The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Works repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, book chapters, datasets, and unpublished works by faculty and staff at PCOM's Philadelphia, Georgia, and South Georgia campuses.
Submissions from 2006
An emerging role for calcineurin Aα in the development and function of the kidney, Jennifer L. Gooch
Loss of calcineurin Aα results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus, Jennifer L. Gooch, R. L. Guler, J. L. Barnes, and J. J. Toro
School-based interventions for anxiety disorders, Elizabeth A. Gosch and E. Flannery-Schroeder
Principles of Cognitive-Behavioral Therapy for Anxiety Disorders in Children, Elizabeth A. Gosch, Ellen C. Flannery-Schroeder, C. F. Mauro, and Scott N. Compton
Implementation of IDEA: Integrating Response to Intervention and Cognitive Assessment Methods, James B. Hale, J. A. Naglieri, and K. A. Kavale
Antibiotic alters inflammation in the mouse brain during persistent Chlamydia pnemoniae infection, Christine J. Hammond, Christopher S. Little, N. Longo, C. Procacci, Denah M. Appelt, and Brian J. Balin
Estrogen receptor α mediates acute potassium channel stimulation in human coronary artery smooth muscle cells, Guichin Han, Xiuping Yu, Luo Lu, Shuyi Li, Handong Ma, Shu Zhu, Xiuyun Cui, and Richard E. White
Taking a bite out of hypertrophic cardiomyopathy: Soy diet and disease, Cathy J. Hatcher and Craig T. Basson
Using the TBX5 transcription factor to grow and sculpt the heart, Cathy J. Hatcher and Deborah A. McDermott
Successful ABO-incompatible pediatric liver transplantation utilizing standard immunosuppression with selective postoperative plasmapheresis, Thomas Heffron, David Welch, Todd Pillen, Massimo Asolati, Gregory Smallwood, Phil Hagedorn, Chang Nam, and et al.
Cytoskeletal Components of an Invasion Machine-The Apical Complex of Toxoplasma gondii, Ke Hu, Jeff Johnson, Laurence Florens, Martin Fraunholz, Sapna Suravajjala, Camille DiLullo, John Yates, David S. Roos, and John M. Murray
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36, Robert J. Klose, Kenichi Yamane, Yangjin Bae, Dianzheng Zhang, Hediye Erdjumnet-Bromage, Paul Tempst, Jiemin Wong, and Yi Zhang
Transcriptional and biochemical analysis of starch metabolism in the hyperthermophilic archaeon Pyrococcus furiosus, H. Lee, K. R. Shockley, G. J. Schut, S. B. Connors, C. I. Montero, M. R. Johnson, C. Chou, S. L. Bridger, Francis E. Jenney Jr, and et al.
Upregulation of calpastatin in regenerating and developing rat liver: Role in resistance against hepatotoxicity, Pallavi B. Limaye, Vishakha Bhave, Prajakta S. Palkar, Udayan M. Apte, Sharmilee P. Sawant, Songtao Yu, John R. Latendresse, Janardan K. Reddy, and Harihara M. Mehendale
Matching judicial supervision to clients' risk status in drug court, D. Marlowe, David Festinger, P. Lee, K. Dugosh, and K. Benasutti
Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction, K. L. Mayer, Y. Qu, S. Bansal, P. D. Leblond, Francis E. Jenney Jr., P. S. Brereton, M. W. Adams, Y. Xu, and J. H. Prestegard
Forensic Evidence. Preserving the Clinical Picture, James P. McCans
Risk Factors for Postpartum Depression: A Retrospective Investigation at 4-Weeks Postnatal and a Review of the Literature, Sarah J. Breese McCoy, J. Martin Beal, Stacia B. Miller Shipman, Mark E. Payton, and Gary H. Watson
Genetics of cardiac septation defects and their pre-implantation diagnosis., Deborah A. McDermott, Craig T. Basson, and Cathy J. Hatcher
The State of Arthritis in Pennsylvania, 2005, Eugene Mochan
The nitrodibenzofuran chromophore: A new caging group for ultra-efficient photolysis in living cells, A. Momotake, N. Lindegger, E. Niggli, Robert J. Barsotti, and G. C. R. Ellis-Davies
Current developments using emerging transdermal technologies in physical enhancement methods, A. Nanda, S. Nanda, and Naushad Ghilzai
Heparin modulates the 99-loop of factor IXa: Effects on reactivity with isolated Kunitz-type inhibitor domains, P. F. Neuenschwander, S. R. Williamson, A. Nalian, and Kimberly J. Baker
Differential expression and transcriptional analysis of the α-2,3-sialyltransferase gene in pathogenic Neisseria spp., M. Packiam, Dawn M. Shell, S. V. Liu, Y. B. Liu, D. J. McGee, R. Srivastava, S. Seal, and R. F. Rest
Editorial introductions, Stanislas Pol, Gregory Smallwood, Emanuel Cavazzoni, and Annibale Donini
Single category and comparative measures of implicit social cognition, Stephen R. Poteau
Endosomal Proteolysis by Cathepsins is Necessary for Murine Coronavirus Mouse Hepatitis Virus Type 2 Spike-Mediated Entry, Zhaozhu Qiu, Susan T. Hingley, Graham Simmons, Christopher Yu, Jayasri Das Sarma, Paul Bates, and Susan R. Weiss
Rapid Ethanol Tolerance Mediated by Adaptations in Acute Tolerance in Inbred Mouse Strains, Richard A. Radcliffe, K. L. Floyd, and Michael Lee
Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases, Richard A. Radcliffe, Michael Lee, and Robert W. Williams
Expression and purification of feline thyrotropin (fTSH): Immunological detection and bioactivity of heterodimeric and yoked glycoproteins, Srujana Rayalam, L. D. Eizenstat, R. R. Davis, M. Hoenig, and D. C. Ferguson
Cloning and sequencing of feline thyrotropin (fTSH): Heterodimeric and yoked constructs, Srujana Rayalam, L. D. Eizenstat, M. Hoenig, and D. C. Ferguson
A neurotoxic phospholipase A2 variant: Isolation and characterization from eastern regional Indian cobra (Naja naja) venom, Rangaiah Shashidharamurthy and K. Kemparaju
The ALSSQOL: Balancing Physical and Nonphysical Factors in Assessing Quality of Life in ALS, Zachary Simmons, Stephanie H. Felgoise, Barbara A. Bremer, Susan M. Walsh, D. J. Hufford, Mark B. Bromberg, W. David, D. A. Forshew, Terry D. Heiman-Patterson, Eugene C. Lai, and Leo McCluskey
Immunosuppressive strategies to avoid complications: The Achilles' heel of transplantation, Gregory Smallwood
Active caspase-3 is required for osteoclast differentiation, K. H. Szymczyk, T. A. Freeman, Christopher S. Adams, V. Srinivas, and M. J. Steinbeck
Involvement of hydrogen peroxide in the differentiation and apoptosis of preosteoclastic cells exposed to arsenite, K. H. Szymczyk, B. A. Kerr, T. A. Freeman, Christopher S. Adams, and M. J. Steinbeck
Initial attachment of osteoblast-like cells on functionalized surfaces coated with calcium phosphate, G. K. Toworfe, R. J. Composto, Christopher S. Adams, I. M. Shapiro, and P. Ducheyne
Attention deficit hyperactivity disorder and scholastic achievement: A model of mediation via academic enablers, R. J. Volpe, George J. DuPaul, J. C. DiPerna, A. K. Jitendra, J. G. Lutz, Katy E. Tresco, and R. V. Junod
Evaluation of PDE4 inhibition for COPD., Desuo Wang and Xiangli Cui
Validation of HPLC analysis method of a novel antihypertensive agent MS23 in rat plasma, Ting Wang, Laura M. Fox, and Desuo Wang
High performance liquid chromatographic analysis of MS23 piperidine analog MSP001 in rat plasma, Ting Wang and Desuo Wang
Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells, Xinyu Wang, Salomon Stavchansky, Phillip D. Bowman, and Sean M. Kerwin
Comparing the electronic properties of the low-spin cyano-ferric [Fe(N 4)(Cys)] active sites of superoxide reductase and P450cam using ENDOR spectroscopy and DFT calculations, T. Yang, R. L. McNaughton, M. D. Clay, Francis E. Jenney Jr., R. Krishnan, D. M. Kurtz Jr., Michael W. Adams, M. K. Johnson, and B. M. Hoffman
Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle, Shu Zhu, Richard E. White, and Scott A. Barman
Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle, Shu Zhu, Richard E. White, and Scott A. Barman
Submissions from 2005
Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent, Yun Bai, David K. Ann, and Wei-Chiang Shen
Hypoxia modulates cyclic AMP activation of BKCa channels in rat pulmonary arterial smooth muscle, Scott A. Barman, Shu Zhu, and Richard E. White
Current issues and treatment strategies for female transplant recipients, Jenny Bell and Gregory A. Smallwood
Bigendothelin-1 (1-21) fragment during early sepsis modulates tau, p38-MAPK phosphorylation and nitric oxide synthase activation, S. Brahmbhatt, A. Gupta, and Avadhesh C. Sharma
Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine, Z. Buraei, Mircea Anghelescu, and K. S. Elmslie
Predictors of interest in psychological treatment for insomnia among older primary care patients with disturbed sleep., Stacey C. Cahn, James W Langenbucher, Michael A Friedman, Peter Reavey, Terry Falco, and Robert M Pallay
A digital atlas to characterize the mouse brain transcriptome, James P. Carson, Tao Ju, Hui-Chen Lu, Christina Thaller, Mei Xu, Sarah Pallas, Michael C. Crair, Joe Warren, Wah Chiu, and Gregor Eichele
PAs and Public Opinion, John M. Cavenagh
Cost-effectiveness analysis of ondansetron and prochlorperazine for the prevention of postoperative nausea and vomiting., Peter Chang, Mark P. Okamoto, Jack Chen, and David Frame
Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction, H. Chen, S. Brahmbhatt, A. Gupta, and Avadhesh C. Sharma
Dopaminergic DA 1 signaling couples growth-associated protein-43 and long-term potentiation in guinea pig hippocampus, S. Chirwa, Adwoa Aduonum, J. Pizarro, J. Reasor, Y. Kawai, M. Gonzalez, B. S. McAdory, E. Onaivi, and E. J. Barea-Rodriguez
Assessment and intervention with youth exposed to sexual homicide of a family member, P. T. Clements, M. R. Asaro, T. Henry, and Gregory McDonald
Hysteresis as a Measure of Ankle Dysfunction, Alissa M. Cohen, James Mertz, Peggy Stewart, Michael J. Warner, and Michael L. Kuchera
A controlled evaluation of behavioral treatment with children with ADHD attending a summer treatment program, E. K. Coles, W. E. Pelham, E. M. Gnagy, L. Burrows-MacLean, G. A. Fabiano, A. Chacko, B. T. Wymbs, Katy E. Tresco, K. S. Walker, and J. A. Robb
Contrasting jail diversion and in-jail services for mental illness and substance abuse: Do they serve the same clients?, Jeffrey Draine, Amy Blank, Petra Kottsieper, and Phyllis Solomon
Do research payments precipitate drug use or coerce participation?, David Festinger, D. Marlowe, J. Croft, K. Dugosh, N. Mastro, P. Lee, D. DeMatteo, and N. Patapis
Medical Students' Perceptions of Medical Education Research and Their Roles as Participants, Joseph P. Forester and David L. McWhorter
Organizational and Individual Factors in Bringing Research to Practice: What We Know, Where We Need to Go, Susan G. Forman, Diane L. Smallwood, and Richard J. Nagle
Organizational and individual factors in bringing research to practice: What we know, where we need to go, Susan G. Forman, Diane Smallwood, and Richard J. Nagle
Histrionic personality disorder, Arthur Freeman, Sharon Morgillo Freeman, and Bradley M. Rosenfield
Osteopathic Management Case Study: Somatic Dysfunction Causing Adolescent Chest Pain - Counterstrain Treatment, David B. Fuller
Law enforcement campaign: Barrier to optimal pain management, Frederick J. Goldstein
Progress in Pain Management: Where Are We?, Frederick J. Goldstein
Preoperative Intravenous Morphine Sulfate with Postoperative Osteopathic Manipulative Treatment Reduces Patient Analgesic Use After Total Abdominal Hysterectomy, Frederick J. Goldstein, Saul Jeck, Alexander S. Nicholas, Marvin J. Berman, and Marilyn Lerario
Apoptosis and survival of osteoblast-like cells are regulated by surface attachment, V. Grigoriou, I. M. Shapiro, E. A. Cavalcanti-Adam, R. J. Composto, P. Ducheyne, and Christopher S. Adams
In vitro reconstitution of an NADPH-dependent superoxide reduction pathway from Pyrococcus furiosus, A. M. Grunden, Francis E. Jenney Jr., K. Ma, M. Ji, M. V. Weinberg, and M. W. Adams
Bigendothelin-1 via p38-MAPK-dependent mechanism regulates adult rat ventricular myocyte contractility in sepsis, A. Gulati, N. S. Aberle II, R. Kapoor, J. Ren, and Avadhesh C. Sharma
Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and apoptosis during sepsis, A. Gulati, N. S. Aberle II, J. Ren, and Avadhesh C. Sharma
Chronic peritoneal sepsis: Myocardial dysfunction, endothelin and signaling mechanisms, A. Gupta, S. Brahmbhatt, and Avadhesh C. Sharma
Transforming growth factor-β1 (TGF-β1) regulates ATDC5 chondrogenic differentiation and fibronectin isoform expression, F. Han, Christopher S. Adams, Z. Tao, C. J. Williams, R. Zaka, R S. Tuan, P. A. Norton, and N. J. Hickok
Regulation of dendritic development by calcium signaling, Lori Redmond Hardy and Anirvan Ghosh
Low incidence of hepatic artery thrombosis after pediatric liver transplantation without the use of intraoperative microscope or parenteral anticoagulation, Thomas Heffron, David Welch, Todd Pillen, Carlos Fasola, Dougg Redd, Gregory Smallwood, Enrique Martinez, George Atkinson, and et al.
Factorial design approach to evaluate interactions between electrically assisted enhancement and skin stripping for delivery of tacrine., Adina C. Hirsch, Rashmi S Upasani, and Ajay K Banga
Fluoroquinolone-resistant Pseudomonas aeruginosa: Risk factors for acquisition and impact on outcomes, Donald I. Hsu, Mark P. Okamoto, Rekha Murthy, and Annie Wong-Beringer
High-throughput production of Pyrococcus furiosus proteins: Considerations for metalloproteins, Francis E. Jenney Jr., P. S. Brereton, M. Izumi, F. L. Poole II, C. Shah, F. J. Sugar, H. Lee, and M. W. Adams
Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules, Foaz Kayali, Heather L. Montie, J. A. Rafols, and Donald J. DeGracia
Considering CBT with Anxious Youth? Think Exposures, Philip C. Kendall, Joanna A. Robin, Kristina A. Hedtke, Cynthia Suveg, Ellen C. Flannery-Schroeder, and Elizabeth A. Gosch
ASHP survey of ambulatory care pharmacy practice in health systems - 2004, K. K. Knapp, Mark P. Okamoto, and B. L. Black
Osteopathic Manipulative Medicine Considerations in Patients with Chronic Pain, Michael L. Kuchera
Prevalence and types of disease management programs in community pharmacies in California., Anandi V. Law, Mark P. Okamoto, and Peter S. Chang
Common ground for spatial cognition? A behavioral and fMRI study of sex differences in mental rotation and spatial working memory | Evolutionary Psychology, Sarah Levin Allen, Feroze B. Mohamed, and Steven M. Platek
Dendritic spine morphogenesis and plasticity, Jocelyn Lippman-Bell and A. Dunaevsky
Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c mice, Christopher S. Little, A. Bowe, R. Lin, J. Litsky, R. M. Fogel, Brian J. Balin, and Kerin L. Fresa-Dillon
Age Alterations in Extent and Severity of Experimental Intranasal Infection with Chlamydophila pneumoniae in BALB/c Mice, Christopher Scott Little, Andrew Bowe, Richard Lin, Jason Litsky, Robert M. Fogel, Brian J. Balin PhD, and Kerin L. Fresa-Dillon
Correlations between purkinje cell single-unit activity and simultaneously recorded field potentials in the immediately underlying granule cell layer, Huo Lu, Mitra J. Hartmann, and James M. Bower
A refined long RT-PCR technique to amplify complete viral RNA genome sequences from clinical samples: Application to a novel hepatitis C virus variant of genotype 6, Ling Lu, Tatsunori Nakano, Gregory Smallwood, Thomas Heffron, Betty H. Robertson, and Curt H. Hagedorn
Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode, Melinda Maris, Su-Jin Kwak, Andreas Fritz, and Bruce B. Riley
Are judicial status hearings a "key component" of drug court? Six and twelve months outcomes, D. Marlowe, David Festinger, K. Dugosh, and P. Lee
Perceived deterrence and outcomes in drug court, D. Marlowe, David Festinger, C. Foltz, P. Lee, and N. Patapis
PERK is activated differentially in peripheral organs following cardiac arrest and resuscitation, Heather L. Montie, Adam J. Haezebrouck, Jennifer C. Gutwald, and Donald J. DeGracia
Renal ischemia and reperfusion activates the eIF2 alpha kinase PERK, Heather L. Montie, Foaz Kayali, Adam J. Haezebrouck, Noreen F. Rossi, and Donald J. DeGracia
Murine coronavirus evolution in vivo: Functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein, Sonia Navas-Martin, Susan T. Hingley, and Susan R. Weiss
American Osteopathic Association's policy statement on end-of-life care, K. J. Nichols, Katherine E. Galluzzi, B. P. Bates, B. A. Husted, J. P. Leleszi, C. Cass, R. L. Sosnowski, J. F. Manfredonia, and D. Lavery
Protein kinase C ßII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury, Didi Omiyi, Richard J. Brue, Philip Taormina II, Margaret Harvey, Norrell Atkinson, and Lindon Young
Protein Kinase C BetaII Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury, Didi Omiyi, Richard J. Brue, Philip Taormina, Margaret Harvey, Norrell Atkinson, and Lindon H. Young