The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.

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Submissions from 1991

Somatic component to myocardial infarction: Three year follow up, Alexander S. Nicholas, Domenic A. DiBias, and Charlotte H. Greene

Effects of MK-801 and ketamine on short-term memory deficits in passive avoidance step-down task paradigm in mice, Avadesh C. Sharma and S. K. Kulkarni

MK-801 produces antianxiety effect in elevated plus-maze in mice, Avadesh C. Sharma and S. K. Kulkarni

Effect of NMDA-receptor ligands on neocortical and hippocampal EEG activity of rat brain, Avadesh C. Sharma, S. K. Kulkarni, and U. Nayar

Dizocilpine, ketamine and ethanol reverse NMDA-induced EEG changes and convulsions in rats and mice, Avadesh C. Sharma, S. N. Thorat, U. Nayar, and S. K. Kulkarni

Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylation, Richard E. White, Agnes Schonbrunn, and David L. Armstrong

Submissions from 1990

Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase, M V. Autieri, Kerin L. Fresa, F. D. Coffman, M. E. Katz, and S. Cohen

Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase., M. V. Autieri, Kerin L. Fresa, F. D. Coffman, M. E. Katz, and S. Cohen

The behavioral treatment of essential hypertension: Implications for medical psychotherapy, Robert A. DiTomasso and Orlando F. Mills

Rehabilitation of the acutely injured hand, Gerald E. Dworkin and J. Spears

Priapism associated with intranasal cocaine abuse, R. L. Fiorelli, S. J. Manfrey, Laurence Belkoff, and Larry Finkelstein

Effect of Chronic Antidepressant Administration upon Opioid Analgesia, Frederick J. Goldstein

Effects of chronic clomipramine on central DADLE antinociception, Frederick J. Goldstein, R. T. Malseed, and J. F. Nutz

The effect of helium-neon laser and osteopathic manipulation on soft-tissue trigger points, Charlotte H. Greene, Domenic A. DiBias, D. Helig, Alexander S. Nicholas, K. England, W. Ehrenfeuchter, and Wanda L. Young

Selecting and using early childhood rating scales, George McCloskey

Pericardial effects on diastolic ventricular interaction during development, Bohdan M. Minczak, M. R. Wolfson, W. P. Santamore, and T. H. Shaffer

Methyldopa-induced hemolytic anemia in a 15 year old presenting as near-syncope, J. S. Naidorf, J. M. Kennedy, and John W. Becher Jr.

Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice, Avadesh C. Sharma and S. K. Kulkarni

A cytoplasmic activator of DNA replication is involved in signal transduction in antigen-specific T cell lines, R. L. Wong, R. B. Clark, J. Gutowski, M. E. Katz, Kerin L. Fresa, and S. Cohen

Submissions from 1989

Paradoxical intention: Its clarification and emergence as a conventional behavioral procedure, L. Michael Ascher

Triggering Terminal Myogenic Differentiation, D. Boettiger, Mindy George-Weinstein, and A. S. Menko

Coping styles, paradox, and the cold pressor task, J. S. Efran, R. L. Chorney, L. Michael Ascher, and M. D. Lukens

Intracellular mechanisms of lymphoid cell activation, Kerin L. Fresa, M. Hameed, and S. Cohen

In Vitro Assays of Cell Adhesion: Application To Teratogenicity Testing, Mindy George-Weinstein

School psychology applied to business, Patti L. Harrison and George McCloskey

Ciliostatic factors from Pseudomonas aeruginosa. Action on respiratory cilia, Susan T. Hingley, A. T. Hastie, Friedrich Kueppers, M. Higgins, and G. Weinbaum

Effect of the somatostatin analogue SMS-201-995 on the adrenergic response to glucose ingestion in patients with postprandial hypotension, R. D. Hoeldtke, Gerald E. Dworkin, S. Gaspar, and B. C. Israel

Sympathotonic orthostatic hypotension: A report of four cases, R. D. Hoeldtke, Gerald E. Dworkin, S. Gaspar, and B. C. Israel

Fibrosarcoma of the nose and the paranasal sinuses, J. Olekszyk, V. Siliunas, Theodore P. Mauer, and R. Biondi

Adrenergic control of intrarenal arteries of rabbits, Mary P. Owen, M. C. Taphorn, and J. G. Walmsley

Anomalous origin of the left coronary artery, E. Placentra, Bruce Kornberg, and A. D'Alonzo

Intraabdominal adhesions: Intraoperative US, F. J. Suslavitch, N. A. Turner, P. S. King, and H. Keith Brown

Diagnosis and management of ventricular dysphonia, C. P. Von Hake, I. Ganzman, and Theodore P. Mauer

Submissions from 1988

Transcytosis of Protein through the Mammalian Cerebral Epithelium and Endothelium. I. Chorioid Plexus and the Blood-cerebrospinal Fluid Barrier, Brian J. Balin and Richard D. Broadwell

Combined transurethral electroresection and neodymium:YAG laser therapy for obstructing prostatism, Laurence Belkoff and Larry Finkelstein

Transcytotic Pathway for Blood-borne Protein Through the Blood-brain Barrier, Richard D. Broadwell, Brian J. Balin, and Michael Salcman

Teacher and observer ratings of children's social skills: Validation of the Social Skills Rating Scales, Stephen N. Elliott, Frank M. Gresham, Terry Freeman, and George McCloskey

Combinations of Monoclonal Antibodies Distinguish Mesenchymal, Myogenic, and Chondrogenic Precursors of the Developing Chick Embryo, Mindy George-Weinstein, Cindy Decker, and Alan Horwitz

Alternate technique for cul-de-sac insufflation for laparoscopy, Joseph M. Kaczmarczyk

Opioid-monoamine interactions in spinal antinociception: evidence for serotonin but not norepinephrine reciprocity, D. E. Kellstein, R. T. Malseed, and Frederick J. Goldstein

Effect of chronic treatment with tricyclic antidepressants upon antinociception induced by intrathecal injection of morphine and monoamines, D. E. Kellstein, R. T. Malseed, M. H. Ossipov, and Frederick J. Goldstein

Infectious disorders of the parotid gland., David H. Loughran and L G Smith

Developmental changes in diastolic ventricular interaction, Bohdan M. Minczak, M. R. Wolfson, W. P. Santamore, and T. H. Shaffer

Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes, Richard E. White and H. C. Hartzell

Submissions from 1987

Lectin-Labeled Membrane is Transferred to the Golgi Complex in Mouse Pituitary Cells in vivo, Brian J. Balin and Richard D. Broadwell

Tubular Profiles do not form Transendothelial Channels through the Blood-brain Barrier, Brian J. Balin, Richard D. Broadwell, and Michael Salcman

Angioarchitecture of the CNS, Pituitary Gland, and Intracerebral Grafts Revealed with Peroxidase Cytochemistry, Richard D. Broadwell, Brian J. Balin, Harry M. Charlton, and Michael Salcman

Use of external muscle stimulation in a patient with unipolar DDD pacemaker, Gerald E. Dworkin, K. Vollision, and G. Herbison

The effect of rhamnolipid hemolysin of Pseudomonas aeruginosa on respiratory epithelium., Annette T. Hastie, Susan T. Hingley, M. L. Higgins, and Friedrich Kueppers

Isolation of Virio alginolyticus from a patient with chronic otitis media: Report of case and review of biochemical activity, J. J. Hasyn, Theodore P. Mauer, R. Warner, and C. Von Hake

Captopril therapy in heart failure, Bruce Kornberg

Burk's Behavior Rating Scales, George McCloskey

Denver Developmental Screening Test, George McCloskey

Hiske-Nebraska Test of Learning Aptitude, George McCloskey

Leiter International Performance Scale, George McCloskey

Test of Language Development, George McCloskey

Wide Range Achievement Test-Revised, George McCloskey

A somatic component to myocardial infarction, Alexander S. Nicholas, Domenic A. DiBias, W. Ehrenfeuchter, K. M. England, R. W. England, Charlotte H. Greene, D. Heilig, and M. Kirschbaum

Sources of activator calcium for extrinsic vascular tone and nimodipine inhibition of that tone in proximal vs. distal rabbit ear arteries, Mary P. Owen, E. H. Joyce, and J. A. Bevan

Cardiac involvement in polymyositis: Report of case and review of literature, D. W. Rhodes and Richard A. Pascucci

Correlation of palpatory observations with the anatomic locus of acute myocardial infarction, H. O. Rosero, Charlotte H. Greene, and Domemic A. DiBias

Submissions from 1986

Enhancing effectiveness of paradoxical intention in treating travel restriction in agoraphobia, L. Michael Ascher, D. E. Schotte, and J. B. Grayson

Avenues for Entry of Peripherally Administered Protein to the Central Nervous System in Mouse, Rat, and Squirrel Monkey, Brian J. Balin, Richard D. Broadwell, Michael Salcman, and Magdy El-Kalliny

Calcium regulation in vascular smooth muscle: Is there a pattern to its variability within the arterial tree?, J. A. Bevan, R. D. Bevan, J. J. Hwa, Mary P. Owen, and F. M. Tayo

Phospholipase C Activity in Palate Mesenchyme Cells: Calcium and pH Requirements, Substrate Specificity, and Subcellular Localization, K P Chepenik, Mindy George-Weinstein, and R Caamano-Haigh

Cystoscopic laser surgery: An animal model, Leonard H. Finkelstein, Domenic A. DeBias, and Charlotte H. Greene

Isolation of cilia from porcine tracheal epithelium and extraction of dynein arms, Annette T. Hastie, David T. Dicker, Susan T. Hingley, Friedrich Kueppers, Michael L. Higgins, and George Weinbaurn

Rhamnolipid from Pseudomonas aeruginosa inactivates mammalian tracheal ciliary axonemes., Annette T. Hastie, Susan T. Hingley, M. L. Higgins, Friedrich Kueppers, and T. Shryock

Use of selective vs standard sheep blood agar for the diagnosis of hemolytic streptococcus group A pharyngitis, J. L. Haym, Robert A. DiTomasso, and S. Colameco

Disruption of respiratory cilia by proteases including those of Pseudomonas aeruginosa, Susan T. Hingley, A. T. Hastie, Friedrich Kueppers, and M. L. Higgins

Effect of ciliostatic factors and Pseudomonas aeruginosa on rabbit respiratory cilia, Susan T. Hingley, A. T. Hastie, Friedrich Kueppers, M. L. Higgins, G. Weinbaum, and T. Shryock

Efficacy of the neodymium:YAG laser in vasovasostomy: A preliminary communication, Perry Weiner, Leonard Finkelstein, Charlotte H. Greene, and Domenic A. DiBias

Submissions from 1985

Local fibrinolysis for the treatment of massive pulmonary embolism: Efficacy of streptokinase infusion through pulmonary arterial catheter, J. E. Ambrose, Michael A. Venditto, and W. H. Dickerson

Paradoxical Intention, L. Michael Ascher

Paradoxical intention in behavior therapy: A review of the experimental literature, L. Michael Ascher

Empirical issues in paradox, L. Michael Ascher, M. Bowers, and D. E. Schotte

Endocytic and Exocytic Pathways of the Neuronal Secretory Process and Trans-Synaptic Transfer of Wheat Germ Agglutinin-Horseradish Peroxidase in vivo, Richard D. Broadwell and Brian J. Balin

Effects of dexamethasone on phospholipase activities in palate mesenchyme cells in vitro., K P Chepenik, Mindy George-Weinstein, and R M Greene

Posttraumatic syringomyelia, Gerald E. Dworkin and W. E. Staas Jr.

Psychological Functioning After Severe Closed Head Injury, David W. Ellis and Bruce S. Zahn

Electroresection followed by neodymium-YAG laser photocoagulation of the dog prostate for establishment of safety parameters, Leonard H. Finkelstein, Bruce Frantz, Lillian Longendorfer Hynes, Domenic A. DeBias, Charlotte H. Greene, and Frederick Monson

Role of natural killer cells in the mechanism of the antitumor effect of interferon on Moloney sarcoma virus-transformed cells, Kerin L. Fresa and D. M. Murasko

Phospholipase A Activities in Embryonic Palate Mesenchyme Cells in Vitro, Mindy George-Weinstein and K P. Chepenik

Rest-exercise radionuclide angiographic assessment of left ventricular function in chronic aortic regurgitation: Significance of serial studies in medically versus surgically treated groups, F. J. Lumia, R. M. MacMillan, P. A. Germon, Bruce Kornberg, J. Fernandez, and V. Maranhao

Clinical analysis of errors, George McCloskey

Mechanical and biochemical characterization of the contraction elicited by a calcium-independent myosin light chain kinase in chemically skinned smooth muscle, U. Mrwa, K. Güth, J. C. Rüegg, R. J. Paul, S. Boström, Robert Barsotti, and D. Hartshorne

Acetylcholine induced endothelial-dependent vasodilation increases as artery diameter decreases in the rabbit ear, Mary P. Owen and J. A. Bevan

Phentolamine-resistant neurogenic constriction occurs in small arteries at higher frequencies, Mary P. Owen, C. Quinn, and J. A. Bevan

Pharmacological Aspects of Drug Abuse, G. V. Rossi and Frederick J. Goldstein

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A Manual for House Staff on Pulmonary Service at PCOM, John P. Simelaro

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Blood Gas and Ventilator Manual for House Staff on Pulmonary Service, John P. Simelaro

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Pulmonary Function Manual, John P. Simelaro

Submissions from 1984

Further Studies of the Secretory Process in Hypothalamo neurohypophysial Neurons. An Analysis Using Immunochemistry, Wheat Germ Agglutinin-Peroxidase and Native Peroxidase, Richard D. Broadwell, Anne M. Cataldo, and Brian J. Balin

Endoscopic diagnosis and removal of a duodenal wall gastrinoma., William J. Gilhool

Comparison of three cognitive strategies in altering pain behaviors on a cold pressor task., R. M. Gilligan, L. Michael Ascher, J. Wolper, and C. Bochachevsky

Contrasting effects of acute vs. chronic tricyclic antidepressant treatment on central morphine analgesia, D. E. Kellstein, R. T. Malseed, and Frederick J. Goldstein

Paradoxical intention in the treatment of agoraphobia and other anxiety disorders, L. Michelson and L. Michael Ascher

Safety considerations and safety protocol for laser surgery, R. M. Mohr, B C. McDonnell, M. Unger, and Theodore P. Mauer

Primary afferent projections to the sacral secondary visceral gray: A quantitative electron microscopic examination in the cat, Michael Nolan and H. Keith Brown

Feline analgesia following central administration of opioids, M. H. Ossipov, Frederick J. Goldstein, and R. T. Malseed