Novel approaches to using PDE4 inhibitors for antihypertensive therapy

Document Type

Article

Publication Date

2005

Abstract

Phosphodiesterase (PDE)4 inhibitors are effective vasodilators. In addition to the treatment of asthma and other inflammatory diseases, such as chronic obstructive pulmonary disease, wide-spectrum PDE4 inhibitors may also be developed for use in antihypertensive therapy, especially in patients with impaired renal function and elevated pulmonary arterial pressure. Rational approaches to overcoming the intrinsic emetogenic response associated with PDE4 inhibition are discussed, and a dual-action drug development that incorporates L-type Ca2+ channel antagonism and selective PDE4 inhibition is proposed. The potential for research and development of such a dual-action agent should eventually provide healthcare professionals with a new category of therapeutic options with which to attempt to combat hypertension.

Publication Title

Current Opinion in Investigational Drugs

Volume

6

Issue

3

First Page

283

Last Page

288

Comments

This article was published in Current Opinion in Investigational Drugs, Volume 6, Issue 3, Pages 283-288.

The published version is not available online. http://www.ncbi.nlm.nih.gov/pubmed/?term=15816505 .

Copyright © 2005 Thomson.

This document is currently not available here.

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