The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2016

Verbal communication impacts quality of life in patients with amyotrophic lateral sclerosis, Stephanie Felgoise, Vincenzo Zaccheo, Jason Duff, and Zachary Simmons

Use of the Internet to Obtain Drugs Without a Prescription Among Treatment-Involved Adolescents and Young Adults, David Festinger, K. Dugosh, N. Clements, A. Flynn, M. Falco, A. McLellan, and A. Arria

Examining the efficacy of a computer facilitated HIV prevention tool in drug court, David Festinger, K. Dugosh, A. Kurth, and D. Metzger


Synchrotron-based Nickel Mössbauer Spectroscopy., Leland B Gee, Chun-Yi Lin, Francis E. Jenney, Michael W W Adams, Yoshitaka Yoda, Ryo Masuda, Makina Saito, Yasuhiro Kobayashi, Kenji Tamasaku, Michael Lerche, Makoto Seto, Charles G Riordan, Ann Ploskonka, Philip P Power, Stephen P Cramer, and Lars Lauterbach


Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis, Abigail Hielscher, Kim Ellis, Connie Qiu, Josh Porterfield, and Sharon Gerecht

Fluorinated Caffeic Acid Phenethyl Ester: a Novel Anti-osteogenic molecule to Attenuate Excessive Bone Damage during Autoimmune Arthritis, Lauren Holland, Ramanjaneya V.R. Mula, Deepa Machiah, Xinyu Wang, and Rangaiah Shashidharamurthy


Microbes and Alzheimer's Disease, Ruth Itzhaki, Richard Lathe, Brian J. Balin, Melvyn J. Ball, Elaine L. Bearer, Heiko Braak, Maria J. Bullido, Chris Carter, Mario Clerici, and et al.


Effects of Anchor Structure and Glycosylation of Fcγ Receptor III on Ligand Binding Affinity, Ning Jiang, Wei Chen, Prithiviraj Jothikumar, Jaina M. Patel, Rangaiah Shashidharamurthy, Periasamy Selvaraj, and Cheng Zhu

Determination of Regional Flow Utilizing Microspheres in ex vivo Myocardial Ischemia/Reperfusion (MI/R) Injury, Tarah Kuhn, Sabrina Clark, Daniel Kuo, Stephanie Liu, Qian Chen, Robert Barsotti, and Lindon Young


Science AMA Series: Antarctic Peninsula Paleontology Project, Matt Lamanna, Julia Clarke, Pat O'Connor, Ross MacPhee, Erik Gorscak, Abby West, Chris Torres, Kerin M. Claeson, Meng Jin, Steve Salisbury, Eric Roberts, and Zubair Jinnah

Characterization of the [3Fe-4S](0/1+) cluster from the D14C variant of Pyrococcus furiosus ferredoxin via combined NRVS and DFT analyses., Lars Lauterbach, Leland B Gee, Vladimir Pelmenschikov, Francis Jenney, Saeed Kamali, Yoshitaka Yoda, Michael W W Adams, and Stephen P Cramer

Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity, Jocelyn Lippman-Bell

Exploring the role of synaptic layering, Jocelyn Lippman-Bell

Staging and Management of Heart Failure, Dusty Lisi and Valerie Tapia


Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis, Q. Liu, W. Yuan, D. Tong, G. Liu, W. Lan, Diangzheng Zhang, H. Xiao, Y. Zhang, J. Yang, and J. Zhang


Cerebellar nuclei neurons show only small excitatory responses to optogenetic olivary stimulation in transgenic mice: in vivo and in vitro studies, Huo Lu, Bo Yang, and Dieter Jaeger

New Horizons: Basal Insulin, Miriam Lulusa, Stephen Lee, Sara Reece, and Jennifer Elliott

Developmental Identity Versus Typology: Lucy Has Only Four Sacral Segments, Allison L Machnicki, C Owen Lovejoy, and Philip L. Reno

The Many Faces of MTA3 Protein in Normal Development and Cancers, Lang Ma, Zhimeng Yao, Weilun Deng, Dianzheng Zhang, and Hao Zhang

Effects of NOX-1 on Real-Time Blood Nitric Oxide and Hydrogen Peroxide in Acute Hyperglycemia, Ashley Mawhinney, Michael Bertolet, Michael Minni, Robert Barsotti, Lindon Young, and Qian Chen

Description of New Postcranial Elements of Mylodon darwinii Owen 1839 (Mammalia: Pilosa: Mylodontinae), and Functional Morphology of the Forelimb, Robert McAfee

Error Analysis: Past, Present, and Future, George McCloskey

Compatibility of Norepinephrine Bitartrate with Levofloxacin and Moxifloxacin During Simulated Y-site Administration, Vicky Mody, Samit Shah, Jaymin Patel, and Michael C. Thomas


Immune Complex-Induced, Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes Is Prevented with Decoy FcyReceptors, Ramanjaneya V. R. Mula, Deepa Machiah, Lauren Holland, Xinyu Wang, Harish Parihar, Avadhesh Sharma, Periasamy Selvaraj, and Rangaiah Shashidharamurthy

Resveratrol Increases Catecholamine Synthesis in Macrophages: Implications on Obesity, Ashish Parmar, Ramanjaneya V. R. Mula, Yusra Azhar, Rangaiah Shashidharamurthy, and Srujana Rayalam

Treatment Sequencing for Childhood ADHD: A Multiple-Randomization Study of Adaptive Medication and Behavioral Interventions, William E. Pelham, Gregory A. Fabiano, James G. Waxmonsky, Andrew R. Greiner, Elizabeth M. Gnagy, Stefany Coxe, Jessica Verley, Ira Bhatia, Katy Tresco, and et al.

The Role of Hox in Pisiform and Calcaneus Growth Plate Formation and the Nature of the Zeugopod/Autopod Boundary., Philip L. Reno, Kelsey M Kjosness, and Jasmine E Hines

Still the Great Debate - "Fair Balance" in Direct-to-Consumer Prescription Drug Advertising; Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters", Brent L. Rollins

Who should receive extended infusion beta-lactam therapy?, Christopher Roman, Tia Solh, and Kendra M. Damer

MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway, Wei Sand, Ying Wang, Cong Zhang, Dianzheng Zhang, Cai Sun, Mingshan Niu, Zhe Zhang, Xiangyu Wei, Bin Pan, and et al.

MicroRNA-150 negatively regulates the function of CD4+ T cells through AKT3/Bim signaling pathway, Wei Sang, Cai Sun, Cong Zhang, Dianzheng Zhang, Ying Wang, Linyan Xu, and et al.

Olecranon and trochlear notch orientation is related to extended limb postures during locomotion, Michael Selby and C. O. Lovejoy

Is Olecranon Length Reflective of Adaptations for Speed or Power in Anthropoids?, Michael S. Selby

The functional anatomy of the carpo-metacarpal complex in anthropoids and its implications for the evolution of the hominoid hand, Michael S. Selby, Scott W. Simpson, and Owen C. Lovejoy

Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis, Vishal Singh, Beng Yeoh, Benoit Chassaing, Benyue Zhang, Piu Saha, Xia Xiao, Deepika Awasthi, Rangaiah Shashidharamurthy, Madhu Dikshit, and et al.

Alestid (Characiformes: Alestidae) fishes from the late Oligocene Nsungwe Formation, Rukwas Rift Basin, of Tanzania, W. Stevens, Kerin Claeson, and N. Stevens

Assessment of the Relationship between Self-Reported Cognitive Distortions and Adult ADHD, Anxiety, Depression, and Hopelessness, Craig Strohmeier, Brad Rosenfield, Robert A. DiTomasso, and J. Russell Ramsay


Management of hypercalcemia of malignancy, Sonia Thomas and Soo-Hwan Chung

A 5-Year-Old Boy With an Acute Onset of Emesis, and Throat and Chest Pain, After Taking a Drink, Deanna B Tocco, Robert A. Bassett, and Julie Fitzgerald

Metformin Inhibits Castration-Induced EMT in Prostate Cancer by Repressing COX2/PGE2/STAT3 Axis, Dali Tong, Qiuli Liu, Gaolei Liu, Jing Xu, Weihua Lan, Yao Jiang, Hualiang Xiao, Dianzheng Zhang, and Jun Jiang


The HIF/PHF8/AR axis promotes prostate cancer progression., D Tong, Q Liu, G Liu, W Yuan, L Wang, Y Guo, W Lan, Dianzheng Zhang, S Dong, Y Wang, H Xiao, J Mu, C Mao, J Wong, and J Jiang


Brief compression-only cardiopulmonary resuscitation training video and simulation with homemade mannequin improves CPR skills., Gregory K Wanner, Arayel Osborne, and Charlotte H. Greene PhD

Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice, Hau Wu, Eric V. Brown, Nimish K. Acharya, Denah M. Appelt, Alexander Marks, Robert G. Nagele, and Venkat Venkataraman

Detecting Subnetwork-Level Dynamic Correlations, Yan Yan, Shangzhao Qiu, Zhuxuan Jin, Sihong Gong, Yun Bai, Jianwei Lu, and Tianwei Yu

Comparing the Effects of Myristic Acid- and TAT-conjugated Peptides to Their Native Counterparts Targeting Intracellular Pathways Mediating Myocardial Ischemia/Reperfusion Injury and Neutrophil Superoxide Release, Lindon H. Young, Robert J. Barsotti, Israel Benjamin, H. Patel, Tejash T. Patel, and Qian Chen

The Role of NADPH Oxidase Isoform 1 (NOX1) in L-NAME-Induced Leukocyte-Endothelial Interactions in Rat Mesenteric Postcapillary Venules, Alita Zabrecky, Hung Pham, Amber Koon, Brian Reuter, Robert Barsotti, Lindon Young, and Qian Chen


Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein., Dianzheng Zhang, Boxv Zhou, Li Zhu, Md Asaduzzaman Khan, Tao He, Sufang Zhou, Jian He, Xiaoling Lu, Hanchun Chen, Yongxiang Zhao, and Junjiang Fu

Submissions from 2015

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase Blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline, Nimish K. Acharya, Eric L. Goldwaser, Martin M. Forsberg, George A. Godsey, Cristina A. Johnson, Abhirup Sarkar, Cassandra DeMarshall, Mary C. Kosciuk, Denah M. Appelt, and et al.

Vascular Mechanics in Decellularized Aortas and Coronary Resistance Microvessels in Type 2 Diabetic db/db Mice, Mircea Anghelescu, J. Tonniges, E. Calomeni, P. E. Shamhart, G. Agarwal, K. J. Gooch, and A. J. Trask

Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation, Charles E. Argoff, Michael J. Brennan, Michael Camilleri, Andrew Davies, Jeffrey Fudin, Katherine Galluzzi, Anthony Lembo, Steven P. Stanos, and R. Webster


Alzheimer's Risk Factors, Brian J. Balin, Christopher S. Little, and Denah Appelt


Hypertensive Crisis in the Setting of Non-Compliance, Kimberly L. Barefield and Scott Lancaster


Finger Pain out of Proportion to Exam: A Case of Occult Hydrofluoric Acid Toxicity, Robert A. Bassett

Comparison of the Effects of Myristoylated and Transactivating Peptide (TAT) Conjugated Mitochondrial Fission Peptide Inhibitor (P110) in Myocardial Ischemia/Reperfusion (I/R) Injury, Israel Benjamin, Jonathan Vu, Christina Lipscombe, Devon Stutzman, Carly Schmigdall, Harsh Patel, Qian Chen, Cathy J. Hatcher, Robert Barsotti, and Lindon H. Young

Identification Of Novel Polyglutamine-Expanded Aggregation Species In Spinal And Bulbar Muscular Atrophy., Tamar R Berger, Heather L. Montie, Pranav Jain, Justin Legleiter, and Diane Merry

Resolution of Hypothyroidism after Correction of Somatovisceral Reflex Dysfunction by Refusion of the Cervical Spine., Murray R. Berkowitz

Supplements, Diets and Other Complementary and Alternative Interventions in Adolescent Mental Health, Bettina Bernstein and Alisa Voll

Consumers' reactions to U.S. Food and drug administration-approved claims in print direct-to-consumer advertising, Nilesh Bhutada, J. Huh, Brent Rollins, and M. Perri

Factors predicting consumers' drug inquiry intention after exposure to a prescription drug advertisement: An exploratory analysis, Nilesh Bhutada, Brent Rollins, and M. Perri

Impact of endorser testimonials in direct-to-consumer advertising, Nilesh Bhutada, Brent Rollins, and M. Perri

Disease-specific direct-to-consumer advertising for reminding consumers to take medications, Nilesh S. Bhutada and Brent L. Rollins

Disease-specific direct-to-consumer advertising of pharmaceuticals: An examination of endorser type and gender effects on consumers' attitudes and behaviors, Nilesh S. Bhutada and Brent L. Rollins

A randomized, double-blind, solifenacin succinate versus placebo control, phase 4, multicenter study evaluating urinary continence after robotic assisted radical prostatectomy, F. J. Bianco, D. Albala, Laurence Belkoff, B. J. Miles, J. O. Peabody, W. He, J. S. Bradt, G. P. Haas, and T. E. Ahlering

Articles You Might Have Missed, William Boroughf, Robert A. Bassett, and Steven Walsh

Sleep-Related Problems and the Effects of Anxiety Treatment in Children and Adolescents., Nicole E Caporino, Kendra L Read, Nina Shiffrin, Cara Settipani, Philip C Kendall, Scott N Compton, Joel Sherrill, John Piacentini, John Walkup, Golda Ginsburg, Courtney Keeton, Boris Birmaher, Dara Sakolsky, Elizabeth Gosch, and Anne M Albano


Disrupting SUMOylation Enhances Transcriptional Function and Ameliorates Polyglutamine Androgen Receptor-Mediated Disease, Jason P. Chua, Satya L. Reddy, Zhigang Yu, Elisa Georgetti, Heather L. Montie, Sarmistha Mukherjee, Jake Higgins, Richard C. McEachin, Diane M. Robins, and Diane E. Merry

New fossil scombrid (Pelagia: Scombridae) fishes preserved as predator and prey from the Eocene of Senegal, Kerin M. Claeson, Raphael Sarr, Robert V. Hill, El Hadji Sow, Raymond Malou, and Maureen O'Leary

Sodium glucose co-transporter inhibitors for the management of diabetes mellitus: an opinion paper from the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy, Jennifer N. Clements, Heather P. Whitley, Jennifer J. D'Souza, Benjamin Gross, Rick Hess, Sara Wilson Reece, Chad Gentry, and Kayce Shealy

A Telemedicine-Based Intervention Reduces the Frequency and Severity of COPD Exacerbation Symptoms: A Randomized, Controlled Trial, Francis C. Cordova, David Ciccolella, Carla Grabianowski, John Gaughan, Kathleen Brennan, Frederick J. Goldstein, Michael R. Jacobs, and Gerard J. Criner


Invasive Breast Cancer Incidence in 2,305,427 Screened Asymptomatic Women: Estimated Long Term Outcomes during Menopause Using a Systematic Review., Winnifred Cutler, Regula Bürki, James Kolter, Catherine Chambliss, Erika Friedmann, and Kari Hart

Tetracycline tethered to titanium inhibits colonization by Gram-negative bacteria, H. Davidson, M. Poon, R. Saunders, I. M. Shapiro, N. J. Hickok, and Christopher S. Adams

A First-Year DPT Student’s Perspectives on a Cadaver with Scoliosis, Caitlin D. Deems and Philip A. Fabrizio


Learners of a New Generation, Camille DiLullo

Symptomatic comorbidity, Robert A. DiTomasso and Bradley M. Rosenfield

Counseling Male Patients on Testosterone Replacement Therapy With Efficacy and Safety in Mind, Andrea G. Douglas, Joylaina Speaks, Jennifer Elliot, and Deirdre B. Fanning


Funding and Other Resources for Beginning Researchers, Jane Z. Dumsha, David Yens, and Grace Brannan

Use of Naloxone Drips in Pediatric Patients: A Retrospective Medication Use Evaluation, Carmen Echols and Marie Katie Bozman

Insulin Therapy: New Options, Jennifer Elliott and Sara Wilson Reece


Suicide in Schools: a Practitioner's Guide to Multi-Level Prevention Assessment, Intervention, and Postvention, Theresa Erbacher, Jonathan B. Singer, and Scott Poland

Unusual Fibularis (Peroneus) Muscle, Philip A. Fabrizio


The effect of osteopathic manipulative treatment on length of stay in posterolateral postthoracotomy patients: A retrospective case note study, Regina K. Fleming, Karen T. Snyder, Kent J. Blanke, and Jane C. Johnson

Progression-free survival by local investigator versus independent central review: Comparative analysis of the AGO-OVAR16 Trial, A. Floquet, I. Vergote, N. Colombo, B. Fiane, B. J. Monk, A. Reinthaller, P. Calvert, T. Herzog, Rocco J. Crescenzo, and et al.

Considerations in the Selection of Antihyperglycemic Therapy for Older Patients With Type 2 Diabetes Mellitus: A Focus on Newer Therapies, Jeffrey Freeman

Considerations in the Selection of Antihyperglycemic Therapy for Older Patients With Type 2 Diabetes Mellitus: A Focus on Newer Therapies, Jeffrey Freeman

Compliance with recommendations made in a multidisciplinary ALS clinic., Timothy Fullam, Helen E Stephens, Stephanie H. Felgoise, Jacqueline K Blessinger, Susan Walsh, and Zachary Simmons

The Patient with Otitis Media, David B. Fuller

The Triune Nature of Humanity: Body, Mind, and Spirit, David B. Fuller

Jackfruit (Artocarpus heteophyllus) seed extract exhibits fibrino(geno)lytic activity, Sowmyashree Gangaraju, Bhagyalakshmi Manjappa, Girish Kesturu Subbaiah, Kemparaju Kempaiah, Rangaiah Shashidharamurthy, Jane Hoover Plow, Sebastin Santhosh Martin, Manohar Shindhe, and Devaraja Sannaningaiah

Hepatocyte Culture in Autologous Decellularized Spleen Matrix, Rui Gao, Wanquan Wu, Junxi Xiang, Yi Lu, Xinglong Zheng, Qian Chen, Haohua Wang, Bo Wang, Zhengwen Liu, and Feng Ma

Strategies for Effective Classroom Coaching, S. Andrew Garbacz, Amanda L. Lannie, Jennifer L. Jeffrey-Pearsall, and Adrea J. Truckenmiller


Motivational Interviewing is a Promising Framework for Collaboration in the Patient-Centered Medical Home, Scott Glassman

Orthopedic uses of stem cell therapy, Whitney B. Greco and Nancy McClaughlin

Neurologic diseases: the tragedy and the hope., Paula M. Gregory

Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer., Valentina Guarneri, Maria Vittoria Dieci, Antonio Frassoldati, Antonino Maiorana, Guido Ficarra, Stefania Bettelli, Enrico Tagliafico, Silvio Bicciato, Daniele Giulio Generali, Katia Cagossi, Giancarlo Bisagni, Samanta Sarti, Antonino Musolino, Catherine Ellis, Rocco J. Crescenzo, and PierFranco Conte

Diagnosis of Migraines and Migraine Variants, Tomia P. Harmon

Developmental Regulation of Epicardial Cell Adhesion and Coronary Vasculogenesis, Cathy J. Hatcher, Brendan Tanner, Dina Abdurahman, Kolby Nelson, William Laidlaw, and Grzegorz Gorski

Abstract 87: Targeting androgen receptor acetylation as a treatment for castrate-resistant prostate cancer, Erin Heine, Diane E. Merry, Scott Dehm, Karen E. Knudsen, and Heather L. Montie

Efficacy of Avanafil 15 Minutes after Dosing in Men with Erectile Dysfunction: A Randomized, Double-Blind, Placebo Controlled Study, W. J. Hellstrom, J. Kaminetsky, Laurence Belkoff, I. Goldstein, J. P. Tursi, J. Uly, C. A. Peterson, C. H. Bowden, and W. W. Day

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer., David T Hoang, Lei Gu, Zhiyong Liao, Feng Shen, Pooja G Talati, Mateusz Koptyra, Shyh-Han Tan, Elyse Ellsworth, Shilpa Gupta, Heather L. Montie, Ayush Dagvadorj, Saija Savolainen, Benjamin Leiby, Tuomas Mirtti, Diane E Merry, and Marja T Nevalainen

Office Evaluation of Dizziness, James D. Hogue