The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2011

Sacroiliac joint sparing in a patient with ankylosing spondylitis - An osteopathic approach, Joy Ishii, W. C. Ehrenfeuchter, K. M. Olds, and Murray R. Berkowitz

Eruptive Kaposi Sarcoma: An Unusual Presentation in an HIV-Negative Patient, Mollie M. Jan, Joseph W. Laskas, and Thomas D. Griffin


Vancomycin Bonded to Bone Grafts Prevents Bacterial Colonization, Constantinos Ketonis, Stephanie Barr, Christopher S. Adams, Irving M. Shapiro, Javad Parvizi, and Noreen J. Hickok


Antibacterial Activity of Bone Allografts: Comparison of a New Vancomycin-Tethered Allograft with Allograft Loaded with Adsorbed Vancomycin, Constantinos Ketonis, Stephanie Barr, Irving M. Shapiro, Javad Parvizi, Christopher S. Adams, and Noreen J. Hickok

Anticancer activities of Nigella sativa (Black Cumin), Md. Asaduzzaman Khan, Hanchun Chen, Mousumi Tania, and Dianzheng Zhang

Medicinal chemistry and the pharmacy curriculum., M O Faruk Khan, Michael J. Deimling, and Ashok Philip

Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals, Chingyi Lai, Jeongyeh Yang, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Richard D. Lewis, Mark W. Hamrick, Diane L. Hartzell, and Clifton A. Baile

Infantile Melanoma-A Triple Threat: Diagnosis and Management, Milena Lambie, Chad Nadler, Paul Glat, Scott Van Duzer, Gregory Halligan, and Evan Geller

A Computational Framework for Proteome-Wide Pursuit and Prediction of Metalloproteins Using ICP-MS and MS/MS Data, W. Andrew Lancaster, Jeremy L. Praissman, Farris L. Poole, Aleksandar Cvetkovic, Angeli Lal Menon, Joseph W. Scott, Francis E. Jenney, Michael P. Thorgersen, Ewa Kalisiak, Junefredo V. Apon, Sunia A. Trauger, Gary Siuzdak, John A. Tainer, and Michael W. W. Adams

Relationship between standardized patient checklist item accuracy and performing arts experience, E. E. Langenau, D. J. Dowling, C. Dyer, and W. L. Roberts

The challenges for physicians of demonstrating continuing competence in the changing world of medical regulation: Osteopathic pediatrician case report, E. E. Langenau and J. R. Gimpel

Competency-based classification of COMLEX-USA cognitive examination test items, E. E. Langenau, G. Pugliano, and W. Roberts


Relationships Between High-Stakes Clinical Skills Exam Scores and Program Director Global Competency Ratings of First-Year Pediatric Residents, E. E. Langenau, G. Pugliano, and W. L. Roberts

Pass/fail patterns of candidates who failed COMLEX-USA level 2-PE because of misrepresentation of clinical findings on postencounter notes, E. E. Langenau and J. M. Sandella

How soon can I play after a concussion?, Kate Laramie and Gretchen Fox


Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse, Sanford Levine, Chhanda Biswas, Jamil Dierov, Robert J. Barsotti, Joseph B. Shrager, Taitan Nguyen, Seema Sonnad, John C. Kucharchzuk, Larry R. Kaiser, Sunil Singhal, and Murat T. Budak

Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse, S. Levine, C. Biswas, J. Dierov, Robert J. Barsotti, J. B. Shrager, T. Nguyen, S. Sonnad, J. C. Kucharchzuk, L. R. Kaiser, and


HElp3 directly modulates the expression of HSP70 gene in HeLa cells via HAT activity, Fen Li, Jixian Ma, Yu Ma, Yanyan Hu, Shuhuan Tian, Richard E. White, and Guichun Han

Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice, Chihwen Lin, Wendy M. Mars, Shirish Paranjpe, Shashikiran Donthamsetty, Vishakha Bhave, Liangi Kang, Anne Orr, William C. Bowen, Aaron W. Bell, and George K. Michalopoulos

Natural competence in the hyperthermophilic archaeon Pyrococcus furiosus facilitates genetic manipulation: Construction of markerless deletions of genes encoding the two cytoplasmic hydrogenases, G. L. Lipscomb, K. Stirrett, G. J. Schut, F. Yang, Francis E. Jenney Jr., R. A. Scott, M. W. Adams, and J. Westpheling

Identification of Heptapeptides Interacting with IFN-α-Sensitive CML cells, Jia Liu, Hanchun Chen, Zhou-zhou Rao, Md. Asaduzzaman Khan, Xin-Xing Wan, Ai-hua Xu, Nuo Zhang, and Dianzheng Zhang

Genetic Polymorphisms of Metabolic Enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and Gastric Carcinoma Susceptibility, Ya-Ping Luo, Hanchun Chen, Md. Asaduzzaman Khan, Fang-Zhi Chen, Xin-Xing Wan, Bo Tan, Fang-Dan Ou-Yang, and Dianzheng Zhang

Targeting dispositions for drug-involved offenders: A field trial of the Risk and Needs Triage (RANT)â„¢, D. Marlowe, David Festinger, and K. Dugosh

Matching consequences to behavior: Implications of failing to distinguish between noncompliance and nonresponsivity, J. Matejkowski, David Festinger, L. Benishek, and K. Dugosh

Feeding Mechanics and Dietary Implications in the Fossil Sloth Neocnus (Mammalia: Xenarthra: Megalonychidae) from Haiti, Robert McAfee

Rehabilitation of the Pelvis and the Sacroiliac Joint, Darren McAuley

Applying a multilevel interpretive framework with an emphasis on the assessment of executive functions, George McCloskey

Evaluating students with emotional and behavioral concerns, Barry L. McCurdy, Amanda L. Lannie, and Jennifer L. Jeffrey-Pearsall

Neuropsychology of auditory processing disorders, Mark R. McGowan, George McCloskey, Art Maerlender, and James Whitaker

Human-Specific Loss of Regulatory DNA and the Evolution of Human-Specific Traits, Cory Y McLean, Philip L. Reno, Alex A Pollen, Abraham I Bassan, Terence D Capellini, Catherine Guenther, Vahan B Indjeian, Xinhong Lim, Douglas B Menke, Bruce T Schaar, Aaron M Wenger, Gill Bejerano, and David M Kingsley

Detection, advice, and referral to services (DARTS) procedures among clients with public defenders, A Mericle, S. Belenko, and David Festinger

Dynamics of the [4Fe-4S] cluster in pyrococcus furiosus D14C ferredoxin via nuclear resonance vibrational and resonance raman spectroscopies, force field simulations, and density functional theory calculations, D. Mitra, V. Pelmenschikov, Y. Guo, D. A. Case, H. Wang, W. Dong, M. Tan, T. Ichiye, Francis E. Jenney Jr., and et al.


SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA, Heather L. Montie, Richard G. Pestell, and Diane E. Merry

Calcium/calmodulin-dependent protein kinase IV mediates distinct features of basal and activity-dependent dendrite complexity, T. Nagendran and Lori Redmond Hardy

Neurologically intact lumbar spine displaced fracture with ankylosing spondylitis, S. N. Patel, A. Turtz, A. Dixon, and Steven S. Yocom

Neurologically intact lumbar spine displaced fracture with ankylosing spondylitis, S. N. Patel, A. Turtz, A. Dixon, and Steven S. Yocom

Efficacy of a Methylphenidate Transdermal System Versus t.i.d. Methylphenidate in a Laboratory Setting, W. E. Pelham, J. G. Waxmonsky, J. Schentag, C. H. Ballow, C. J. Panahon, Elizabeth M. Gnagy, M. T. Hoffman, L. Burrows-MacLean, Katy E. Tresco, and et al.

IUD Use in HIV-Positive Women, Sheila M. Quinn and Courtney M. Schreiber

Assessment of Psychiatric Status and Personality Qualities, J. R. Ramsay, Bradley M. Rosenfield, and L. H. Harris

Synergism between resveratrol and other phytochemicals: Implications for obesity and osteoporosis, Srujana Rayalam, Mary Anne Della-Fera, and Clifton A. Baile

Emerging role of apelin as a therapeutic target in cancer: A patent review, Srujana Rayalam, Mary Anne Della-Fera, Thomas Kasser, William Warren, and Clifton A. Baile

Novel molecular targets for prevention of obesity and osteoporosis, Srujana Rayalam, Jeongyeh Yang, Mary Anne Della-Fera, and Clifton A. Baile


Gestational Diabetes Clinic for Indigent Latinos, Sara Wilson Reece

Gestational Diabetes Clinic in the Public Health Setting, Sara Wilson Reece

An investigation of construct validity of humanistic clinical skills on a medical licensure examination, W. L. Roberts, M. Solomon, and E. E. Langenau

Nonbranded or Branded Direct-to-Consumer Prescription Drug Advertising-Which is More Effective?, Brent L. Rollins, Karen King, George Zinkhan, and Matthew Perri

Estrogen signaling in microvascular arteries: Parturition reduces vasodilation by reducing 17ß-estradiol and nNOS, Crista R. Royal, Handong Ma, Richard Walker, and Richard E. White

Relationship between encounter time and candidate performance on COMLEX-USA level 2-PE, J. M. Sandella, W. L. Roberts, and E. E. Langenau

Osteopathic Manipulative Treatment of Isolated Chronic Sphenoidal Sinusitis in a Post-sinus Surgery Patient: A Case Report, Rani Shah and Murray R. Berkowitz

Making a career of school psychology, Diane Smallwood and Leigh D. Armistead

Shortness of breath and chest pain worsened by fruits and vegetables, Carrie S. Smith PA-C, Sara Haddow, and Carrie Nold

CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity, Brandon Stauffer, Kathleen Wallis, Steven Wilson, Michaela Egertovac, Maurice R. Elphick, Deborah L. Lewis, and Lori Redmond Hardy

Contemporary Interventions to Prevent and Reduce Community Violence Among African American Youth, Duane E. Thomas, Elizabeth M. Woodburn, Celine I. Thompson, and Stephen S. Leff

Building competency in cross-cultural school psychology, Yuma I. Tomes

Cultural Considerations in Educational Training: a look at Multicultural Learning Modules, Yuma Iannotti Tomes

Expression of GPR30, ERα and ERß in endometrium during window of implantation in patients with polycystic ovary syndrome: A pilot study, Aiming Wang, Lijuan Ji, Wei Shang, Min Li, Lei Chan, Richard E. White, and Guichun Han

ED Procedural Sedation of Elderly Patients: Is It Safe?, Christopher S Weaver, Kevin M Terrell, Robert A. Bassett, William Swiler, Beth Sandford, Sara Avery, and Anthony J Perkins

Management Strategies for Acne Vulgaris, Kristen M. Whitney and Chérie M. Ditre

Axonal localization of transgene mRNA in mature PNS and CNS neurons, D. E. Willis, Mei Xu, C. J. Donnelly, C. Tep, M. Kendall, and et al.

Paget disease of bone in a Jurassic dinosaur, Florian Witzmann, Kerin M. Claeson, Oliver Hampe, Frank Wieder, Andre Hilger, Ingo Manke, Manuel Niederhagen, Bruce M. Rothschild, and Patrick Asbach

Preclinical pharmacokinetics and metabolism of MNP001, a piperidine analog of 3-carbamyl compounds, Binfeng Xia, Desuo Wang, and Laura M. Fox

Analytical methods for heavy metals in herbal medicines, Xudong Yuan, Robert L. Chapman, and Zhiqian Wu

Recent advances of siRNA delivery by nanoparticles, Xudong Yuan, Sandy Naguib, and Zhiqian Wu


Capturing changes in gene expression dynamics by gene set differential coordination analysis, Tianwei Yu and Yun Bai


Improving gene expression data interpretation by finding latent factors that co-regulate gene modules with clinical factors, Tianwei Yu and Yun Bai

Activation of G protein-coupled estrogen receptor induces endotheliumindependent relaxation of coronary artery smooth muscle, Xuan Yu, Handong Ma, Scott A. Barman, Alexander T. Liu, Minga Sellers, John N. Stallone, Eric R. Prossnitz, Richard E. White, and Guichun Han


Bone Cell Autophagy is Regulated by Environmental Factors, Adam M. Zahm, Jolene Bohensky, Christopher S. Adams, Irving M. Shapiro, and Vickram Srinivas

Submissions from 2010

Central leptin versus ghrelin: Effects on bone marrow adiposity and gene expression, Suresh Ambati, Qiang Li, Srujana Rayalam, Diane L. Hartzell, Mary Anne Della-Fera, Mark W. Hamrick, and Clifton A. Baile

Phytochemicals and adipogenesis, Charlotte Andersen, Srujana Rayalam, Mary Anne Della-Fera, and Clifton A. Baile

Admitting allopathic physicians to osteopathic graduate medical education programs: The case for competency-based NMM/OMM training in OGME, Murray R. Berkowitz

Admitting international osteopathic physicians and osteopaths to osteopathic graduate medical education programs, Murray R. Berkowitz

Evidence does not grow stale with age, Murray R. Berkowitz

Holistic osteopathic approach reveals unusual etiology for vertigo with co-morbid headache: A case report, Murray R. Berkowitz

On the role of the glossary, Murray R. Berkowitz

Cancer vaccine development: Designing tumor cells for greater immunogenicity, Erica N. Bozeman, Rangaiah Shashidharamurthy, Simon A; Paulos, Ravi D. Palaniappan, Martin D'Souza, and Periasamy Selvaraj

Malignant Fibrous Histiocytoma of the Mandible, Lana E. Brahmakulam and Bosco E. Noronha

Eating disorders in primary care: Assessment and treatment., Stacey C. Cahn and R. McFillin

The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion, Qian Chen, Elizabeth Eun Jung Kim, Katrina Elio, Christopher Zambrano, Samuel Krass, Jane Chun-Wen Teng, Helen Kay, Kerry-Anne Perkins, Sailesh Pershad, Sloane McGraw, Jeffrey Emrich, Jovan S. Adams, and Lindon H. Young

The potential clinical application of protein kinase C beta II peptide inhibitor or Gö 6983 in vascular endothelial dysfunction, Qian Chen, Brian Rueter, Samuel Krass, Christopher Zambrano, Shawn Thomas, Catherine Prince, Brandon Bell, Vincent Chai, Jeffery Emrich, and Lindon Young

Design of an in vivo cleavable disulfide linker in recombinant fusion proteins, Xiaoying Chen, Yun Bai, Jennifer L. Zaro, and Wei-Chiang Shen

Norepinephrine Induces Systolic Failure and Inhibits Antiapoptotic Genes in a Polymicrobial Septic Rat Model, Mani Chopra, Padmalaya Das, Honey Golden, David E. Dostal, Linley E. Watson, and Avadhesh C. Sharma

Caspase-3 Knock-Down Reverses Contractile Dysfunction Induced by Sepsis in Adult Rat Ventricular Myocytes, Mani Chopra, Padmalaya Das, and Avadhesh C. Sharma

Norepinephrine induces systolic failure and inhibits antiapoptotic genes in a polymicrobial septic rat model, M. Chopra, P. Das, H. Golden, D. E. Dostal, L. E. Watson, and Avadhesh C. Sharma

Caspase-3 knock-down reverses contractile dysfunction induced by sepsis in adult rat ventricular myocytes, M. Chopra, P. Das, and Avadhesh C. Sharma

To the point: Reviews in medical education- taking control of the hidden curriculum, A W. Chuang, F. Nuthalapty, P. M. Casey, Joseph M. Kaczmarczyk, A. J. Cullimore, J. L. Dalrymple, L. Dugoff, E. L. Espey, and M. Hammoud


First Mesozoic record of the stingray myliobatis wurnoensis from Mali and a phylogenetic analysis of myliobatidae incorporating dental characters, Kerin M. Claeson, Maureen A. O'Leary, Eric M. Roberts, Famory Sissoko, Mamadou Bouare, Leif Tapanila, David Goodwin, and Michael D. Gottfried

3D digital imaging of a concretion-preserved batoid (Chondrichthyes, Elasmobranchii) from the Turonian (Upper Cretaceous) of Morocco, Kerin M. Claeson, David J. Ward, and Charlie J. Underwood

The consultation process in primary care, Travis A. Cos; Robert A. DiTomasso; Carla Cirilli; and Larry H, Finkelstein

Microbial Metalloproteomes Are Largely Uncharacterized, Aleksandar Cvetkovic, Angeli Lal Menon, Michael P. Thorgersen, Joseph W. Scott, Farris L. Poole, Francis E. Jenney, W. Andrew Lancaster, Jeremy L. Praissman, Saratchandra Shanmukh, Brian J. Vaccaro, Sunia A. Trauger, Ewa Kalisiak, Junefredo V. Apon, Gary Siuzdak, Steven M. Yannone, John A. Tainer, and Michael W. W. Adams

Type 2 diabetes, Robert A. DiTomasso, Patrick D. Boyle, Larry H. Finkelstein, and Harry J. Morris

Evidence-based models and interventions in primary care, Robert A. DiTomasso, Stacey C. Cahn, Carla Cirilli, and Eugene Mochan

Essential hypertension, Robert A. DiTomasso, Deborah Chiumento, and Harry J. Morris

Nonadherence in primary care, Robert A. DiTomasso, Deborah Chiumento, Marsha S. Singer, and Oliver Bullock

Cognitive-behavioral concepts of anxiety, Robert A. DiTomasso, Arthur Freeman, Raymond Carvajal, and Bruce Zahn


Conclusion: The future of cognitive-behavioral approaches in primary care, Robert A. DiTomasso, Barbara A. Golden, and Harry J. Morris

Handbook of cognitive behavioral approaches in primary care, Robert A. DiTomasso, Barbara A. Golden, and Harry J. Morris

Primary care: The biopsychosocial model and cognitive-behavioral approaches, Robert A. DiTomasso, Barbara A. Golden, Harry J. Morris, and Deborah Chiumento

The cognitive-behavioral clinician: Roles and functions and ethical challenges in primary care, Robert A. DiTomasso, Samuel Knapp, Barbara A. Golden, Harry J. Morris, and Kenneth J. Veit

Psychological Morbidity in ALS: The Importance of Psychological Assessment Beyond Depression Alone, Stephanie H. Felgoise, Beatrice H. Chakraborty, Elisabeth Bond, Jamie Rodriguez, Barbara A. Bremer, Susan M. Walsh, Eugene C. Lai, Leo McCluskey, and Zachary Simmons

Corrected feedback: A procedure to enhance recall of informed consent to research among substance abusing offenders, David Festinger, K. Dugosh, J. Croft, P. Arabia, and D. Marlowe