The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2014

Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships, Abigail Hielscher and S. Gerecht

Detection of Anorexia Nervosa in Primary Care: Effects of Patient Ethnicity, History of Mental Illness, Physician Gender, and Years of Experience., Ashley Higgins, Stacey C. Cahn, Robert A. DiTomasso, and Harry J. Morris


A capstone course with a comprehensive and integrated review of the pharmacy curriculum and student assessment as a preparation for advanced pharmacy practice experiences, Adina C. Hirsch and Harish S. Parihar

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation., P. E. Hooijman, M. A. Paul, G. J. Stienen, A. Beishuizen, H. W. Van Hees, S. Singhal, M. Bashir, M. T. Budak, Robert J. Barsotti, and

Unaffected Contractility of Diaphragm Muscle Fibers in Humans on Mechanical Ventilation., Pleuni E Hooijman, Marinus A Paul, Ger J M Stienen, Albertus Beishuizen, Hieronymus W H Van Hees, Sunil Singhal, Muhammad Bashir, Murat T. Budak, Jacqueline Morgen, Robert J. Barsotti, Sanford Levine, and Coen A C Ottenheijm


Child involvement, alliance, and therapist flexibility: Process variables in cognitive-behavioural therapy for anxiety disorders in childhood, Jennifer L. Hudson, Philip C. Kendall, Brian C. Chu, Elizabeth A. Gosch, Erin Martin, Alan Taylor, and Ashleigh Knight

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export, M. B. Hudson, M. E. Woodworth-Hobbs, B. Zheng, J. A. Rahnert, M. A. Blount, Jennifer L. Gooch, C. D. Searles, and S. Russ Price

The Pisiform Growth Plate Is Lost in Humans and Supports a Role for Hox in Growth Plate Formation, Kelsey M Kjosness, Jasmine E Hines, C Owen Lovejoy, and Philip L. Reno


Web-Based Objective Structured Clinical Examination with Remote Standardized Patients and Skype: Resident Experience, Erik E. Langenau, Elizabeth Kachur, and Dot Horber


Introducing Blended Learning to Medical Students in a Clinical Training Environment, Erik Langenau and Douglas Koch

Somatic dysfunction and use of osteopathic manual treatment techniques during ambulatory medical care visits: a CONCORD-PRBN study, John C. Licciardone; Cathleen M. Kearns; Hollis H, King; Michael A. Seffinger; W. Thomas Crow; Peter Zajac; William H. Devine; Reem Y. Abu_Sbaih; Stephen J. Miller; and Murray R. Berkowitz


Chlamydia pneumoniae Infection of Monocytes in vitro Stimulates Innate and Adaptive Immune Responses Relevant to those in Alzheimer's Disease., Charles Lim, Christine Hammond, Susan Hingley, and Brian J. Balin PhD


Detection of Bacterial Antigens and Alzheimer's Disease-like Pathology in the Central Nervous System of BALB/c Mice Following Intranasal Infection with a Laboratory Isolate of Chlamydia pneumoniae, C. Scott Little PhD, Timothy A. Joyce, Christine Hammond, Hazem Matta, David Cahn, Denah Appelt, and Brian J. Balin PhD

Use of a Small Intestine Submucosa Extracellular Matrix Patch in Repeated Carotid Endarterectomy, Nicholas J. Madden, Douglas A. Troutman, and Arthur J. DeMarsico

Pediatric Arytenoid Dislocation: Diagnosis and Treatment., Andrew S. Mallon, Joel E. Portnoy, Tré Landrum, and Robert T. Sataloff

Pediatric Shopping-Cart-Related Injuries Treated in US Emergency Departments, 1990-2011, Keith Martin, Thiphalak Chounthirath, Huiyun Xiang, and Gary A. Smith

Acute and Chronic Compartment Syndromes: Know When to Act Fast, Nancy McLaughlin, Hank Heard, and Steven Kelham

Staff Perspectives on Juvenile Drug Court Operations: A Multi-Site Qualitative Study, A. Mericle, S. Belenko, David Festinger, J. Fairfax-Colombo, and M. McCart

Acute Exposure to High-Fat Diets Increases Hepatic Expression of Genes Related to Cell Repair and Remodeling in Female Rats, Colette N. Miller, Heidi P. Morton, Paula T. Cooney, Tricia G. Winters, Keshia R. Ramseur, Srujana Rayalam, Mary Anne Della-Fera, Clifton A. Baile, and Lynda M. Brown


A Combined Therapeutic Regimen of Buspirone and Environmental Enrichment is more Efficacrious than Either Alone in Enhancing Spatial Learning in Brain-Injured Rats, Christina M. Monaco, Kory M. Gebhardt, Sarah M. Chlebowski, Kaitlyn E. Shaw, and Jeffrey P. Cheng


Chewing Through the Miocene: An Examination of the Feeding Musculature in the Ground Sloth Hapalops from South America (Mammalia: Pilosa), Virginia L Naples and Robert McAfee

Molecular Functions and Significance of the MTA Family in Hormone-Independent Cancer, Zhifeng Ning, Jinfeng Gan, Chaoying Chen, Dianzheng Zhang, and Hao Zhang

Cardiac catheterization: A review for pharmacists, Mebanga Ojong, Chad Weinhold, Afeez Salako, and Jennifer Andres

The Primacy of IQ Subtest Analysis to Understand Reading Performance for Culturally Diverse Groups, Samuel O. Ortiz, Harriet N. Johnson, Gabrielle Wilson, Stella F. Francis, and Yuma Iannotti Tomes

Overview of Adult Outpatient Cancer Pain Management, Sonia Patel

Safe Handling of Chemotherapy for Pharmacists, Sonia Patel

Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism, Youjuan Pei, Aiming Wang, Yong Zhao, Ling Yan, Min Li, Richard E. White, and Gui Chun Han

Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism, Y. Pei, A. Wang, Y. Zhao, L. Yan, M. Li, Richard E. White, and G. C. Han

Trajectories of Change in Youth Anxiety During Cognitive-Behavior Therapy., Tara S Peris, Scott N Compton, Philip C Kendall, Boris Birmaher, Joel Sherrill, John March, Elizabeth Gosch, Golda Ginsburg, Moira Rynn, James T McCracken, Courtney P Keeton, Dara Sakolsky, Cynthia Suveg, Sasha Aschenbrand, Daniel Almirall, Satish Iyengar, John T Walkup, Anne Marie Albano, and John Piacentini

Cognitive-Behavioral Therapy for Anxious Youth with a Disability: a Case Study, Jeremy S. Peterman, Alexandra L. Hoff, Elizabeth Gosch, and Philip C. Kendall

Thyroglossal Duct Papillary Carcinoma in a 15-year old Female and Review of Pediatric Cases of thyroglossal duct carcinoma., Michael S Pfeiffer, Grace H Kim, and Miguel Krishnan


24- and 36-Week Outcomes for the Child/Adolescent Anxiety Multimodal Study (CAMS), John Piacentini, Shannon Bennett, Scott N. Compton, Phillip C. Kendall, Boris Birmaher, Anne Marie Albano, John March, Joel Sherrill, Dara Sakolsky, Golda Ginsburg, Moira Rynn, R. Lindsey Bergman, Elizabeth Gosch, Bruce Waslick, Satish Iyengar, James McCracken, and John T. Walkup

Efficacy of Super High Dose Proton Pump Inhibitor Administration in Refractory Laryngopharyngeal Reflux: A Pilot Study, Joel E. Portnoy, Naomi D. Gregory, Claudia E. Cerulli, Mary J. Hawkshaw, Deborah Lurie, Philip O. Katz, and Robert T. Sataloff

Inhibition of Long Chain Fatty Ccyl-CoA Synthetase (ACSL) and Ischemia Reperfusion Injury, Allan M. Prior, Man Zhang, Nina Blakeman, Palika Datta, Hung Pham, Qian Chen, Lindon H. Young, Margaret T. Weis, and Duy H. Hua

Bilateral Vocal Fold Immobility, Kelli A. Quercetti and Amanda Hu

Predicting Anxiety Diagnoses and Severity with the CBCL-A: Improvement Relative to Other CBCL Scales?, Kendra L. Read, Cara A. Settipani, Jeremy Peterman, Philip C. Kendall, Scott Compton, John Piacentini, James McCracken, Linsey Bergman, Elizabeth A. Gosch, and et al.

Use of Rapid-Acting Insulin Analogs During Pregnancy, Sara Wilson Reece, Alexander Kanopka, and Iana Mervin

Metformin in gestational diabetes mellitus, Sara Wilson Reece, Harish S. Parihar, and Christina LoBello

Genetic and Developmental Basis for Parallel Evolution and Its Significance for Hominoid Evolution, Philip L. Reno

The Beauty Bias: the Injustice of Appearance in Life and Law, Deborah L. Rhode

Perioperative Nonopioid Agents for Pain Control in Spinal Surgery., Anna Rivkin and Mark Rivkin

Novel free-hand T1 pedicle screw method: Review of 44 consecutive cases, Mark A. Rivkin, J. F. Okun, and Steven S. Yocom

Novel free-hand T1 pedicle screw method: Review of 44 consecutive cases, Mark A. Rivkin, J. F. Okun, and Steven S. Yocom

Thoracolumbar instrumentation with CT-guided navigation (O-arm) in 270 consecutive patients: Accuracy rates and lessons learned, Mark A. Rivkin and Steven S. Yocom

Thoracolumbar instrumentation with CT-guided navigation (O-arm) in 270 consecutive patients: Accuracy rates and lessons learned, Mark A. Rivkin and Steven S. Yocom

Stratigraphy and Vertebrate Paleoecology of Upper Cretaceous? Lowest Paleogene Strata on Vega Island, Antarctica, Eric M. Roberts, Matthew C. Lamanna, Julia A. Clarke, Jin Meng, Eric Gorscak, Joseph J. W. Sertich, Patrick M. O'Connor, Kerin M. Claeson, and Ross D. E. MacPhee

Pubic Bone Osteomyelitis after Salvage High-Intensity Focused Ultrasound for Prostate Cancer, Christopher Robison, R. A. Gor, and M. J. Metro

Impact of celebrity endorsements in disease-specific direct-to-consumer (DTC) advertisements, Brent L. Rollins and Nilesh Bhutada

A Pharmacy Business Management Simulation Exercise as a Practical Application of Business Management Material and Principles, Brent L. Rollins, Rahul Gunturi, and Donald Sullivan

Direct-to-Consumer Advertising of Predictive Genetic Tests: A Health Belief Model Based Examination of Consumer Response., Brent L. Rollins, Shravanan Ramakrishnan, and Matthew Perri

Measuring Community Participation of Adults with Psychiatric Disabilities: Reliability of Two Modes of Data Collection., Mark S. Salzer, Eugene Brusilovskiy, Janet Prvu-Bettger, and Petra Kottsieper

Patterns of Misrepresentation of Clinical Findings on Patient Notes during the COMLEX-USA Level 2-PE, Jeanne M. Sandella, Larissa A. Smith, Laurie A. Gallagher, and Erik E. Langenau

Use of Therapeutic Hypothermia in Cocaine-Induced Cardiac Arrest: Further Evidence, Dane Scantling, Emily Klonoski, and Dominic J. Valentino

Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia, Xiaoshen Sun, Zainul S. Hasanali, Allshine Chen, Dianzheng Zhang, Zin Liu, Hong Gang Wang, David J. Feith, Thomas P. Loughran Jr., and Kailin Xu

Vorapaxar: A Novel Antiplatelet Agent, Stephen Thompson, Carly Duncan, and Jennifer Andres

Cytoprotection of human endothelial cells against oxidative stress by 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im): Application of systems biology to understand the mechanism of action, Xinyu Wang, James A. Bynum, Solomon Stavchansky, and Phillip D. Bowman

Androgen therapy in women, Julie M. Wickman, Ashley Groves, Lauren Wiggins, and Nishman Patel


EgoNet: Identification of human disease ego-network modules, Rendong Yang, Yun Bai, Zhaohui Qin, and Tianwei Yu

A Research Primer, Part 2: Guidelines for Developing a Research Project, David P. Yens, Grace D. Brannan, and Jane Z. Dumsha

Steroid Receptor Coactivator-3 Regulates Glucose Metabolism in Bladder Cancer Cells through Coactivation of Hypoxia Inducible Factor 1α, Wei Zhao, Cunjie Chang, Yangyan Cui, Xiaozhi Zhao, Jun Yang, Lan Shen, Ji Zhou, Zhibo Hou, Zhen Zhang, Changxiao Ye, Donald Hasenmayer, Robert Perkins, Xiaojing Huang, Xin Yao, Like Yu, Ruimin Huang, Dianzheng Zhang, Hongqian Guo, and Jun Yan


Alternative splicing in the variable domain of CaMKIIβ affects the level of F-actin association in developing neurons., Jun Zheng, Lori R. Hardy, Chengshi Xu, Jing Kuang, and Weijing Liao

Submissions from 2013

Biomaterials, Christopher S. Adams

Gallbladder disease: Pathophysiology, diagnosis, and treatment, S. Afamefuna and Shari N. Allen

Treatment of depression in patients on anticoagulation therapy: Antidepressant-warfarin drug interactions, Shari N. Allen, Samuel John, Jennifer Shannon, and Jenna Ferrara

Movie Review: My left foot, Shari N. Allen and Mebanga Ojong

Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer, A. J. Armstrong, M. Haggman, W. M. Stadler, J. R. Gingrich, V. Assikiss, J. Polikoff, J. E. Damber, Laurence Belkoff, A. Nordle, and G. Forsberg

Basis for resveratrol's potential prevention and treatment of obesity osteoporosis, Clifton A. Baile, Mary Anne Della-Fera, and Srujana Rayalam


Analysis of autophagy and inflammasome regulation in neuronal cells and monocytes infected with Chlamydia pneumoniae: Implications for Alzheimer’s disease, Brian J. Balin, Christine J. Hammond, Juliana Zoga, Ahmad B. Cader, Annette K. Slutter, Jonathan M. Anzman, Ian Kohler, Susan T. Hingley, and Denah M. Appelt

Combination Pharmacotherapy in the Treatment of Pulmonary Arterial Hypertension, Kimberly L. Barefield and Gregory V. Stajich

A Comparative Study of Cervical Hysteresis Characteristics after Various Osteopathic Manipulative Treatment (OMT) Modalities, Precious Barnes, Francisco Laboy, Lauren Noto-Bell, Veronica Ferencz MBA, Jeffrey A. Nelson, and Michael L. Kuchera

An open-label, long-term evaluation of the safety, efficacy and tolerability of avanafil in male patients with mild to severe erectile dysfunction, Laurence Belkoff, A. McCullough, I. Goldstein, L. Jones, C. H. Bowden, K. Didonato, B. Trask, and W. W. Day

Assessing impact of not attending lectures on osteopathic medical student performance: Brief survey of the literature and proposed future research, Murray R. Berkowitz

High-Level Specification of a Proposed Information Architecture for Support of a Bioterrorism Early-Warning System, Murray R. Berkowitz

New graduate medical education opportunities found - and lost, Murray R. Berkowitz


Public Health Considerations of Launching Nuclear Waste to the Sun, Murray R. Berkowitz

Regulation of liver growth by glypican 3, CD81, hedgehog, and hhex, Vishakha Bhave, Wendy Mars, Shashikiran Donthamsetty, Xiyue Zhang, Langzhu Tan, Jianhua Luo, William C. Bowen, and George K. Michalopoulos

The Digitization of Historical Artifacts in a Hospital Library, Skye Bickett


What Factors Contribute to or Inhibit Publishing Among Medical Librarians, Skye Bickett, Christine Willis, and Melissa Wright

Expression of membrane anchored cytokines and B7-1 alters tumor microenvironment and induces protective antitumor immunity in a murine breast cancer model, Erica N. Bozeman, Ashley Cimino-Mathews, Deepa K. Machiah, Jaina M. Patel, Arun Krishnamoorthy, Linda Tien, Rangaiah Shashidharamurthya, and Periasamy Selvaraj

A research primer: Basic guidelines for the novice researcher, Grace D. Brannan, Jane Z. Dumsha, and David P. Yens

Defining Treatment Response and Remission in Child Anxiety: Signal Detection Analysis Using the Pediatric Anxiety Rating Scale, Nicole E. Caporino, Douglas M. Brodman, Philip C. Kendall, Anne Marie Albano, Joel Sherrill, John Piacentini, Dara Sakolsky, Boris Birmaher, Scott N. Compton, Golda Ginsburg, Moira Rynn, James McCracken, Elizabeth A. Gosch, Courtney Pierce Keeton, John March, and John T. Walkup


Chlamydia pneumoniae infection of neuronal cells induces changes in calcium-associated gene expression consistent with Alzheimer’s disease, Christopher Andrew Cappellini, Ahmad B. Cader, Keith G. Williams, Juliana Zoga, and Susan T. Hingley

Office-Based Pulsed-Dye Laser Surgery for Laryngeal Lesions: A Retrospective Review, Aaron Centric, Amanda Hu, Yolanda D. Heman-Ackah, Venu Divi, and Robert T. Sataloff

IL-4 Inhibition of IL-1 Induced Matrix Metalloproteinase-3 (MMP-3) Expression in Human Fibroblasts Involves Decreased AP-1 Activation Via Negative Crosstalk Involving of Jun N-Terminal Kinase (JNK), Mariah Chambers, Garrett Kirkpatrick, Michel Evans, Grzegorz Gorski, Sara Foster, and Ruth C. Borghaei

A Review of Tuberculosis: Focus on Bedaquiline, Bonnie Chan, Tina M. Khadem, and Jack Brown


Keratin gene expression profiles after digit amputation in C57BL/6 vs. regenerative MRL mice imply an early regenerative keratinocyte activated-like state, Chia-ho Cheng, John Leferovich, Xiangming Zhang, Khamilia Bedelbaeva, Dmitri Gourevitch, Cathy J. Hatcher, Craig T. Basson, Ellen Heber-Katz, and Kenneth A. Marx

Comparison of smallpox vs. HIV/AIDS eradication strategies, Annie Chung and Murray R. Berkowitz

Tingitanius tenuimandibulus, a new platyrhinid batoid from the Turonian (Cretaceous) of Morocco and the cretaceous radiation of the Platyrhinidae, Kerin M. Claeson, Charlie J. Underwood, and David J. Ward

The Therapeutic Relationship in Cognitive-Behavioral Therapy and Pharmacotherapy for Anxious Youth, Colleen M. Cummings, Nicole E. Caporino, Cara A. Settipani, Kendra L. Read, Scott N. Compton, John March, Joel Sherrill, John Piacentini, James McCracken, John T. Walkup, Golda Ginsburg, Anne Marie Albano, Moira Rynn, Boris Birmaher, Dara Sakolsky, Elizabeth A. Gosch, Courtney Pierce Keeton, and Philip C. Kendall

Specialty competencies in clinical psychology, Robert A. DiTomasso, Stacey C. Cahn, Susan Panichelli Mindel, and Roger K. McFillin

Primary care psychology, Robert A. DiTomasso, Barbara A. Golden, Stacey C. Cahn, and Amelia G. Gradwell

Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis, Shashikiran Donthamsetty, Vishakha Bhave, Wendy M. Mars, William C. Bowen, Anne Orr, Meagan M. Haynes, Chuanyue Wu, and George K. Michalopoulos

Moving beyond BAC in DUI: Identifying who is at risk of recidivating Dugosh, Festinger, and Marlowe DUI recidivism, K. Dugosh, David Festinger, and D. Marlowe

Overview of: "Moving beyond BAC in DUI: Identifying who is at risk of recidivating", K. Dugosh, David Festinger, and D. Marlowe

Potential roles of adenosine deaminase-2 in diabetic retinopathy, N. M. Elsherbiny, M. Naime, S. Ahmad, A. M. Elsherbini, S. Mohammad, S. Fulzele, A. B. El-Remessy, M. M. Al-Gayyar, Richard E. White, and et al.

Oral Anatomy Laboratory Examinations in a Physical Therapy Program, Philip A. Fabrizio

Initial Combination Therapy for Patients with Type 2 Diabetes Mellitus: Considerations for Metformin Plus Linagliptin, Jeffrey S. Freeman

Review of Insulin-Dependent and Insulin-Independent Agents for Treating Patients with Type 2 Diabetes Mellitus and Potential Role for Sodium-Glucose Co-Transporter 2 Inhibitors, Jeffrey S. Freeman

Review of insulin-dependent and insulin-independent agents for treating patients with type-2 Diabetes Mellitus and potential role for sodium-glucose co-transporter 2 inhibitors, Jeffrey S. Freeman

Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists, Thota Ganesh, Jianxiong Jiang, Rangaiah Shashidharamurthy, and Ray Dingledine