T. Vigneswaran, B. G. Fogelson, M. A. McMillen, J. L. Ferguson, Avadhesh C. Sharma, and W. R. Law

Osteopathic Manipulation for Management of Pain, Alexander S. Nicholas, T. Bezilla, and R. Jones

COX-2-specific inhibition: implications for clinical practice., Richard A. Pascucci

Internal representational models of peers: implications for the development of problematic behavior., Virginia Burks Salzer, K. A. Dodge, J. M. Price, and R. D. Laird

Knowledge structures, social information processing, and children's aggressive behavior, Virginia Burks Salzer, R. D. Laird, K. A. Dodge, G. S. Pettit, and J. E. Bates

Sepsis produces depression of testosterone and steroidogenic acute regulatory (StAR) protein, A. D. Sam II, Avadhesh C. Sharma, L. Y. Lee, D. B. Hales, W. R. Law, J. L. Ferguson, and H. B. Bosmann

In situ localization and characterization of active proteases in chronically inflamed and healthy human gingival tissues, David P. Sarment, Jonathan Korostoff, Marina D'Angelo, Alan Polson, Ray Feldman, and Paul Billings

Elevated coronary endothelin-1 but not Nitric oxide in diabetics during CABG, Avadhesh C. Sharma, B. G. Fogelson, S. I. Nawas, W. T. Vigneswaran, A. D. Sam II, K. J. Alden, J. L. Ferguson, and W. R. Law

Secondary structure extensions in Pyrococcus furiosus ferredoxin destabilize the disulfide bond relative to that in other hyperthermostable ferredoxins. Global consequences for the disulfide orientational heterogeneity, P. L. Wang, L. Calzolai, K. L. Bren, Q. Teng, Francis E. Jenney Jr., P. S. Brereton, J. B. Howard, M. W. Adams, and G. N. La Mar

Suspected Medicine Theft by a Co-Worker: What Role Should a Nurse Play?, Matthew D. Weinberg

Molecular cloning and characterization of LKv1, a novel voltage-gated potassium channel in leech, Jamie L. Weiss, Jay Yang, Chunfa Jie, Diana L. Walker, Shawn Ahmed, Yunxia Zhu, Yueqiao Huang, Kristen M. Johansen, and Jørgen Johansen

Making cents out of caring for patients., Julie M. Wickman, R. Jackson, and J. Marquess

Submissions from 1998

Chondrocyte apoptosis increases with age in the articular cartilage of adult animals, Christopher S. Adams and W. E. Horton Jr.

Increased apoptosis of articular chondrocytes in a Bcl-2 knockout transgenic mouse line, Christopher S. Adams and W. E. Horton Jr.

Effect of aminoguanidine on plasma nitric oxide by-products and blood flow during chronic peritoneal sepsis, K. J. Alden, S. J. Motew, Avadhesh C. Sharma, and J. L. Ferguson

Interleukin-4 suppression of interleukin-1-induced transcription of collagenase (MMP-1) and stromelysin 1 (MMP-3) in human synovial fibroblasts, Ruth C. Borghaei, P. L. Rawlings Jr., and Eugene Mochan

Induction of mitogen-inducible nuclear orphan receptor by interleukin 1 in human synovial and gingival fibroblasts, Ruth C. Borghaei, R. S. Sinai, Eugene Mochan, and E. A. Pease

Idiopathic ulcerative colitis in patients with primary sclerosing colitis undergoing orthotopic liver transplantation (OLT) [2], Naga Chalasani and Gregory Smallwood

Is vaccination against hepatitis B infection indicated in patients waiting for or after orthotopic liver transplantation, Naga Chalasani, Gregory Smallwood, Joanne Halcomb, Michael W. Fried, and Thomas D. Boyer

Activation of TGFß2 accompanies chondrocyte maturation and is metalloprotease-mediated, Marina D'Angelo, D. Sarment, P. Billings, and Maurizio Pacifici

Diabetic patients produce an increase in coronary sinus endothelin 1 after coronary artery bypass grafting, B. G. Fogelson, S. I. Nawas, W. T. Vigneswaran, J. L. Ferguson, W. R. Law, and Avadhesh C. Sharma

Induction of bone morphogenetic protein-2 by interleukin-1 in human fibroblasts, M. J. Fowler Jr., M. S. Neff, Ruth C. Borghaei, E. A. Pease, and Eugene Mochan

Unexpected Effects of Wnt-1 on the Differentiation and Adhesion of Myogenic Cells., Mindy George-Weinstein, Jeffrey Dare, Jacquelyn Gerhart, Anthony M.C Brown, Ann Redfield, Heather Brown, and Karen A. Kmidsen

The Role of Stably Committed and Uncommitted Cells in Establishing Tissues of the Somite, Mindy George-Weinstein, Jacquelyn Gerhart, Michele Mattiacci-Paessler, Eileen Simak, Jennifer Blitz, Rebecca Reed, and Karen Knudsen

Sclerotherapists receive tips on managing addicts' pain., Frederick J. Goldstein

Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells, Jennifer L. Gooch, A. V. Lee, and D. Yee

Effect of exercise training on passive stiffness in locomotor skeletal muscle: Role of extracellular matrix, L. E. Gosselin; Christopher S. Adams; T. A. Cotter; R, J. Mccormick; and D. P. Thomas

The mouse hepatitis virus A59 spike protein is not cleaved in primary hepatocyte and glial cell cultures, Susan T. Hingley, Isabelle Leparc-Goffart, and Susan R. Weiss

The spike protein of murine coronavirus mouse hepatitis virus strain A59 is not cleaved in primary glial cells and primary hepatocytes, Susan T. Hingley, Isabelle Leparc-Goffart, and Susan R. Weiss

Chondrocyte apoptosis in development, aging and disease, W. E. Horton Jr., L. Feng, and Christopher S. Adams

Development and pathway formation of peripheral neurons during leech embryogenesis, Yueqiao Huang, John Jellies, Kristen M. Johansen, and Jørgen Johansen

Targeted recombination within the spike gene of murine coronavirus mouse hepatitis virus-A59: Q159 is a determinant of hepatotropism, Isabelle Leparc-Goffart, Susan T. Hingley, Ming Chua, J. Phillips, Ehud Lavi, and Susan R. Weiss

Cognitive, Neuroimaging, and Pathological Studies of Pick's Disease, Andrew P. Lieberman, John Q. Trojanowski, Virginia M.-Y. Lee, Brian J. Balin, Xin-Shen Ding, Joel Greenberg, and Donald Morrison

The role of feedforward and feedback inhibition on frequency-dependent information processing in a cerebellar granule cell, Huo Lu, F. W. Prior, and L. J. Larson-Prior

Adenosine receptor antagonism affects regional resting vascular resistance during rat peritoneal sepsis, S. J. Motew, A. D. Sam II, M. G. Mourelatos, Avadhesh C. Sharma, K. J. Alden, J. L. Ferguson, and W. R. Law

Helping cancer patients cope: A problem-solving approach, Arthur Nezu, Christine Nezu, Stephanie H. Felgoise (née Friedman), Shirley Faddis, and Peter Houts

Use of in vitro systems to study male germ cell development in neonatal rats, J. M. Orth, Michael P. McGuinness, J. Qiu, W. F. Jester Jr., and L. H. Li

Differences in the immune response during the acute phase of E-55+ murine leukemia virus infection in progressor BALB and long term nonprogressor C57BL mice., Vily Panoutsakopoulou, C. Scott Little PhD, Thomas G. Sieck, Elizabeth P. Blankenhorn, and Kenneth J. Blank

Cartilage formation in a hollow fiber bioreactor studied by proton magnetic resonance microscopy, K. Potter, J. J. Butler, Christopher S. Adams, K. W. Fishbein, E. W. Mcfarland, W. E. Horton, and R. G. Spencer


The predictive validity of parent and teacher reports of ADHD symptoms, Thomas J. Power, Brian J. Doherty, Susan Panichelli-Mindel, James L. Karustis, Ricaro B. Eiraldi, Arthur D. Anastopoulos, and George J. DuPaul

The Neuropathology of Chromosome 17-linked Autosomal Dominant Parkinsonism-Dementia (Pallo-ponto-nigral Degeneration), L.A. Reed, M.L. Schmidt, Z.K. Wszolek, Brian J. Balin, V. Soontornniyomkij, V. M. Lee, and T. J. Trojanowski

Renal osteodystrophy with leontiasis ossea deformity, J. M. Reidy, K. Motamedi, D. Berens, M. Haar, and Theodore P. Mauer

The Taskforce 200 Survey on Medical Education in Sleep and Sleep Disorders, R. Rosen, M. Mahowald, A. Chesson, K. Doghramji, R. Goldberg, M. Moline, R. Millman, Burton Mark, G. Zammit, and W. Dement

Estrogenic xenobiotics affect the intracellular activation signal in mitogen-induced human peripheral blood lymphocytes: Immunotoxicological impact, K. Sakabe, M. Okuma, M. Kazuno, T. Yamaguchi, T. Yoshida, H. Furuya, F. Kayama, Y. Suwa, W. Fujii, and Kerin L. Fresa

A differential response of diffuse brain injury on the concentrations of endothelin and nitric oxide in the plasma and brain regions in rats, Avadhesh C. Sharma, M. Misra, R. Prat, K. J. Alden, A. D. Sam II, V. Z. Markiv, M. Dujovny, and J. L. Ferguson

Effect of NG-nitro-L-arginine methyl ester on testicular blood flow and serum steroid hormones during sepsis, Avadhesh C. Sharma, A. D. Sam II, L. Y. Lee, D. B. Hales, W. R. Law, J. L. Ferguson, and H. B. Bosmann

Induction of microglial reaction and expression of nitric oxide synthase I in the nucleus dorsalis and red nucleus following lower thoracic spinal cord hemisection, Mei Xu, Yee-Kong Ng, and Seng-Kee Leong

Expression of a vitamin D-regulated gene (VDUP-1) in untreated- and MNU-treated rat mammary tissue, X. Yang, Lindon H. Young, and J. M. Voigt

Protein phosphorylation associated with epipodophyllotoxin-induced apoptosis of lymphoid cells: Role of a serine/threonine protein kinase, Xiaodan Ye, Neeta S. Mody, Susan T. Hingley, Frederick D. Coffman, Stanley Cohen, and Kerin Fresa

Submissions from 1997

The Association of Tissue Transglutaminase with Human Recombinant tau Results in the Formation of Insoluble Filamentous Structures, Denah M. Appelt and Brian J. Balin

Study reveals successful removal of unwanted hair with LPIR laser, Coyle Connolly and Laurence Paolini

Neural crest is involved in development of abnormal myocardial function, Simon J. Conway, Robert E. Godt, Cathy J. Hatcher, Linda Leatherbury, Vladimir V. Zolotouchnikov, Marco A.P. Brotto, Andrew J. Cobb, Margaret L. Kirby, and Tony L. Creazzo

Articular chondrocytes produce factors that inhibit maturation of sternal chondrocytes in serum-free agarose cultures: A TGF-ß independent process, Marina D'Angelo and Maurizio Pacifici

The internal open reading frame within the nucleocapsid gene of mouse hepatitis virus encodes a structural protein that is not essential for viral replication, Francois Fisher, Ding Peng, Susan T. Hingley, Susan R. Weiss, and Paul S. Masters

Hepatitis g virus co-infection in liver transplantation recipients with chronic hepatitis c and nonviral chronic liver disease, M. W. Fried, Y. E. Khudyakov, Gregory Smallwood, M. Cong, B. Nichols, E. Diaz, P. Siefert, K. Gutekunst, R. D. Gordon, and T. D. Boyer

Osteopathic Medical Component Missed in Treating Anterior Hip Pain, David B. Fuller

N-cadherin Promotes the Commitment and Differentiation of Skeletal Muscle Precursor Cells, Mindy George-Weinstein, Jacquelyn Gerhart, Jennifer Blitz, Eileen Simak, and Karen A. Knudsen

Safe passage: pain management, advance directives key to end-of-life care., Frederick J. Goldstein

Role of et and NO in resuscitative effect of diaspirin cross-linked hemoglobin after hemorrhage in rat, A. Gulati, A. P. Sen, Avadhesh C. Sharma, and G. Singh

Role of spinal σ1 and σ2 opioid receptors in the antinociception produced by microinjection of L-glutamate in the ventromedial medulla of the rat, D. L. Hammond, B. B. Donahue, and Peggy E. Stewart

Cues intrinsic to the spinal cord determine the pattern and timing of primary afferent growth, Lori Redmond Hardy, Huiwen Xie, Lea Ziskind-Conhaim, and Susan Hockfield

Differential glycosylation of Tractin and LeechCAM, two novel Ig superfamily members, regulates neurite extension and fascicle formation, Yueqiao Huang, John Jellies, Kristen M. Johansen, and Jørgen Johansen

Therapy for youths with anxiety disorders: A second randomized clinical trial, P. C. Kendall, E. Flannery-Schroeder, Susan Panichelli-Mindel, M. Southam-Gerow, A. Henin, and M. Warman

Exposure to child anxiety: Theory, research, and practice, P. C. Kendall, Susan Panichelli-Mindel, A. Sugarman, and S. A. Callahan

Maternal expectations and attributions about coping in anxious children, E. Kortlander, P. C. Kendall, and Susan Panichelli-Mindel


Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein, Isabelle Leparc-Goffart, Susan T. Hingley, Ming Chua, Xinhe Jiang, Ehud Lavi, and Susan R. Weiss

Quality of life: A process view, Howard E. Leventhal and Stacey Cahn (neé Colman)

Information processing in a cerebellar granule cell, Huo Lu, R. W. Prior, and L. J. Larson-Prior

Breath-holding in healthy and pulmonary-compromised populations: Effects of hyperventilation and oxygen inspiration, B. Marks, D. G. Mitchell, and John P. Simelaro

Transurethral microwave hyperthermia in the treatment of chronic nonbacterial prostatitis, M P. Mene, P. C. Ginsburg, Larry Finkelstein, S. J. Manfrey, Laurence Belkoff, F. Ogbolu, and D. Osborne

Interleukin-1β increases airway epithelial cell mitogenesis partly by stimulating endothelin-1 production, C. G. Murlas, Avadhesh C. Sharma, A. Gulati, and F. Najmabadi

Cytochrome c(y) of Rhodobacter capsulatus is attached to the cytoplasmic membrane by an uncleaved signal sequence-like anchor, H. Myllykallio, Francis E. Jenney Jr., C. R. Moomaw, C. A. Slaughter, and F. Daldal

DGLA discoordinately suppresses IL-1 induced metalloproteinase mRNA levels in human synovial fibroblasts, X. Ni, H. Borghaei, Ruth C. Borghaei, Ruth D. Thornton, E. A. Pease, William Laidlaw, and Eugene Mochan

Hypoxemia and recurrent epistaxis in an 81-year-old woman, Daniel J. Parenti, John P. Simelaro, and Michael Venditto

Splanchnic vascular control during sepsis and endotoxemia., A. D. Sam II, Avadhesh C. Sharma, W. R. Law, and J. L. Ferguson

Sepsis alters myocardial and plasma concentrations of endothelin and nitric oxide in rats, Avadhesh C. Sharma, S. J. Motew, S. Farias, K. J. Alden, H. B. Bosmann, W. R. Law, and J. L. Ferguson

A carboxy-terminal peptide of the α1-subunit of the dihydropyridine receptor inhibits Ca2+-release channels, Kenneth J. Slavik, J. P. Wang, B. Aghdasi, J. Z. Zhang, F. Mandel, N. Malouf, and S. L. Hamilton

Patient treatment choice and compliance: Data from a substance abuse treatment program, Robert C. Sterling, Edward Gottheil, Scott D. Glassman, S. P. Weinstein, and Ronald D. Serota

Specific testicular cellular localization and hormonal regulation of the PKIα and PKIß isoforms of the inhibitor protein of the cAMP-dependent protein kinase, S. M. Van Patten, L. F. Donaldson, Michael P. McGuinness, P. Kumar, A. Alizadeh, M. D. Griswold, and D. A. Walsh

Submissions from 1996

Analysis of Paired Helical Fragments Found in Alzheimer's Disease Using Freeze-Drying/Rotary Shadowing, Denah M. Appelt and Brian J. Balin

Localization of Transglutaminase in Hippocampal Neurons: Implications for Alzeimer's Disease, Denah M. Appelt, G.C. Kopen, L.J. Boyne, and Brian J. Balin

Myosin isoforms show different strokes for different blokes, Robert J. Barsotti, J. A. Dantzig, and Y. E. Goldman

Reliability of performance-based clinical skill assessment of emergency medicine residents, W. P. Burdick, M. F. Ben-David, L. Swisher, John W. Becher Jr., D. Magee, R. McNamara, and M. Zwanger

DSM-IV and internalizing disorders: Modifications, limitations, and utility, S. A. Callahan, Susan Panichelli-Mindel, and P. C. Kendall

Chemical modifcation and inactivation of rat liver arginase by N-bromosuccinimide: Reaction with his141, Farzaneh Daghigh, R. Christoper Cavalli, Dianne R. Soprano, and David E. Ash

Laser photolysis of caged calcium: Rates of calcium release by nitrophenyl-EGTA and DM-nitrophen, G. C. R. Ellis-Davies, J. H. Kaplan, and Robert J. Barsotti

Skeletal Myogenesis: The Preferred Pathway of Chick Embryo Epiblast Cells in Vitro, Mindy George-Weinstein, Jacquelyn Gerhart, Rebecca Reed, Joseph Flynn, Beth Callihan, Michele Mattiacci, Carolyn Miehle, Gerard Foti, James W. Lash, and Harold Weintraub

Intrinsic and Extrinsic Regulation of the Development of Myogenic Precursors of the Chick Embryo, Mindy George-Weinstein, Jacquelyn Gerhart, R. Reed, A. Steinberg, M. Mattiacci, H. Weintraub, and K. Knudsen

Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin, A. Gulati, Avadhesh C. Sharma, and G. Singh

The membrane-bound cytochrome cy of Rhodobacter capsulatus can serve as an electron donor to the photosynthetic reaction center of Rhodobacter sphaeroides, Francis E. Jenney Jr., R. C. Prince, and F. Daldal

Reproductive health hazards in the workplace: Guidelines for policy development and implementation, Joseph M. Kaczmarczyk and M. E. Paul

Rhodobacter capsulatus CycH: A bipartite gene product with pleiotropic effects on the biogenesis of structurally different c-type cytochromes, S. E. Lang, Francis E. Jenney Jr., and F. Daldal

Serotonergic modulation of evoked responses in turtle cerebellar Purkinje cells., Huo Lu and L J Larson-Prior

Assessment of coercive and noncoercive pressures to enter drug abuse treatment, D. Marlowe, K. Kirby, L. Bonieskie, D. Glass, L. Dodds, S. .. Husband, J. Platt, and David Festinger

Identification of Phosphorylated Sites in PHF-tau from Patients with Guam Amytrophic Lateral Sclerosis/Parkinsonism-Dementia Complex, M. Mawal-Dewan, M.L. Schmidt, Brian J. Balin, D.P. Perl, V. M. Lee, and John. Q. Trojanowski

Metastatic Sertoli cell carcinoma of the testis, M P. Mene, Larry Finkelstein, S. J. Manfrey, and Larry Belkoff

Heat-related deaths in Philadelphia - 1993, H. G. Mirchandani, Gregory McDonald, I. C. Hood, and C. Fonseca

Thoracic Somatic Dysfunction: a Case Report, Alexander S. Nicholas and G. Gross