Location
Suwanee, GA
Start Date
7-5-2024 1:00 PM
End Date
7-5-2024 4:00 PM
Description
Alzheimer’s Disease is a fatal and progressive neurodegenerative disease that results in losses in memory and cognitive function. Menopause is known as a woman’s transition from reproductive to post-reproductive life. During menopause, the levels of ovarian hormones, such as estrogen, decrease eventually to an undetectable level. Estrogen plays essential roles throughout the body, and the loss of estrogen during menopause has been shown to cause various symptoms, including vasomotor symptoms, changes in mood, and changes in cognition. Given that Alzheimer’s Disease is more common in postmenopausal women than men, this review aims to examine the connection between the loss of ovarian estrogen after menopause and the risk of developing Alzheimer’s Disease. This review will also discuss steroidogenesis, estrogen signaling, menopause, and Alzheimer’s Disease pathologies in detail. It was found that the lack of estrogen after menopause creates a hypometabolic state within the brain that can contribute to the development of mitochondrial dysfunction. Increased cerebral microvasculature energy need, combined with increased mitochondrial dysfunction due to the lack of estrogen, promotes an increased risk for the development of neurodegenerative diseases such as Alzheimer’s Disease.
Embargo Period
7-2-2024
Included in
Estrogen mediated mitochondrial dysfunction, menopause, and the progression of Alzheimer’s Disease
Suwanee, GA
Alzheimer’s Disease is a fatal and progressive neurodegenerative disease that results in losses in memory and cognitive function. Menopause is known as a woman’s transition from reproductive to post-reproductive life. During menopause, the levels of ovarian hormones, such as estrogen, decrease eventually to an undetectable level. Estrogen plays essential roles throughout the body, and the loss of estrogen during menopause has been shown to cause various symptoms, including vasomotor symptoms, changes in mood, and changes in cognition. Given that Alzheimer’s Disease is more common in postmenopausal women than men, this review aims to examine the connection between the loss of ovarian estrogen after menopause and the risk of developing Alzheimer’s Disease. This review will also discuss steroidogenesis, estrogen signaling, menopause, and Alzheimer’s Disease pathologies in detail. It was found that the lack of estrogen after menopause creates a hypometabolic state within the brain that can contribute to the development of mitochondrial dysfunction. Increased cerebral microvasculature energy need, combined with increased mitochondrial dysfunction due to the lack of estrogen, promotes an increased risk for the development of neurodegenerative diseases such as Alzheimer’s Disease.