The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 1996

Immunohistochemical detection of alpha2-adrenoceptor subtypes using subtype-specific antibodies in rabbit intrarenal resistance arteries, C. A. Patel, Mary P. Owen, and Jiang Gu

Immunohistochemical detection of alpha-adrenoceptor subtypes using subtype-specific antibodies in rabbit interlobular arteries, C. A. Patel, Mary P. Owen, and Jiang Gu

Manduca sexta hemolymph ferritin: CDNA sequence and mRNA expression, Daphne Q. Pham, Dianzheng Zhang, David H. Hufnagel, and Joy J. Winzerling

Neuroradiologic MR applications with multiparametric color composite display, W. E. Phillips and H. Keith Brown

Parent and child representations of social relationships: Linkages between families and peers, Virginia Burks Salzer and R. D. Parke

Steroid hormone alterations following induction of chronic intraperitoneal sepsis in male rats, Avadhesh C. Sharma, H. B. Bosmann, S. J. Motew, K. H. Hales, D. B. Hales, and J. L. Ferguson

Effect of Spent Wash Recycling on Fermentation of Corn Mashes, S. K. Soni, Avadhesh C. Sharma, and R. Soni

Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition, D. R. Soprano, L. X. Chen, S. Wu, A. M. Donigan, Ruth C. Borghaei, and K. J. Soprano

Angiotensin II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem., Desuo Wang, Jeffrey R. Martens, Philip Posner, Colin Sumners, and Craig H. Gelband

Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells., Desuo Wang, John C. Shryock, and Luiz Belardinelli

Interaction between ryanodine and neomycin binding sites on Ca2+ release channel from skeletal muscle sarcoplasmic reticulum, J. P. Wang; D. H, Needleman; A. B. Sheryshev; B. Aghdasi; Kenneth J. Slavik; S. Q. Liu; S. E. Pedersen; and S. L. Hamilton

Submissions from 1995

Modulation of topoisomerase activities by tumor necrosis factor, Z. Baloch, S. Cohen, Kerin L. Fresa, and F. D. Coffman

Loss of adenosine-induced negative inotropic effect in hyperexcited rabbit hearts: Relationship to PKC, C. Cano, Kenneth J. Slavik, and K. U. Malik

Hepatobiliary pruritus: what are effective treatments?, Coyle Connolly, G R Kantor, and H Menduke

Isolation and characterization of mosquito ferritin and cloning of a cDNA that encodes one subunit., Boris Dunkov, Dianzheng Zhang, Kyril Choumarov, Joy Winzerling, and John H. Law

Pretreatment dropout as a function of treatment delay and client variables, David Festinger, R. Lamb, M. Kountz, K. Kirby, and D. Marlowe

Pharmacological Aspects of Substance Abuse, Frederick J. Goldstein

Preemptive analgesia: a research review., Frederick J. Goldstein

Endothelin ETA receptor antagonist, BQ-123, blocks the vasoconstriction induced by sarafotoxin 6b in the heart but not in other vascular beds, A. Gulati, Avadhesh C. Sharma, G. Robbie, and P. R. Saxena

Effect of diaspirin crosslinked and stroma-reduced hemoglobin on mean arterial pressure and endothelin-1 concentration in rats, A. Gulati, G. Singh, S. Rebello, and Avadhesh C. Sharma

Antinociception and σ-1 opioid receptors in the rat spinal cord: Studies with intrathecal 7-benzylidenenaltrexone, D. L. Hammond, Peggy E. Stewart, and L. Littell

Hepatitis mutants of mouse hepatitis virus strain A59, Susan T. Hingley, James L. Gombold, Ehud Lavi, and Susan R. Weiss

Membrane-associated cytochrome c(y) of Rhodobacter capsulatus is an electron carrier from the cytochrome bc1 complex to the cytochrome c oxidase during respiration, A. Hochkoeppler, Francis E. Jenney Jr., S. E. Lang, D. Zannoni, and F. Daldal

Cognitive-behavioral treatments, P. C. Kendall and Susan Panichelli-Mindel

Pharmacology: Drug Therapy and Nursing Considerations, R. T. Malseed, Frederick J. Goldstein, and N. Balkon

Yohimbine modulates diaspirin crosslinked hemoglobin-induced systemic hemodynamics and regional circulatory effects, Avadesh C. Sharma and A. Gulati

Role of NO mechanism in cardiovascular effects of diaspirin cross-linked hemoglobin in anesthetized rats, Avadhesh C. Sharma, G. Singh, and A. Gulati

Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism, Richard E. White, David J. Darkow, and Jessica L. Falvo Lang

Submissions from 1994

Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel, C. Callaway, A. Seryshev, J. P. Wang, Kenneth J. Slavik, C. Cantu III, Y. Wu, T. Jayaraman, A. R. Marks, and S. L. Hamilton

Comprehensive geriatric assessment: Applications for community-residing, elderly people with mental retardation/developmental disabilities, W. R. Carlsen, Katherine E. Galluzzi, L. F. Forman, and T. A. Cavalieri

Current issues in the selection and use of broad-spectrum antibiotics. Roundtable discussion., L. M. Cortez, C. Dempsey, John P. Simelaro, and R. Wilson

Inhibition of rat liver arginase by an intermediate in NO biosynthesis, N(G)-hydroxy-L-arginine: Implications for the regulation of nitric oxide biosynthesis by arginase, Farzaneh Daghigh, J. M. Fukoto, and D. E. Ash

TGFbeta1 regulation of collagen metabolism by embryonic palate mesenchymal cells, Marina D'Angelo, Jing-May Chen, Kenneth Ugen, and Robert M. Greene

Medical patients, Robert A. DiTomasso and Karel D. Kovnat

The cognitive theory of anxiety, Arthur Freeman and Robert A. DiTomasso

Maturation of Myogenic and Chondrogenic Cells in the Presomitic Mesoderm of the Chick Embryo, Mindy George-Weinstein, Jacquelyn Gerhart, Gerard J. Foti, and James W. Lash

Identification of peplomer cleavage site mutations arising during persistence of MHV-A59, James L. Gombold, Susan T. Hingley, and Susan R. Weiss

Healing of incisions in the tongue: A comparison of results with milliwatt carbon dioxide laser tissue welding versus suture repair, Charlotte H. Greene, Domenic A. DiBias, Maryanne J. Henderson, Rosemary Fair-Covely, Bryan Dorf, Alex L. Radin, and Wanda L. Young-Seidman

Prazosin blocks the pressor but not the regional circulatory effects of diaspirin crosslinked hemoglobin, A. Gulati and Avadhesh C. Sharma

Effect of stroma-free hemoglobin and diaspirin cross-linked hemoglogbin on the regional circulation and systematic hemodynamics, A. Gulati, Avadhesh C. Sharma, and K. E. Burhop

MHV-A59 fusion mutants are attenuated and display altered hepatotropism, Susan T. Hingley, James L. Gombold, Ehud Lavi, and Susan R. Weiss

Are there two types of diabetic foot ulcers?, R. D. Hoeldtke, K. M. Davis, P. B. Hshieh, S. Gaspar, and Gerald E. Dworkin

Roles of the soluble cytochrome c2 and membrane-associated cytochrome cy of rhodobacter capsulatus in photosynthetic electron transfer, Francis E. Jenney Jr.

Cognitive-behavioral interventions, Philip C. Kendall and Elizabeth A. Gosch

Gaba-B receptors and nociception, S. K. Kulkarni and Avadhesh C. Sharma

Rat anococcygeus: A dynamic smooth muscle preparation for experimental pharmacology, S. K. Kulkarni and Avadhesh C. Sharma

Reversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat(R)), a herbal preparation, S. K. Kulkarni and Avadhesh C. Sharma

Activation of skinned trabeculae of the guinea pig induced by laser photolysis of caged ATP, H. Martin and Robert J. Barsotti

Relaxation from rigor of skinned trabeculae of the guinea pig induced by laser photolysis of caged ATP, H. Martin and Robert J. Barsotti

Interactions between Sertoli cells and germ cells in the testis, Michael P. McGuinness and M. P. Griswold

Relationship of a mouse Sertoli cell line (MSC-1) to normal Sertoli cells, Michael P. McGuinness, C. C. Linder, C. R. Morales, L. L. Heckert, J. Pikus, and M. D. Griswold

Fibronectin inhibition of platelet thrombus formation in an in vivo porcine model of vascular injury., D G Moon, Brian Matayoshi, L K Weston, F L Minnear, and J E Kaplan

Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini, J. W. Regan, T. J. Bailey, J. E. Donello, K. L. Pierce, D. J. Pepperl, Dianzheng Zhang, K. M. Kedzie, C. E. Fairbairn, A. M. Bogardus, and D. F. Woodward

Effect of diaspirin cross-linked hemoglobin and norepinephrine on systemic hemodynamics and regional circulation in rats., Avadesh C. Sharma and A. Gulati

Dopamine receptor mediated antidepressant action of B-HT 920 in mice, Avadesh C. Sharma and S. K. Kulkarni

On the characterization of dopamine-induced contractile response of rat anococcygeus muscle preparation, Avadesh C. Sharma and S. K. Kulkarni

Regional circulatory and systemic hemodynamic effects of diaspirin cross-linked hemoglobin in the rat, Avadesh C. Sharma, S. K. Kulkarni, and A. Gulati

Renal endothelin mechanism in altered thyroid states, G. Singh, Avadhesh C. Sharma, E. B. Thompson, and A. Gulati

σ antagonist and k agonist activity of naltriben: Evidence for differential k interaction with the σ1 and σ2 opioid receptor subtypes, Peggy E. Stewart, E. M. Holper, and D. L. Hammond

Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes., Desuo Wang and Luiz Belardinelli

Submissions from 1993

PC-based multiparameter full-color display for tissue segmentation in MRI of adnexal masses, H. Keith Brown, T. R. Hazelton, A. K. Parsons, J. V. Fiorica, C. G. Berman, and M. L. Silbiger

Characteristics of DNA replication in isolated nuclei initiated by an aprotinin-binding protein, F. D. Coffman, Kerin L. Fresa, M. Hameed, and S. Cohen

In vitro replication of plasmids containing human ribosomal gene sequences: Origin localization and dependence on an aprotinin-binding cytosolic protein, F. D. Coffman, I. Georgoff, Kerin L. Fresa, J. Sylvester, I. Gonzalez, and S. Cohen

In Vitro and in Vivo Expression of Alpha 7 Integrin and Desmin Define the Primary and Secondary Myogenic Lineages, Mindy George-Weinstein, Rachel F. Foster, Jacquelyn Gerhart, and Stephen J. Kaufman

Fusion-defective mutants of mouse hepatitis virus A59 contain a mutation in the spike protein cleavage signal, James L. Gombold, Susan T. Hingley, and Susan R. Weiss

Basic fibroblast growth factor is a testicular germ cell product which may regulate sertoli cell function, I. S. Han, S. R. Sylvester, K. H. Kim, M. E. Schelling, S. Venkateswaran, V. D. Blanckaert, Michael P. McGuinness, and M. D. Griswold

A novel membrane-associated c-type cytochrome, cyt cy, can mediate the photosynthetic growth of Rhodobacter capsulatus and Rhodobacter sphaeroides, Francis E. Jenney Jr. and F. Daldal

GABA receptor mediated anticonvulsant action of Withania somnifera root extract, S. K. Kulkarni, Avadhesh C. Sharma, A. Verma, and M. K. Ticku

Fatal fulminant autoimmune haemolytic anaemia associated with tolmetin use and gastric carcinoma. Case report and literature review, J. R. Larsen and John W. Becher Jr.

Functional characterization of alpha adrenoceptors on rabbit intrarenal arteries in vitro, Mary P. Owen

Similarities and differences in the postjunctional role for neuropeptide Y in sympathetic vasomotor control of large vs. small arteries of rabbit renal and ear vasculature, Mary P. Owen

(±)Baclofen sensitive scopolamine-induced short-term memory deficits in mice, Avadesh C. Sharma and S. K. Kulkarni

Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats, Avadesh C. Sharma and S. K. Kulkarni

Involvement of inhibitory dopamine-2 receptors in resting bradycardia in exercise-conditioned rats, Kenneth J. Slavik and J. LaPointe

Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia, Kenneth J. Slavik and J. E. Szilagyi

Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation, Richard E. White, A. B. Lee, A. D. Shcherbatko, T. M. Lincoln, A. Schonbrunn, and D. L. Armstrong

The Survivors Project, Bruce S. Zahn and Seran E. Schug

Submissions from 1992

Composite and classified color display in MR imaging of the female pelvis, H. Keith Brown, T. R. Hazelton, J. V. Fiorica, A. K. Parsons, L. P. Clarke, and M. L. Silbiger

Tomographic abdominal anatomy with magnetic resonance color composites, H. Keith Brown, T. R. Hazelton, L. M. Putnam, and M. L. Silbiger

Cognitive therapy of personality disorders., A. Freeman, D. D. Davis, and Robert A. DiTomasso

Factors Affecting Drug Response, Frederick J. Goldstein and R. F. Orzechowski

Pharmacodynamics, Frederick J. Goldstein and R. F. Orzechowski

Angiographic magnetic resonance color composites of the normal brain and its vasculature, T. R. Hazelton and H. Keith Brown

Autonomic surface potential analysis: Assessment of reproducibility and sensitivity, R. D. Hoeldtke, K. M. Davis, P. B. Hshieh, S. Gaspar, and Gerald E. Dworkin

Crystallization and oligomeric structure of rat liver arginase, Zoltan F. Kanyo, Cheau-Yun Chen, Farzaneh Daghigh, David E. Ash, and David W. Christianson

Cw holmium for medical applications: a preliminary study, Ronald A. Kirschner, Domenic DiBias, Charlotte H. Greene, Eric Brown, Corneliu Dimitriu, Alexander C. Keszeli, and Andrew Kirschner

Recent trends in information storage mechanisms, S. K. Kulkarni and Avadhesh C. Sharma

Benign Metastasizing Leiomyoma A Case Report and Review of the Literature, Daniel Parenti, T. F. Morley, and J. C. Giudice

Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice, Avadesh C. Sharma and S. K. Kulkarni

Naloxone-induced bradycardia in pithed rats: Evidence for an interaction with the peripheral sympathetic nervous system and alpha-2 adrenoceptors, Kenneth J. Slavik and J. E. Szilagyi

Therapeutic considerations: Lower respiratory tract infections in smokers, Michael A. Venditto

Differential Morphologic and Metabolic Alterations in Permissive Versus Nonpermissive Murine Macrophages Infected with Legionella Pneumophila, Yoshimasa Yamamoto, Thomas W. Klein, H. Keith Brown, and Herman Friedman

Submissions from 1991

Neurofilament Assembly in vitro: Biochemical, morphological and Immunoelectron Microscopic Studies Employing Monoclonal Antibodies to Defined Epitopes, Brian J. Balin, Edwin A. Clark, John Q. Trojanowski, and Virginia M.-Y. Lee

Individual Neurofilament Subunits Reassembled in vitro Exhibit Unique Biochemical, Morphological and Immunological Properties, Brian J. Balin and Virginia M.-Y. Lee

Uterine junctional zone: Correlation between histologic findings and MR imaging, H. Keith Brown

Generation of Color Composites for Enhanced Tissue Differentiation in Magnetic Resonance Imaging of the Brain, H. Keith Brown, T R Hazelton, and M L Silbiger

Initiation of lymphocyte DNA synthesis, F. D. Coffman, Kerin L. Fresa, and S. Cohen

Control of DNA replication in a transformed lymphoid cell line: Coexistence of activator and inhibitor activities, F. D. Coffman, Kerin L. Fresa, I. Oglesby, and S. Cohen

Transforming growth factor-ß modulation of glycosaminoglycan production by mesenchymal cells of the developing murine secondary palate, Marina D'Angelo and Robert M. Greene

Airway foreign bodies: A diagnostic challenge, C. J. Di Marco, Theodore P. Mauer, and R. N. Reinhard