The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.
Submissions from 1996
Immunohistochemical detection of alpha2-adrenoceptor subtypes using subtype-specific antibodies in rabbit intrarenal resistance arteries, C. A. Patel, Mary P. Owen, and Jiang Gu
Immunohistochemical detection of alpha-adrenoceptor subtypes using subtype-specific antibodies in rabbit interlobular arteries, C. A. Patel, Mary P. Owen, and Jiang Gu
Manduca sexta hemolymph ferritin: CDNA sequence and mRNA expression, Daphne Q. Pham, Dianzheng Zhang, David H. Hufnagel, and Joy J. Winzerling
Neuroradiologic MR applications with multiparametric color composite display, W. E. Phillips and H. Keith Brown
Parent and child representations of social relationships: Linkages between families and peers, Virginia Burks Salzer and R. D. Parke
Steroid hormone alterations following induction of chronic intraperitoneal sepsis in male rats, Avadhesh C. Sharma, H. B. Bosmann, S. J. Motew, K. H. Hales, D. B. Hales, and J. L. Ferguson
Effect of Spent Wash Recycling on Fermentation of Corn Mashes, S. K. Soni, Avadhesh C. Sharma, and R. Soni
Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition, D. R. Soprano, L. X. Chen, S. Wu, A. M. Donigan, Ruth C. Borghaei, and K. J. Soprano
Angiotensin II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem., Desuo Wang, Jeffrey R. Martens, Philip Posner, Colin Sumners, and Craig H. Gelband
Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells., Desuo Wang, John C. Shryock, and Luiz Belardinelli
Interaction between ryanodine and neomycin binding sites on Ca2+ release channel from skeletal muscle sarcoplasmic reticulum, J. P. Wang; D. H, Needleman; A. B. Sheryshev; B. Aghdasi; Kenneth J. Slavik; S. Q. Liu; S. E. Pedersen; and S. L. Hamilton
Submissions from 1995
Modulation of topoisomerase activities by tumor necrosis factor, Z. Baloch, S. Cohen, Kerin L. Fresa, and F. D. Coffman
Loss of adenosine-induced negative inotropic effect in hyperexcited rabbit hearts: Relationship to PKC, C. Cano, Kenneth J. Slavik, and K. U. Malik
Hepatobiliary pruritus: what are effective treatments?, Coyle Connolly, G R Kantor, and H Menduke
Isolation and characterization of mosquito ferritin and cloning of a cDNA that encodes one subunit., Boris Dunkov, Dianzheng Zhang, Kyril Choumarov, Joy Winzerling, and John H. Law
Pretreatment dropout as a function of treatment delay and client variables, David Festinger, R. Lamb, M. Kountz, K. Kirby, and D. Marlowe
Pharmacological Aspects of Substance Abuse, Frederick J. Goldstein
Preemptive analgesia: a research review., Frederick J. Goldstein
Endothelin ETA receptor antagonist, BQ-123, blocks the vasoconstriction induced by sarafotoxin 6b in the heart but not in other vascular beds, A. Gulati, Avadhesh C. Sharma, G. Robbie, and P. R. Saxena
Effect of diaspirin crosslinked and stroma-reduced hemoglobin on mean arterial pressure and endothelin-1 concentration in rats, A. Gulati, G. Singh, S. Rebello, and Avadhesh C. Sharma
Antinociception and σ-1 opioid receptors in the rat spinal cord: Studies with intrathecal 7-benzylidenenaltrexone, D. L. Hammond, Peggy E. Stewart, and L. Littell
Hepatitis mutants of mouse hepatitis virus strain A59, Susan T. Hingley, James L. Gombold, Ehud Lavi, and Susan R. Weiss
Membrane-associated cytochrome c(y) of Rhodobacter capsulatus is an electron carrier from the cytochrome bc1 complex to the cytochrome c oxidase during respiration, A. Hochkoeppler, Francis E. Jenney Jr., S. E. Lang, D. Zannoni, and F. Daldal
Cognitive-behavioral treatments, P. C. Kendall and Susan Panichelli-Mindel
Pharmacology: Drug Therapy and Nursing Considerations, R. T. Malseed, Frederick J. Goldstein, and N. Balkon
Yohimbine modulates diaspirin crosslinked hemoglobin-induced systemic hemodynamics and regional circulatory effects, Avadesh C. Sharma and A. Gulati
Role of NO mechanism in cardiovascular effects of diaspirin cross-linked hemoglobin in anesthetized rats, Avadhesh C. Sharma, G. Singh, and A. Gulati
Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism, Richard E. White, David J. Darkow, and Jessica L. Falvo Lang
Submissions from 1994
Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel, C. Callaway, A. Seryshev, J. P. Wang, Kenneth J. Slavik, C. Cantu III, Y. Wu, T. Jayaraman, A. R. Marks, and S. L. Hamilton
Comprehensive geriatric assessment: Applications for community-residing, elderly people with mental retardation/developmental disabilities, W. R. Carlsen, Katherine E. Galluzzi, L. F. Forman, and T. A. Cavalieri
Current issues in the selection and use of broad-spectrum antibiotics. Roundtable discussion., L. M. Cortez, C. Dempsey, John P. Simelaro, and R. Wilson
Inhibition of rat liver arginase by an intermediate in NO biosynthesis, N(G)-hydroxy-L-arginine: Implications for the regulation of nitric oxide biosynthesis by arginase, Farzaneh Daghigh, J. M. Fukoto, and D. E. Ash
TGFbeta1 regulation of collagen metabolism by embryonic palate mesenchymal cells, Marina D'Angelo, Jing-May Chen, Kenneth Ugen, and Robert M. Greene
Medical patients, Robert A. DiTomasso and Karel D. Kovnat
The cognitive theory of anxiety, Arthur Freeman and Robert A. DiTomasso
Maturation of Myogenic and Chondrogenic Cells in the Presomitic Mesoderm of the Chick Embryo, Mindy George-Weinstein, Jacquelyn Gerhart, Gerard J. Foti, and James W. Lash
Identification of peplomer cleavage site mutations arising during persistence of MHV-A59, James L. Gombold, Susan T. Hingley, and Susan R. Weiss
Healing of incisions in the tongue: A comparison of results with milliwatt carbon dioxide laser tissue welding versus suture repair, Charlotte H. Greene, Domenic A. DiBias, Maryanne J. Henderson, Rosemary Fair-Covely, Bryan Dorf, Alex L. Radin, and Wanda L. Young-Seidman
Prazosin blocks the pressor but not the regional circulatory effects of diaspirin crosslinked hemoglobin, A. Gulati and Avadhesh C. Sharma
Effect of stroma-free hemoglobin and diaspirin cross-linked hemoglogbin on the regional circulation and systematic hemodynamics, A. Gulati, Avadhesh C. Sharma, and K. E. Burhop
MHV-A59 fusion mutants are attenuated and display altered hepatotropism, Susan T. Hingley, James L. Gombold, Ehud Lavi, and Susan R. Weiss
Are there two types of diabetic foot ulcers?, R. D. Hoeldtke, K. M. Davis, P. B. Hshieh, S. Gaspar, and Gerald E. Dworkin
Roles of the soluble cytochrome c2 and membrane-associated cytochrome cy of rhodobacter capsulatus in photosynthetic electron transfer, Francis E. Jenney Jr.
Cognitive-behavioral interventions, Philip C. Kendall and Elizabeth A. Gosch
Gaba-B receptors and nociception, S. K. Kulkarni and Avadhesh C. Sharma
Rat anococcygeus: A dynamic smooth muscle preparation for experimental pharmacology, S. K. Kulkarni and Avadhesh C. Sharma
Reversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat(R)), a herbal preparation, S. K. Kulkarni and Avadhesh C. Sharma
Activation of skinned trabeculae of the guinea pig induced by laser photolysis of caged ATP, H. Martin and Robert J. Barsotti
Relaxation from rigor of skinned trabeculae of the guinea pig induced by laser photolysis of caged ATP, H. Martin and Robert J. Barsotti
Interactions between Sertoli cells and germ cells in the testis, Michael P. McGuinness and M. P. Griswold
Relationship of a mouse Sertoli cell line (MSC-1) to normal Sertoli cells, Michael P. McGuinness, C. C. Linder, C. R. Morales, L. L. Heckert, J. Pikus, and M. D. Griswold
Fibronectin inhibition of platelet thrombus formation in an in vivo porcine model of vascular injury., D G Moon, Brian Matayoshi, L K Weston, F L Minnear, and J E Kaplan
Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini, J. W. Regan, T. J. Bailey, J. E. Donello, K. L. Pierce, D. J. Pepperl, Dianzheng Zhang, K. M. Kedzie, C. E. Fairbairn, A. M. Bogardus, and D. F. Woodward
Effect of diaspirin cross-linked hemoglobin and norepinephrine on systemic hemodynamics and regional circulation in rats., Avadesh C. Sharma and A. Gulati
Dopamine receptor mediated antidepressant action of B-HT 920 in mice, Avadesh C. Sharma and S. K. Kulkarni
On the characterization of dopamine-induced contractile response of rat anococcygeus muscle preparation, Avadesh C. Sharma and S. K. Kulkarni
Regional circulatory and systemic hemodynamic effects of diaspirin cross-linked hemoglobin in the rat, Avadesh C. Sharma, S. K. Kulkarni, and A. Gulati
Renal endothelin mechanism in altered thyroid states, G. Singh, Avadhesh C. Sharma, E. B. Thompson, and A. Gulati
σ antagonist and k agonist activity of naltriben: Evidence for differential k interaction with the σ1 and σ2 opioid receptor subtypes, Peggy E. Stewart, E. M. Holper, and D. L. Hammond
Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes., Desuo Wang and Luiz Belardinelli
Submissions from 1993
PC-based multiparameter full-color display for tissue segmentation in MRI of adnexal masses, H. Keith Brown, T. R. Hazelton, A. K. Parsons, J. V. Fiorica, C. G. Berman, and M. L. Silbiger
Characteristics of DNA replication in isolated nuclei initiated by an aprotinin-binding protein, F. D. Coffman, Kerin L. Fresa, M. Hameed, and S. Cohen
In vitro replication of plasmids containing human ribosomal gene sequences: Origin localization and dependence on an aprotinin-binding cytosolic protein, F. D. Coffman, I. Georgoff, Kerin L. Fresa, J. Sylvester, I. Gonzalez, and S. Cohen
In Vitro and in Vivo Expression of Alpha 7 Integrin and Desmin Define the Primary and Secondary Myogenic Lineages, Mindy George-Weinstein, Rachel F. Foster, Jacquelyn Gerhart, and Stephen J. Kaufman
Fusion-defective mutants of mouse hepatitis virus A59 contain a mutation in the spike protein cleavage signal, James L. Gombold, Susan T. Hingley, and Susan R. Weiss
Basic fibroblast growth factor is a testicular germ cell product which may regulate sertoli cell function, I. S. Han, S. R. Sylvester, K. H. Kim, M. E. Schelling, S. Venkateswaran, V. D. Blanckaert, Michael P. McGuinness, and M. D. Griswold
A novel membrane-associated c-type cytochrome, cyt cy, can mediate the photosynthetic growth of Rhodobacter capsulatus and Rhodobacter sphaeroides, Francis E. Jenney Jr. and F. Daldal
GABA receptor mediated anticonvulsant action of Withania somnifera root extract, S. K. Kulkarni, Avadhesh C. Sharma, A. Verma, and M. K. Ticku
Fatal fulminant autoimmune haemolytic anaemia associated with tolmetin use and gastric carcinoma. Case report and literature review, J. R. Larsen and John W. Becher Jr.
Functional characterization of alpha adrenoceptors on rabbit intrarenal arteries in vitro, Mary P. Owen
(±)Baclofen sensitive scopolamine-induced short-term memory deficits in mice, Avadesh C. Sharma and S. K. Kulkarni
Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats, Avadesh C. Sharma and S. K. Kulkarni
Involvement of inhibitory dopamine-2 receptors in resting bradycardia in exercise-conditioned rats, Kenneth J. Slavik and J. LaPointe
Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia, Kenneth J. Slavik and J. E. Szilagyi
Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation, Richard E. White, A. B. Lee, A. D. Shcherbatko, T. M. Lincoln, A. Schonbrunn, and D. L. Armstrong
The Survivors Project, Bruce S. Zahn and Seran E. Schug
Submissions from 1992
Composite and classified color display in MR imaging of the female pelvis, H. Keith Brown, T. R. Hazelton, J. V. Fiorica, A. K. Parsons, L. P. Clarke, and M. L. Silbiger
Tomographic abdominal anatomy with magnetic resonance color composites, H. Keith Brown, T. R. Hazelton, L. M. Putnam, and M. L. Silbiger
Cognitive therapy of personality disorders., A. Freeman, D. D. Davis, and Robert A. DiTomasso
Factors Affecting Drug Response, Frederick J. Goldstein and R. F. Orzechowski
Pharmacodynamics, Frederick J. Goldstein and R. F. Orzechowski
Angiographic magnetic resonance color composites of the normal brain and its vasculature, T. R. Hazelton and H. Keith Brown
Autonomic surface potential analysis: Assessment of reproducibility and sensitivity, R. D. Hoeldtke, K. M. Davis, P. B. Hshieh, S. Gaspar, and Gerald E. Dworkin
Crystallization and oligomeric structure of rat liver arginase, Zoltan F. Kanyo, Cheau-Yun Chen, Farzaneh Daghigh, David E. Ash, and David W. Christianson
Cw holmium for medical applications: a preliminary study, Ronald A. Kirschner, Domenic DiBias, Charlotte H. Greene, Eric Brown, Corneliu Dimitriu, Alexander C. Keszeli, and Andrew Kirschner
Recent trends in information storage mechanisms, S. K. Kulkarni and Avadhesh C. Sharma
Benign Metastasizing Leiomyoma A Case Report and Review of the Literature, Daniel Parenti, T. F. Morley, and J. C. Giudice
Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice, Avadesh C. Sharma and S. K. Kulkarni
Naloxone-induced bradycardia in pithed rats: Evidence for an interaction with the peripheral sympathetic nervous system and alpha-2 adrenoceptors, Kenneth J. Slavik and J. E. Szilagyi
Therapeutic considerations: Lower respiratory tract infections in smokers, Michael A. Venditto
Differential Morphologic and Metabolic Alterations in Permissive Versus Nonpermissive Murine Macrophages Infected with Legionella Pneumophila, Yoshimasa Yamamoto, Thomas W. Klein, H. Keith Brown, and Herman Friedman
Submissions from 1991
Neurofilament Assembly in vitro: Biochemical, morphological and Immunoelectron Microscopic Studies Employing Monoclonal Antibodies to Defined Epitopes, Brian J. Balin, Edwin A. Clark, John Q. Trojanowski, and Virginia M.-Y. Lee
Individual Neurofilament Subunits Reassembled in vitro Exhibit Unique Biochemical, Morphological and Immunological Properties, Brian J. Balin and Virginia M.-Y. Lee
Uterine junctional zone: Correlation between histologic findings and MR imaging, H. Keith Brown
Generation of Color Composites for Enhanced Tissue Differentiation in Magnetic Resonance Imaging of the Brain, H. Keith Brown, T R Hazelton, and M L Silbiger
Initiation of lymphocyte DNA synthesis, F. D. Coffman, Kerin L. Fresa, and S. Cohen
Control of DNA replication in a transformed lymphoid cell line: Coexistence of activator and inhibitor activities, F. D. Coffman, Kerin L. Fresa, I. Oglesby, and S. Cohen
Transforming growth factor-ß modulation of glycosaminoglycan production by mesenchymal cells of the developing murine secondary palate, Marina D'Angelo and Robert M. Greene
Airway foreign bodies: A diagnostic challenge, C. J. Di Marco, Theodore P. Mauer, and R. N. Reinhard