Failure to Improve a Thin Endometrium in the Late Proliferative Phase with Uterine Infusion of Granulocyte-Colony Stimulating Factor

Document Type

Article

Publication Date

1-1-2014

Abstract

PURPOSE: To determine if the treatment with uterine infusion of granulocyte colony-stimulating factor (G-CSF) can improve endometrial thickness in an infertile woman with a double uterus, who consistently showed a thin endometrium in the late proliferative phase either in controlled ovarian hyperstimulation (COH) IVF-ET cycles or with graduated estrogen/sildenafil protocols for frozen embryo transfer (ET).

MATERIALS AND METHODS: A single uterine infusion of G-CSF was performed in the late proliferative phase in a woman who only attained a five-mm thickness despite a high dose vaginal and oral estradiol regimen plus sildenafil.

RESULTS: No increase was found within a couple days.

CONCLUSIONS: A previous four-case study in another center found 100% improvement in the endometrial thickness in women with consistently thin endometria. Perhaps the uterine anomaly in the present case prevented the response of the endometrium.

Publication Title

Clinical and Experimental Obstetrics & Gynecology

Volume

41

Issue

4

First Page

473

Last Page

475

PubMed ID

25134304

Comments

This article was published in Clinical and Experimental Obstetrics & Gynecology, Volume 41, Issue 4, August 2014, Pages 473-5.

Copyright © 2014 - 7847050 CANADA Inc.

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