The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2010


Unique precursors for the mesenchymal cells involved in injury response and fibrosis, J. L. Walker, N. Zhai, L. Zhang, B. Bleaken, I. Wolff, Jacquelyn Gerhart, Mindy George-Weinstein, and A. S. Menko

Cardiovascular Agents, Ted Walton and Rebekah Thomas

Structure-activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: effects on heme oxygenase-1 induction and antioxidant activities, Xinyu Wang, Salomon Stavchansky, Sean M. Kerwin, and Phillip D. Bowman

The Functions of ISG15 Ubiquitin-like Modifier and its Modifier Enzymes, Xinxing Wan, Dianzheng Zhang, and Hanchun Chen

Brain MRI image segmentation using fuzzy C-means clustering, Y. Wei, H. Keith Brown, X. Tao, and S. Moore

Estrogen and oxidative stress: A novel mechanism that may increase the risk for cardiovascular disease in women, Richard E. White, Ross Gerrity, Scott A. Barman, and Guichun Han

Development of acetaminophen proline prodrug, Zhiqian Wu, Ashish Patel, Rutesh Dave, and Xudong Yuan

Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cells, Zhiqian Wu, Anandkumar Shah, Namrata Patel, and Xudong Yuan

The dual role of TNF in pulmonary edema, Guang Yang, Boris Gorshkov, Supriya Sridhar, Alexander Verin, Rudolf Lucas, Jurg Hamacher, Richard E. White, and Trinad Chakraborty

The development and mechanism studies of cationic chitosan-modified biodegradable PLGA nanoparticles for efficient siRNA drug delivery, Xudong Yuan, Bruhal Shah, Naimish K. Kotadia, Jian Li, Hua Gu, and Zhiqian Wu

Numerical Modeling of Oxygen Distributions in Cortical and Cancellous Bone: Oxygen Availability Governs Osteonal and Trabecular Dimensions, Adam M. Zahm, Michael A. Bucaro, Portonovo S. Ayyaswamy, Vickram Srinivas, Irving M. Shapiro, Christopher S. Adams, and Karthik Mukundakrishnan

Submissions from 2009

Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis, Christopher S. Adams, V. Antoci Jr., G. Harrison, P. Patal, T. A. Freeman, I. M. Shapiro, J. Parvizi, N. J. Hickok, S. Radin, and P. Ducheyne

Ajoene exerts potent effects in 3t3-l1 adipocytes by inhibiting adipogenesis and inducing apoptosis i, Suresh Ambati, Jeongyeh Yang, Srujana Rayalam, Hea Jin Park, Mary Anne Della-Fera, and Clifton A. Baile

Factors That Influence Physicians to Practice in Rural Locations: A Review and Commentary, Darra Ballance, Denise Kornegay, and Paul Evans

Sickle cell disease, Lamia P. Barakat, D Collette Nicolaou, Emily A. O'Hara, and Sarah Levin Allen

Complementary and Alternative Medicines for the Treatment of Diabetes, Kimberly L. Barefield and Melissa C. Jones

Diabetes-Related Medication-Induced Hypoglycemia, Kimberly L. Barefield and Scott Lancaster


RhoA/Rho-kinase signaling: A therapeutic target in pulmonary hypertension, Scott A. Barman, Shu Zhu, and Richard E. White

Application of osteopathy in the cranial field to successfully treat vertigo:A case series, Murray R. Berkowitz

Editorial, Murray R. Berkowitz

From Hildreth, AG. The Lengthening Shadow of Dr. Andrew Taylor Still. Kirksville: The Journal Publishing Company, 1938, Chapter VVI, pp. 181-184. A glimpse of some of Dr. still's philosophy and technic, Murray R. Berkowitz

Osteopathic education and training-Advocating the adoption of an external paradigm for residency training in NMM/OMM, Murray R. Berkowitz

Hip Fractures in Children, Matthew J. Boardman, Martin J. Herman, Brian Buck, and Peter D. Pizzutillo

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy, J. Bohensky, S. P. Terkhorn, T. A. Freeman, Christopher S. Adams, J. A. Garcia, I. M. Shapiro, and V. Srinivas


Expression of transcription factor zinc-binding protein-89 (ZBP-89) is inhibited by inflammatory cytokines., Ruth C. Borghaei and Mariah Chambers

NF-kB and ZBP-89 regulate MMP-3 expression via a polymorphic site in the promoter, Ruth C. Borghaei, G. Gorski, and Masoud Javadi

Research Highlights, Erica N. Bozeman, Jennifer D. Hood, Rangaiah Shashidharamurthy, and Periasamy Selvaraj

Surface engineering of microparticles by novel protein transfer for targeted antigen/drug delivery, Gary W. Bumgarner, Rangaiah Shashidharamurthy, Shanmugam Nagarajan, Martin J. D'Souza, and Periasamy Selvaraj

To the point: reviews in medical education-the Objective Structured Clinical Examination, P. M. Casey, A. R. Goepfert, E. L. Aspey, M. M. Hammond, Joseph M. Kaczmarczyk, N. T. Katz, J. J. Neutens, F. S. Nuthalapaty, and E. Peskin

Acute lung injury: Apoptosis and signaling mechanisms, M. Chopra, J. S. Reuben, and Avadhesh C. Sharma

Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heart, M. Chopra and Avadhesh C. Sharma

A Novel Approach to the Dissection of the Human Knee, F Richard Clemente, Philip A. Fabrizio, and Michael Shumaker

Upregulation of myocardial syntaxin1A is associated with an early stage of polymicrobial sepsis, P. Das, M. Chopra, and Avadhesh C. Sharma

Age-dependent differential expression of apoptosis markers in the gingival tissue, P. Das, M. Chopra, Y. Sun, D. G. Kerns, S. Vastardis, and Avadhesh C. Sharma

Mechanisms of Primary Axonal Damage in a Viral Model of Multiple Sclerosis, Jayasri Das Sarma, Lawrence C. Kenyon, Susan T. Hingley, and Kenneth S. Shindler

Outcome trajectories in drug court: Do all participants have serious drug problems?, D. DeMatteo, D. Marlowe, David Festinger, and P. Arabia

Clinical Competencies and the Basic Sciences: An Online Case Tutorial Paradigm for Delivery of Integrated Clinical and Basic Science Content, Camille DiLullo, Harry J. Morris, and Richard M. Kriebel

The other diversity: The cost of being GLBT in America's health care, Terri A. Erbacher, Yuma Tomes, Tania Wismar, Caitlin Gilmartin, Deanna Ryder, Narrimone Thammavongsa, Eric Watson, and Lauren Webb

Special topic: Research brief, W. P. Erchul, George J. DuPaul, M. S. Bennett, P. F. Grissom, A. K. Jitendra, Katy E. Tresco, R. J. Volpe, R. E. Vile Junod, L. M. Flammer-Rivera, and M. C. Mannella

Ergonomic Intervention in the Treatment of a Patient with Upper Extremity and Neck Pain, Philip A. Fabrizio

The SEIQoL-DW for Assessing Quality of Life in ALS: Strengths and Limitations, Stephanie H. Felgoise, Jessica L. Stewart, Barbara A. Bremer, Susan M. Walsh, Mark B. Bromberg, and Zachary Simmons

Monetary Incentives Improve Recall of Research Consent Information: It Pays to Remember, David Festinger, D. Marlowe, J. Croft, K. Dugosh, P. Arabia, and K. Benasutti

Loneliness as a Partial Mediator of the Relation Between Low Social Preference in Childhood and Anxious/Depressed Symptoms in Adolescence, Reid Griffith Fontaine, Chongming Yang, Virginia Salzer Burks, Kenneth A. Dodge, Joseph M. Price, Gregory S. Pettit, and John E. Bates

Insulin Analog Therapy: Improving the Match with Physiologic Insulin Secretion, Jeffrey S. Freeman

Role of the Incretin Pathway in the Pathogenesis of Type 2 Diabetes Mellitus, Jeffrey S. Freeman

Case Report: Tackling Challenges of Postherpetic Neuralgia, Katherine E. Galluzzi

Managing Herpes Zoster and Postherpetic Neuralgia, Katherine E. Galluzzi

Noggin producing, MyoD-positive cells are crucial for eye development, Jacquelyn Gerhart, J. Pfautz, C. Neely, J. Elder, K. DuPrey, A. Menko, K. Knudsen, and Mindy George-Weinstein

South Asian subcontinent not represented in international pharmacy education supplement, Naushad Ghilzai

A novel short hairpin RNA (shRNA) expression system promotes Sox9-dependent gene silencing, J. R. Gilbert, Christopher S. Adams, I. M. Shapiro, and N. J. Hickok

Anthrax toxin: Pathologic effects on the cardiovascular system, H. B. Golden, L. E. Watson, H. Lal, S. K. Verma, D. M. Foster, S. R. Kuo, Avadhesh C. Sharma, A. Frankel, and D. E. Dostal

Bilateral Occult Mucosal Bridges of the True Vocal Folds, John Gull, Venu Divi, Mahmoud Ghaderi, and Robert T. Sataloff


The Comorbidity of Psychopathology in Cognitive and Academic SLD Subtypes, Lisa A. Hain, James B. Hale, and Jessica Glass Kendorksi

Development and Validation of an Attention-Deficit/Hyperactivity Disorder (ADHD) Executive Function and Behavior Rating Screening Battery, James B. Hale, Linda A. Reddy, Scott L. Decker, Rebecca Thompson, Julie N. Henzel, Annemarie Teodori, Elizabeth Forrest, Eleazar Eusebio, and Martha Bridge Denckla

Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle, Guichun Han, Handong Ma, Rajesh Chintala, David J. R. Fulton, Scott A. Barman, and Richard E. White

Specification of the cardiac conduction system by transcription factors, Cathy J. Hatcher and Craig T. Basson

Successful outcome after early combined liver and en bloc-kidney transplant in an infant with primary hyperoxaluria type 1: A case report, Thomas Heffron, John Rodriguez, Carlos G. Fasola, Katherine Casper, Todd Pillen, Gregory Smallwood, Barry Warshaw, and Rene Romero

Delayed Salicylate Toxicity with Undetectable Initial Levels after Large-Dose Aspirin Ingestion, Joseph Herres, Danielle Ryan, and Matthew Salzman

Robust, High-Throughput Solution Structural Analyses by Small Angle X-Ray Scattering (SAXS), Greg L. Hura, Angeli L. Menon, Michal Hammel, Robert P. Rambo, Farris L. Poole, Susan E. Tsutakawa, Francis E. Jenney, Scott Classen, Kenneth A. Frankel, Robert C. Hopkins, Sung-Jae Yang, Joseph W. Scott, Bret D. Dillard, Michael W. W. Adams, and John A. Tainer

Adoption and Safe Families Act State Statutes Regarding Parents with Mental Illnesses: A Review and Targeted Intervention, Katy Kaplan, Petra Kottsieper, Jeniece Scott, Mark S. Salzer, and Phyllis Solomon

TGF-β upregulation drives tertiary lymphoid organ formation and kidney dysfunction in calcineurin A-α heterozygous mice, F. M. Kelly, R. N. Reddy, B. R. Roberts, S. Gangappa, I. R. Williams, and Jennifer L. Gooch

Topographic features retained after antibiotic modification of Ti alloy surfaces: Retention of topography with attachment of antibiotics, C. Ketonis, J. Parvizi, Christopher S. Adams, I. M. Shapiro, and N. J. Hickok

Clinical Performance of the TRUE2go Blood Glucose System-A Novel Integrated System for Meter and Strips, Mark S. Kipnes, Hal Joseph, Harry J. Morris, Jason Manko, and Douglas E. Bell

Myosin-II Negatively Regulates minor process extension and the temporal development of neuronal polarity, K. M. Kollins, J. Hu, Yueqiao Huang, and G. Gallo

Experiential knowledge of serious mental health problems: One clinician and academic's perspective, Petra Kottsieper

Correlation between an email based board review program and American Board of Pediatrics General Pediatrics Certifying Examination scores., E. E. Langenau, J. Fogel, H. A. Schaeffer, and Wilson

Ready, Willing, and Able to Provide MTM Services? A Survey of Community Pharmacists in the USA, Anandi V. Law, Mark P. Okamoto, and Kelly Brock


Overexpression of truncated ERG from TMPRSS2-ERG fusion and prostate cancer development , Melanie Leong, Wenfeng Shi, Jun Tian, Ellen Cho, Abbas Raza, Saquib A. Siddiqi, Abdulhafez Selim, Hanchun Chen, and Dianzheng Zhang

Neuronal CaMKII acts as a structural kinase, Yuchih Lin and Lori Redmond Hardy

Effects of MS23 on KCl-, a-adrenoceptor agonists- and U46619-induced contractions of arteries isolated from rat different organs, Y. Liu, Ming-sheng Zhang, Desuo Wang, D. B. Liu, W. X. Xue, L. G. Niu, and Y. Q. Liang

Activation of glycogen synthase kinase-3ß is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex, Yan-Chun Li, Dong Xi, Joy Roman, Yueqiao Huang, and Wen-Jun Gao

3D electron microscopic reconstruction of segments of rat cerebellar Purkinje cell dendrites receiving ascending and parallel fiber granule cell synaptic inputs, Huo Lu, Angelica V. Esquivel, and James M. Bower

Physiologically evoked neuronal current MRI in a bloodless turtle brain: Detectable or not?, Qingfei Luo, Huo Lu, Hanbing Lu, David Senseman, Keith Worsley, Yihong Yang, and Jia-Hong Gao

Middle Adulthood and Aging, Burton Mach and D. Baron

Adaptive interventions may optimize outcomes in drug courts: A pilot study, D. Marlowe, David Festinger, P. Arabia, K. Dugosh, and K. Benasutti

Reassessment of the Cranial Characters of Glossotherium and Paramylodon (Mammalia: Xenarthra: Mylodontidae), Robert McAfee

Applying an Executive Function Framework in Educational Therapy, George McCloskey

Clinical applications I: A neuropsychological approach to interpretation of the WAIS-IV and the use of the WAIS-IV in learning disability assessments, George McCloskey

The WISC-IV Integrated, George McCloskey

Executive functions and emotional disturbance, George McCloskey, Joseph Hewitt, Julie N. Henzel, and Eleazar Eusebio

Assessment and intervention for executive function difficulties, George McCloskey, Lisa A. Perkins, and Bob Van Divner

Reducing Disruptive Behavior in an Urban School Cafeteria: An Extension of the Good Behavior Game, Barry L. McCurdy, Amanda L. Lannie, and Ernesto Barnabas

Novel multiprotein complexes identified in the hyperthermophilic archaeon pyrococcus furiosus by non-denaturing fractionation of the native proteome, A. L. Menon, F. L. Poole II, A. Cvetkovic, S. A. Trauger, E. Kalisiak, J. W. Scott, S. Shanmukh, J. Praissman, Francis E. Jenney Jr., and et al.

Current Diagnosis and Treatment [Media Review], Bohdan Minczak

The underrecognized epilepsy spectrum: The effects of levetiracetam on neuropsychological functioning in relation to subclinical spike production, Mark Mintz, Daniel Legoff, Jean Scornaienchi, Micah Brown, Sarah Levin Allen, Pnina Mintz, and Cathy Smith

Risk-Assessment Tools for Detecting Undiagnosed Diabetes., Eugene Mochan and Mark H. Ebell

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy, Heather L. Montie, Maria Cho, Latia Holder, Yuhong Liu, Andrey S. Tsvetkov, Steven Finkbeiner, and Diane E. Merry

Autophagy and access: Understanding the role of androgen receptor subcellular localization in SBMA, Heather L. Montie and Diane E. Merry

Problem Solving Skills Predict Quality of Llife and Psychological Morbidity in ALS Caregivers, Virginia Murphy, Stephanie H. Felgoise, Susan M. Walsh, and Zachary Simmons

An 11-Year-Old Boy with a Patella Fracture, Jason A. Nydick, Martin J. Herman, and Jean-Pierre de Chadarévian

Regression Analysis for Prediction: Understanding the Process, Phillip B. Palmer and Dennis G O'Connell

Genistein inhibits differentiation of primary human adipocytes, Heajin Park, Mary Anne Della-Fera, Dorothy B. Hausman, Srujana Rayalam, Suresh Ambati, and Clifton A. Baile

Thiazolidinediones and Congestive Heart Failure: A Judicious Balance of Risks and Benefits, Rujul R. Patel

Functional interactions between distinct sodium channel cytoplasmic domains through the action of calmodulin, F. Potet, B. Chagot, Mircea Anghelescu, P. Viswanathan, S. J. Stepanovic, S. Kuperschmidt, W. J. Chazin, and J. R. Balser

School-based interventions for students with attention-deficit/ hyperactivity disorder, T. J. Power, Katy E. Tresco, and M. C. Cassano

Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes, Srujana Rayalam, Jeongyeh Yang, Mary Anne Della-Fera, Heajin Park, Suresh Ambati, and Clifton A. Baile

Patient note fabrication and consequences of unprofessional behavior in a high-stakes clinical skills licensing examination, J. M. Sandella, W. L. Roberts, L. A. Gallagher, J. R. Gimpel, E. E. Langenau, and J. R. Boulet

Soy phytoestrogens are neuroprotective against stroke-like injury in vitro, D. A, Schreifhofer and Lori Redmond Hardy

Dynamics of the interaction of human IgG subtype immune complexes with cells expressing R and H allelic forms of a low-affinity Fcγ receptor CD32A, Rangaiah Shashidharamurthy, Fang Zhang, Aaron Amano, Aparna Kamat, Ravichandran Panchanathan, Daniel Ezekwudo, Cheng Zhu, and Periasamy Selvaraj


Repressive effects of resveratrol on androgen receptor transcriptional activity, Wenfeng Shi, Melanie Leong, Ellen Cho, Joseph Farrell, Hanchun Chen, Jun Tian, and Dianzheng Zhang