The Functions of ISG15 Ubiquitin-like Modifier and its Modifier Enzymes

Document Type

Article

Publication Date

2010

Abstract

Interferon\|stimulated gene 15 　encoded protein (ISG15) was identified as one of the first ubiquitin\|like modifier that induced by interferons. Numerous ISG15\|target proteins have been identified in tumors and virus\|infected cells. Multiple lines of evidence suggest that ISG15 plays important roles in the innate immune pathways and in cancer development. We focus on the structure and biochemical features of ISG15, as well as the mechanisms of the ISGylation of target proteins assisted with ISG15 modifier enzymes. The anti\|viral and anti\|cancer activities of ISG15 and its modifier enzymes are also discussed.

Publication Title

Chinese Journal of Biochemistry and Molecular Biology

Volume

26

Issue

4

First Page

295

Last Page

300

Comments

This article was published in The Chinese Journal of Biochemistry and Molecular Biology, Volume 26, Issue 4 Pages 295-300.

The published version is available at http://cjbmb.bjmu.edu.cn/EN/Y2010/V26/I04/295.

Copyright © 2010 Chinese J. of Biochem. and Molecular Bio.

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