The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2013

Potential roles of adenosine deaminase-2 in diabetic retinopathy, N. M. Elsherbiny, M. Naime, S. Ahmad, A. M. Elsherbini, S. Mohammad, S. Fulzele, A. B. El-Remessy, M. M. Al-Gayyar, Richard E. White, and et al.

Oral Anatomy Laboratory Examinations in a Physical Therapy Program, Philip A. Fabrizio

Initial Combination Therapy for Patients with Type 2 Diabetes Mellitus: Considerations for Metformin Plus Linagliptin, Jeffrey S. Freeman

Review of Insulin-Dependent and Insulin-Independent Agents for Treating Patients with Type 2 Diabetes Mellitus and Potential Role for Sodium-Glucose Co-Transporter 2 Inhibitors, Jeffrey S. Freeman

Review of insulin-dependent and insulin-independent agents for treating patients with type-2 Diabetes Mellitus and potential role for sodium-glucose co-transporter 2 inhibitors, Jeffrey S. Freeman

Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists, Thota Ganesh, Jianxiong Jiang, Rangaiah Shashidharamurthy, and Ray Dingledine

How Closely Related are Allergic Rhinitis, Asthma, and Chronic Sinusitis?, Mahmoud Ghaderi

Motivational interviewing and recovery: Experiences of hope, meaning, and empowerment, Scott Glassman, Petra Kottsieper, Allan Zuckoff, and Elizabeth A. Gosch

The Effectiveness of Probiotics for Managing Diarrhoea in People with HIV Infection: A Critically Appraised Topic, Sean Guinane

Training on demand: A solution to clinical education through simulation, Sean Guinane and Laura A. Molloy

Nuclear resonance vibrational spectroscopy (NRVS) of rubredoxin and MoFe protein crystals, Y Guo, E. Brecht, K. Aznavour, J. C. Nix, Y. Xiao, H. Wang, S. J. George, R. Bau, Francis E. Jenney Jr., and et al.

Nuclear resonance vibrational spectroscopy (NRVS) of rubredoxin and MoFe protein crystals, Y. Guo, E. Brecht, K. Aznavour, J. C. Nix, Y. Xiao, H. Wang, S. J. George, R. Bau, Francis E. Jenney Jr., and et al.

GPER: A novel target for non-genomic estrogen action in the cardiovascular system, G. Han, F. Li, X. Xu, and Richard E. White


Matrigel modulates a stem cell phenotype and promotes tumor cell formation in a mantle cell lymphoma cell line, Abigail Hielscher, Timothy McGuire, Dennis Weisenburger, and John Graham Sharp


Hypoxia Affects the Structure of Breast Cancer Cell Derived Matrix to Support Angiogenic Responses of Endothelial Cells, Abigail Hielscher, Connie Qiu, Josh Porterfield, Quinton Smith, and Sharon Gerecht


A physical sciences network characterization of non-tumorigenic and metastatic cells, Abigail Hielscher, D. Wirtz, and et al.

A Virtual Phytosaur Endocast and its Implications for Sensory System Evolution in Archosaurs, Waymon L. Holloway, Kerin M. Claeson, and F. Robin O'Keefe

Problem-Based Pain Management, Eric Hsu, Charles Argoff, Katherine E. Galluzzi, Raphael Leo, and Andrew Dubin

CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from Central South China, Fengmao Huang, Hanchun Chen, Md. Asaduzzaman Khan, Fulan Yang, Xinxing Wan, Aihua Xu, Fangdan Ouyang, and Dianzheng Zhang


Effect of estrogen on manganese-induced toxicity on embryonic astrocytes, Tyler T. Huynh, Kimberly J. Baker, and Harold L. Komiskey

Age as a Predictor of Osteoporotic Fracture Compared with Current Risk-Prediction Models, Xuezhi Jiang, Lauren B. Westermann, Gabriella V. Galleo, John Demko, Kimberly A. Marakovits, and Peter F. Schnatz

e-Professionalism: a New Frontier in Medical Education., Joseph M Kaczmarczyk, Alice W. Chuang, Lorraine Dugoff, Jodi Abbott, Amie J. Cullimore, John Dalrymple, Katrina R. Davis, Nancy A. Hueppchen, Nadine T. Katz, Francis S. Nuthalapaty, Archana Pradhan, Abigail Wolf, and Petra M. Casey

Observation of the Fe-CN and Fe-CO vibrations in the active site of [NiFe] hydrogenase by nuclear resonance vibrational spectroscopy, S. Kamali, H. Wang, D. Mitra, H. Ogata, W. Lubitz, B. C. Manor, T. B. Rauchfuss, D. Byrne, Francis E. Jenney Jr., and et al.

Osteopathic manipulative treatment of pelvic dysfunction in a postpartum patient with co-morbid headaches: A case report, Rebecca Kant and Murray R. Berkowitz

Robotic-Assisted Giant Paraesophageal Hernia Repair and Nissen Fundoplication, Justin Karush and Inderpal S. Sarkaria

RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis., Shiva Kazerounian, Damien Gerald, Minzhou Huang, Y Rebecca Chin, Durga Udayakumar, Ningning Zheng, Rebekah K O'Donnell, Carole Perruzzi, Lee Mangiante, Jacob Pourat, Thuy L Phung, Arturo Bravo Nuevo, Sharon Shechter, Stephanie McNamara, James B Duhadaway, Olivier N Kocher, Lawrence F Brown, Alex Toker, George C Prendergast, and Laura E Benjamin

Regulatory effects of resveratrol on antioxidant enzymes: A mechanism of growth inhibition and apoptosis induction in cancer cells, Md. Assaduzzaman Khan, Hanchun Chen, Xinxing Wan, Mousumi Tania, Aihua Xu, Fangzhi Chen, and Dianzheng Zhang

Twist: A molecular target in cancer therapeutics, Md. Assaduzzaman Khan, Hanchun Chen, Dianzheng Zhang, and Junjiang Fu

Adenovirus 36, adiposity, and bone strength in late-adolescent females, Emma M. Laing, Ralph A. Tripp, Norman K. Pollock, Clifton A. Baile, Mary Anne Della-Fera, Srujana Rayalam, Stephen M. Tompkins, Deborah A. Keys, and Richard D. Lewis

The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells, Weihua Lan and Dianzheng Zhang

The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells, Weihua Lan, Dianzheng Zhang, and Jun Jiang

Treatment of Primary Hip Osteoarthritis for the Primary Care Physician and the Indications for Total Hip Arthroplasty, Mathew E. Levine, James Nace, Bhaveen H. Kapadia, Kimona Issa, Samik Banerjee, Jeffery J. Cherian, and Michael A. Mont


Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation, F. Li, X. Yu, C. K. Szynarski, C. Meng, B. Zhou, R. Barhoumi, Richard E. White, C. L. Heaps, J. N. Stallone, and G. Han

AMPA Receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures, Jocelyn Lippman-Bell, S. N. Rakhade, P. M. Klein, M. Obeid, M. C. Jackson, A. Joseph, and F. E. Jensen


Nutritional Intervention Restores Muscle but Not Kidney Phenotypes in Adult Calcineurin Aα Null Mice, K. Madsen, R. N. Reddy, S. R. Price, C. R. Williams, and Jennifer L. Gooch

Outcomes after anterior cervical discectomy and fusion in professional athletes, J. C. Maroon, J. W. Bost, A. L. Petraglia, D. B. Lepere, J. Norwig, C. Amman, Michael Sampson, and M. El-Kadi

Psychopathology of auditory processing disorders, Mark R. McGowan, George McCloskey, Art Maerlender, and James Whitaker

Complications after Breast Augmentation, Nancy McLaughlin

Novel Coronavirus, Nancy McLaughlin


Helping Haiti's transportation issues: Increasing Haiti's medical liabilities., Nancy McLaughlin and Hannah Rogers

How to Reduce Surgical Site Infections in Orthopaedics: A Systematic Review, Nancy McLaughlin and Nicholas Rossi

Magnetic nanoparticle drug delivery systems for targeting tumor, Vicky V. Mody, Arthur Cox, Samit Shah, Ajay Singh, Wesley Bevins, and Harish S. Parihar


The Cell and Molecular Biology of Neurodegenerative Diseases: An Overview, Heather L. Montie and Thomas M. Durcan

Pazopanib versus sunitinib in metastatic renal-cell carcinoma, R. J. Motzer, T. E. Hutson, D. Cella, J. Reeves, R. Hawkind, J. Guo, P. Nathan, M. Staehler, Rocco J. Crescenzo, and et al.

The 2012-2013 Influenza Epidemic and the Role of Osteopathic Manipulative Medicine, Donna M. Mueller

Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population, Fangdan Ouyang, Fulan Yang, Hanchun Cheng, Md. Assduzzaman Khan, Fengmao Huang, Xinxing Wan, Aihua Xu, Xing Huang, Meijuan Zhou, and Dianzheng Zhang

Bacillus cereus, Harish S. Parihar

Differential regulation of calcineurin isoforms in transplant patients: A new look at an old problem, J. A. Pena, L. Titus, J. Jackson, A. D. Kirk, and Jennifer L. Gooch

Therapist factors and outcomes in CBT for anxiety in youth, Jennifer L. Podell, Philip C. Kendall, Elizabeth A. Gosch, Scott N. Compton, John S. March, Anne-Marie Albano, Moira A. Rynn, John T. Walkup, Joel T. Sherrill, and et al.

Peroxynitrite mediates testosterone-induced vasorelaxation of microvascular resistance vessels, Yashoda Puttabyatappa, John N. Stallone, Adviye Ergul, Azza B. El-Remessy, Sanjiv Kumar, Stephen Black, Maribeth Johnson, Mary Owen, and Richard E. White

Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels, Y. Puttabyatappa, J. N. Stallone, A. Ergul, A. B. El-Remessy, S. Kumar, S. Black, M. Johnson, M. P. Owen, and Richard E. White


Multifacted Role of TNF-α During the Pathogenesis of Rheumatoid Arthritis, Mula Ramanjaneya and Rangaiah Shashidharamurthy


Pediatric Obesity Class: Teaching Kids How to Live Healthy Lifestyle, Sara Wilson Reece


Implementation of Active Learning Components into an OTC Course, Sara Wilson Reece and Nicole Phipps

Metapodial or Phalanx? An Evolutionary and Developmental Perspective on the Homology of the First Ray's Proximal Segment, Philip L. Reno, Walter E Horton, and C Owen Lovejoy


A Penile Spine/Vibrissa Enhancer Sequence Is Missing in Modern and Extinct Humans but Is Retained in Multiple Primates with Penile Spines and Sensory Vibrissae, Philip L. Reno, Cory Y McLean, Jasmine E Hines, Terence D Capellini, Gill Bejerano, and David M Kingsley

Reconstructing Paleodiet in Ground Sloths (Mammalia, Xenarthra) Using Dental Microwear Analysis, Nicholas A. Resar, Jeremy L. Green, and Robert McAfee

Metastatic Brain Tumors: Current Therapeutic Options and Historical Perspective, Mark Rivkin and Richard B. Kanoff

Metastatic Brain Tumors: Current Therapeutic Options and Historical Perspective, Mark Rivkin and Richard B. Kanoff

Pharmaceutical Marketing, Brent Rollins and Matthew Perri

Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies, Vishal Sachdeva, Yun Bai, Agis Kydonieus, and Ajay Banga

Accuracy and Reproducibility of Seven Brands of Small-Volume Syringes Used for Intraocular Drug Delivery, Kapil M. Sampat, Jeremy D. Wolfe, Mona K. Shah, and Sunir J. Garg

An educational tool for teaching medication history taking to pharmacy students., Karen R. Sando, Jennifer Elliott, Melonie L. Stanton, and Randell Doty

Allyl Alcohol, S. P. Sawant, Harish S. Parihar, and H. M. Mehendale

Anabolic Steroids, S. P. Sawant, Harish S. Parihar, and H. M. Mehendale

British Anti-Lewisite (BAL), S. P. Sawant, Harish S. Parihar, and H. M. Mehendale

Good Clinical Practice, S. P. Sawant, Harish S. Parihar, H. M. Mehendale, and K. M. Hanson

A 52-Year-Old Male with Bilaterally Duplicated Collecting Systems with Obstructing Ureteral Stones: A Case Report, Dane Scantling, Curtis P. Ross, and Howard Altman

Primary Clear Cell Adenocarcinoma of a Urethral Diverticulum Treated with Multidisciplinary Robotic Anterior Pelvic Exenteration, Dane Scantling, Curtis P. Ross, and Jamison Jaffe

A clinical review of statin-associated myopathy, Jennifer Shannon, Samuel John, Harish S. Parihar, Shari N. Allen, and Jenna Ferrara

Regulatory T cell dysfunction in lipocalin 2 knockout mice exacerbates serum-induced arthritis (P1326), Rangaiah Shashidharamurthy, Erica Bozeman, Jesse Aitken, Periasamy Selvaraj, and Matam Vijay-Kumar

Differential Role of Lipocalin 2 During Immune Complex-Mediated Acute and Chronic Inflammation in Mice, Rangaiah Shashidharamurthy, Deepa Machiah, Jesse D. Aitken, Kalyani Putty, Gayathri Srinivasan, Benoit Chassaing, Charles A. Parkos, Periasamy Selvaraj, and Matam Vijay-Kumar

Retrospective medical record review of an osteopathic manipulative medicine hospital consultation service., Karen T Snider, Eric J Snider, Brett R DeGooyer, Allison M Bukowski, Regina K. Fleming, and Jane C Johnson

Potential of the SPY Intraoperative Perfusion Assessment System to Reduce Ischemic Complications in Immediate Postmastectomy Breast Reconstruction, Mohit Sood and Paul Glat

Regulation of ephrin-A expression in compressed retinocollicular maps, T. Tadesse, Q. Cheng, Mei Xu, D. J. Baro, Lindon J. Young, and S. L. Pallas

Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma, Qishan Tang, Guanwu Li, Xiaoning Wei, Jun Zhang, Jenfu Chiu, Don Hasenmayer, Dianzheng Zhang, and Hao Zhang


The Skinny on the hCG Diet, Rebekah Thomas and Kathy Dexter

Cross-Cultural Interaction and Understanding: Theory, Practice, & Reality, Yuma Iannotti Tomes

Aberrant Origin of Left Vertebral Artery, Douglas A. Troutman, Griffin K. Bicking, Nicholas J. Madden, and Gregory S. Domer


ISG15 inhibits IFN- a -Resistant liver cancer cell growth, Xin-xing Wan, Hanchun Chen, Md. Asaduzzaman Khan, Ai-hua Xu, Fu-lan Yang, Yun-yi Zhang, and Dianzheng Zhang

Assessing Anxiety in Youth with the Multidimensional Anxiety Scale for Children., Chiaying Wei, Alexandra Hoff, Marianne A. Villabø, Jeremy Peterman, Philip C. Kendall, John Piacentini, James McCracken, John T. Walkup, Anne Marie Albano, Moira Rynn, Joel Sherrill, Dara Sakolsky, Boris Birmaher, Golda Ginsburg, Courtney Pierce Keeton, Elizabeth A. Gosch, Scott N. Compton, and John March

Relationship of Oxidative Stress with Cardiovascular Disease, Richard E. White, Scott Barman, Shu Zhu, and Guichun Han

Novel Role for Perinatal Myosin in Skeletal Muscle Development, David Wilkes, Konstantinos Charitakis, Joseph S. Lee, and Cathy J. Hatcher

A study of regional variation in the inpatient cost of lower extremity amputation among patients with diabetes in the United States, Hongjun Yin, Larry Radican, and Sheldon X. Kong

A Study of Regional Variation in the Inpatient Cost of Lower Extremity Amputation Among Patients with Diabetes in the United States, Hongjun Yin, Larry Radican, and Sheldon X. Kong

Analyzing LC/MS Metabolic Profiling Data in the Context of Existing Metabolic Networks, Tianwei Yu and Yun Bai

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking, Xiaoping Zhang, Hong Wang, Matthew T. Duvernay, Shu Zhu, and Guangyu Wu

1122 AIB1 Reprograms Bladder Cancer Cell Metabolism Through Enhancing HIF1α Activation, Wei Zhao, Cunjie Chang, Ji Zhou, Diangzheng Zhang, Xiaozhi Zhao, Hongqian Guo, and Jun Tan

Submissions from 2012

Understanding Youth Street Gangs, Cliff Akiyama

Pharmacologic management of stroke, Shari N. Allen and DeAna Augustus


Autophagy and apoptotic genes implicated in Alzheimer’s disease are modulated following infection of neuronal cells with Chlamydia pneumoniae, Denah M. Appelt, Ian Kohler, Annette K. Slutter, Juliana Zoga, Susan T. Hingley, and Brian J. Balin


Emerging Microbial and Viral Infections of the Central Nervous System, Brian J. Balin and Christine J. Hammond

Evidence-Based Acute Bronchitis Therapy, Kimberly L. Barefield and Aaron Atkins

Pharmacotherapy Options in the Treatment of Obstructive Sleep Apnea, Kimberly L. Barefield and Heather DeBellis


TGFßRIIb mutations trigger aortic aneurysm pathogenesis by altering transforming growth factor ß2 signal transduction, Katherine J. Bee, David C. Wilkes, Richard B. Devereux, Craig T. Basson, and Cathy J. Hatcher

A Motor Vehicle Collision Involving a Veteran: A Teaching Case from the Joining Forces Teaching Curriculum for Medical Students, Murray Berkowitz, Dès Anges Cruser, Alan Podawiltz, Charles E. Henley, Andrew Yuan, Anita M. Navarro, and Tyler Cymet

Application of osteopathic manipulative treatment to a patient with unremitting chest pain and shortness of breath undergoing " Rule-Out Myocardial Infarction" protocol for one week, Murray R. Berkowitz

A resource journal on traumatic brain injury and post-traumatic stress disorder in veterans, Murray R. Berkowitz

Looking back; Looking forward, Murray R. Berkowitz

Military medicine and civilian medicine: a comparison., Murray R. Berkowitz