The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.


Submissions from 2012

Use of the Anti-Inflammatory Cytokine Interleukin-11 to Reverse HIV-1gp120 Repression of a Natural Killer Cell Line, Sheena E. Favors, Lindsay M. Curd, and Randal K. Gregg

Improving the informed consent process in research with substance-abusing participants, David Festinger and K. Dugosh

Paying substance abusers in research studies: Where does the money go?, David Festinger and K. Dugosh

Denial of Prescription Opioids Among Young Adults with Histories of Opioid Misuse, Meghan Fibbi, Karol Silva, Kristen Johnson, Debra Langer, and Stephen E. Lankenau

Improving Glucagon-Like Peptide-1 Dynamics in Patients with Type 2 Diabetes Mellitus, Jeffrey S. Freeman

Common Patient Concerns about the Use of Glucagon-Like Peptide-1 Receptor Agonists in Diabetes Mellitus Management, Jeffrey S. Freeman, James R. Gavin, and Craig W. Spellman

Potential Drug Interactions Associated with Treatments for Type 2 Diabetes and its Comorbidities: A Clinical Pharmacology Review, Jeffrey S. Freeman and Benjamin Gross

What Have We Learned about the Treatment of Type 2 Diabetes? The Evolving Paradigms, Jeffrey S. Freeman and Edward S. Horton

Osteopathy and Swedenborg: The Influence of Emanuel Swedenborg on the Genesis and Development of Osteopathy, Specifically on Andrew Taylor Still and William Garner Sutherland, David B. Fuller

Myo/Nog cells in normal, wounded and tumor-bearing skin, Jacquelyn Gerhart, C. Hayes, V. Scheinfeld, M. Chernick, Mindy George-Weinstein, and S. Gilmour

Can schools train students as well as the Navy trains pilots?, Frederick J. Goldstein

Avanafil for the treatment of erectile dysfunction: A multicenter, randomized, double-blind study in men with diabetes mellitus, I. Goldstein, L. A. Jones, Laurence Belkoff, G. S. Karlin, C. H. Bowden, and C. A. Peterson

Don't Quit on a Quitter: Helping Your Patient Stop Smoking, Sean Guinane

Fluorescence Recovery after Photobleaching (FRAP) with a Focus on F-Actin, Lori R. Hardy

Cents and Sensibility: Understanding the numbers, Keith N. Herist and Brent Rollins

Personal Finance, Keith N. Herist and Brent Rollins

Engineering approaches for investigating tumor angiogenesis: Exploiting the role of the extracellular matrix, Abigail Hielscher and Sharon Gerecht

Breast cancer cell-derived matrix supports vascular morphogenesis, Abigail Hielscher, Connie Qiu, and Sharon Gerecht

Shoulder Injuries in the Throwing Athlete, Jason J. Jancosko and Jack E. Kazanjian

Frequency of specific osteopathic manipulative treatment modalities used by candidates while taking COMLEX-USA Level 2-PE, E. E. Langenau, D. J. Dowling, C. Dyer, and W. L. Roberts

Fairness to students top priority, E. E. Langenau, J. Sandella, and J. R. Gimpel


Clinical Skills Assessment of Procedural and Advanced Communication Skills: Performance Expectations of Residency Program Directors., E. E. Langenau, X. Zhang, W. L. Roberts, A. F. DeChamplain, and J. R. Boulet


Reducing the Stigma of Mental Illness Among Medical Students, Victoria Lawn, Matthew Jaffa, Catherine Babbitt-Cook, Burton Mark, Jane Dumsha, Marcus G. Bell, and Denah M. Appelt

LEGO-based play therapy for improving social competence in children and adolescents with Autism spectrum disorders, Daniel B. Legoff, G. W. Krauss, and Sarah Levin Allen


Genome-Wide Expression Analysis in Down Syndrome: Insight into Immunodeficiency, Chong Li, Lei Jin, Yun Bai, Qimin Chen, Lijun Fu, Minjun Yang, Huasheng Xiao, Guoping Zhao, and Shengyue Wang

Holistic osteopathic approach to the care of veterans with post-traumatic stress disorder: Case report, Andrew Lovy and Murray R. Berkowitz

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema, Rudolf Lucas, Supriya Sridhar, Ferenc Rick, Boris Gorshkov, Nagavedy S. Umapathy, Richard E. White, and et al.

Clipping of Distal Superior Cerebellar Artery Aneurysm with Preservation of the Parent Vessel: A Case Report, Leslie Lyness and Amir R. Dehdashti

Biomarkers and neuroimaging techniques to detect blast-induced traumatic brain injury (bTBI), Patrick M. Malie and Murray R. Berkowitz

Clinical management and multipotential treatment strategies for blast-induced traumatic brain injury (bTBI), Patrick M. Malie and Murray R. Berkowitz

Understanding blast-induced traumatic brain injury (bTBI) through mechanisms and patterns of injury, Patrick M. Malie, M. Q. Sonnier Jr., and Murray R. Berkowitz

Adaptive Programming Improves Outcomes in Drug Court: An Experimental Trial, D. Marlowe, David Festinger, K. Dugosh, K. Benasutti, and J. Croft

Notice on the Ocurrence of Supernumerary Teeth in the Two-toad Sloths Choloepus didactylus and C. hoffmanni, Robert McAfee

Essentials of Executive Functions Assessment, George McCloskey and Lisa A. Perkins

Intellectual, cognitive, and neuropsychological assessment in three-tier service delivery systems in schools, George McCloskey, James Whitaker, Ryan Murphy, and James Rogers

Social Information-Processing and Coping in Adolescent Females Diagnosed with an Eating Disorder: Toward a Greater Understanding of Control, Roger K. McFillin, Stacey C. Cahn, Virginia Salzer Burks, Martha Peaslee Levine, Susan Lane Loney, and Richard L. Levine

Prosthetic Management for the Older Adult with Lower Limb Amputation, Carol A. Miller

Using the Nintendo Wii Fit and Body Weight Support to Improve Aerobic Capacity, Balance, Gait Ability, and Fear of Falling: Two Case Reports, Carol A. Miller, Dawn M. Hayes, Kelli Dye, Courtney Johnson, and Jennifer Meyers

Estrogens, inflammation and obesity: An overview, Colette N. Miller, Lynda M. Brown, Srujana Rayalam, Mary Anne Della-Fera, and Clifton A. Baile

Managing Chronic Plantar Fasciitis: When Conservative Strategies Fail, Laura A. Molloy

Reconstruction of the Cranial Musculature and Masticatory Function of the Pleistocene Panamerican Ground Sloth Eremotherium Laurillardi (Mammalia, Xenarthra, Megatheriidae), Virginia L. Naples and Robert McAfee

Correlation of factor IXa subsite modulations with effects on substrate discrimination, P. F. Neuenschwander, Kimberly J. Baker, K. Zepeda, and J. Rutland

Atlas of Osteopathic Techniques, Alexander S. Nicholas and Evan A. Nicholas

To the point: A primer on medical education research, F. S. Nuthalapty, P. M. Casey, A. J. Cullimore, L. Dugoff, J. F. Abbott, A. W. Chuang, J. L. Dalrymple, N. A. Hueppchen, Joseph M. Kaczmarczyk, and et al.

Modifying an evidence-based summer treatment program for use in a summer school setting: A pilot effectiveness evaluation, Briannon C. O'Connor, Katy E. Tresco, William E. J. R. Pelham, Daniel A. Waschbusch, Elizabeth M. Gnagy, and Andrew R. Greiner

Treatment of depression in patients with epilepsy, Mebanga Ojong and Shari N. Allen

Isolated calcaneofibular ligament injuries treated with osteopathic manipulative treatment: A case series, Kristie M. Olds and Murray R. Berkowitz

Total Knee Arthroplasty in a Patient with Skeletal Fluorosis, Mark Paiste, Mathew Levine, and James V. Bono

Therapeutic Effect of Hyperbaric Oxygen on Inclusion Body Myositis, Max Pell, Poovendran Saththasivam, Peter L. Stephens, and George Mychaskiw

The Effects of Modulating eNOS Activity and Coupling in Ischemia/Reperfusion (I/R), Kerry-Anne Perkins, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan S Adams, Christopher Zambrano, Samuel Krass, Jeffrey Emrich, Brandon Bell, Michael Lyamu, Catherine Prince, Helen Kay, Jane Chun-wen Teng, and Lindon H. Young


Insulin Pump School: Back to the Basics of Pump Therapy, Sara Wilson Reece and Cheryl Williams

Modeling relationships between traditional preadmission measures and clinical skills performance on a medical licensure examination, W. L. Roberts, G. Pugliano, E. E. Langenau, and J. R. Boulet

An Evaluation of Cost and Appropriateness of Care as Recommended by Candidates on a National Clinical Skills Examination, J. Sandella, J. R. Boulet, and E. E. Langenau

Pegloticase: A Novel Agent for Treatment-Refractory Gout, Jennifer A. Shannon and Sabrina W. Cole

Statin-associated myopathy, Jennifer Shannon, Samuel John, Jenna Ferrara, Sylvia Best, and Shari N. Allen

Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development, Rangaiah Shashidharamurthy, Erica N. Bozeman, Jaina Patel, Ramneet Kaur, Jayendra Meganathan, and Periasamy Selvaraj

Hydrodynamic delivery of plasmid DNA encoding human FcYR-Ig dimers blocks immune-complex mediated inflammation in mice, Rangaiah Shashidharamurthy, D. Machiah, Erica N. Bozeman, S. Srivatsan, J. Patel, A. Cho, J. Jacob, and Periasamy Selvaraj

Atraumatic Acute Carpal Tunnel Syndrome in a Patient Taking Dabigatran, Paul A. Sibley and Richard J. Mandel

Osteopathic manipulative treatment (OMT) during labor facilitates a natural, drug-free childbirth for a primigravida patient: A case report, Carolyn R. Smallwood, C. J. Borgerding, M. S. Cox, and Murray R. Berkowitz

A collaborative approach to myasthenia gravis, Carrie Smith PA-C, David Stickler, and Carrie Nold

Blast-induced mild traumatic brain injury as etiology of post-traumatic stress disorder in military veterans, M. Q. Sonnier Jr. and Murray R. Berkowitz

Blast-induced mild traumatic brain injury as etiology of post-traumatic stress disorder in military veterans, M. Q. Sonnier Jr. and Murray R. Berkowitz

Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis, Gayathri Srinivasan, Jesse D. Aitken, Benyue Zhang, Frederic A. Carvalho, Benoit Chassaing, Rangaiah Shashidharamurthy, Niels Borregaard, Dean P. Jones, Andrew T. Gewirtz, and Matam Vijay-Kumar

The preformulation stability studies of a proline prodrug of methotrexate, Ann Stephenson, Zhiqian Wu, and Xudong Yuan


NLRP3 Inflammasome is a Target for Development of Broad-Spectrum Anti-Infective Drugs, James D. Thacker, Brian J. Balin, Denah M. Appelt, Sihem Sassi-Gaha, Mitali Purohit, Richard F. Rest, and Carol M. Artlett

On researching the agency of youth: Moving beyond traditional theorizing. Commentary on Nsamenang, Celine I. Thompson

In vivo iontophoretic delivery of salmon calcitonin across microporated skin, Viswatej Vemulapalli, Yun Bai, Haripriya Kalluri, Anushree Herwadkar, Hyun Kim, Shawn P. Davis, Phil M. Fridin, and Ajay K. Banga

Streamlining Undergraduate Medical Education: Something We Should Have Discussed Decades Ago, Mark Vila

The West Virginia Prescription Drug Abuse Quitline: Challenges and Lessons Learned from Running a Remote Quitline, Rebecca J. White, Keith J. Zullig, Laura Lander, Clara Shockley, Robert Pack, and Carl Sullivan

Cooperative roles of BDNF expression in neurons and schwann cells are modulated by exercise to facilitate nerve regeneration, J. C. Wilhelm, Mei Xu, D. Cucoranu, S. Chmielewski, T. Holmes, K. S. Lau, G. J. Bassell, and A. W. English


Cooperative Roles of BDNF Expression in Neurons and Schwann Cells are Modulated by Exercise to Facilitate Nerve Regeneration, Jennifer C. Wilhelm, Mei Xu, Delia Cucoranu, Sarah E. Chmielewski, Tiffany M. Holmes, Kelly S. Lau, Gary J. Bassell, and Arthur W. English

Non-Invasive Ventilation and Gastrostomy May Not Impact Overall Quality of Life in Patients with ALS, Kristen Zamietra, Erik B. Lehman, Stephanie H. Felgoise, Susan M. Walsh, Helen E. Stephens, and Zachary Simmons

Non-invasive ventilation and gastrostomy may not impact overall quality of life in patients with ALS, Kristen Zamietra, Erik B. Lehman, Stephanie S. Felgoise, Helen E. Stephens, and Zachary Simmons

Allergic reaction to peripheral nerve stimulator, L. Zhou, A. Lee, R. Schaffner, and Gerald E. Dworkin

Submissions from 2011

Oseltamivir use in psychiatric inpatients taking clozapine: effect on neuropsychiatric events, Shari N. Allen, Tammie Lee Demler, Eileen Trigoboff, and Lewis A. Opler

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of a7*nAChR function, Tanguy Araud, Sharon Graw, Ralph Berger, Michael Lee, Estele Neveu, Daniel Bertrand, and Sherry Leonard

Effect of resveratrol on fat mobilization, Clifton A. Baile, Jeongyeh Yang, Srujana Rayalam, Diane L. Hartzell, Chingyi Lai, Charlotte Andersen, and Mary Anne Della-Fera


Evidence for an Infectious Etiology in Alzheimer's Disease, Brian J. Balin PhD, Christine Hammond, C. Scott Little PhD, Denah Appelt, and Susan Hingley


Analysis of Chlamydia pneumoniae-infected monocytes following incubation with a novel peptide, acALY18, implicates the inflammasome in clearance of infection, Brian J. Balin, James D. Thacker, Charles Lim, Corey M. Caruthers, Susan T. Hingley, Juliana Zoga, and Denah M. Appelt

Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice, Shoshana M. Bartell, Srujana Rayalam, Suresh Ambati, Dhanunjaya Gaddam, Diane L. Hartzell, Mark Hamrick, Jinxiong She, Mary Anne Della-Fera, and Clifton A. Baile


Analysis of Chlamydia pneumoniae and AD-like Pathology in the Brains of BALB/c Mice Following Direct Intra-cranial Infection, Jessica Rachel Barton, Christine J. Hammond, Amy L. Brady, Denah M. Appelt, Brian J. Balin, and Christopher Scott Little

MRSA Otorrhea: A Case Series and Review of the Literature, Katherine M. Baugher, Troy Sommers Hemme, Mary Hawkshaw, and Robert T. Sataloff

Flawed science is not evidence-based osteopathic medicine, Murray R. Berkowitz

Increasing the number of osteopathic graduate medical education programs-"The time has come", Murray R. Berkowitz

Osteopathic scholarship, research and publication, Murray R. Berkowitz

Bipolar Affective Disorder in Young People: A Review, Bettina Bernstein

Secretory phospholipase A 2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2, Vishakha Bhave, Shashikiran Donthamsetty, John R. Latendresse, Michael L. Cunningham, and Harihara M. Mehendale

Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo, Vishakha Bhave, Shirish Paranjpe, William C. Bowen, Shashikiran Donthamsetty, Aaron W. Bell, Jaspal S. Khillan, and George K. Michalopoulos

A novel microparticulate vaccine for melanoma cancer using transdermal delivery, Tuhin Bhowmik, Bernadette D'Souza, Rangaiah Shashidharamurthy, Carl Oettinger, Periasamy Selvaraj, and Martin D'Souza

RhoB Deficiency in Thymic Medullary Epithelium Leads to Early Thymic Atrophy, Arturo Bravo Nuevo, Rebekah O'Donnell, Alexander Rosendahl, Jae Hoon Chung, Laura E Benjamin, and Chikako Odaka

RhoB Loss Prevents Streptozotocin-induced Diabetes and Ameliorates Diabetic Complications in Mice, Arturo Bravo Nuevo, Hikaru Sugimoto, Seema Iyer, Zachary Fallon, Jason M Lucas, Shiva Kazerounian, George C Prendergast, Raghu Kalluri, Nathan I Shapiro, and Laura E Benjamin

Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China, Hanchun Chen, H. Chen, Md. Asaduzzaman Khan, Zhouzhou Rao, Xinxing Wan, Bo Tan, and Dianzheng Zhang

Osteopathic approach to a patient with chronic fatigue syndrome, Anne Chong and Murray R. Berkowitz


Modulation of Myocardial Mitochondrial Mechanisms during severe Polymicrobial Sepsis in the Rat, M. Chopra, H. B. Golden, S. Mullapudi, W. Dowhan, D. E. Dostal, and Avadhesh C. Sharma

Mechanisms involved in apoptosis events contributing to sepsis-induced myocardial dysfunction, M. Chopra and Avadhesh C. Sharma

The synarcual cartilage of batoids with emphasis on the synarcual of Rajidae, Kerin M. Claeson

The skeleton | Cartilaginous Fish Skeletal Anatomy, Kerin M. Claeson and M. N. Dean

Morphology of the anterior vertebral region in elasmobranchs: Special focus, Squatiniformes, Kerin M. Claeson and A. Hilger

Youth Gangs: Reason for Concern, Paul Thomas Clements and Cliff Akiyama

Psychological Health in Patients with ALS is Maintained as Physical Function Declines, Julia Cupp, Zachary Simmons, Arthur Berg, Stephanie H. Felgoise, Susan M. Walsh, and Helen E. Stephens