The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2007

Covalently attached vancomycin provides a nanoscale antibacterial surface, V. Antoci Jr., Christopher S. Adams, J. Parvizi, P. Ducheyne, I. M. Shapiro, and N. J. Hickok

Vancomycin covalently bonded to titanium alloy prevents bacterial colonization, V. Antoci Jr., S. B. King, B. Jose, J. Parvizi, A. R. Zieger, E. Wickstrom, T. A. Freeman, R. J. Composto, Christopher S. Adams, and et al.


A Review of Cretaceous dipnoans from Argentina (Sarcopterygii Dipnoi) with Descriptions of New Species, Sebastian Apasteguia, Federico L. Agnolin, and Kerin M. Claeson

Inhibition of Apoptosis in Neuronal Cells Infected with Chlamydophila (Chlamydia) pneumoniae, Denah M. Appelt, Maria Roupas, Deana Way, Marcus G. Bell, Elizabeth V. Albert, Christine J. Hammond, and Brian J. Balin

HIF-1 Regulation of Chondrocyte Apoptosis: Induction of the Autophagic Pathway, J. Bohensky, I. M. Shapiro, S. Leshinsky, S. P. Terkhorn, Christopher S. Adams, and V. Srinivas

Decision analysis model evaluating the cost-effectiveness of risperidone, olanzapine and haloperidol in the treatment of schizophrenia, Mark Bounthavong and Mark P. Okamoto

Relationship Between Mitochondrial DNA Damage and Photoreceptor Death in Developing and Adult Retina, Assessed in Normal and Degenerative Rat Strains, Arturo Bravo Nuevo, Neal K Williams, Krisztina Valter, and Jonathan Stone

The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis, M. A. Bucaro, A. M. Zahm, M. V. Risbud, P. S. Ayyaswamy, K. Munkundakrishnan, M. J. Steinbeck, I. M. Shapiro, and Christopher S. Adams

The first agmatine/cadaverine aminopropyl transferase: Biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon Pyrococcus furiosus, G. Cacciapuoti, M. Porcelli, M. Moretti, F. Sorrentino, L. Concilio, V. Zappia, Z. Liu, W. Tempel, Francis E. Jenney Jr., and et al.

Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons, Qian Chen and H. L. Pan

Apoptotic cardiomyocyte hypertrophy during sepsis and septic shock results from prolonged exposure to endothelin precursor, M. Chopra and Avadhesh C. Sharma

Effect of nesiritide infusion duration on renal function in acutely decompensated heart failure patients, Sheryl L. Chow, Jessiva T. Peng, Mark P. Okamoto, and J. Thomas Heywood

Taking Cognitive-Behavior Therapy to School: A School-Based Mental Health Approach, Ray W. Christner, Elizabeth Forrest, Jessica Morley, and Elana Weinstein

New interpretations of the skull of a primitive bony fish Erpetoichthys calabaricus (Actinopterygii: Cladistia), Kerin M. Claeson, William E. Bemis, and James W. Hagadorn

NFATc is required for TGFß-mediated transcriptional regulation of fibronectin, Scott L. Cobbs and Jennifer L. Gooch

Reactive oxidant species and emerging therapies in clinical medicine, Farzaneh Daghigh

An Empirical Survey on Psychological Testing and the Use of the Term Psychological: Turf Battles or Clinical Necessity?, F. M. Dattilio, Katy E. Tresco, and A. Siegel

Solvent tuning of electrochemical potentials in the active sites of HiPIP versus ferredoxin, A. Dey, Francis E. Jenney Jr., M. W. Adams, E. Babini, Y. Takahashi, K. Fukuyama, K. O. Hodgson, B. Hedman, and E. I. Solomon

Sulfur K-edge X-ray absorption spectroscopy and density functional theory calculations on superoxide reductase: Role of the axial thiolate in reactivity, A. Dey, Francis E. Jenney Jr., M. W. Adams, M. K. Johnson, K. O. Hodgson, B. Hedman, and E. I. Solomon

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation, Christiana Dimitropoulou, Lashondra West, Mary B. Field, Richard E. White, L. Manmohan Reddy, John R. Falck, and John D. Imig

Behavioral perspectives, Robert A. DiTomasso, James B. Hale, and S. M. Timchack

The behavioral model of personality disorders, Robert A. DiTomasso, James B. Hale, and Stephen M. Timchack

Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity, Shashikiran Donthamsetty, Vishakha Bhave, Mayarranjan S. Mitra, John R. Latendresse, and Harihara M. Mehendale

Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization, O. P. Edupuganti, V. Antoci Jr., S. B. King, B. Jose, Christopher S. Adams, J. Parvizi, I. M. Shapiro, A. R. Zeiger, N. J. Hickok, and E. Wickstrom

Relationships among relational communication processes and consultation outcomes for students with attention deficit hyperactivity disorder, W. P. Erchul; George J. DuPaul; P. F. Grissom; R. E. Vile Junod; A. K. Jitendra; M. C. Mannella; Katy E, Tresco; L. M. Flammer-Rivera; and R. J. Volpe

Does the Medical College Admission Test Predict Global Academic Performance in Osteopathic Medical School?, Paul Evans and Frances K. Wen

Neuropsychological functioning and recall of research consent information among drug court clients, David Festinger, K. Ratanadilok, D. Marlowe, K. Dugosh, N. Patapis, and D. Dematteo

Interpreting Intelligence Test Results for Children with Disabilities: Is Global Intelligence Relevant?, Catherine A. Fiorello, James B. Hale, James A. Holdnack, Jack A. Kavanagh, Joy Terrell, and Lisa Long

The Use of Homework in Cognitive Behavior Therapy: Working with Complex Anxiety and Insomnia, Arthur Freeman

Introduction, Arthur Freeman, Mark A. Reinecke, and Yuma I. Tomes

Management Strategies for Herpes Zoster and Postherpetic Neuralgia, Katherine E. Galluzzi

Managing Neuropathic Pain, Katherine E. Galluzzi

Providing Patient-Centered Care for Chronic Nonmalignant Pain, Katherine E. Galluzzi


What is a D.O.? How do Osteopathic Physicians Approach the Problem of Pain, Katherine E. Galluzzi

Use of AlloDerm in Primary Nipple Reconstruction to Improve Long-Term Nipple Projection, Charles E. Garramone and Benjamin Lam

Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage, Jacquelyn Gerhart, C. Neely, J. Elder, J. Pfautz, J. Perlman, L. Narciso, K. Linask, K. Knudsen, and Mindy George-Weinstein

Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: A component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon, B. Gerwe, L. Kelley, B. D. Dillard, T. Lai, Z. J. Liu, W. Tempel, L. Chen, J. Habel, Francis E. Jenney Jr., and et al.

India to introduce five-year doctor of pharmacy program., Naushad Ghilzai, Arjun P. Dutta, and David W. Newton

Loss of the alpha-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-beta, Jennifer L. Gooch, B. R. Roberts, S. L. Cobbs, and J. A. Tumlin

Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension, A. Gupta, D. T. Berg, B. Gerlitz, M. A. Richardson, E. Galbreath, S. Syed, Avadhesh C. Sharma, S. F. Lowry, and B. W. Grinnell

Neural correlates of sex differences in spatial cognition, R. C. Gur, Sarah Levin Allen, F. Irani, I. S. Panyavin, and Stephen M. Platek

Is the Demise of IQ Interpretation Justified? A Response to Special Issue Authors, James B. Hale, Catherine A. Fiorello, Jack A. Kavanagh, James A. Holdnack, and A. M. Aloe

Transforming growth factor-β1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation, F. Han, J. R. Gilbert, G. Harrison, Christopher S. Adams, T. Freeman, Z. Tao, R. Zaka, H. Liang, C. Williams, and et al.

Nongenomic, endothelium-independent effects of estrogen on human coronary smooth muscle are mediated by type I (neuronal) NOS and PI3-kinase-Akt signaling, Guichun Han, Handong Ma, Rajesh Chintala, Katsuya Miyaki, David J. R. Fulton, Scott A. Barman, and Richard E. White

Roles of religion and geography in organ donation in the African-American community., Tomia P. Harmon

TBX5 Regulates Cardiac Cell Behavior During Cardiogenesis, Cathy J. Hatcher, Minsu Kim, David Pennisi, Yan Song, Nata Diman, Marsha M. Goldstein, Takashi Mikawa, and Craig T. Basson

Once-daily tacrolimus extended-release formulation: 1-Year post-conversion in stable pediatric liver transplant recipients, Thomas Heffron, M. D. Pescovitz, S. Florman, M. Kalayoglu, S. Emre, Gregory Smallwood, K. Wisemandle, and et al.

Medical and surgical treatment of neonatal hemochromatosis: Single center experience, Thomas Heffron, Todd Pillen, David Welch, Massimo Asolati, Gregory Smallwood, Phil Hagedorn, David Solis, and et al.

Consultation-based academic intervention for children with attention deficit hyperactivity disorder: School functioning outcomes, A. K. Jitendra, George J. Dupaul, R. J. Volpe, Katy E. Tresco, R. E. V. Junod, J. G. Lutz, K. S. Cleary, Lizette M. Flammer-Rivera, and M. C. Mannella

Potassium channel blockers and openers as CNS neurologic therapeutic agents, S. I. V. Judge, P. J. Smith, Peggy E. Stewart, and C. T. Bever Jr.

Structure of the Hypothetical Protein PF0899 from Pyrococcus furiosus at 1.85 A Resolution, Laura-Lee Clancy Kelley, Bret D. Dillard, Wolfram Tempel, Lirong Chen, Neil Shaw, Doowon Lee, M. Gary Newton, Frank J. Sugar, Francis E. Jenney, Han Seung Lee, Claudia Shah, Farris L. Poole, Michael W. W. Adams, Jane S. Richardson, David C. Richardson, Zhi-Jie Liu, Bi-Cheng Wang, and John Rose

Counterfeit and substandard quality of drugs: The need for an effective and stringent regulatory control in India and other developing countries, Azhar Khan and Naushad Ghilzai

Applying Osteopathic Principles to Formulate Treatment for Patients with Chronic Pain, Michael L. Kuchera

Preventing Disruptive Behavior in the Urban Classroom: Effects of the Good Behavior Game on Student and Teacher Behavior, Amanda L. Lannie

In situ oxygen utilization in the rat intervertebral disc, D. C. Lee, Christopher S. Adams, T. J. Albert, I. M. Shapiro, S. M. Evans, and C. J. Koch

Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: Detachment strength and correlation with long-term cellular function, M. J. Lee, Christopher S. Adams, D. Boettinger, W. F. Degrado, I. M. Shapiro, R. J. Composto, and P. Ducheyne

Modeling oxygen effects in tissue-preparation neuronal-current MRI, Qingfei Luo, Ho-Ling Liu, Brent Parris, Huo Lu, David M. Senseman, and Jia-Hong Gao

Adapting judicial supervision to the risk level of drug offenders: Discharge and 6-month outcomes from a prospective matching study, D. Marlowe, David Festinger, K. Dugosh, P. Lee, and K. Benasutti

Low Back Pain, Kendra McCamey and Paul Evans

Assessment of personality disorders in childhood, George McCloskey, Peter Kane, Carrie Champ Morera, Kathryn Gipe, and Amy McClaughlin

Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs, T. Miyahara, K. Hamanaka, D. S. Weber, D. A. Drake, Mircea Anghelescu, and J. C. Parker

Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome, R. S. Muddashetty, S. Keli, C. Gross, Mei Xu, and G. J. Bassell

HERG is protected from pharmacological block by a-1,2- glucosyltransferase function, T. Nakajima, K. Hayashi, P. Viswanathan, M. Kim, Mircea Anghelescu, K. A. Barksdale, W. Shuai, J. R. Balser, and S. Kuperschmidt

The Food and Drug Administration Office of Women's Health: Impact of science on regulatory policy, D. Obias-Manno, P. E. Scott, Joseph M. Kaczmarczyk, M. Miller, E. Pinnow, L. Lee-Bishop, M. Jones-London, K. Chapman, D. Kallgren, and K. Uhl

Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation, B. Pucci, Christopher S. Adams, J. Fertala, B. C. Snyder, K. D. Mansfield, M. Tafani, T. Freeman, and I. M. Shapiro

In vitro and in vivo bactericidal effect of sol-gel/antibiotic thin films on fixation devices, S. Radin, V. Antoci Jr., N. Hickok, Christopher S. Adams, J. Parvizi, I. M. Shapiro, and P. Ducheyne

Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Barbara Boyan, and Clifton A. Baile

Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes, Srujana Rayalam, Mary Anne Della-Fera, J. Y. Yang, J. P. Hea, S. Ambati, and C. A. Baile

Resistance to combined ganciclovir and foscarnet therapy in a liver transplant recipient with possible dual-strain cytomegalovirus coinfection, John Rodriguez, Katherine Casper, Gregory Smallwood, Andrei Stieber, Carlos Fasola, Jennifer Lehneman, and Thomas Heffron

Standing on the Shoulders of Giants, Frederick Rotgers

Matrix regulation of skeletal cell apoptosis III: Mechanism of ion pair-induced apoptosis, R. Saunders, K. H. Szymczyk, I. M. Shapiro, and Christopher S. Adams

RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis, A. G. Secchi, V. Grigoriou, I. M. Shapiro, E. A. Cavalcanti-Adam, R. J. Composto, P. Ducheyne, and Christopher S. Adams

Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface, I. M. Shapiro, Christopher S. Adams, V. Srinivas, and T. A. Freeman

Sepsis-induced myocardial dysfunction, Avadhesh C. Sharma

Analysis of competitive interaction of H and R allelic forms of CD32A with rabbit IgG immune-complex, Rangaiah Shashidharamurthy, A. Amano, D. Ezekwudo, and P. Selvaraj

Region-specific neutralization of Indian cobra (Naja naja) venom by polyclonal antibody raised against the eastern regional venom: A comparative study of the venoms from three different geographical distributions, Rangaiah Shashidharamurthy and K. Kemparaju


Interleukin-4 Inhibition of Interleukin-1-Induced Expression of Matrix Metalloproteinase-3 (MMP-3) is Independent of Lipoxygenase and PPARgamma Activation in Human Gingival Fibroblasts, Denise Stewart, Masoud Javadi, Mariah Chambers, Chad Gunsolly, Grzegorz Gorski, and Ruth C. Borghaei

An Analysis of the Relationship between Irrational Beliefs and Automatic Thoughts in Predicting Distress, A. Szentagotai and Arthur Freeman

Observation of terahertz vibrations in Pyrococcus furiosus rubredoxin via impulsive coherent vibrational spectroscopy and nuclear resonance vibrational spectroscopy - interpretation by molecular mechanics, M. L. Tan, A. R. Bizzarri, Y. Xiao, S. Cannistraro, T. Ichiye, C. Manzoni, G. Cerullo, M. W. Adams, Francis E. Jenney Jr., and S. P. Cramer


Herpes Simplex Virus 1 and Chlamydophila (Chlamydia) pneumoniae promote Ab 1-42 amyloid processing in murine astrocytes linking an infectious process to Alzheimer's disease, Laura R. Triplett, Adam L. Dore, Kevin S. Kralik, Brian J. Balin, Susan T. Hingley, and Denah M. Appelt

Dispersion interactions govern the strong thermal stability of a protein, Jiří Vondrášek, T. Kubař, Francis E. Jenney Jr., Michael W. Adams, Milan Kožíšek, Jiří Černý, Vladimír Sklenář, and Pavel Hobza

Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma, Xinyu Wang, Phillip D. Bowman, Sean M. Kerwin, and Salomon Stavchansky

PF0610, a novel winged helix-turn-helix variant possessing a rubredoxin-like Zn ribbon motif from the hyperthermophilic archaeon, Pyrococcus furiosus, X. Wang, H. Lee, F. J. Sugar, Francis E. Jenney Jr., Michael W. Adams, and J. H. Prestegard

Working with adult survivors of sexual and physical abuse, Beverly White

Hormone replacement therapy and cardiovascular function: Evidence for dual and opposite effects of estrogen on vascular reactivity, Richard E. White

Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes, Jeongyeh Yang, Mary Anne Della-Fera, Srujana Rayalam, Suresh Ambati, and Clifton A. Baile

Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis, Jeongyeh Yang, Mary Anne Della-Fera, Srujana Rayalam, and Clifton A. Baile

A Critical Role for the Co-Repressor N-CoR in Erythroid Differentiation and Heme Synthesis, Dianzheng Zhang, Ellen Cho, and Jiemin Wong

An enhancer mutant of Arabidopsis salt overly sensitive 3 mediates both ion homeostasis and the oxidative stress response, J. Zhu, X. Fu, Y. Koo, J. Zhu, Francis E. Jenney Jr, Michael W. Adams, Y. Zhu, H. Shi, S. Yub, and et al.

Submissions from 2006

Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization, Yun Bai and Wei-Chiang Shen

Cyclic nucleotide and protein kinase signaling in hypertensive pulmonary arterial smooth muscle, Scott A. Barman, Shu Zhu, and Richard E. White

Protein kinase signaling in hypertensive pulmonary arterial smooth muscle, Scott A. Barman, Shu Zhu, and Richard E. White

The National Report Card on the State of Emergency Medicine, John W. Becher

Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned guinea pig trabeculae, Marcus G. Bell, E. B. Lankford, G. E. Gonye, G. C. R. Ellis-Davies, D. A. Martyn, M. Regnier, and Robert J. Barsotti


Kinetics of Cardiac Thin-Filament Activation Probed by Fluorescence Polarization of Rhodamine-Labeled Troponin C in Skinned Guinea Pig Trabeculae, Marcus G. Bell, Edward B. Lankford, Gregory E. Gonye, Graham C. R. Ellis-Davies, Donald A. Martyn, Michael Regnier, and Robert J. Barsotti

Effect of night vision goggles on performance of advanced life support skills by emergency personnel., Savoy Brummer, Edward T Dickinson, Frances S Shofer, James P. McCans, and C Crawford Mechem

PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG, Jason O. Burnette and Richard E. White

Influence of Route of Entry to a Physician Assistant Education Program on Selected Characteristics of Practices of Physician Assistants, John M. Cavenagh

Presynaptic a1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons, Qian Chen, D. P. Li, and H. L. Pan

Regulation of synaptic input to hypothalamic presympathetic neurons by GABAB receptors, Qian Chen and H. L. Pan