The role of Notch and Rho GTPase signaling in the control of dendritic development

Document Type

Article

Publication Date

2001

Abstract

Dendritic patterning exerts a profound influence on neuronal connectivity. Recent studies indicate that mammalian Notch receptors are expressed by postmitotic neurons and that Notch signaling has a considerable influence on dendritic growth and branching. Investigations into the intracellular effectors of dendritic development have revealed that dendritic growth and branching are differentially affected by activation of the Rho-family GTPases, RhoA, Rac1, and Cdc42. These observations suggest that the differential activation of Notch receptors and Rho-family GTPases by extracellular signals may be important in the generation of morphological diversity in the developing nervous system.

Publication Title

Current opinion in neurobiology

Volume

11

Issue

1

First Page

111

Last Page

117

Comments

This article was published in Current opinion in neurobiology, Volume 11, Issue 1, Pages 111-117.

The published version is available at http://dx.doi.org/10.1016/S0959-4388(00)00181-1.

Copyright © 2001 Elsevier.

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