The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Works repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, book chapters, datasets, and unpublished works by faculty and staff at PCOM's Philadelphia, Georgia, and South Georgia campuses.
Submissions from 2006
Active caspase-3 is required for osteoclast differentiation, K. H. Szymczyk, T. A. Freeman, Christopher S. Adams, V. Srinivas, and M. J. Steinbeck
Involvement of hydrogen peroxide in the differentiation and apoptosis of preosteoclastic cells exposed to arsenite, K. H. Szymczyk, B. A. Kerr, T. A. Freeman, Christopher S. Adams, and M. J. Steinbeck
Initial attachment of osteoblast-like cells on functionalized surfaces coated with calcium phosphate, G. K. Toworfe, R. J. Composto, Christopher S. Adams, I. M. Shapiro, and P. Ducheyne
Attention deficit hyperactivity disorder and scholastic achievement: A model of mediation via academic enablers, R. J. Volpe, George J. DuPaul, J. C. DiPerna, A. K. Jitendra, J. G. Lutz, Katy E. Tresco, and R. V. Junod
Evaluation of PDE4 inhibition for COPD., Desuo Wang and Xiangli Cui
Validation of HPLC analysis method of a novel antihypertensive agent MS23 in rat plasma, Ting Wang, Laura M. Fox, and Desuo Wang
High performance liquid chromatographic analysis of MS23 piperidine analog MSP001 in rat plasma, Ting Wang and Desuo Wang
Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells, Xinyu Wang, Salomon Stavchansky, Phillip D. Bowman, and Sean M. Kerwin
Comparing the electronic properties of the low-spin cyano-ferric [Fe(N 4)(Cys)] active sites of superoxide reductase and P450cam using ENDOR spectroscopy and DFT calculations, T. Yang, R. L. McNaughton, M. D. Clay, Francis E. Jenney Jr., R. Krishnan, D. M. Kurtz Jr., Michael W. Adams, M. K. Johnson, and B. M. Hoffman
Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle, Shu Zhu, Richard E. White, and Scott A. Barman
Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle, Shu Zhu, Richard E. White, and Scott A. Barman
Submissions from 2005
Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent, Yun Bai, David K. Ann, and Wei-Chiang Shen
Hypoxia modulates cyclic AMP activation of BKCa channels in rat pulmonary arterial smooth muscle, Scott A. Barman, Shu Zhu, and Richard E. White
Current issues and treatment strategies for female transplant recipients, Jenny Bell and Gregory A. Smallwood
Bigendothelin-1 (1-21) fragment during early sepsis modulates tau, p38-MAPK phosphorylation and nitric oxide synthase activation, S. Brahmbhatt, A. Gupta, and Avadhesh C. Sharma
Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine, Z. Buraei, Mircea Anghelescu, and K. S. Elmslie
Predictors of interest in psychological treatment for insomnia among older primary care patients with disturbed sleep., Stacey C. Cahn, James W Langenbucher, Michael A Friedman, Peter Reavey, Terry Falco, and Robert M Pallay
A digital atlas to characterize the mouse brain transcriptome, James P. Carson, Tao Ju, Hui-Chen Lu, Christina Thaller, Mei Xu, Sarah Pallas, Michael C. Crair, Joe Warren, Wah Chiu, and Gregor Eichele
PAs and Public Opinion, John M. Cavenagh
Cost-effectiveness analysis of ondansetron and prochlorperazine for the prevention of postoperative nausea and vomiting., Peter Chang, Mark P. Okamoto, Jack Chen, and David Frame
Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction, H. Chen, S. Brahmbhatt, A. Gupta, and Avadhesh C. Sharma
Dopaminergic DA 1 signaling couples growth-associated protein-43 and long-term potentiation in guinea pig hippocampus, S. Chirwa, Adwoa Aduonum, J. Pizarro, J. Reasor, Y. Kawai, M. Gonzalez, B. S. McAdory, E. Onaivi, and E. J. Barea-Rodriguez
Assessment and intervention with youth exposed to sexual homicide of a family member, P. T. Clements, M. R. Asaro, T. Henry, and Gregory McDonald
Hysteresis as a Measure of Ankle Dysfunction, Alissa M. Cohen, James Mertz, Peggy Stewart, Michael J. Warner, and Michael L. Kuchera
A controlled evaluation of behavioral treatment with children with ADHD attending a summer treatment program, E. K. Coles, W. E. Pelham, E. M. Gnagy, L. Burrows-MacLean, G. A. Fabiano, A. Chacko, B. T. Wymbs, Katy E. Tresco, K. S. Walker, and J. A. Robb
Contrasting jail diversion and in-jail services for mental illness and substance abuse: Do they serve the same clients?, Jeffrey Draine, Amy Blank, Petra Kottsieper, and Phyllis Solomon
Do research payments precipitate drug use or coerce participation?, David Festinger, D. Marlowe, J. Croft, K. Dugosh, N. Mastro, P. Lee, D. DeMatteo, and N. Patapis
Medical Students' Perceptions of Medical Education Research and Their Roles as Participants, Joseph P. Forester and David L. McWhorter
Organizational and Individual Factors in Bringing Research to Practice: What We Know, Where We Need to Go, Susan G. Forman, Diane L. Smallwood, and Richard J. Nagle
Organizational and individual factors in bringing research to practice: What we know, where we need to go, Susan G. Forman, Diane Smallwood, and Richard J. Nagle
Histrionic personality disorder, Arthur Freeman, Sharon Morgillo Freeman, and Bradley M. Rosenfield
Osteopathic Management Case Study: Somatic Dysfunction Causing Adolescent Chest Pain - Counterstrain Treatment, David B. Fuller
Law enforcement campaign: Barrier to optimal pain management, Frederick J. Goldstein
Progress in Pain Management: Where Are We?, Frederick J. Goldstein
Preoperative Intravenous Morphine Sulfate with Postoperative Osteopathic Manipulative Treatment Reduces Patient Analgesic Use After Total Abdominal Hysterectomy, Frederick J. Goldstein, Saul Jeck, Alexander S. Nicholas, Marvin J. Berman, and Marilyn Lerario
Apoptosis and survival of osteoblast-like cells are regulated by surface attachment, V. Grigoriou, I. M. Shapiro, E. A. Cavalcanti-Adam, R. J. Composto, P. Ducheyne, and Christopher S. Adams
In vitro reconstitution of an NADPH-dependent superoxide reduction pathway from Pyrococcus furiosus, A. M. Grunden, Francis E. Jenney Jr., K. Ma, M. Ji, M. V. Weinberg, and M. W. Adams
Bigendothelin-1 via p38-MAPK-dependent mechanism regulates adult rat ventricular myocyte contractility in sepsis, A. Gulati, N. S. Aberle II, R. Kapoor, J. Ren, and Avadhesh C. Sharma
Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and apoptosis during sepsis, A. Gulati, N. S. Aberle II, J. Ren, and Avadhesh C. Sharma
Chronic peritoneal sepsis: Myocardial dysfunction, endothelin and signaling mechanisms, A. Gupta, S. Brahmbhatt, and Avadhesh C. Sharma
Transforming growth factor-β1 (TGF-β1) regulates ATDC5 chondrogenic differentiation and fibronectin isoform expression, F. Han, Christopher S. Adams, Z. Tao, C. J. Williams, R. Zaka, R S. Tuan, P. A. Norton, and N. J. Hickok
Regulation of dendritic development by calcium signaling, Lori Redmond Hardy and Anirvan Ghosh
Low incidence of hepatic artery thrombosis after pediatric liver transplantation without the use of intraoperative microscope or parenteral anticoagulation, Thomas Heffron, David Welch, Todd Pillen, Carlos Fasola, Dougg Redd, Gregory Smallwood, Enrique Martinez, George Atkinson, and et al.
Factorial design approach to evaluate interactions between electrically assisted enhancement and skin stripping for delivery of tacrine., Adina C. Hirsch, Rashmi S Upasani, and Ajay K Banga
Fluoroquinolone-resistant Pseudomonas aeruginosa: Risk factors for acquisition and impact on outcomes, Donald I. Hsu, Mark P. Okamoto, Rekha Murthy, and Annie Wong-Beringer
High-throughput production of Pyrococcus furiosus proteins: Considerations for metalloproteins, Francis E. Jenney Jr., P. S. Brereton, M. Izumi, F. L. Poole II, C. Shah, F. J. Sugar, H. Lee, and M. W. Adams
Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules, Foaz Kayali, Heather L. Montie, J. A. Rafols, and Donald J. DeGracia
Considering CBT with Anxious Youth? Think Exposures, Philip C. Kendall, Joanna A. Robin, Kristina A. Hedtke, Cynthia Suveg, Ellen C. Flannery-Schroeder, and Elizabeth A. Gosch
ASHP survey of ambulatory care pharmacy practice in health systems - 2004, K. K. Knapp, Mark P. Okamoto, and B. L. Black
Osteopathic Manipulative Medicine Considerations in Patients with Chronic Pain, Michael L. Kuchera
Prevalence and types of disease management programs in community pharmacies in California., Anandi V. Law, Mark P. Okamoto, and Peter S. Chang
Common ground for spatial cognition? A behavioral and fMRI study of sex differences in mental rotation and spatial working memory | Evolutionary Psychology, Sarah Levin Allen, Feroze B. Mohamed, and Steven M. Platek
Dendritic spine morphogenesis and plasticity, Jocelyn Lippman-Bell and A. Dunaevsky
Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c mice, Christopher S. Little, A. Bowe, R. Lin, J. Litsky, R. M. Fogel, Brian J. Balin, and Kerin L. Fresa-Dillon
Age Alterations in Extent and Severity of Experimental Intranasal Infection with Chlamydophila pneumoniae in BALB/c Mice, Christopher Scott Little, Andrew Bowe, Richard Lin, Jason Litsky, Robert M. Fogel, Brian J. Balin PhD, and Kerin L. Fresa-Dillon
Correlations between purkinje cell single-unit activity and simultaneously recorded field potentials in the immediately underlying granule cell layer, Huo Lu, Mitra J. Hartmann, and James M. Bower
A refined long RT-PCR technique to amplify complete viral RNA genome sequences from clinical samples: Application to a novel hepatitis C virus variant of genotype 6, Ling Lu, Tatsunori Nakano, Gregory Smallwood, Thomas Heffron, Betty H. Robertson, and Curt H. Hagedorn
Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode, Melinda Maris, Su-Jin Kwak, Andreas Fritz, and Bruce B. Riley
Are judicial status hearings a "key component" of drug court? Six and twelve months outcomes, D. Marlowe, David Festinger, K. Dugosh, and P. Lee
Perceived deterrence and outcomes in drug court, D. Marlowe, David Festinger, C. Foltz, P. Lee, and N. Patapis
PERK is activated differentially in peripheral organs following cardiac arrest and resuscitation, Heather L. Montie, Adam J. Haezebrouck, Jennifer C. Gutwald, and Donald J. DeGracia
Renal ischemia and reperfusion activates the eIF2 alpha kinase PERK, Heather L. Montie, Foaz Kayali, Adam J. Haezebrouck, Noreen F. Rossi, and Donald J. DeGracia
Murine coronavirus evolution in vivo: Functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein, Sonia Navas-Martin, Susan T. Hingley, and Susan R. Weiss
American Osteopathic Association's policy statement on end-of-life care, K. J. Nichols, Katherine E. Galluzzi, B. P. Bates, B. A. Husted, J. P. Leleszi, C. Cass, R. L. Sosnowski, J. F. Manfredonia, and D. Lavery
Protein kinase C ßII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury, Didi Omiyi, Richard J. Brue, Philip Taormina II, Margaret Harvey, Norrell Atkinson, and Lindon Young
Protein Kinase C BetaII Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury, Didi Omiyi, Richard J. Brue, Philip Taormina, Margaret Harvey, Norrell Atkinson, and Lindon H. Young
Disclosure of distress among anxiety-disordered youth: Differences in treatment outcome, Susan Panichelli-Mindel, E. Flannery-Schroeder, P. C. Kendall, and A. G. Angelosante
A dose-ranging study of a methylphenidate transdermal system in children with ADHD, W. E. Pelham Jr., M. J. Manos, C. E. Ezzell, Katy E. Tresco, E. M. Gnagy, M. T. Hoffman, A. N. Onyango, G. A. Fabiano, Katy E. Tresco, and et al.
Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD, W. E. Pelham, L. Burrows-MacLean, E. M. Gnagy, G. A. Fabiano, E. K. Coles, Katy E. Tresco, A. Chacko, B. T. Wymbs, A. L. Wienke, and et al.
Protein Kinase C-Zeta Inhibition Exerts Cardioprotective Effects in Ischemia-Reperfusion Injury, Aisha Phillipson, Ellen E. Peterman, Philip Taormina, Margaret Harvey, Richard J. Brue, Norrell Atkinson, Didi Omiyi, Uchenna Chukwu, and Lindon H. Young
Only the Mean Survive?, Steven M. Platek and Sarah Levin Allen
Defining genes in the genome of the hyperthermophilic archaeon Pyrococcus furiosus: Implications for all microbial genomes, F. L. Poole II, B. A. Gerwe, R. C. Hopkins, G. J. Schut, M. V. Weinberg, Francis E. Jenney Jr, and M. W. Adams
AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain, R. M. Sanchez, W. Dai, R. E. Levada, Jocelyn Lippman-Bell, and F. E. Jensen
Bottlenecks and roadblocks in high-throughput XAS for structural genomics, R. A. Scott, J. E. Shokes, N. J. Cosper, Francis E. Jenney Jr., and M. W. Adams
Fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate, I. M. Shapiro, Christopher S. Adams, T. Freeman, and V. Srinivas
Mechanism of chaperone function in small heat shock proteins: Dissociation of the HSP27 oligomer is required for recognition and binding of destabilized T4 lysozyme, Rangaiah Shashidharamurthy, Hanane A. Koteiche, Jinhui Dong, and Hassane S. Mchaoruab
Joint and Bone Disease in Mucopolysaccharidoses VI and VII: Identification of New Therapeutic Targets and Biomarkers Using Animal Models, Calogera M. Simonaro, Marina D'Angelo, Mark E. Haskins, and Edward H. Schuchman
Relationship between immunosuppression and osteoporosis in an outpatient liver transplant clinic, Gregory Smallwood, D. Burns, C. G. Fasola, A. C. Stieber, and Thomas Heffron
Characterization of a novel zinc-containing, lysine-specific aminopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus, S. V. Story, C. Shah, Francis E. Jenney Jr., and M. W. Adams
NeuroM and MyoD are Expressed in Separate Subpopulations of Cells in the Pregastrulating Epiblast, Robert Strony, Jacquelyn Gerhart, Dolores Tornambe, Jordanna Perlman, Christine Neely, Jeffrey Dare, Benjamin Stewart, and Mindy George-Weinstein
Comparison of small- and large-scale expression of selected Pyrococcus furiosus genes as an aid to high-throughput protein production, F. J. Sugar, Francis E. Jenney Jr., F. L. Poole II, P. S. Brereton, M. Izumi, C. Shah, and M. W. Adams
Protein production and crystallization at SECSG - An overview, B. C. Wang, Michael W. Adams, H. Dailey, L. DeLucas, M. Luo, J. Rose, R. Bunzel, T. Dailey, Francis E. Jenney Jr., and et al.
Novel approaches to using PDE4 inhibitors for antihypertensive therapy, Desuo Wang and Ting Wang
The expression of COX-2, PCNA and Cyclin D1 in the model of reflux esophagitis, T. Wang, J. Gong, Qian Chen, and J. Wang
Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle, Richard E. White, Guichun Han, Christiana Dimitropoulou, Shu Zhu, Katsuya Miyake, David Fulton, Shaylee Dave, and Scott A. Barman
Normal mode analysis of Pyrococcus furiosus rubredoxin via nuclear resonance vibrational spectroscopy (NRVS) and resonance Raman spectroscopy, Y. Xiao, H. Wang, S. J. George, M. C. Smith, Michael W. Adams, Francis E. Jenney Jr., W. Sturhahn, E. E. Alp, J. Zhao, and et al.
Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection, Mei Xu, George Wei-Cheong Yip, Le-Ting Gan, and Yee-Kong Ng
Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice, S. Yoshikawa, T. Miyahara, S. D. Reynolds, B. R. Stripp, Mircea Anghelescu, F. G. Eyal, and J. C. Parker
Gö 6983: A Fast Acting Protein Kinase C Inhibitor That Attenuates Myocardial Ischemia/Reperfusion Injury, Lindon H. Young, Brian J. Balin PhD, and Margaret T. Weis
Protein kinase C (PKC) isoform peptide activator/inhibitors exert cardioprotective effects in polymorphonuclear leukocyte (PMN) induced ischemia/reperfusion (I/R) injury, Lindon H. Young, A. Phillipson, D. Omiyi, N. Atkinson, M. Jivani, J. Adams, and E E. Peterman
JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2), Dianzheng Zhang, Hoguen Yoon, and Jiemin Wong
Submissions from 2004
PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase, Scott A. Barman, Shu Zhu, and Richard E. White
NF-kB binds to a polymorphic repressor element in the MMP-3 promoter, Ruth C. Borghaei, P. L. Rawlings Jr., Masoud Javadi, and J. Woloshin
Photoreceptor Degeneration and Loss of Retinal Function in the C57BL/6-C2J Mouse, Arturo Bravo Nuevo, Natalie Walsh, and Jonathan Stone
Factors supporting quality of life over time for individuals with amyotrophic lateral sclerosis: The role of positive self-perception and religiosity, Barbara A. Bremer, Ann Louise Simone, Susan Walsh, Zachary Simmons, and Stephanie H. Felgoise
Bone cell survival in microgravity: Evidence that modeled microgravity increases osteoblast sensitivity to apoptogens, M. A. Bucaro, J. Fertala, Christopher S. Adams, M. Steinbeck, P. Ayyaswamy, K. Munkundakrishnan, I. M. Shapiro, and M. V. Risbud
Identifying United States substance abuse treatment programs: A test in one mid-sized city, D. Carise, A. McLellan, David Festinger, and H. Kleber
A neutron crystallographic analysis of a rubredoxin mutant at 1.6 Ã… resolution, T Chatake, K. Kurihara, I. Tanaka, I. Tsyba, R. Bau, Francis E. Jenney Jr., M. W. Adams, and N. Niimura
Cerebral ischemia and the unfolded protein response, Donald J. DeGracia and Heather L. Montie
Functionalized surfaces for bone cell adhesion, P. Ducheyne, G. Toworfe, M. H. Lee, R. J. Composto, Christopher S. Adams, and I. M. Shapiro