The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2013

Cross-Cultural Interaction and Understanding: Theory, Practice, & Reality, Yuma Iannotti Tomes

Aberrant Origin of Left Vertebral Artery, Douglas A. Troutman, Griffin K. Bicking, Nicholas J. Madden, and Gregory S. Domer


ISG15 inhibits IFN- a -Resistant liver cancer cell growth, Xin-xing Wan, Hanchun Chen, Md. Asaduzzaman Khan, Ai-hua Xu, Fu-lan Yang, Yun-yi Zhang, and Dianzheng Zhang

Assessing Anxiety in Youth with the Multidimensional Anxiety Scale for Children., Chiaying Wei, Alexandra Hoff, Marianne A. Villabø, Jeremy Peterman, Philip C. Kendall, John Piacentini, James McCracken, John T. Walkup, Anne Marie Albano, Moira Rynn, Joel Sherrill, Dara Sakolsky, Boris Birmaher, Golda Ginsburg, Courtney Pierce Keeton, Elizabeth A. Gosch, Scott N. Compton, and John March

Relationship of Oxidative Stress with Cardiovascular Disease, Richard E. White, Scott Barman, Shu Zhu, and Guichun Han

Novel Role for Perinatal Myosin in Skeletal Muscle Development, David Wilkes, Konstantinos Charitakis, Joseph S. Lee, and Cathy J. Hatcher

A Study of Regional Variation in the Inpatient Cost of Lower Extremity Amputation Among Patients with Diabetes in the United States, Hongjun Yin, Larry Radican, and Sheldon X. Kong

A study of regional variation in the inpatient cost of lower extremity amputation among patients with diabetes in the United States, Hongjun Yin, Larry Radican, and Sheldon X. Kong

Analyzing LC/MS Metabolic Profiling Data in the Context of Existing Metabolic Networks, Tianwei Yu and Yun Bai

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking, Xiaoping Zhang, Hong Wang, Matthew T. Duvernay, Shu Zhu, and Guangyu Wu

1122 AIB1 Reprograms Bladder Cancer Cell Metabolism Through Enhancing HIF1α Activation, Wei Zhao, Cunjie Chang, Ji Zhou, Diangzheng Zhang, Xiaozhi Zhao, Hongqian Guo, and Jun Tan

Submissions from 2012

Understanding Youth Street Gangs, Cliff Akiyama

Pharmacologic management of stroke, Shari N. Allen and DeAna Augustus


Autophagy and apoptotic genes implicated in Alzheimer’s disease are modulated following infection of neuronal cells with Chlamydia pneumoniae, Denah M. Appelt, Ian Kohler, Annette K. Slutter, Juliana Zoga, Susan T. Hingley, and Brian J. Balin


Emerging Microbial and Viral Infections of the Central Nervous System, Brian J. Balin and Christine J. Hammond

Evidence-Based Acute Bronchitis Therapy, Kimberly L. Barefield and Aaron Atkins

Pharmacotherapy Options in the Treatment of Obstructive Sleep Apnea, Kimberly L. Barefield and Heather DeBellis


TGFßRIIb mutations trigger aortic aneurysm pathogenesis by altering transforming growth factor ß2 signal transduction, Katherine J. Bee, David C. Wilkes, Richard B. Devereux, Craig T. Basson, and Cathy J. Hatcher

A Motor Vehicle Collision Involving a Veteran: A Teaching Case from the Joining Forces Teaching Curriculum for Medical Students, Murray Berkowitz, Dès Anges Cruser, Alan Podawiltz, Charles E. Henley, Andrew Yuan, Anita M. Navarro, and Tyler Cymet

Application of osteopathic manipulative treatment to a patient with unremitting chest pain and shortness of breath undergoing " Rule-Out Myocardial Infarction" protocol for one week, Murray R. Berkowitz

A resource journal on traumatic brain injury and post-traumatic stress disorder in veterans, Murray R. Berkowitz

Looking back; Looking forward, Murray R. Berkowitz

Military medicine and civilian medicine: a comparison., Murray R. Berkowitz

Military Medicine Content in an Osteopathic Medical School's Curriculum, Murray R. Berkowitz

Occupational and Public Health Considerations for Work-Hour Limitations Policy Regarding Public Health Workers during Response to Natural and Human-Caused Disasters, Murray R. Berkowitz

The Doctor as patient, Murray R. Berkowitz

Triacsin C, a Fatty Acyl CoA Synthetase Inhibitor, Improves Cardiac Performance Following Global Ischemia, Nina Blakeman, Qian Chen, Jasmine Tolson, Brian Rueter, Brian Diaz, Brenan Casey, Lindon H. Young, and Margaret T. Weis

Finasteride in the Treatment of Female Pattern (Androgenic) Alopecia: A Case Report and Review of the Literature, Olga Boychenko, Robert M. Bernstein, and Eric S. Schweiger

Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice, Erica N. Bozeman, S. Srivatsan, H. Mohammadi, D. Daniels, Rangaiah Shashidharamurthy, and Periasamy Selvaraj

Predictors of Successful Weight Loss Following Bariatric Surgery., F. R. Broder, Stacey C. Cahn, Robert A. DiTomasso, R. J. Petrucci, and P. S. Geno

Development and preliminary results of the Financial Incentive Coercion Assessment questionnaire, M. Byrne, J. Croft, M. French, K. Dugosh, and David Festinger

Sociodemographic analysis of psychiatric emergency services in a state with greater than average veteran density, Livia Cara and Murray R. Berkowitz

Engineering hyperthermophilic archaeon Pyrococcus furiosus to overproduce its cytoplasmic [NiFe]-hydrogenase, S. K. Chanrayan, P. M. McTernan, R. C. Hopkins, J. Sun, Francis E. Jenney Jr., and M. W. Adams

Definitive specimens of Merlucciidae (Gadiformes) from the Eocene James Ross Basin of Isla Marambio (Seymour Island), Antarctic Peninsula, Kerin M. Claeson, Joseph T. Eastman, and Ross D. MacPhee

Nonprescription steroids on the Internet., C. Clement, D. Marlowe, N. Patapis, and David Festinger

From Adherence to Self-Determination: Evolution of a Treatment Paradigm for People with Serious Mental Illnesses, Patrick W. Corrigan, Beth Angell, Larry Davidson, Steven C. Marcus, Mark S. Salzer, Petra Kottsieper, Jonathon E. Larson, Colleen A. Mahoney, Maria J. O'Connell, and Victoria Stanhope

Georgia Campus-Philadelphia College of Osteopathic Medicine, H. William Craver

Georgia Campus-Philadelphia College of Osteopathic Medicine., H. William Craver

Pro-Tumour Activity of Interleukin-22 in HPAFII Human Pancreatic Cancer Cells, Lindsay M. Curd, Sheena E. Favors, and Randal K. Gregg

Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate, V. De Cracy-Lagard, G. Phillips, L. L. Grochowski, B. Yacoubi, Francis E. Jenney Jr., M. W. Adams, A. G. Murzin, and R. H. White

Testosterone-induced relaxation of coronary arteries: Activation of Bk ca channels via the cGMP-dependent protein kinase, Viju Deenadayalu, Yashoda Puttabyatappa, Alexander T. Liu, John N. Stallone, and Richard E. White


Managing Health Worker Migration: A Qualitative Study of the Philippine Response to Nurse Brain Drain, Roland Dimaya, Mary K. McEwen, Leslie A. Curry, and Elizabeth H. Bradley

Oral microparticulate vaccine for melanoma using M-cell targeting, Bernadette D'Souza, Tuhin Bhowmik, Rangaiah Shashidharamurthy, Carl Oettinger, Periasamy Selvaraj, and Martin D'Souza

Restoring balance: a consensus statement on the protection of vulnerable research participants., J. DuBois, L. Beskow, J. Campbell, K. Dugosh, David Festinger, S. Hartz, R. James, and C. Lidz


Clostridium Septicum Growth from a Total Knee Arthroplasty Associated with Intestinal Malignancy: A Case Report, Demetri M. Economedes, Jerome Santoro, and Carl A. Deirmengian


Effect of Age and Vaccination on Extent and Spread of Chlamydia pneumoniae Infection in C57BL/6 Mice, Taylor Eddens, Sarah Beaudoin, Amanda Steinberger, Christopher Scott Little, Dawn Shell, Benjamin Wizel, Brian J. Balin PhD, and Kerin L. Fresa-Dillon

Unusual Ligament of the Scapula, Philip A. Fabrizio

Use of the Anti-Inflammatory Cytokine Interleukin-11 to Reverse HIV-1gp120 Repression of a Natural Killer Cell Line, Sheena E. Favors, Lindsay M. Curd, and Randal K. Gregg

Improving the informed consent process in research with substance-abusing participants, David Festinger and K. Dugosh

Paying substance abusers in research studies: Where does the money go?, David Festinger and K. Dugosh

Denial of Prescription Opioids Among Young Adults with Histories of Opioid Misuse, Meghan Fibbi, Karol Silva, Kristen Johnson, Debra Langer, and Stephen E. Lankenau

Improving Glucagon-Like Peptide-1 Dynamics in Patients with Type 2 Diabetes Mellitus, Jeffrey S. Freeman

Common Patient Concerns about the Use of Glucagon-Like Peptide-1 Receptor Agonists in Diabetes Mellitus Management, Jeffrey S. Freeman, James R. Gavin, and Craig W. Spellman

Potential Drug Interactions Associated with Treatments for Type 2 Diabetes and its Comorbidities: A Clinical Pharmacology Review, Jeffrey S. Freeman and Benjamin Gross

What Have We Learned about the Treatment of Type 2 Diabetes? The Evolving Paradigms, Jeffrey S. Freeman and Edward S. Horton

Osteopathy and Swedenborg: The Influence of Emanuel Swedenborg on the Genesis and Development of Osteopathy, Specifically on Andrew Taylor Still and William Garner Sutherland, David B. Fuller

Myo/Nog cells in normal, wounded and tumor-bearing skin, Jacquelyn Gerhart, C. Hayes, V. Scheinfeld, M. Chernick, Mindy George-Weinstein, and S. Gilmour

Can schools train students as well as the Navy trains pilots?, Frederick J. Goldstein

Avanafil for the treatment of erectile dysfunction: A multicenter, randomized, double-blind study in men with diabetes mellitus, I. Goldstein, L. A. Jones, Laurence Belkoff, G. S. Karlin, C. H. Bowden, and C. A. Peterson

Don't Quit on a Quitter: Helping Your Patient Stop Smoking, Sean Guinane

Fluorescence Recovery after Photobleaching (FRAP) with a Focus on F-Actin, Lori R. Hardy

Cents and Sensibility: Understanding the numbers, Keith N. Herist and Brent Rollins

Personal Finance, Keith N. Herist and Brent Rollins

Engineering approaches for investigating tumor angiogenesis: Exploiting the role of the extracellular matrix, Abigail Hielscher and Sharon Gerecht

Breast cancer cell-derived matrix supports vascular morphogenesis, Abigail Hielscher, Connie Qiu, and Sharon Gerecht

Shoulder Injuries in the Throwing Athlete, Jason J. Jancosko and Jack E. Kazanjian

Frequency of specific osteopathic manipulative treatment modalities used by candidates while taking COMLEX-USA Level 2-PE, E. E. Langenau, D. J. Dowling, C. Dyer, and W. L. Roberts

Fairness to students top priority, E. E. Langenau, J. Sandella, and J. R. Gimpel


Clinical Skills Assessment of Procedural and Advanced Communication Skills: Performance Expectations of Residency Program Directors., E. E. Langenau, X. Zhang, W. L. Roberts, A. F. DeChamplain, and J. R. Boulet


Reducing the Stigma of Mental Illness Among Medical Students, Victoria Lawn, Matthew Jaffa, Catherine Babbitt-Cook, Burton Mark, Jane Dumsha, Marcus G. Bell, and Denah M. Appelt

LEGO-based play therapy for improving social competence in children and adolescents with Autism spectrum disorders, Daniel B. Legoff, G. W. Krauss, and Sarah Levin Allen


Genome-Wide Expression Analysis in Down Syndrome: Insight into Immunodeficiency, Chong Li, Lei Jin, Yun Bai, Qimin Chen, Lijun Fu, Minjun Yang, Huasheng Xiao, Guoping Zhao, and Shengyue Wang

Holistic osteopathic approach to the care of veterans with post-traumatic stress disorder: Case report, Andrew Lovy and Murray R. Berkowitz

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema, Rudolf Lucas, Supriya Sridhar, Ferenc Rick, Boris Gorshkov, Nagavedy S. Umapathy, Richard E. White, and et al.

Clipping of Distal Superior Cerebellar Artery Aneurysm with Preservation of the Parent Vessel: A Case Report, Leslie Lyness and Amir R. Dehdashti

Biomarkers and neuroimaging techniques to detect blast-induced traumatic brain injury (bTBI), Patrick M. Malie and Murray R. Berkowitz

Clinical management and multipotential treatment strategies for blast-induced traumatic brain injury (bTBI), Patrick M. Malie and Murray R. Berkowitz

Understanding blast-induced traumatic brain injury (bTBI) through mechanisms and patterns of injury, Patrick M. Malie, M. Q. Sonnier Jr., and Murray R. Berkowitz

Adaptive Programming Improves Outcomes in Drug Court: An Experimental Trial, D. Marlowe, David Festinger, K. Dugosh, K. Benasutti, and J. Croft

Notice on the Ocurrence of Supernumerary Teeth in the Two-toad Sloths Choloepus didactylus and C. hoffmanni, Robert McAfee

Essentials of Executive Functions Assessment, George McCloskey and Lisa A. Perkins

Intellectual, cognitive, and neuropsychological assessment in three-tier service delivery systems in schools, George McCloskey, James Whitaker, Ryan Murphy, and James Rogers

Social Information-Processing and Coping in Adolescent Females Diagnosed with an Eating Disorder: Toward a Greater Understanding of Control, Roger K. McFillin, Stacey C. Cahn, Virginia Salzer Burks, Martha Peaslee Levine, Susan Lane Loney, and Richard L. Levine

Prosthetic Management for the Older Adult with Lower Limb Amputation, Carol A. Miller

Using the Nintendo Wii Fit and Body Weight Support to Improve Aerobic Capacity, Balance, Gait Ability, and Fear of Falling: Two Case Reports, Carol A. Miller, Dawn M. Hayes, Kelli Dye, Courtney Johnson, and Jennifer Meyers

Estrogens, inflammation and obesity: An overview, Colette N. Miller, Lynda M. Brown, Srujana Rayalam, Mary Anne Della-Fera, and Clifton A. Baile

Managing Chronic Plantar Fasciitis: When Conservative Strategies Fail, Laura A. Molloy

Reconstruction of the Cranial Musculature and Masticatory Function of the Pleistocene Panamerican Ground Sloth Eremotherium Laurillardi (Mammalia, Xenarthra, Megatheriidae), Virginia L. Naples and Robert McAfee

Correlation of factor IXa subsite modulations with effects on substrate discrimination, P. F. Neuenschwander, Kimberly J. Baker, K. Zepeda, and J. Rutland

Atlas of Osteopathic Techniques, Alexander S. Nicholas and Evan A. Nicholas

To the point: A primer on medical education research, F. S. Nuthalapty, P. M. Casey, A. J. Cullimore, L. Dugoff, J. F. Abbott, A. W. Chuang, J. L. Dalrymple, N. A. Hueppchen, Joseph M. Kaczmarczyk, and et al.

Modifying an evidence-based summer treatment program for use in a summer school setting: A pilot effectiveness evaluation, Briannon C. O'Connor, Katy E. Tresco, William E. J. R. Pelham, Daniel A. Waschbusch, Elizabeth M. Gnagy, and Andrew R. Greiner

Treatment of depression in patients with epilepsy, Mebanga Ojong and Shari N. Allen

Isolated calcaneofibular ligament injuries treated with osteopathic manipulative treatment: A case series, Kristie M. Olds and Murray R. Berkowitz

Total Knee Arthroplasty in a Patient with Skeletal Fluorosis, Mark Paiste, Mathew Levine, and James V. Bono

Therapeutic Effect of Hyperbaric Oxygen on Inclusion Body Myositis, Max Pell, Poovendran Saththasivam, Peter L. Stephens, and George Mychaskiw

The Effects of Modulating eNOS Activity and Coupling in Ischemia/Reperfusion (I/R), Kerry-Anne Perkins, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan S Adams, Christopher Zambrano, Samuel Krass, Jeffrey Emrich, Brandon Bell, Michael Lyamu, Catherine Prince, Helen Kay, Jane Chun-wen Teng, and Lindon H. Young


Insulin Pump School: Back to the Basics of Pump Therapy, Sara Wilson Reece and Cheryl Williams

Modeling relationships between traditional preadmission measures and clinical skills performance on a medical licensure examination, W. L. Roberts, G. Pugliano, E. E. Langenau, and J. R. Boulet

An Evaluation of Cost and Appropriateness of Care as Recommended by Candidates on a National Clinical Skills Examination, J. Sandella, J. R. Boulet, and E. E. Langenau