Document Type

Article

Publication Date

1-1-2015

Abstract

Probabilistic association discovery aims at identifying the association between random vectors, regardless of number of variables involved or linear/nonlinear functional forms. Recently, applications in high-dimensional data have generated rising interest in probabilistic association discovery. We developed a framework based on functions on the observation graph, named MeDiA (Mean Distance Association). We generalize its property to a group of functions on the observation graph. The group of functions encapsulates major existing methods in association discovery, e.g. mutual information and Brownian Covariance, and can be expanded to more complicated forms. We conducted numerical comparison of the statistical power of related methods under multiple scenarios. We further demonstrated the application of MeDiA as a method of gene set analysis that captures a broader range of responses than traditional gene set analysis methods.

Publication Title

PLoS One

Volume

10

Issue

4

First Page

0124620

Last Page

0124620

PubMed ID

25915206

Comments

This article was published in PLoS One, Volume 10, Issue 4, April 2015.

The published article is available at http://dx.doi.org/10.1371/journal. pone.0124620

Copyright ©2015 Peng et al. and licensed CC-BY.

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