The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2008

Predicting Rheumatoid Arthritis Risk in Adults With Undifferentiated Arthritis, Eugene Mochan and Mark H. Ebell

Modifying an Evidence-Based Summer Treatment Program for Use in a Summer School Setting, Briannon C. O'Connor, Katy E. Tresco, William E. J. R. Pelham, Anne Ryan, Nicole C. Bycina, Maggie Hoeltke, Pamela McGarvey, and Kelly Ziegler

Clonidine for attention-deficit/hyperactivity disorder: I. Efficacy and tolerability outcomes, D. R. Palumbo, F. R. Sallee, W. E. Pelham Jr., O. G. Bukstein, W. B. Daviss, M. P. McDermott, L. Burrows-MacLean, P. Como, Katy E. Tresco, and et al.

Withaferin A induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes, Heajin Park, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Jeongyeh Yang, and Clifton A. Baile

Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes, Heajin Park, Jeongyeh Yang, Suresh Ambati, Mary Anne Della-Fera, Dorothy B. Hausman, Srujana Rayalam, and Clifton A. Baile

The comparison study on effects of water-soluble components of fine particulate matter on vasomotor functions in aortas from rats after exposure in different time, Gang Qin, Ming-sheng Zhang, Desuo Wang, Yue-suo Liang, Hong-mei Yao, Shou-gan Qi, and Ji-yuan Lu

Enhanced effects of 1,25(OH)"2D"3 plus genistein on adipogenesis and apoptosis in 3T3-L1 adipocytes, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Jeongyeh Yang, Heajin Park, and Clifton A. Baile

Phytochemicals and regulation of the adipocyte life cycle, Srujana Rayalam, Mary Anne Della-Fera, and Clifton A. Baile

A putative role for apelin in the etiology of obesity, Srujana Rayalam, Mary Anne Della-Fera, Paul A. Krieg, Christopher M. Cox, Allan Robins, and Clifton A. Baile

Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes, Srujana Rayalam, Jeongyeh Yang, Suresh Ambati, Mary Anne Della-Fera, and Clifton A. Baile

Patterns of Correlation and Covariation of Anthropoid Distal Forelimb Segments Correspond to Hoxd Expression Territories, Philip L. Reno, Melanie A McCollum, Martin J Cohn, Richard S Meindl, Mark Hamrick, and C Owen Lovejoy

Extreme makeover: The case of a young adult man with severe ADHD, Bradley M. Rosenfield, J. R. Ramsay, and A. L. Rostain


Chlamydophila (Chlamydia) pneumoniae promotes Ab 1-42 amyloid processing in Neuronal Cells: A Pathogenic Trigger for Alzheimer's Disease, Elizabeth K. Ruszak, Karen C. McCarthy, Marcus G. Bell, Brian J. Balin, and Denah M. Appelt

Debt Control for Young DOs, Matthew Schure

Custom designing therapeutic cancer vaccines. Delivery of immunostimulatory molecule adjuvants by protein transfer, Periasamy Selvaraj, A. Yerra, L. Tien, and Rangaiah Shashidharamurthy

Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with FcY receptors and can be effectively blocked by decoy FcY receptors, Rangaiah Shashidharamurthy, Randolph A. Hennigar, Sebastian Fuchs, Purani Palaniswami, Melanie Sherman, and Periasamy Selvaraj

End-product pathways in the xylose fermenting bacterium, Thermoanaerobacterium saccharolyticum, A. Joe Shaw, Francis E. Jenney Jr., M. W. Adams, and L. R. Lynd

Experimental Optic Neuritis Induced by a Demyelinating Strain of Mouse Hepatitis Virus, Kenneth S. Shindler, Lawrence C. Kenyon, Mahasweta Dutt, Susan T. Hingley, and Jayasri Das Sarma

Mechanism of Glycosaminoglycan-Mediated Bone and Joint Disease: Implications for the Mucopolysaccharidoses and Other Connective Tissue Diseases, Calogera M. Simonaro, Marina D'Angelo, Xingxuan He, Efrat Eliyahu, Nataly Shtraizent, Mark E. Haskins, and Edward H. Schuchman

Does interferon use prior to liver transplant influence hepatitis C outcomes following transplantation?, Gregory Smallwood; Renee Devine; Carlos Fasola; A, C, Stieber; and Thomas Heffron

Coexistence of Tumid Lupus Erythematosus with Systemic Lupus Erythematosus and Discoid Lupus Erythematosus: A Report of Two Cases of Tumid Lupus, Jennifer Stead, Catherine Headley, Michael Ioffreda, Carrie Kovarik, and Victoria Werth

Mechanisms Related to the Cardioprotective Effects of Protein Kinase C Epsilon (PKC Epsilon) Peptide Activator or Inhibitor in Rat Ischemia/Reperfusion Injury, Jane Chun-wen Teng, Helen Kay, Qian Chen, Jovan S Adams, Christopher Grilli, Giuseppe Guglielmello, Christopher Zambrano, Samuel Krass, Adrian Bell, and Lindon H. Young

Double jeopardy: Child and school characteristics that predict aggressive-disruptive behavior in first grade, Duane E. Thomas, K. L. Bierman, Celine I. Thompson, and C. J. Powers

Ethnicity, Cognitive Styles, and Math Achievement: Variability within African-American Post-Secondary Students, Yuma I. Tomes

Academic Interventions for Students With ADHD: Predictors of Achievement Outcomes, Katy E. Tresco, George J. Dupaul, and Asha K. Jitendra

Quantitative determination of fluorinated caffeic acid phenethyl ester derivative from rat blood plasma by liquid chromatography-electrospray ionization tandem mass spectrometry, Xinyu Wang, Jihai Pang, Robert A. Newman, Sean M. Kerwin, Phillip D. Bowman, and Salomon Stavchansky

Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: the role of heme oxygenase-1, Xinyu Wang, Salomon Stavchansky, Baiteng Zhaoa, James A. Bynum, Sean M. Kerwin, and Phillip D. Bowman

HIV testing and prevention for older adults: Is the office the proper setting for discussion?, Ilene Warner-Maron

Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin, Jeongyeh Yang, Mary Anne Della-Fera, Srujana Rayalam, Suresh Ambati, Diane L. Hartzell, Heajin Park, and Clifton A. Baile

Enhanced effects of xanthohumol plus honokiol on apoptosis in 3T3-L1 adipocytes, Jeongyeh Yang, Mary Anne Della-Fera, Srujana Rayalam, and Clifton A. Baile

Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle, Shu Zhu, Richard E. White, and Scott A. Barman

Submissions from 2007

Transcriptomics, Proteomics, and Structural Genomics of Pyrococcus Furiosus, M. W. Adams, Francis E. Jenney Jr., C. Chou, S. Hamilton-Brehm, F. L. Poole, K. R. Shockley, S. Tachdjian, and R. M. Kelly

Ectopic expression of the homeobox gene Cux-1 rescues calcineurin inhibition in mouse embryonic kidney cultures, N. I. Alcalay, J. G. Brantley, M. Sharma, Jennifer L. Gooch, and G. B. Vanden Heuvel

Covalently attached vancomycin provides a nanoscale antibacterial surface, V. Antoci Jr., Christopher S. Adams, J. Parvizi, P. Ducheyne, I. M. Shapiro, and N. J. Hickok

Vancomycin covalently bonded to titanium alloy prevents bacterial colonization, V. Antoci Jr., S. B. King, B. Jose, J. Parvizi, A. R. Zieger, E. Wickstrom, T. A. Freeman, R. J. Composto, Christopher S. Adams, and et al.


A Review of Cretaceous dipnoans from Argentina (Sarcopterygii Dipnoi) with Descriptions of New Species, Sebastian Apasteguia, Federico L. Agnolin, and Kerin M. Claeson

Inhibition of Apoptosis in Neuronal Cells Infected with Chlamydophila (Chlamydia) pneumoniae, Denah M. Appelt, Maria Roupas, Deana Way, Marcus G. Bell, Elizabeth V. Albert, Christine J. Hammond, and Brian J. Balin

HIF-1 Regulation of Chondrocyte Apoptosis: Induction of the Autophagic Pathway, J. Bohensky, I. M. Shapiro, S. Leshinsky, S. P. Terkhorn, Christopher S. Adams, and V. Srinivas

Decision analysis model evaluating the cost-effectiveness of risperidone, olanzapine and haloperidol in the treatment of schizophrenia, Mark Bounthavong and Mark P. Okamoto

Relationship Between Mitochondrial DNA Damage and Photoreceptor Death in Developing and Adult Retina, Assessed in Normal and Degenerative Rat Strains, Arturo Bravo Nuevo, Neal K Williams, Krisztina Valter, and Jonathan Stone

The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis, M. A. Bucaro, A. M. Zahm, M. V. Risbud, P. S. Ayyaswamy, K. Munkundakrishnan, M. J. Steinbeck, I. M. Shapiro, and Christopher S. Adams

The first agmatine/cadaverine aminopropyl transferase: Biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon Pyrococcus furiosus, G. Cacciapuoti, M. Porcelli, M. Moretti, F. Sorrentino, L. Concilio, V. Zappia, Z. Liu, W. Tempel, Francis E. Jenney Jr., and et al.

Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons, Qian Chen and H. L. Pan

Apoptotic cardiomyocyte hypertrophy during sepsis and septic shock results from prolonged exposure to endothelin precursor, M. Chopra and Avadhesh C. Sharma

Effect of nesiritide infusion duration on renal function in acutely decompensated heart failure patients, Sheryl L. Chow, Jessiva T. Peng, Mark P. Okamoto, and J. Thomas Heywood

Taking Cognitive-Behavior Therapy to School: A School-Based Mental Health Approach, Ray W. Christner, Elizabeth Forrest, Jessica Morley, and Elana Weinstein

New interpretations of the skull of a primitive bony fish Erpetoichthys calabaricus (Actinopterygii: Cladistia), Kerin M. Claeson, William E. Bemis, and James W. Hagadorn

NFATc is required for TGFß-mediated transcriptional regulation of fibronectin, Scott L. Cobbs and Jennifer L. Gooch

Reactive oxidant species and emerging therapies in clinical medicine, Farzaneh Daghigh

An Empirical Survey on Psychological Testing and the Use of the Term Psychological: Turf Battles or Clinical Necessity?, F. M. Dattilio, Katy E. Tresco, and A. Siegel

Solvent tuning of electrochemical potentials in the active sites of HiPIP versus ferredoxin, A. Dey, Francis E. Jenney Jr., M. W. Adams, E. Babini, Y. Takahashi, K. Fukuyama, K. O. Hodgson, B. Hedman, and E. I. Solomon

Sulfur K-edge X-ray absorption spectroscopy and density functional theory calculations on superoxide reductase: Role of the axial thiolate in reactivity, A. Dey, Francis E. Jenney Jr., M. W. Adams, M. K. Johnson, K. O. Hodgson, B. Hedman, and E. I. Solomon

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation, Christiana Dimitropoulou, Lashondra West, Mary B. Field, Richard E. White, L. Manmohan Reddy, John R. Falck, and John D. Imig

Behavioral perspectives, Robert A. DiTomasso, James B. Hale, and S. M. Timchack

The behavioral model of personality disorders, Robert A. DiTomasso, James B. Hale, and Stephen M. Timchack

Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity, Shashikiran Donthamsetty, Vishakha Bhave, Mayarranjan S. Mitra, John R. Latendresse, and Harihara M. Mehendale

Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization, O. P. Edupuganti, V. Antoci Jr., S. B. King, B. Jose, Christopher S. Adams, J. Parvizi, I. M. Shapiro, A. R. Zeiger, N. J. Hickok, and E. Wickstrom

Relationships among relational communication processes and consultation outcomes for students with attention deficit hyperactivity disorder, W. P. Erchul; George J. DuPaul; P. F. Grissom; R. E. Vile Junod; A. K. Jitendra; M. C. Mannella; Katy E, Tresco; L. M. Flammer-Rivera; and R. J. Volpe

Does the Medical College Admission Test Predict Global Academic Performance in Osteopathic Medical School?, Paul Evans and Frances K. Wen

Neuropsychological functioning and recall of research consent information among drug court clients, David Festinger, K. Ratanadilok, D. Marlowe, K. Dugosh, N. Patapis, and D. Dematteo

Interpreting Intelligence Test Results for Children with Disabilities: Is Global Intelligence Relevant?, Catherine A. Fiorello, James B. Hale, James A. Holdnack, Jack A. Kavanagh, Joy Terrell, and Lisa Long

The Use of Homework in Cognitive Behavior Therapy: Working with Complex Anxiety and Insomnia, Arthur Freeman

Introduction, Arthur Freeman, Mark A. Reinecke, and Yuma I. Tomes

Management Strategies for Herpes Zoster and Postherpetic Neuralgia, Katherine E. Galluzzi

Managing Neuropathic Pain, Katherine E. Galluzzi

Providing Patient-Centered Care for Chronic Nonmalignant Pain, Katherine E. Galluzzi


What is a D.O.? How do Osteopathic Physicians Approach the Problem of Pain, Katherine E. Galluzzi

Use of AlloDerm in Primary Nipple Reconstruction to Improve Long-Term Nipple Projection, Charles E. Garramone and Benjamin Lam

Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage, Jacquelyn Gerhart, C. Neely, J. Elder, J. Pfautz, J. Perlman, L. Narciso, K. Linask, K. Knudsen, and Mindy George-Weinstein

Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: A component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon, B. Gerwe, L. Kelley, B. D. Dillard, T. Lai, Z. J. Liu, W. Tempel, L. Chen, J. Habel, Francis E. Jenney Jr., and et al.

India to introduce five-year doctor of pharmacy program., Naushad Ghilzai, Arjun P. Dutta, and David W. Newton

Loss of the alpha-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-beta, Jennifer L. Gooch, B. R. Roberts, S. L. Cobbs, and J. A. Tumlin

Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension, A. Gupta, D. T. Berg, B. Gerlitz, M. A. Richardson, E. Galbreath, S. Syed, Avadhesh C. Sharma, S. F. Lowry, and B. W. Grinnell

Neural correlates of sex differences in spatial cognition, R. C. Gur, Sarah Levin Allen, F. Irani, I. S. Panyavin, and Stephen M. Platek

Is the Demise of IQ Interpretation Justified? A Response to Special Issue Authors, James B. Hale, Catherine A. Fiorello, Jack A. Kavanagh, James A. Holdnack, and A. M. Aloe

Transforming growth factor-β1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation, F. Han, J. R. Gilbert, G. Harrison, Christopher S. Adams, T. Freeman, Z. Tao, R. Zaka, H. Liang, C. Williams, and et al.

Nongenomic, endothelium-independent effects of estrogen on human coronary smooth muscle are mediated by type I (neuronal) NOS and PI3-kinase-Akt signaling, Guichun Han, Handong Ma, Rajesh Chintala, Katsuya Miyaki, David J. R. Fulton, Scott A. Barman, and Richard E. White

Roles of religion and geography in organ donation in the African-American community., Tomia P. Harmon

TBX5 Regulates Cardiac Cell Behavior During Cardiogenesis, Cathy J. Hatcher, Minsu Kim, David Pennisi, Yan Song, Nata Diman, Marsha M. Goldstein, Takashi Mikawa, and Craig T. Basson

Once-daily tacrolimus extended-release formulation: 1-Year post-conversion in stable pediatric liver transplant recipients, Thomas Heffron, M. D. Pescovitz, S. Florman, M. Kalayoglu, S. Emre, Gregory Smallwood, K. Wisemandle, and et al.

Medical and surgical treatment of neonatal hemochromatosis: Single center experience, Thomas Heffron, Todd Pillen, David Welch, Massimo Asolati, Gregory Smallwood, Phil Hagedorn, David Solis, and et al.

Consultation-based academic intervention for children with attention deficit hyperactivity disorder: School functioning outcomes, A. K. Jitendra, George J. Dupaul, R. J. Volpe, Katy E. Tresco, R. E. V. Junod, J. G. Lutz, K. S. Cleary, Lizette M. Flammer-Rivera, and M. C. Mannella

Potassium channel blockers and openers as CNS neurologic therapeutic agents, S. I. V. Judge, P. J. Smith, Peggy E. Stewart, and C. T. Bever Jr.

Structure of the Hypothetical Protein PF0899 from Pyrococcus furiosus at 1.85 A Resolution, Laura-Lee Clancy Kelley, Bret D. Dillard, Wolfram Tempel, Lirong Chen, Neil Shaw, Doowon Lee, M. Gary Newton, Frank J. Sugar, Francis E. Jenney, Han Seung Lee, Claudia Shah, Farris L. Poole, Michael W. W. Adams, Jane S. Richardson, David C. Richardson, Zhi-Jie Liu, Bi-Cheng Wang, and John Rose

Counterfeit and substandard quality of drugs: The need for an effective and stringent regulatory control in India and other developing countries, Azhar Khan and Naushad Ghilzai

Applying Osteopathic Principles to Formulate Treatment for Patients with Chronic Pain, Michael L. Kuchera

Preventing Disruptive Behavior in the Urban Classroom: Effects of the Good Behavior Game on Student and Teacher Behavior, Amanda L. Lannie

In situ oxygen utilization in the rat intervertebral disc, D. C. Lee, Christopher S. Adams, T. J. Albert, I. M. Shapiro, S. M. Evans, and C. J. Koch

Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: Detachment strength and correlation with long-term cellular function, M. J. Lee, Christopher S. Adams, D. Boettinger, W. F. Degrado, I. M. Shapiro, R. J. Composto, and P. Ducheyne

Modeling oxygen effects in tissue-preparation neuronal-current MRI, Qingfei Luo, Ho-Ling Liu, Brent Parris, Huo Lu, David M. Senseman, and Jia-Hong Gao

Adapting judicial supervision to the risk level of drug offenders: Discharge and 6-month outcomes from a prospective matching study, D. Marlowe, David Festinger, K. Dugosh, P. Lee, and K. Benasutti

Low Back Pain, Kendra McCamey and Paul Evans

Assessment of personality disorders in childhood, George McCloskey, Peter Kane, Carrie Champ Morera, Kathryn Gipe, and Amy McClaughlin

Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs, T. Miyahara, K. Hamanaka, D. S. Weber, D. A. Drake, Mircea Anghelescu, and J. C. Parker

Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome, R. S. Muddashetty, S. Keli, C. Gross, Mei Xu, and G. J. Bassell

HERG is protected from pharmacological block by a-1,2- glucosyltransferase function, T. Nakajima, K. Hayashi, P. Viswanathan, M. Kim, Mircea Anghelescu, K. A. Barksdale, W. Shuai, J. R. Balser, and S. Kuperschmidt

The Food and Drug Administration Office of Women's Health: Impact of science on regulatory policy, D. Obias-Manno, P. E. Scott, Joseph M. Kaczmarczyk, M. Miller, E. Pinnow, L. Lee-Bishop, M. Jones-London, K. Chapman, D. Kallgren, and K. Uhl

Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation, B. Pucci, Christopher S. Adams, J. Fertala, B. C. Snyder, K. D. Mansfield, M. Tafani, T. Freeman, and I. M. Shapiro

In vitro and in vivo bactericidal effect of sol-gel/antibiotic thin films on fixation devices, S. Radin, V. Antoci Jr., N. Hickok, Christopher S. Adams, J. Parvizi, I. M. Shapiro, and P. Ducheyne

Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Barbara Boyan, and Clifton A. Baile