The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.
Submissions from 2005
Common ground for spatial cognition? A behavioral and fMRI study of sex differences in mental rotation and spatial working memory | Evolutionary Psychology, Sarah Levin Allen, Feroze B. Mohamed, and Steven M. Platek
Dendritic spine morphogenesis and plasticity, Jocelyn Lippman-Bell and A. Dunaevsky
Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c mice, Christopher S. Little, A. Bowe, R. Lin, J. Litsky, R. M. Fogel, Brian J. Balin, and Kerin L. Fresa-Dillon
Age Alterations in Extent and Severity of Experimental Intranasal Infection with Chlamydophila pneumoniae in BALB/c Mice, Christopher Scott Little, Andrew Bowe, Richard Lin, Jason Litsky, Robert M. Fogel, Brian J. Balin PhD, and Kerin L. Fresa-Dillon
Correlations between purkinje cell single-unit activity and simultaneously recorded field potentials in the immediately underlying granule cell layer, Huo Lu, Mitra J. Hartmann, and James M. Bower
A refined long RT-PCR technique to amplify complete viral RNA genome sequences from clinical samples: Application to a novel hepatitis C virus variant of genotype 6, Ling Lu, Tatsunori Nakano, Gregory Smallwood, Thomas Heffron, Betty H. Robertson, and Curt H. Hagedorn
Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode, Melinda Maris, Su-Jin Kwak, Andreas Fritz, and Bruce B. Riley
Are judicial status hearings a "key component" of drug court? Six and twelve months outcomes, D. Marlowe, David Festinger, K. Dugosh, and P. Lee
Perceived deterrence and outcomes in drug court, D. Marlowe, David Festinger, C. Foltz, P. Lee, and N. Patapis
PERK is activated differentially in peripheral organs following cardiac arrest and resuscitation, Heather L. Montie, Adam J. Haezebrouck, Jennifer C. Gutwald, and Donald J. DeGracia
Renal ischemia and reperfusion activates the eIF2 alpha kinase PERK, Heather L. Montie, Foaz Kayali, Adam J. Haezebrouck, Noreen F. Rossi, and Donald J. DeGracia
Murine coronavirus evolution in vivo: Functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein, Sonia Navas-Martin, Susan T. Hingley, and Susan R. Weiss
American Osteopathic Association's policy statement on end-of-life care, K. J. Nichols, Katherine E. Galluzzi, B. P. Bates, B. A. Husted, J. P. Leleszi, C. Cass, R. L. Sosnowski, J. F. Manfredonia, and D. Lavery
Protein kinase C ßII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury, Didi Omiyi, Richard J. Brue, Philip Taormina II, Margaret Harvey, Norrell Atkinson, and Lindon Young
Protein Kinase C BetaII Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury, Didi Omiyi, Richard J. Brue, Philip Taormina, Margaret Harvey, Norrell Atkinson, and Lindon H. Young
Disclosure of distress among anxiety-disordered youth: Differences in treatment outcome, Susan Panichelli-Mindel, E. Flannery-Schroeder, P. C. Kendall, and A. G. Angelosante
A dose-ranging study of a methylphenidate transdermal system in children with ADHD, W. E. Pelham Jr., M. J. Manos, C. E. Ezzell, Katy E. Tresco, E. M. Gnagy, M. T. Hoffman, A. N. Onyango, G. A. Fabiano, Katy E. Tresco, and et al.
Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD, W. E. Pelham, L. Burrows-MacLean, E. M. Gnagy, G. A. Fabiano, E. K. Coles, Katy E. Tresco, A. Chacko, B. T. Wymbs, A. L. Wienke, and et al.
Protein Kinase C-Zeta Inhibition Exerts Cardioprotective Effects in Ischemia-Reperfusion Injury, Aisha Phillipson, Ellen E. Peterman, Philip Taormina, Margaret Harvey, Richard J. Brue, Norrell Atkinson, Didi Omiyi, Uchenna Chukwu, and Lindon H. Young
Only the Mean Survive?, Steven M. Platek and Sarah Levin Allen
Defining genes in the genome of the hyperthermophilic archaeon Pyrococcus furiosus: Implications for all microbial genomes, F. L. Poole II, B. A. Gerwe, R. C. Hopkins, G. J. Schut, M. V. Weinberg, Francis E. Jenney Jr, and M. W. Adams
AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain, R. M. Sanchez, W. Dai, R. E. Levada, Jocelyn Lippman-Bell, and F. E. Jensen
Bottlenecks and roadblocks in high-throughput XAS for structural genomics, R. A. Scott, J. E. Shokes, N. J. Cosper, Francis E. Jenney Jr., and M. W. Adams
Fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate, I. M. Shapiro, Christopher S. Adams, T. Freeman, and V. Srinivas
Mechanism of chaperone function in small heat shock proteins: Dissociation of the HSP27 oligomer is required for recognition and binding of destabilized T4 lysozyme, Rangaiah Shashidharamurthy, Hanane A. Koteiche, Jinhui Dong, and Hassane S. Mchaoruab
Joint and Bone Disease in Mucopolysaccharidoses VI and VII: Identification of New Therapeutic Targets and Biomarkers Using Animal Models, Calogera M. Simonaro, Marina D'Angelo, Mark E. Haskins, and Edward H. Schuchman
Relationship between immunosuppression and osteoporosis in an outpatient liver transplant clinic, Gregory Smallwood, D. Burns, C. G. Fasola, A. C. Stieber, and Thomas Heffron
Characterization of a novel zinc-containing, lysine-specific aminopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus, S. V. Story, C. Shah, Francis E. Jenney Jr., and M. W. Adams
NeuroM and MyoD are Expressed in Separate Subpopulations of Cells in the Pregastrulating Epiblast, Robert Strony, Jacquelyn Gerhart, Dolores Tornambe, Jordanna Perlman, Christine Neely, Jeffrey Dare, Benjamin Stewart, and Mindy George-Weinstein
Comparison of small- and large-scale expression of selected Pyrococcus furiosus genes as an aid to high-throughput protein production, F. J. Sugar, Francis E. Jenney Jr., F. L. Poole II, P. S. Brereton, M. Izumi, C. Shah, and M. W. Adams
Protein production and crystallization at SECSG - An overview, B. C. Wang, Michael W. Adams, H. Dailey, L. DeLucas, M. Luo, J. Rose, R. Bunzel, T. Dailey, Francis E. Jenney Jr., and et al.
Novel approaches to using PDE4 inhibitors for antihypertensive therapy, Desuo Wang and Ting Wang
The expression of COX-2, PCNA and Cyclin D1 in the model of reflux esophagitis, T. Wang, J. Gong, Qian Chen, and J. Wang
Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle, Richard E. White, Guichun Han, Christiana Dimitropoulou, Shu Zhu, Katsuya Miyake, David Fulton, Shaylee Dave, and Scott A. Barman
Normal mode analysis of Pyrococcus furiosus rubredoxin via nuclear resonance vibrational spectroscopy (NRVS) and resonance Raman spectroscopy, Y. Xiao, H. Wang, S. J. George, M. C. Smith, Michael W. Adams, Francis E. Jenney Jr., W. Sturhahn, E. E. Alp, J. Zhao, and et al.
Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection, Mei Xu, George Wei-Cheong Yip, Le-Ting Gan, and Yee-Kong Ng
Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice, S. Yoshikawa, T. Miyahara, S. D. Reynolds, B. R. Stripp, Mircea Anghelescu, F. G. Eyal, and J. C. Parker
Gö 6983: A Fast Acting Protein Kinase C Inhibitor That Attenuates Myocardial Ischemia/Reperfusion Injury, Lindon H. Young, Brian J. Balin PhD, and Margaret T. Weis
Protein kinase C (PKC) isoform peptide activator/inhibitors exert cardioprotective effects in polymorphonuclear leukocyte (PMN) induced ischemia/reperfusion (I/R) injury, Lindon H. Young, A. Phillipson, D. Omiyi, N. Atkinson, M. Jivani, J. Adams, and E E. Peterman
JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2), Dianzheng Zhang, Hoguen Yoon, and Jiemin Wong
Submissions from 2004
PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase, Scott A. Barman, Shu Zhu, and Richard E. White
NF-kB binds to a polymorphic repressor element in the MMP-3 promoter, Ruth C. Borghaei, P. L. Rawlings Jr., Masoud Javadi, and J. Woloshin
Photoreceptor Degeneration and Loss of Retinal Function in the C57BL/6-C2J Mouse, Arturo Bravo Nuevo, Natalie Walsh, and Jonathan Stone
Factors supporting quality of life over time for individuals with amyotrophic lateral sclerosis: The role of positive self-perception and religiosity, Barbara A. Bremer, Ann Louise Simone, Susan Walsh, Zachary Simmons, and Stephanie H. Felgoise
Bone cell survival in microgravity: Evidence that modeled microgravity increases osteoblast sensitivity to apoptogens, M. A. Bucaro, J. Fertala, Christopher S. Adams, M. Steinbeck, P. Ayyaswamy, K. Munkundakrishnan, I. M. Shapiro, and M. V. Risbud
Identifying United States substance abuse treatment programs: A test in one mid-sized city, D. Carise, A. McLellan, David Festinger, and H. Kleber
A neutron crystallographic analysis of a rubredoxin mutant at 1.6 Ã… resolution, T Chatake, K. Kurihara, I. Tanaka, I. Tsyba, R. Bau, Francis E. Jenney Jr., M. W. Adams, and N. Niimura
Cerebral ischemia and the unfolded protein response, Donald J. DeGracia and Heather L. Montie
Functionalized surfaces for bone cell adhesion, P. Ducheyne, G. Toworfe, M. H. Lee, R. J. Composto, Christopher S. Adams, and I. M. Shapiro
Model surfaces engineered with nanoscale roughness and RGD tripeptides promote osteoblast activity, A. R. El-Ghannam, P. Ducheyne, M. Risbud, Christopher S. Adams, I. M. Shapiro, D. Castner, S. Golledge, and R. J. Composto
Encyclopedia of cognitive behavior therapy, Arthur Freeman and Stephanie H. Felgoise
Dreams and the Dream Image: Using Dreams in Cognitive Therapy, Arthur Freeman and Beverly White
Professionalism: Orientation Exercises for Incoming Osteopathic Medical Students and Developing Class Vision Statements, Kerin L. Fresa-Dillon, Robert G. Cuzzolino, and Kenneth J. Veit
Influence of age, gender, and race on depression in heart failure patients., Ronald Freudenberger, Stacey C. Cahn, and Christine Skotzko
Visualizing the needle in the haystack: In situ hybridization with fluorescent dendrimers, Jacquelyn Gerhart, M. Baytion, J. Perlman, C. Neely, B. Hearon, T. Nilsen, R. Getts, J. Kadushin, and Mindy George-Weinstein
Epiblast cells that express MyoD recruit pluripotent cells to the skeletal muscle lineage, Jacquelyn Gerhart, C. Neely, B. Stewart, J. Perlman, D. Beckmann, M. Wallon, K. Knaudsen, and Mindy George-Weinstein
Emerging drug delivery systems: Scientific reality or media hype?, Naushad Ghilzai
Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2, Jeffrey R. Gingrich, Kenneth A. Pelkey, Sami R. Fam, Yueqiao Huang, Ronald S. Petralia, Robert J. Wenthold, and Michael W. Salter
Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom, K. S. Girish, Rangaiah Shashidharamurthy, T. V. Gowda, and K. Kemparaju
[contributions], Frederick J. Goldstein
Involvement of Calcineurin in Transforming Growth Factor-ß-mediated Regulation of Extracellular Matrix Accumulation, Jennifer L. Gooch, Y. Gorin, B. X. Zhang, and H. E. Abboud
Differential expression of calcineurin A isoforms in the diabetic kidney, Jennifer L. Gooch, P. E. Pargola, R. L. Guler, H. E. Abboud, and J. L. Barnes
Calcineurin A-α but not A-ß is required for normal kidney development and function, Jennifer L. Gooch, J. J. Toro, R. L. Guler, and J. L. Barnes
Left ventricular mitogen activated protein kinase signaling following polymicrobial sepsis during streptozotocin-induced hyperglycemia, A. Gupta, S. Brahmbhatt, and Avadhesh C. Sharma
Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases, A. Gupta and Avadhesh C. Sharma
Calcium signaling in dendrite development, Lori Redmond Hardy
A role for Tbx5 in proepicardial cell migration during cardiogenesis, Cathy J. Hatcher, Nata Diman, Minsu Kim, David Pennisi, Yan Song, Marsha M. Goldstien, Takashi Mikawa, and Craig T. Basson
Interleukin-4 suppresses IL-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts, K. Jenkins and M. Javadi
Neutron crystallographic study on rubredoxin from Pyrococcus furiosus by BIX-3, a single-crystal diffractometer for biomacromolecules, K. Kurihara, I. Tanaka, T. Chatake, M. W. Adams, Francis E. Jenney Jr., N. Moiseeva, R. Bau, and N. Niimura
Effects of Task Difficulty and Type of Contingency on Students' Allocation of Responding to Math Worksheets, Amanda L. Lannie and Brian K Martens
Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice, C. Scott Little, Christine J. Hammond, Brian J. Balin, and Denah M. Appelt
W3Y single mutant of rubredoxin from Pyrococcus furiosus: a preliminary time-of-flight neutron study., X. Li, P. Langan, R. Bau, I. Tsyba, Francis E. Jenney Jr., Michael W. Adams, and B. P. Schoenborn
Activation Kinetics of Skinned Cardiac Muscle by Laser Photolysis of Nitrophenyl-EGTA, H. Martin, Marcus G. Bell, G. C. R. Ellis-Davies, and Robert J. Barsotti
Activation Kinetics of Skinned Cardiac Muscle by Laser Photolysis of Nitrophenyl-EGTA, Hunter Martin, Marcus G. Bell, Graham C. Ellis-Davis, and Robert J. Barsotti
Effects of sham air and cigarette smoke on A549 lung cells: Implications for iron-mediated oxidative damage, Jonathan J. Mayo, Pete Kohlhepp, Dianzheng Zhang, and Joy J. Winzerling
Functional Characterization of Na(+)/(H+) Exchangers in Primary Cultures of Prairie Dog Gallbladder, S.C. Narin, E.H. Park, R. Ramakrishnan, R. Garcia, J. N. Diven, Brian J. Balin, and Christine J. Hammond
NMDA receptors are movin' in, Yi Nong, Yueqiao Huang, and Michael W. Salter
Frank Stinchfield award: Titanium surface with biologic activity against infection, J. Parvizi, E. Wickstrom, A. R. Zeiger, Christopher S. Adams, I. M. Shapiro, J. J. Purtill, P. F. Sharkey, W. J. Hozack, R. H. Rothman, and N. J. Hickok
The UME-21 Project: Connecting Medical Education and Medical Practice, J. M. Pascoe, D. Babbott, K. L. Pye, H. V. Rabinowitz, Kenneth J. Veit, and D. L. Wood
Gö 6983 Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion, Ellen E. Peterman, Philip Taormina II, Margaret Harvey, and Lindon Young
Cross-bridge versus thin filament contributions to the level and rate of force development in cardiac muscle, M. Regnier, H. Martin, Robert J. Barsotti, A. J. Rivera, D. A. Martyn, and E. Clemmens
Role of small intestine submucosa (SIS) as a nerve conduit: preliminary report, Ryan M. Smith, Christina Wiedl, Paul Chubb, and Charlotte H. Greene
Ionizing radiation sensitizes bone cells to apoptosis, K. H. Szymczyk, I. M. Shapiro, and Christopher S. Adams
Regeneration of uterine horn using porcine small intestine submucosa grafts in rabbits, Jon W. Taveau, Michele Tartaglia, Dana Buchanan, Bret Smith, George Koenig, Kevin Thomfohrde, Bruce Stouch, Saul Jeck, and Charlotte H. Greene
Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin, W. Tempel, Z. Liu, F. D. Schubot, A. Shah, M. V. Weinberg, Francis E. Jenney Jr., W. B. Arendall III, M. W. Adams, J. S. Richardson, and J. P. Rose
Regulation of the p300 HAT domain via a novel activation loop, Paul R. Thompson, Dongxia Wang, Marcella Fulco, Natalia Pediconi, Dianzheng Zhang, Woojin An, Qingyuan Ge, Robert R. Roeder, Jiemin Wong, and Massimo Levrero
Effect of surface activated poly(dimethylsiloxane) on fibronectin adsorption and cell function, G. K. Toworfe, R. J. Composto, Christopher S. Adams, I. M. Shapiro, and P. Ducheyne
Fibronectin adsorption on surface-activated poly(dimethylsiloxane) and its effect on cellular function, G. K. Toworfe, R. J. Composto, Christopher S. Adams, I. M. Shapiro, and P. Ducheyne
Backbone solution structures of proteins using residual dipolar couplings: Application to a novel structural genomics target, H. Valafar, K. L. Mayer, C. M. Bougault, P. D. LeBlond, Francis E. Jenney Jr., P. S. Brereton, Michael W. Adams, and J. H. Prestegard
Osteopathic medical education - 2004, Kenneth J. Veit
Resistance of Photoreceptors in the C57BL/6-c2j, C57BL/6j, and BALB/CJ Mouse Strains to Oxygen Stress: Evidence of an Oxygen Phenotype, Natalie Walsh, Arturo Bravo Nuevo, Scott Geller, and Jonathan Stone
Rubrerythrin from the hyperthermophilic archaeon Pyrococcus furiosus is a rubredoxin-dependent, iron-containing peroxidase, M. V. Weinberg, Francis E. Jenney Jr., X. Cui, and Michael W. Adams
Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium, Margaret T. Weiss, Jason L. Crumley, Lindon Young, and John N. Stallone
The Transepithelial Transport of a G-CSF-Transferrin Conjugate in Caco-2 Cells and Its Myelopoietic Effect in BDF1 Mice, Adam Widera, Yun Bai, and Wei-Chiang Shen
Lessons Learned - UME-21 Project, D. L. Wood, D. Babbott, J. M. Pascoe, K. L. Pye, H. K. Rabinowitz, and Kenneth J. Veit
Submissions from 2003
Estradiol relaxes rat aorta via endothelium-dependent and -independent mechanisms, G. Abou-Mohamed, A. Elmorakby, G. O. Carrier, J. D. Catraval, R. W. Caldwell, and Richard E. White
Response to 'does weight gain lead to weight loss?', Christopher S. Adams and J. L. Blank
Mechanisms by which extracellular matrix components induce osteoblast apoptosis, Christopher S. Adams and I. M. Shapiro
Chlamydia pneumoniae in the Pathogenesis of Alzheimer's Disease, Brian J. Balin PhD, Christine J. Hammond, C. Scott Little PhD, Amanda McIntyre, and Denah M. Appelt
Observation of Fe - H/D modes by nuclear resonant vibrational spectroscopy, U. Bergman, W. Sturhahn, D. E. Linn Jr., Francis E. Jenney, M. W. Adams, K. Rupnik, B. J. Hales, E. E. Alp, A. Mayse, and S. P. Kramer