Cytoprotective Effects of Natural Compounds against Oxidative Stress

Authors

Jay Mehta, Philadelphia College of Osteopathic Medicine
Srujana Rayalam, Philadelphia College of Osteopathic MedicineFollow
Xinyu Wang, Philadelphia College of Osteopathic MedicineFollow

Document Type

Article

Publication Date

10-20-2018

Abstract

Oxidative stress, an imbalance between reactive oxygen species and antioxidants, has been witnessed in pathophysiological states of many disorders. Compounds identified from natural sources have long been recognized to ameliorate oxidative stress due to their inherent antioxidant activities. Here, we summarize the cytoprotective effects and mechanisms of natural or naturally derived synthetic compounds against oxidative stress. These compounds include: caffeic acid phenethyl ester (CAPE) found in honey bee propolis, curcumin from turmeric roots, resveratrol abundant in grape, and 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), a synthetic triterpenoid based on naturally occurring oleanolic acid. Cytoprotective effects of these compounds in diseases conditions like cardiovascular diseases and obesity to decrease oxidative stress are discussed.

Publication Title

Antioxidants

Volume

7

Issue

10

PubMed ID

30347819

Comments

This article was published in Antioxidants, Voume 7, Issue 10.

The published version is available at https://doi.org/10.3390/antiox7100147.

Copyright © 2018 the authors. CC BY 4.0

Recommended Citation

Mehta, Jay; Rayalam, Srujana; and Wang, Xinyu, "Cytoprotective Effects of Natural Compounds against Oxidative Stress" (2018). PCOM Scholarly Works. 1957.
https://digitalcommons.pcom.edu/scholarly_papers/1957