Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells
Document Type
Article
Publication Date
2006
Abstract
Caffeic acid phenethyl ester (CAPE), a natural polyphenolic compound with many biological activities, has been shown to be protective against ischemia-reperfusion injury. We have synthesized six new catechol ring-fluorinated CAPE derivatives and evaluated their cytotoxic and cytoprotective effects against menadione-induced cytotoxicity in human umbilical vein endothelial cells. These results provide some insights into the structural basis of CAPE cytoprotection in this assay, which does not appear to be based solely on direct antioxidant properties.
Publication Title
Bioorganic & medicinal chemistry
Volume
14
Issue
14
First Page
4879
Last Page
4887
Recommended Citation
Wang, Xinyu; Stavchansky, Salomon; Bowman, Phillip D.; and Kerwin, Sean M., "Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells" (2006). PCOM Scholarly Papers. 441.
https://digitalcommons.pcom.edu/scholarly_papers/441
Comments
This article was published in Bioorganic & medicinal chemistry, Volume 14, Issue 14, Pages 4879-4887.
The published version is available at http://dx.doi.org/10.1016/j.bmc.2006.03.015.Copyright © 2006 .