The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2017

Huntington Disease, Carrie Nold


Trends in Hospital Admissions Due to Antidepressant-Related Adverse Drug Events from 2001 to 2011 in the U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, and Jianwei Xuan

Comparing and Contrasting the Use of Problem-Based Learning in Child and Adolescent Psychiatry Programs., Dale Peeples, Anthony Guerrero, Bettina Bernstein, Jeffrey Hunt, Say How Ong, Cynthia Santos, Sandra Sexson, and Norbert Skokauskas

Missing Links, Philip L. Reno

Managing Chronic Pain: A Review of the CDC Guidelines, Essie Samuel

Sodium-Glucose Cotransporter 2 Inhibitors: An Overview, Essie Samuel and Jiehyun Lee

Xanthohumol Stimulates the Secretion of Catecholamines and Induces M2 Polarization in Raw 264.7 Macrophages, J. Samuels, S. Alavarez, H. Dinh, Rangaiah Shashidharamurthy, and Srujana Rayalam

The Anti-Obesity Effects of Xanthohumol Are Partly Mediated by the Adenosine Monophosphate-activated Protein Kinase Signaling Pathway, J. Samuels, Z. Fitch, H.-G. Chae, and Srujana Rayalam

Evolution of the Hominoid Scapula and Its Implications for Earliest Hominid Locomotion, Michael S. Selby and C Owen Lovejoy

Hominoid Scapular Morphology Suggests a Generalized Last Common Ancestor, Michael S. Selby and C. Owen Lovejoy

Treatment of Pregnant Patients With Orthopaedic Trauma, Nirmal Tejwani, Kevin Klifto, Christopher Looze, and Christopher Scott Klifto

Chemotherapy Agents That Cause Cardiotoxicity, Sonia Amin Thomas

Isolation of Intact, Whole Mouse Mammary Glands for Analysis of Extracellular Matrix Expression and Gland Morphology., Christopher Thompson, Katherine Keck, and Abigail Hielscher


Loss of Caveolin-1 Alters Extracellular Matrix Protein Expression and Ductal Architecture in Murine Mammary Glands., Christopher Thompson, Sahar Rahim, Jeremiah Arnold, and Abigail Hielscher


Influences on Patient Satisfaction in Healthcare Centers: A Semi-Quantitative Study Over 5 Years, Ruth D. Thornton, Nicole Nurse, Laura Snavely, Stacey Hackett-Zahler, Kenice Frank, and Robert A. DiTomasso

The Late Jurassic Ray Kimmerobatis etchesi gen. et sp. nov. and the Jurassic Radiation of the Batoidea, Charlie J. Underwood and Kerin M. Claeson

Burden of Illness in Cystic Fibrosis: A Retrospective Analysis of Medical Expenditure Panel Survey (MEPS) Data, P Vadagam, K M. Kamal, Kumar Mukherjee, J R. Covvey, and V Giannetti

Preceptor's Grading Scale Preference for Student Pharmacy Practice Experience and Assessment of the Common Grading Scale among Us Schools of Pharmacy, Leanne Honecutt Varner, Remya Radhakrishnan, and Brent L. Rollins


Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting, Jennifer Peyling Wang and Abigail Hielscher


Resveratrol Enhances Polyubiquitination-Mediated ARV-7 Degradation in Prostate Cancer Cells, Sara Wilson Reece, Lucia Cavero, Dali Tong, Qiuli Liu, Kyla Geary, Nicholas Talamonti, Jing Xu, Junjiang Fu, Jun Jiang, and Dianzheng Zhang

An Overview of the Management of Concussion, Todd J. Woodard and Shari N. Allen


Mechanically Tuned 3 Dimensional Hydrogels Support Human Mammary Fibroblast Growth and Viability, Kathryn Woods, Catlyn Thigpen, Jennifer Peyling Wang, Hana Park, and Abigail Hielscher

ISG15 Inhibits Cancer Cell Growth and Promotes Apoptosis, Mei-Juan Zhou, Fang-Zhi Chen, Han-Chun Chen, Xin-Xing Wan, Xi Zhou, Qian Fang, and Dianzheng Zhang


TGFβƒ1 Promotes Gemcitabine Resistance Through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer, Junlong Zhuang, Lan Shen, Lin Yang, Xiaojing Huang, Qun Lu, Yangyan Cui, Xi Zheng, Xiaozhi Zhao, Dianzheng Zhang, Ruimin Huang, Hongqian Guo, and Jun Yan

Submissions from 2016

Chlamydia Pneumoniae-Infected Astrocytes Alter Their Expression of ADAM10, BACE1, and Presenilin-1 Proteases, Zein Al-Atrache, Ahmad Cader, and Denah Appelt


Phytochemicals as Novel Agents for the Induction of Browning in White Adipose Tissue, Yusra Azhar, Ashish Parmar, Colette N Miller, Janaiya S Samuels, and Srujana Rayalam

Multifaceted Effects of Guggulsterone as Anti-obesity Agent, Yusra Azhar, Ashish Parmar, and Srujana Rayalam

Osteopathic Approach to Treating a Patient with New Onset Low Back Pain Following Injury Reveals Unusual Presentation of Bilateral and Symmetric Symptoms: A Case Report, Murray R. Berkowitz

Impact of Animated Spokes-Characters in Print Direct-to-Consumer Prescription Drug Advertising: An Elaboration Likelihood Model Approach., Nilesh S Bhutada, Brent L. Rollins, and Matthew Perri

Zinc-Binding Protein-89 (ZBP-89) Cooperates with NF-kB to Regulate Expression of Matrix Metalloproteinases (MMPs) in Response to Inflammatory Cytokines, Ruth C. Borghaei, Grzegorz Gorski, Sara Seutter, Janny Chun, Nelly Khaselov, and Stephanie Scianni

Neuroprotective effect of Myo/Nog cells in the stressed retina, Arturo Bravo Nuevo, A. A. Brandli, Jacquelyn Gerhart, J. Nichols, M. Pitts, C. Sutera, S. Assali, V. Scheinfeld, Mindy George-Weinstein, and et al.


Apocynin Exerts Dose-Dependent Cardioprotective Effects by Attenuating Reactive Oxygen Species in Ischemia/Reperfusion, Qian Chen, Woodworth C. Parker, Issachar Devine, Regina Ondraskik, Tsion Habtamu, Kyle Bartol, Brendan Casey, Harsh Patel, William Chau, and Tarah Kuhn

The Sabertooth Salmon, Oncorhynchus rastrosus, gets a facelift., Kerin M. Claeson, E. B. Davis, B. L. Sidlauskas, and Z. M. Prescott

Distal triceps rupture associated with septic olecranon bursitis, Mark Denzine and Jack E. Kazanjian

Reciprocal Androgen Receptor/Interleukin-6 Crosstalk Drives Oesophageal Carcinoma Progression and Contributes to Patient Prognosis, Hongmei Dong, Jinjin Xu, Weiwei Li, Jinfeng Gan, Wan Lin, Jierong Ke, Jiali Jiang, Liang Du, Yuping Chen, Xueyun Zhong, Dianzheng Zhang, Sai-Ching Jim Yeung, Xiaotao Li, and Hao Zhang


Pelvic and Breast Examination Skills Curricula in United States Medical Schools: A Survey of Obstetrics and Gynecology Clerkship Directors, Lorraine Dugoff, Archana Pradhan, Petra Casey, John L Dalrymple, Jodi F Abbott, Samantha D Buery-Joyner, Alice Chuang, Amie J Cullimore, David A Forstein, Brittany S Hampton, Joseph M. Kaczmarczyk, Nadine T Katz, Francis S Nuthalapaty, Sarah M Page-Ramsey, Abigail Wolf, and Nancy A Hueppchen


A Systematic Review on the Use of Psychosocial Interventions in Conjunction with Medications for the Treatment of Opioid Addiction, K Dugosh, A. Abraham, B. Seymour, K. McLoyd, M. Chalk, and David Festinger

Recurrent Varicella in an Immunocompetent Woman, Joseph Dyer and Melinda Greenfield

Verbal communication impacts quality of life in patients with amyotrophic lateral sclerosis, Stephanie Felgoise, Vincenzo Zaccheo, Jason Duff, and Zachary Simmons

Use of the Internet to Obtain Drugs Without a Prescription Among Treatment-Involved Adolescents and Young Adults, David Festinger, K. Dugosh, N. Clements, A. Flynn, M. Falco, A. McLellan, and A. Arria

Examining the efficacy of a computer facilitated HIV prevention tool in drug court, David Festinger, K. Dugosh, A. Kurth, and D. Metzger


Synchrotron-based Nickel Mössbauer Spectroscopy., Leland B Gee, Chun-Yi Lin, Francis E. Jenney, Michael W W Adams, Yoshitaka Yoda, Ryo Masuda, Makina Saito, Yasuhiro Kobayashi, Kenji Tamasaku, Michael Lerche, Makoto Seto, Charles G Riordan, Ann Ploskonka, Philip P Power, Stephen P Cramer, and Lars Lauterbach


Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis, Abigail Hielscher, Kim Ellis, Connie Qiu, Josh Porterfield, and Sharon Gerecht

Fluorinated Caffeic Acid Phenethyl Ester: a Novel Anti-osteogenic molecule to Attenuate Excessive Bone Damage during Autoimmune Arthritis, Lauren Holland, Ramanjaneya V.R. Mula, Deepa Machiah, Xinyu Wang, and Rangaiah Shashidharamurthy


Microbes and Alzheimer's Disease, Ruth Itzhaki, Richard Lathe, Brian J. Balin, Melvyn J. Ball, Elaine L. Bearer, Heiko Braak, Maria J. Bullido, Chris Carter, Mario Clerici, and et al.


Effects of Anchor Structure and Glycosylation of Fcγ Receptor III on Ligand Binding Affinity, Ning Jiang, Wei Chen, Prithiviraj Jothikumar, Jaina M. Patel, Rangaiah Shashidharamurthy, Periasamy Selvaraj, and Cheng Zhu

Determination of Regional Flow Utilizing Microspheres in ex vivo Myocardial Ischemia/Reperfusion (MI/R) Injury, Tarah Kuhn, Sabrina Clark, Daniel Kuo, Stephanie Liu, Qian Chen, Robert Barsotti, and Lindon Young


Science AMA Series: Antarctic Peninsula Paleontology Project, Matt Lamanna, Julia Clarke, Pat O'Connor, Ross MacPhee, Erik Gorscak, Abby West, Chris Torres, Kerin M. Claeson, Meng Jin, Steve Salisbury, Eric Roberts, and Zubair Jinnah

Characterization of the [3Fe-4S](0/1+) cluster from the D14C variant of Pyrococcus furiosus ferredoxin via combined NRVS and DFT analyses., Lars Lauterbach, Leland B Gee, Vladimir Pelmenschikov, Francis Jenney, Saeed Kamali, Yoshitaka Yoda, Michael W W Adams, and Stephen P Cramer

Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity, Jocelyn Lippman-Bell

Exploring the role of synaptic layering, Jocelyn Lippman-Bell

Staging and Management of Heart Failure, Dusty Lisi and Valerie Tapia


Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis, Q. Liu, W. Yuan, D. Tong, G. Liu, W. Lan, Diangzheng Zhang, H. Xiao, Y. Zhang, J. Yang, and J. Zhang


Cerebellar nuclei neurons show only small excitatory responses to optogenetic olivary stimulation in transgenic mice: in vivo and in vitro studies, Huo Lu, Bo Yang, and Dieter Jaeger

New Horizons: Basal Insulin, Miriam Lulusa, Stephen Lee, Sara Reece, and Jennifer Elliott

Developmental Identity Versus Typology: Lucy Has Only Four Sacral Segments, Allison L Machnicki, C Owen Lovejoy, and Philip L. Reno

The Many Faces of MTA3 Protein in Normal Development and Cancers, Lang Ma, Zhimeng Yao, Weilun Deng, Dianzheng Zhang, and Hao Zhang

Effects of NOX-1 on Real-Time Blood Nitric Oxide and Hydrogen Peroxide in Acute Hyperglycemia, Ashley Mawhinney, Michael Bertolet, Michael Minni, Robert Barsotti, Lindon Young, and Qian Chen

Description of New Postcranial Elements of Mylodon darwinii Owen 1839 (Mammalia: Pilosa: Mylodontinae), and Functional Morphology of the Forelimb, Robert McAfee

Error Analysis: Past, Present, and Future, George McCloskey

Compatibility of Norepinephrine Bitartrate with Levofloxacin and Moxifloxacin During Simulated Y-site Administration, Vicky Mody, Samit Shah, Jaymin Patel, and Michael C. Thomas


Immune Complex-Induced, Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes Is Prevented with Decoy FcyReceptors, Ramanjaneya V. R. Mula, Deepa Machiah, Lauren Holland, Xinyu Wang, Harish Parihar, Avadhesh Sharma, Periasamy Selvaraj, and Rangaiah Shashidharamurthy

Resveratrol Increases Catecholamine Synthesis in Macrophages: Implications on Obesity, Ashish Parmar, Ramanjaneya V. R. Mula, Yusra Azhar, Rangaiah Shashidharamurthy, and Srujana Rayalam

Treatment Sequencing for Childhood ADHD: A Multiple-Randomization Study of Adaptive Medication and Behavioral Interventions, William E. Pelham, Gregory A. Fabiano, James G. Waxmonsky, Andrew R. Greiner, Elizabeth M. Gnagy, Stefany Coxe, Jessica Verley, Ira Bhatia, Katy Tresco, and et al.

The Role of Hox in Pisiform and Calcaneus Growth Plate Formation and the Nature of the Zeugopod/Autopod Boundary., Philip L. Reno, Kelsey M Kjosness, and Jasmine E Hines

Still the Great Debate - "Fair Balance" in Direct-to-Consumer Prescription Drug Advertising; Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters", Brent L. Rollins

Who should receive extended infusion beta-lactam therapy?, Christopher Roman, Tia Solh, and Kendra M. Damer

MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway, Wei Sand, Ying Wang, Cong Zhang, Dianzheng Zhang, Cai Sun, Mingshan Niu, Zhe Zhang, Xiangyu Wei, Bin Pan, and et al.

MicroRNA-150 negatively regulates the function of CD4+ T cells through AKT3/Bim signaling pathway, Wei Sang, Cai Sun, Cong Zhang, Dianzheng Zhang, Ying Wang, Linyan Xu, and et al.

Olecranon and trochlear notch orientation is related to extended limb postures during locomotion, Michael Selby and C. O. Lovejoy

Is Olecranon Length Reflective of Adaptations for Speed or Power in Anthropoids?, Michael S. Selby

The functional anatomy of the carpo-metacarpal complex in anthropoids and its implications for the evolution of the hominoid hand, Michael S. Selby, Scott W. Simpson, and Owen C. Lovejoy

Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis, Vishal Singh, Beng Yeoh, Benoit Chassaing, Benyue Zhang, Piu Saha, Xia Xiao, Deepika Awasthi, Rangaiah Shashidharamurthy, Madhu Dikshit, and et al.

Alestid (Characiformes: Alestidae) fishes from the late Oligocene Nsungwe Formation, Rukwas Rift Basin, of Tanzania, W. Stevens, Kerin Claeson, and N. Stevens

Assessment of the Relationship between Self-Reported Cognitive Distortions and Adult ADHD, Anxiety, Depression, and Hopelessness, Craig Strohmeier, Brad Rosenfield, Robert A. DiTomasso, and J. Russell Ramsay


Management of hypercalcemia of malignancy, Sonia Thomas and Soo-Hwan Chung

A 5-Year-Old Boy With an Acute Onset of Emesis, and Throat and Chest Pain, After Taking a Drink, Deanna B Tocco, Robert A. Bassett, and Julie Fitzgerald

Metformin Inhibits Castration-Induced EMT in Prostate Cancer by Repressing COX2/PGE2/STAT3 Axis, Dali Tong, Qiuli Liu, Gaolei Liu, Jing Xu, Weihua Lan, Yao Jiang, Hualiang Xiao, Dianzheng Zhang, and Jun Jiang


The HIF/PHF8/AR axis promotes prostate cancer progression., D Tong, Q Liu, G Liu, W Yuan, L Wang, Y Guo, W Lan, Dianzheng Zhang, S Dong, Y Wang, H Xiao, J Mu, C Mao, J Wong, and J Jiang


Brief compression-only cardiopulmonary resuscitation training video and simulation with homemade mannequin improves CPR skills., Gregory K Wanner, Arayel Osborne, and Charlotte H. Greene PhD

Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice, Hau Wu, Eric V. Brown, Nimish K. Acharya, Denah M. Appelt, Alexander Marks, Robert G. Nagele, and Venkat Venkataraman

Detecting Subnetwork-Level Dynamic Correlations, Yan Yan, Shangzhao Qiu, Zhuxuan Jin, Sihong Gong, Yun Bai, Jianwei Lu, and Tianwei Yu

Comparing the Effects of Myristic Acid- and TAT-conjugated Peptides to Their Native Counterparts Targeting Intracellular Pathways Mediating Myocardial Ischemia/Reperfusion Injury and Neutrophil Superoxide Release, Lindon H. Young, Robert J. Barsotti, Israel Benjamin, H. Patel, Tejash T. Patel, and Qian Chen

The Role of NADPH Oxidase Isoform 1 (NOX1) in L-NAME-Induced Leukocyte-Endothelial Interactions in Rat Mesenteric Postcapillary Venules, Alita Zabrecky, Hung Pham, Amber Koon, Brian Reuter, Robert Barsotti, Lindon Young, and Qian Chen


Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein., Dianzheng Zhang, Boxv Zhou, Li Zhu, Md Asaduzzaman Khan, Tao He, Sufang Zhou, Jian He, Xiaoling Lu, Hanchun Chen, Yongxiang Zhao, and Junjiang Fu

Submissions from 2015

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase Blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline, Nimish K. Acharya, Eric L. Goldwaser, Martin M. Forsberg, George A. Godsey, Cristina A. Johnson, Abhirup Sarkar, Cassandra DeMarshall, Mary C. Kosciuk, Denah M. Appelt, and et al.

Vascular Mechanics in Decellularized Aortas and Coronary Resistance Microvessels in Type 2 Diabetic db/db Mice, Mircea Anghelescu, J. Tonniges, E. Calomeni, P. E. Shamhart, G. Agarwal, K. J. Gooch, and A. J. Trask

Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation, Charles E. Argoff, Michael J. Brennan, Michael Camilleri, Andrew Davies, Jeffrey Fudin, Katherine Galluzzi, Anthony Lembo, Steven P. Stanos, and R. Webster


Alzheimer's Risk Factors, Brian J. Balin, Christopher S. Little, and Denah Appelt


Hypertensive Crisis in the Setting of Non-Compliance, Kimberly L. Barefield and Scott Lancaster


Finger Pain out of Proportion to Exam: A Case of Occult Hydrofluoric Acid Toxicity, Robert A. Bassett

Comparison of the Effects of Myristoylated and Transactivating Peptide (TAT) Conjugated Mitochondrial Fission Peptide Inhibitor (P110) in Myocardial Ischemia/Reperfusion (I/R) Injury, Israel Benjamin, Jonathan Vu, Christina Lipscombe, Devon Stutzman, Carly Schmigdall, Harsh Patel, Qian Chen, Cathy J. Hatcher, Robert Barsotti, and Lindon H. Young

Identification Of Novel Polyglutamine-Expanded Aggregation Species In Spinal And Bulbar Muscular Atrophy., Tamar R Berger, Heather L. Montie, Pranav Jain, Justin Legleiter, and Diane Merry

Resolution of Hypothyroidism after Correction of Somatovisceral Reflex Dysfunction by Refusion of the Cervical Spine., Murray R. Berkowitz

Supplements, Diets and Other Complementary and Alternative Interventions in Adolescent Mental Health, Bettina Bernstein and Alisa Voll

Consumers' reactions to U.S. Food and drug administration-approved claims in print direct-to-consumer advertising, Nilesh Bhutada, J. Huh, Brent Rollins, and M. Perri

Factors predicting consumers' drug inquiry intention after exposure to a prescription drug advertisement: An exploratory analysis, Nilesh Bhutada, Brent Rollins, and M. Perri

Impact of endorser testimonials in direct-to-consumer advertising, Nilesh Bhutada, Brent Rollins, and M. Perri

Disease-specific direct-to-consumer advertising for reminding consumers to take medications, Nilesh S. Bhutada and Brent L. Rollins

Disease-specific direct-to-consumer advertising of pharmaceuticals: An examination of endorser type and gender effects on consumers' attitudes and behaviors, Nilesh S. Bhutada and Brent L. Rollins