The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.

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Submissions from 2016

Alestid (Characiformes: Alestidae) fishes from the late Oligocene Nsungwe Formation, Rukwas Rift Basin, of Tanzania, W. Stevens, Kerin Claeson, and N. Stevens

Assessment of the Relationship between Self-Reported Cognitive Distortions and Adult ADHD, Anxiety, Depression, and Hopelessness, Craig Strohmeier, Brad Rosenfield, Robert A. DiTomasso, and J. Russell Ramsay

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Management of hypercalcemia of malignancy, Sonia Thomas and Soo-Hwan Chung

A 5-Year-Old Boy With an Acute Onset of Emesis, and Throat and Chest Pain, After Taking a Drink, Deanna B Tocco, Robert A. Bassett, and Julie Fitzgerald

Metformin Inhibits Castration-Induced EMT in Prostate Cancer by Repressing COX2/PGE2/STAT3 Axis, Dali Tong, Qiuli Liu, Gaolei Liu, Jing Xu, Weihua Lan, Yao Jiang, Hualiang Xiao, Dianzheng Zhang, and Jun Jiang

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The HIF/PHF8/AR axis promotes prostate cancer progression., D Tong, Q Liu, G Liu, W Yuan, L Wang, Y Guo, W Lan, Dianzheng Zhang, S Dong, Y Wang, H Xiao, J Mu, C Mao, J Wong, and J Jiang

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Brief compression-only cardiopulmonary resuscitation training video and simulation with homemade mannequin improves CPR skills., Gregory K Wanner, Arayel Osborne, and Charlotte H. Greene PhD

Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice, Hau Wu, Eric V. Brown, Nimish K. Acharya, Denah M. Appelt, Alexander Marks, Robert G. Nagele, and Venkat Venkataraman

Detecting Subnetwork-Level Dynamic Correlations, Yan Yan, Shangzhao Qiu, Zhuxuan Jin, Sihong Gong, Yun Bai, Jianwei Lu, and Tianwei Yu

Comparing the Effects of Myristic Acid- and TAT-conjugated Peptides to Their Native Counterparts Targeting Intracellular Pathways Mediating Myocardial Ischemia/Reperfusion Injury and Neutrophil Superoxide Release, Lindon H. Young, Robert J. Barsotti, Israel Benjamin, H. Patel, Tejash T. Patel, and Qian Chen

The Role of NADPH Oxidase Isoform 1 (NOX1) in L-NAME-Induced Leukocyte-Endothelial Interactions in Rat Mesenteric Postcapillary Venules, Alita Zabrecky, Hung Pham, Amber Koon, Brian Reuter, Robert Barsotti, Lindon Young, and Qian Chen

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Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein., Dianzheng Zhang, Boxv Zhou, Li Zhu, Md Asaduzzaman Khan, Tao He, Sufang Zhou, Jian He, Xiaoling Lu, Hanchun Chen, Yongxiang Zhao, and Junjiang Fu

Submissions from 2015

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase Blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline, Nimish K. Acharya, Eric L. Goldwaser, Martin M. Forsberg, George A. Godsey, Cristina A. Johnson, Abhirup Sarkar, Cassandra DeMarshall, Mary C. Kosciuk, Denah M. Appelt, and et al.

Vascular Mechanics in Decellularized Aortas and Coronary Resistance Microvessels in Type 2 Diabetic db/db Mice, Mircea Anghelescu, J. Tonniges, E. Calomeni, P. E. Shamhart, G. Agarwal, K. J. Gooch, and A. J. Trask

Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation, Charles E. Argoff, Michael J. Brennan, Michael Camilleri, Andrew Davies, Jeffrey Fudin, Katherine Galluzzi, Anthony Lembo, Steven P. Stanos, and R. Webster

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Alzheimer's Risk Factors, Brian J. Balin, Christopher S. Little, and Denah Appelt

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Finger Pain out of Proportion to Exam: A Case of Occult Hydrofluoric Acid Toxicity, Robert A. Bassett

Comparison of the Effects of Myristoylated and Transactivating Peptide (TAT) Conjugated Mitochondrial Fission Peptide Inhibitor (P110) in Myocardial Ischemia/Reperfusion (I/R) Injury, Israel Benjamin, Jonathan Vu, Christina Lipscombe, Devon Stutzman, Carly Schmigdall, Harsh Patel, Qian Chen, Cathy J. Hatcher, Robert Barsotti, and Lindon H. Young

Identification Of Novel Polyglutamine-Expanded Aggregation Species In Spinal And Bulbar Muscular Atrophy., Tamar R Berger, Heather L. Montie, Pranav Jain, Justin Legleiter, and Diane Merry

Resolution of Hypothyroidism after Correction of Somatovisceral Reflex Dysfunction by Refusion of the Cervical Spine., Murray R. Berkowitz

Supplements, Diets and Other Complementary and Alternative Interventions in Adolescent Mental Health, Bettina Bernstein and Alisa Voll

Consumers' reactions to U.S. Food and drug administration-approved claims in print direct-to-consumer advertising, Nilesh Bhutada, J. Huh, Brent Rollins, and M. Perri

Factors predicting consumers' drug inquiry intention after exposure to a prescription drug advertisement: An exploratory analysis, Nilesh Bhutada, Brent Rollins, and M. Perri

Impact of endorser testimonials in direct-to-consumer advertising, Nilesh Bhutada, Brent Rollins, and M. Perri

Disease-specific direct-to-consumer advertising for reminding consumers to take medications, Nilesh S. Bhutada and Brent L. Rollins

Disease-specific direct-to-consumer advertising of pharmaceuticals: An examination of endorser type and gender effects on consumers' attitudes and behaviors, Nilesh S. Bhutada and Brent L. Rollins

A randomized, double-blind, solifenacin succinate versus placebo control, phase 4, multicenter study evaluating urinary continence after robotic assisted radical prostatectomy, F. J. Bianco, D. Albala, Laurence Belkoff, B. J. Miles, J. O. Peabody, W. He, J. S. Bradt, G. P. Haas, and T. E. Ahlering

Articles You Might Have Missed, William Boroughf, Robert A. Bassett, and Steven Walsh

Sleep-Related Problems and the Effects of Anxiety Treatment in Children and Adolescents., Nicole E Caporino, Kendra L Read, Nina Shiffrin, Cara Settipani, Philip C Kendall, Scott N Compton, Joel Sherrill, John Piacentini, John Walkup, Golda Ginsburg, Courtney Keeton, Boris Birmaher, Dara Sakolsky, Elizabeth Gosch, and Anne M Albano

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Disrupting SUMOylation Enhances Transcriptional Function and Ameliorates Polyglutamine Androgen Receptor-Mediated Disease, Jason P. Chua, Satya L. Reddy, Zhigang Yu, Elisa Georgetti, Heather L. Montie, Sarmistha Mukherjee, Jake Higgins, Richard C. McEachin, Diane M. Robins, and Diane E. Merry

New fossil scombrid (Pelagia: Scombridae) fishes preserved as predator and prey from the Eocene of Senegal, Kerin M. Claeson, Raphael Sarr, Robert V. Hill, El Hadji Sow, Raymond Malou, and Maureen O'Leary

Sodium glucose co-transporter inhibitors for the management of diabetes mellitus: an opinion paper from the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy, Jennifer N. Clements, Heather P. Whitley, Jennifer J. D'Souza, Benjamin Gross, Rick Hess, Sara Wilson Reece, Chad Gentry, and Kayce Shealy

A Telemedicine-Based Intervention Reduces the Frequency and Severity of COPD Exacerbation Symptoms: A Randomized, Controlled Trial, Francis C. Cordova, David Ciccolella, Carla Grabianowski, John Gaughan, Kathleen Brennan, Frederick J. Goldstein, Michael R. Jacobs, and Gerard J. Criner

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Invasive Breast Cancer Incidence in 2,305,427 Screened Asymptomatic Women: Estimated Long Term Outcomes during Menopause Using a Systematic Review., Winnifred Cutler, Regula Bürki, James Kolter, Catherine Chambliss, Erika Friedmann, and Kari Hart

Tetracycline tethered to titanium inhibits colonization by Gram-negative bacteria, H. Davidson, M. Poon, R. Saunders, I. M. Shapiro, N. J. Hickok, and Christopher S. Adams

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Learners of a New Generation, Camille DiLullo

Symptomatic comorbidity, Robert A. DiTomasso and Bradley M. Rosenfield

Counseling Male Patients on Testosterone Replacement Therapy With Efficacy and Safety in Mind, Andrea G. Douglas, Joylaina Speaks, Jennifer Elliot, and Deirdre B. Fanning

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Funding and Other Resources for Beginning Researchers, Jane Z. Dumsha, David Yens, and Grace Brannan

Use of Naloxone Drips in Pediatric Patients: A Retrospective Medication Use Evaluation, Carmen Echols and Marie Katie Bozman

Insulin Therapy: New Options, Jennifer Elliott and Sara Wilson Reece

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Suicide in Schools: a Practitioner's Guide to Multi-Level Prevention Assessment, Intervention, and Postvention, Theresa Erbacher, Jonathan B. Singer, and Scott Poland

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The effect of osteopathic manipulative treatment on length of stay in posterolateral postthoracotomy patients: A retrospective case note study, Regina K. Fleming, Karen T. Snyder, Kent J. Blanke, and Jane C. Johnson

Progression-free survival by local investigator versus independent central review: Comparative analysis of the AGO-OVAR16 Trial, A. Floquet, I. Vergote, N. Colombo, B. Fiane, B. J. Monk, A. Reinthaller, P. Calvert, T. Herzog, Rocco J. Crescenzo, and et al.

Considerations in the Selection of Antihyperglycemic Therapy for Older Patients With Type 2 Diabetes Mellitus: A Focus on Newer Therapies, Jeffrey Freeman

Considerations in the Selection of Antihyperglycemic Therapy for Older Patients With Type 2 Diabetes Mellitus: A Focus on Newer Therapies, Jeffrey Freeman

Compliance with recommendations made in a multidisciplinary ALS clinic., Timothy Fullam, Helen E Stephens, Stephanie H. Felgoise, Jacqueline K Blessinger, Susan Walsh, and Zachary Simmons

The Patient with Otitis Media, David B. Fuller

The Triune Nature of Humanity: Body, Mind, and Spirit, David B. Fuller

Jackfruit (Artocarpus heteophyllus) seed extract exhibits fibrino(geno)lytic activity, Sowmyashree Gangaraju, Bhagyalakshmi Manjappa, Girish Kesturu Subbaiah, Kemparaju Kempaiah, Rangaiah Shashidharamurthy, Jane Hoover Plow, Sebastin Santhosh Martin, Manohar Shindhe, and Devaraja Sannaningaiah

Hepatocyte Culture in Autologous Decellularized Spleen Matrix, Rui Gao, Wanquan Wu, Junxi Xiang, Yi Lu, Xinglong Zheng, Qian Chen, Haohua Wang, Bo Wang, Zhengwen Liu, and Feng Ma

Strategies for Effective Classroom Coaching, S. Andrew Garbacz, Amanda L. Lannie, Jennifer L. Jeffrey-Pearsall, and Adrea J. Truckenmiller

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Motivational Interviewing is a Promising Framework for Collaboration in the Patient-Centered Medical Home, Scott Glassman

Orthopedic uses of stem cell therapy, Whitney B. Greco and Nancy McClaughlin

Neurologic diseases: the tragedy and the hope., Paula M. Gregory

Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer., Valentina Guarneri, Maria Vittoria Dieci, Antonio Frassoldati, Antonino Maiorana, Guido Ficarra, Stefania Bettelli, Enrico Tagliafico, Silvio Bicciato, Daniele Giulio Generali, Katia Cagossi, Giancarlo Bisagni, Samanta Sarti, Antonino Musolino, Catherine Ellis, Rocco J. Crescenzo, and PierFranco Conte

Diagnosis of Migraines and Migraine Variants, Tomia P. Harmon

Developmental Regulation of Epicardial Cell Adhesion and Coronary Vasculogenesis, Cathy J. Hatcher, Brendan Tanner, Dina Abdurahman, Kolby Nelson, William Laidlaw, and Grzegorz Gorski

Abstract 87: Targeting androgen receptor acetylation as a treatment for castrate-resistant prostate cancer, Erin Heine, Diane E. Merry, Scott Dehm, Karen E. Knudsen, and Heather L. Montie

Efficacy of Avanafil 15 Minutes after Dosing in Men with Erectile Dysfunction: A Randomized, Double-Blind, Placebo Controlled Study, W. J. Hellstrom, J. Kaminetsky, Laurence Belkoff, I. Goldstein, J. P. Tursi, J. Uly, C. A. Peterson, C. H. Bowden, and W. W. Day

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer., David T Hoang, Lei Gu, Zhiyong Liao, Feng Shen, Pooja G Talati, Mateusz Koptyra, Shyh-Han Tan, Elyse Ellsworth, Shilpa Gupta, Heather L. Montie, Ayush Dagvadorj, Saija Savolainen, Benjamin Leiby, Tuomas Mirtti, Diane E Merry, and Marja T Nevalainen

Office Evaluation of Dizziness, James D. Hogue

The Mechanisms of Genetically Modified Vaccinia Viruses for the Treatment of Cancer, Artrish Jefferson, Valerie E. Cadet, and Abigail Hielscher

Antifactor Xa Monitoring in Patients on IV Unfractionated Heparin, Samuel N. John, Dusty L. Lisi, Nathan Greenfield, and Mary Littleton George

Low-Level Laser Therapy: An Alternative Treatment for Capsular Contraction, Jason D. Johnson, Paul M. Glat, and William L. Scarlett

Mediators of Change in the Child/Adolescent Anxiety Multimodal Treatment Study, Phillip C. Kendall, Colleen M. Cummings, Marianne A. Villa, Martina K. Narayanan, Kimberli Treadwell, Boris Birmaher, Scott Compton, John Piacentini, Elizabeth Gosch, and et al.

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Gliopathy of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus, Lawrence Charles Kenyon, Kaushiki Biswas, Kenneth Shindler, Manasi Nabar, Marjorie Stout, Susan T. Hingley, Judith B. Grinspan, and Jayasri Das Sarma

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Nutri One-on-One: The Assessment and Evaluation of a Brief One-on-One Nutritional Coaching in Patients Affected by Metabolic Syndrome, Jennifer King, Jeffrey E. Harris, David Kuo, and Farzaneh Daghigh

Reversal of novel oral anticoagulants, Winnie Lee, Deepa V. Patel, and Dusty L. Lisi

Protein Kinase C Beta II (PKC ßII) Peptide Inhibitor Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion Injury, Christina Lipscombe, Israel Benjamin, Devon Stutzman, Amelie Bottex, Chinyere Ebo, William Chau, Harsh Patel, Qian Chen, Cathy Hatcher, Robert Barsotti, and Lindon Young

Celiac Artery Stent Placement for Coronary Ischemia, Nicholas J. Madden, Carmen Piccolo, Chittur Mohan, Ali Khoobehi, and Richard Sohn

A Flipped Classroom Approach to Teaching Lab-Based Techniques Leads to Greater Learning Gains, Melinda Maris

Pilot testing of an online training for criminal justice professionals on medication-assisted treatment, J. Matjekowski, K. Dugosh, N. Clements, and David Festinger

Assessing the Quality of Parent-Teacher Relationships for Students with ADHD, Jennifer A. Mautone, Enitan Marcelle, Katy E. Tresco, and Thomas J. Power

Dental Anomalies Within Extant Members of the Mammalian Order Pilosa, Robert McAfee

The Role of Bite Force in the Formation of Orthodentine Microwear in Tree Sloths (Mammalia: Xenarthra: Folivora): Implications for Feeding Ecology, Robert McAfee and Jeremy L Green

A dietary phytochemical blend prevents liver damage associated with adipose tissue mobilization in ovariectomized rats., Colette N Miller, Jeong-Yeh Yang, Tucker Avra, Suresh Ambati, Mary Anne Della-Fera, Srujana Rayalam, and Clifton A Baile

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Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes., Colette N Miller, Jeong-Yeh Yang, Emily England, Amelia Yin, Clifton A Baile, and Srujana Rayalam

The Efficacy of Participation in a Survivorship Program on Functional Abilities and Quality of Life in Cancer Survivors: A Descriptive, Retrospective Study, Phillip B. Palmer, Katie Wallace, David Clay, Corey Gill, and Kelly Moore

Comparing the effectiveness of TAT and Myristoylation of gp91ds on Leukocyte Superoxide (SO) Release, Harsh Patel, Kyle Bartol, Amelie Bottex, Ryan Remarcke, William Chau, Sydney Walker, Qian Chen, Robert Barsotti, and Lindon Young

Lung Cancer Overview: Focus on Newer Therapies, Sonia Patel

Opioid Overdose Rescue Kits, Sonia Patel

Osteopathic manipulative treatment for an unusual presentation of fibromyalgia: A case report demonstrating the effectiveness of disease guidelines, Lauren Paul and Murray R. Berkowitz

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MeDiA: Mean Distance Association and Its Applications in Nonlinear Gene Set Analysis., Hesen Peng, Junjie Ma, Yun Bai, Jianwei Lu, and Tianwei Yu

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Learn About PCOM's Plastination Process, Philadelphia College of Osteopathic Medicine and Kerin M. Claeson

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release, P. B. Radwanski, L. Brunello, R. Veeraraghavan, H. T. Ho, Q. Lou, M. A. Makara, A. E. Belevych, Mircea Anghelescu, and et al.

Management of Complications After Revision Shoulder Arthroplasty, Hithem Rahmi and Andrew Jawa

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From Lucy to Kadanuumuu: Balanced Analyses of Australopithecus afarensis Assemblages Confirm Only Moderate Skeletal Dimorphism, Philip L. Reno and C Owen Lovejoy

Consumer use of social media for health care and drug information: An exploratory study, Brent Rollins, Nilesh Bhutada, C. Crawford, and A. Hvizdos

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Milking the Information: Resources on Herbal Lactation Aids, Erica Rosalle

Transradial Peripheral Arterial Procedures, Kintur Sanghvi and John Coppola

MicroRNA-181a, a potential diagnosis marker, alleviates acute graft versus host disease by regulating IFN-γ production., Wei Sang, Cong Zhang, Dianzheng Zhang, Ying Wang, Cai Sun, Mingshan Niu, Xiaoshen Sun, Cui Zhou, Lingyu Zeng, Bin Pan, Wei Chen, Dongmei Yan, Feng Zhu, Qingyun Wu, Jiang Cao, Kai Zhao, Chong Chen, Zhenyu Li, Depeng Li, Thomas P Loughran, and Kailin Xu

Addiction Severity Index Scores and Urine Drug Screens at Baseline as Predictors of Graduation From Drug Court, S. Shah, D. DiMatteo, M. Keesler, J. Davis, K. Heilbrun, and David Festinger

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Clinically Significant Drug Interactions Associated With HIV Medications [CE Module], Kinjal Sidhpura

Osteopathic approach to chronic constipation in Prader-Willi Syndrome: A case report, Lauren Smith and Murray Berkowitz

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Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options, Tia Solh, Ashley Botsford, and Melhem Solh

Improving the psychiatric interview in the physician assistant behavioral medicine curriculum: A novel approach, Tia Solh, Daniel Paulson, and Dixie Pennington

Recessive dystrophic epidermolysis bullosa: A review of disease pathogenesis and update on future therapies, Luis Soro, Cynthia Bartus, and Stephen Purcell

Multidisciplinary ALS Clinics in the USA: a comparison of those who attend and those who do not, Helen E. Stephens, Stephanie Felgoise, Jared Young, and Zachary Simmons

A Qualitative Study of Multidisciplinary ALS Clinic Use in the United States., Helen E Stephens, Jared L. Young, Stephanie H. Felgoise, and Zachary Simmons