Endothelin ETA receptor antagonist, BQ-123, blocks the vasoconstriction induced by sarafotoxin 6b in the heart but not in other vascular beds

Document Type

Article

Publication Date

1995

Abstract

1. 1. The cardiovascular effects of SRT6b in control and BQ-123, a specific ETA receptor antagonist, pretreated rats were determined in anesthetized rats using a radioactive microsphere technique. 2. 2. Infusion of SRT6b produced an increase in blood pressure and total peripheral resistance, decrease in cardiac output and stroke volume, and no change in heart rate of control or BQ-123 treated rats. 3. 3. SRT6b induced a decrease in blood flow to the heart which was completely blocked by BQ-123 pretreatment. The decrease in blood flow to other organs by SRT6b was not affected by BQ-123 pretreatment. 4. 4. This study indicates that ET receptors in the coronary blood vessels are of a different type (neither ETA nor ETB) to those in other vascular beds. © 1995.

Publication Title

General pharmacology

Volume

26

Issue

1

First Page

183

Last Page

193

Comments

This article was published in General pharmacology, Volume 26, Issue 1, Pages 183-193.

The published version is available at http://dx.doi.org/10.1016/0306-3623(94)00152-D.

Copyright © 1995.

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