The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2011

Activation of G protein-coupled estrogen receptor induces endotheliumindependent relaxation of coronary artery smooth muscle, Xuan Yu, Handong Ma, Scott A. Barman, Alexander T. Liu, Minga Sellers, John N. Stallone, Eric R. Prossnitz, Richard E. White, and Guichun Han


Bone Cell Autophagy is Regulated by Environmental Factors, Adam M. Zahm, Jolene Bohensky, Christopher S. Adams, Irving M. Shapiro, and Vickram Srinivas

Submissions from 2010

Central leptin versus ghrelin: Effects on bone marrow adiposity and gene expression, Suresh Ambati, Qiang Li, Srujana Rayalam, Diane L. Hartzell, Mary Anne Della-Fera, Mark W. Hamrick, and Clifton A. Baile

Phytochemicals and adipogenesis, Charlotte Andersen, Srujana Rayalam, Mary Anne Della-Fera, and Clifton A. Baile

Admitting allopathic physicians to osteopathic graduate medical education programs: The case for competency-based NMM/OMM training in OGME, Murray R. Berkowitz

Admitting international osteopathic physicians and osteopaths to osteopathic graduate medical education programs, Murray R. Berkowitz

Evidence does not grow stale with age, Murray R. Berkowitz

Holistic osteopathic approach reveals unusual etiology for vertigo with co-morbid headache: A case report, Murray R. Berkowitz

On the role of the glossary, Murray R. Berkowitz

Cancer vaccine development: Designing tumor cells for greater immunogenicity, Erica N. Bozeman, Rangaiah Shashidharamurthy, Simon A; Paulos, Ravi D. Palaniappan, Martin D'Souza, and Periasamy Selvaraj

Malignant Fibrous Histiocytoma of the Mandible, Lana E. Brahmakulam and Bosco E. Noronha

Eating disorders in primary care: Assessment and treatment., Stacey C. Cahn and R. McFillin

The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion, Qian Chen, Elizabeth Eun Jung Kim, Katrina Elio, Christopher Zambrano, Samuel Krass, Jane Chun-Wen Teng, Helen Kay, Kerry-Anne Perkins, Sailesh Pershad, Sloane McGraw, Jeffrey Emrich, Jovan S. Adams, and Lindon H. Young

The potential clinical application of protein kinase C beta II peptide inhibitor or Gö 6983 in vascular endothelial dysfunction, Qian Chen, Brian Rueter, Samuel Krass, Christopher Zambrano, Shawn Thomas, Catherine Prince, Brandon Bell, Vincent Chai, Jeffery Emrich, and Lindon Young

Design of an in vivo cleavable disulfide linker in recombinant fusion proteins, Xiaoying Chen, Yun Bai, Jennifer L. Zaro, and Wei-Chiang Shen

Norepinephrine Induces Systolic Failure and Inhibits Antiapoptotic Genes in a Polymicrobial Septic Rat Model, Mani Chopra, Padmalaya Das, Honey Golden, David E. Dostal, Linley E. Watson, and Avadhesh C. Sharma

Caspase-3 Knock-Down Reverses Contractile Dysfunction Induced by Sepsis in Adult Rat Ventricular Myocytes, Mani Chopra, Padmalaya Das, and Avadhesh C. Sharma

Norepinephrine induces systolic failure and inhibits antiapoptotic genes in a polymicrobial septic rat model, M. Chopra, P. Das, H. Golden, D. E. Dostal, L. E. Watson, and Avadhesh C. Sharma

Caspase-3 knock-down reverses contractile dysfunction induced by sepsis in adult rat ventricular myocytes, M. Chopra, P. Das, and Avadhesh C. Sharma

To the point: Reviews in medical education- taking control of the hidden curriculum, A W. Chuang, F. Nuthalapty, P. M. Casey, Joseph M. Kaczmarczyk, A. J. Cullimore, J. L. Dalrymple, L. Dugoff, E. L. Espey, and M. Hammoud


First Mesozoic record of the stingray myliobatis wurnoensis from Mali and a phylogenetic analysis of myliobatidae incorporating dental characters, Kerin M. Claeson, Maureen A. O'Leary, Eric M. Roberts, Famory Sissoko, Mamadou Bouare, Leif Tapanila, David Goodwin, and Michael D. Gottfried

3D digital imaging of a concretion-preserved batoid (Chondrichthyes, Elasmobranchii) from the Turonian (Upper Cretaceous) of Morocco, Kerin M. Claeson, David J. Ward, and Charlie J. Underwood

The consultation process in primary care, Travis A. Cos; Robert A. DiTomasso; Carla Cirilli; and Larry H, Finkelstein

Microbial Metalloproteomes Are Largely Uncharacterized, Aleksandar Cvetkovic, Angeli Lal Menon, Michael P. Thorgersen, Joseph W. Scott, Farris L. Poole, Francis E. Jenney, W. Andrew Lancaster, Jeremy L. Praissman, Saratchandra Shanmukh, Brian J. Vaccaro, Sunia A. Trauger, Ewa Kalisiak, Junefredo V. Apon, Gary Siuzdak, Steven M. Yannone, John A. Tainer, and Michael W. W. Adams

Type 2 diabetes, Robert A. DiTomasso, Patrick D. Boyle, Larry H. Finkelstein, and Harry J. Morris

Evidence-based models and interventions in primary care, Robert A. DiTomasso, Stacey C. Cahn, Carla Cirilli, and Eugene Mochan

Essential hypertension, Robert A. DiTomasso, Deborah Chiumento, and Harry J. Morris

Nonadherence in primary care, Robert A. DiTomasso, Deborah Chiumento, Marsha S. Singer, and Oliver Bullock

Cognitive-behavioral concepts of anxiety, Robert A. DiTomasso, Arthur Freeman, Raymond Carvajal, and Bruce Zahn


Conclusion: The future of cognitive-behavioral approaches in primary care, Robert A. DiTomasso, Barbara A. Golden, and Harry J. Morris

Handbook of cognitive behavioral approaches in primary care, Robert A. DiTomasso, Barbara A. Golden, and Harry J. Morris

Primary care: The biopsychosocial model and cognitive-behavioral approaches, Robert A. DiTomasso, Barbara A. Golden, Harry J. Morris, and Deborah Chiumento

The cognitive-behavioral clinician: Roles and functions and ethical challenges in primary care, Robert A. DiTomasso, Samuel Knapp, Barbara A. Golden, Harry J. Morris, and Kenneth J. Veit


Overview of Thoracic Outlet Syndrome, Philip A. Fabrizio, Starla Deaton, Jenna Kwasny, Sidney Lamb, and Nicole Pawlowski

Psychological Morbidity in ALS: The Importance of Psychological Assessment Beyond Depression Alone, Stephanie H. Felgoise, Beatrice H. Chakraborty, Elisabeth Bond, Jamie Rodriguez, Barbara A. Bremer, Susan M. Walsh, Eugene C. Lai, Leo McCluskey, and Zachary Simmons

Corrected feedback: A procedure to enhance recall of informed consent to research among substance abusing offenders, David Festinger, K. Dugosh, J. Croft, P. Arabia, and D. Marlowe

Lower back pain in rowers, Regina K. Fleming and Karen T. Snider


Treatment of depression in primary care medical practice, Arthur Freeman, Eileen Lightner, and Barbara A. Golden

A Physiologic and Pharmacological Basis for Implementation of Incretin Hormones in the Treatment of Type 2 Diabetes Mellitus, Jeffrey S. Freeman

Are Analogue Insulins Superior to Human Insulin in Clinical Practice?, Jeffrey S. Freeman

Managing Hyperglycemia in Patients with Type 2 Diabetes Mellitus: Rationale for the Use of Dipeptidyl Peptidase-4 Inhibitors in Combination with Other Oral Antidiabetic Drugs, Jeffrey S. Freeman

New Therapeutic Options: Management Strategies to Optimize Glycemic Control, Jeffrey S. Freeman

The Increasing Epidemiology of Diabetes and Review of Current Treatment Algorithms, Jeffrey S. Freeman

Emanuel Swedenborg's influence on William G. Sutherland's cranial concept, David B. Fuller

Modern Care for Patients with Alzheimer Disease: Rationale for Early Intervention, Katherine E. Galluzzi, Denah M. Appelt, and Brian J. Balin

Immune complex-mediated enhancement of secondary antibody responses, Chelsey L. Goins, Craig P. Chappell, Rangaiah Shashidharamurthy, Periasamy Selvaraj, and Joshy Jacob


Acute and chronic pain in primary care settings, Barbara A. Golden, Robert J. Gatchel, and Scott Glassman


Somatoform disorders, Barbara A. Golden, Clint C. Stankiewicz, and Jeanne R. Kestel

Behavioral strategies, Elizabeth A. Gosch, Amelia G. Findiesen, and Robert A. DiTomasso

Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: Its role in the genesis of atrial arrhythmias, Donglin Guo, Lindon Young, Ying Wu, Luiz Belardinelli, Peter R. Kowey, and Ganxin Yan

Critical Issues in Response-To-Intervention, Comprehensive Evaluation, and Specific Learning Disabilities Identification and Intervention: An Expert White Paper Consensus, J. Hale, V Alfonso, V. Berninger, B. Bracken, C. Christo, E. Clark, M. Cohen, A. Davis, George McCloskey, and et al.


Immunohistological Detection of Chlamydia pneumoniae in the Alzheimer's Disease Brain, Christine J. Hammond, Loretta R. Hallock, Raymond J. Howanski, Denah M. Appelt, Christopher Scott Little, and Brian J. Balin PhD

Incidence, impact, and treatment of portal and hepatic venous complications following pediatric liver transplantation: A single-center 12 year experience, Thomas Heffron, Todd Pillen, Gregory Smallwood, Stuart Henry, Sundari Sekar, Katherine Casper, David Solis, Wenhao Tang, Carlos Fasola, and Rene Romero

Pediatric liver transplantation for acute liver failure at a single center: A 10-yr experience, Thomas Heffron, Todd Pillen, Gregory Smallwood, John Rodriguez, Sundari Sekar, Stuart Henry, Miriam Vos, Katherine Casper, Nitika Arora Gupta, and Carlos G. Fasola

Engineering bioactive scaffolds for stem cell vascular therapy, Abigail Hielscher, Yui Shen, and Sharon Gerecht


Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons, Jian-Li Hu, Gang Liu, Yan-Chun Li, Wen-Jun Gao, and Yueqiao Huang


Pramlintide in the Management of Obesity, Melissa C. Jones, Heather F. DeBellis, and Kimberly L. Barefield

Contraception, Joanna Kakaty-Monzo, Joan A. Keegan, Mehdi Prava, and Camilo A. Ruiz


Clinical Characteristics of Anxiety Disordered Youth, Philip C. Kendall, Scott N. Compton, John T. Walkup, Boris Birmaher, Anne Marie Albano, Joel Sherrill, Golda Ginsburg, Moira Rynn, James McCracken, Elizabeth A. Gosch, Courtney Pierce Keeton, Lindsey Bergman, Dara Sakolsky, Cindy Suveg, Satish Iyengar, John March, and John Piacentini

The Coping Cat: a parent companion, Philip C. Kendall, J. Podell, and Elizabeth A. Gosch

Antibiotic modification of native grafts: Improving upon nature's scaffolds, C. Ketonis, Christopher S. Adams, S. Barr, A. Aiyer, I. M. Shapiro, J. Parvizi, and N. J. Hickok

Bacterial colonization of bone allografts: Establishment and effects of antibiotics, C. Ketonis, S. Barr, Christopher S. Adams, N. J. Hickok, and J. Parvizi

Antioxidant Enzymes and Cancer, Md. Asaduzzaman Khan, Mousumi Tania, Dianzheng Zhang, and Hanchun Chen


Cordyceps Mushroom: a Potent Anticancer Nutraceutical, Md. Asaduzzaman Khan, Mousumi Tania, Dianzheng Zhang, and Hanchun Chen

A Teacher in Pain, Chadd K. Kraus

Five-year summary of COMLEX-USA Level 2-PE examinee performance and survey data, E. E. Langenau, C. Dyer, W. L. Roberts, C. Wilson, and J. Gimpel

The Use of Change-Sensitive Measures to Assess School-Based Therapeutic Interventions: Linking Theory to Practice at the Tertiary Level, Amanda L. Lannie, Robin S. Codding, James L. McDougal, and Scott Meier

Conduct Disorder: Information for Parents, Amanda L. Lannie and Barry L. McCurdy

"LEGO Club": a peer-based and naturalistic group for enhancing social competence., Daniel B. Legoff, G. W. Krauss, and Sarah Levin Allen

Bergmann glial ensheathment of dendritic spines regulates synapse number without affecting spine motility, Jocelyn Lippman-Bell, T. Lordkipanidze, and A. Dunaevsky


Dopamine D1 receptor-mediated enhancement of NMDA receptor trafficking requires rapid PKC-dependent synaptic insertion in the prefrontal neurons, Yan-Chun Li, Gang Liu, Jian-Li Hu, Wen-Jun Gao, and Yueqiao Huang

Primary Parotid Gland Sarcoidosis: Case Report and Discussion of Diagnosis and Treatment, Nicole Longo and Mahmoud Ghaderi

Comparison of Visually Evoked Local Field Potentials in Isolated Turtle Brain: Patterned Versus Blank Stimulation, Qingfei Luo, Huo Lu, Hanbing Lu, Yihong Yang, and Jia-Hong Gao

Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells, K. Madsen, U. G. Friis, J. L. Gooch, P. B. Hansen, L. Holmgaard, O. Skatt, and B. L. Jensen

Otolaryngologic Uses for Spinal Drains, Raymond C. Maguire, John Gull, Michael Weaver, and Robert T. Sataloff

Spontaneous coronary artery dissection in a postpartum woman presenting with chest pain., Leo Marcoff, Andra Popescu, Letitia Price, Gilbert A Leidig, Anthony W. Clay, John J Kelly, and Ehsanur Rahman

The D5 dopamine receptor mediates large-conductance, calcium- and voltage-activated potassium channel activation in human coronary artery smooth muscle cells, Aruna Natarajan, Guichun Han, Shiyou Chen, Peiying Yu, Richard E. White, and Pedro Jose

The Use of Clopidogrel (Plavix) in Patients Undergoing Nonelective Orthopaedic Surgery, Jason A. Nydick, Eric D. Farrell, Andrew J. Marcantonio, Eric L. Hume, Robert Marburger, and Robert F. Ostrum

An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy, Christopher R. Orr, Heather L. Montie, Yuhong Liu, Elena Bolzoni, Shannon C. Jenkins, James D. Joseph, Donald P. McDonnell, and Diane E. Merry

F-Spondin Regulates Chondrocyte Terminal Differentiation and Endochondral Bone Formation, Glyn D. Palmer, Alejandro H. Piton, Lwin Mon Thant, Serafim M. Oliveira, Marina D'Angelo, Mukundan G. Attur, Steven B. Abramson, and Cristina C. Teixeira

Loss of calcineurin Aα alters keratinocyte survival and differentiation, J. A. Pena, J. L. Losi-Sasaki, and J. L. Gooch

A 41-Year-Old Male with Cough, Wheeze, and Dyspnea Poorly Responsive to Asthma Therapy, Peter A. Ricketti, Anthony J. Ricketti, Dennis J. Cleri, Marc Seelagy, David W. Unkle, and John R. Vernaleo

Somatic dysfunction following sigmoid colon resection for diverticulitis: A case report, V. Ridgeway and Murray R. Berkowitz

Cognitive Behavioral Therapy for Insomnia: Evidence Based Treatments and Encouraging Innovations for Primary Care, Bradley Michael Rosenfield, J. R. Ramsay, Stacey C. Cahn, and P. Pelligrino

Complications of Intravitreal Injections, Kapil M. Sampat and Sunir J. Garg

Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local ß-actin synthesis and growth cone turning, Y. Sasaki, K. Welshhans, Z. Wen, J. Yao, Mei Xu, Y. Goshima, J. Q. Zheng, and G. J. Bassell

A 65-Year-Old Man with Shortness of Breath, Pleuritic Chest Pain, and Recurrent Pneumonia, Nicole A. Scivoletti-Polan, Dominic J. Valentino, Scott B. Rosenberg, Scott W. Cowan, and Erik I. Soiferman

Analysis of cross-species IgG binding to human and mouse Fc gamma receptors (FcgammaRs), Rangaiah Shashidharamurthy, Erica Bozeman, J. Patel, R. Kaur, J. Meganathan, and P. Selvaraj

Systemic pathological effects induced by cobra (Naja naja) venom from geographically distinct origins of Indian peninsula, Rangaiah Shashidharamurthy, Y. H. Mahadeswaraswamy, L. Ragupathi, V. S. Vishwanath, and K. Kemparaju

Alzheimer Disease: The Crisis is Upon Us, James W. Simpkins, Brian E. Wood, and Brian J. Balin

Acrodermatitis Chronica Atrophicans: A Case Report and Review of the Literature, Matthew T Smetanick, Sharon L. Zellis, and Tanya Ermolovich

Cartilage Hinge Flap for the Repair of Antihelical Defects, John G. Stoner and Tanya Ermolovich

Oxidative Stress Protection and the Repair Response to Hydrogen Peroxide in the Hyperthermophilic Archaeon Pyrococcus furiosus and in Related Species, Kari R. Strand, Chengjun Sun, Ting Li, Francis E. Jenney, Gerrit J. Schut, and Michael W. W. Adams

Heterologous expression and maturation of an NADP-Dependent [NiFe]-Hydrogenase: A key enzyme in biofuel production, J. Sun, R. C. Hopkins, Francis E. Jenney Jr., P. M. McTernan, and M. W. Adams

Psychoeducation and cultural competence in the primary care setting, Takako Suzuki, Beverly White, and Ivette Velez

Culture and psychoeducational assessment: Cognition and achievement, Yuma I. Tomes

Identification of Protein-Bound Dinitrosyl Iron Complexes by Nuclear Resonance Vibrational Spectroscopy, Zachary J. Tonzetich, Hongxin Wang, Devrani Mitra, Christine E. Tinberg, Loi H. Do, Francis E. Jenney, Michael W. W. Adams, Stephen P. Cramer, and Stephen J. Lippard

Psychosocial Interventions to Improve the School Performance of Students with Attention-Deficit/Hyperactivity Disorder, Katy E. Tresco, Elizabeth K. Lefler, and Thomas J. Power

Endovascular Repair of Carotid Artery Pseudoaneurysm after Carotid Endarterectomy with Self-Expanding Covered Stents: A Long-Term Follow-Up, Douglas A. Troutman, Chittur R. Mohan, Farouq A. Samhouri, and Richard L. Sohn

Open Repair and Endovascular Covered Stent Placement in the Management of Bilateral Axillary Artery Aneurysms, Douglas A. Troutman, Chittur R. Mohan, Farouq A. Samhouri, and Richard L. Sohn