In vivo iontophoretic delivery of salmon calcitonin across microporated skin

Document Type

Article

Publication Date

2012

Abstract

The purpose of this study was to determine the effect of microneedle (MN) technology and its combination with iontophoresis (ITP) on the in vivo transdermal delivery of salmon calcitonin (sCT). Maltose MNs (500 µm) were used to porate skin prior to application of the drug, with or without ITP. Micropores created by maltose MNs were characterized by histological sectioning and calcein imaging studies, which indicated uniformity of the created micropores. In vivo studies were performed in hairless rats to assess the degree of enhancement achieved by ITP (0.2 mA/cm 2 for 1 h), MNs (81 MNs), and their combination. In vivo studies indicate a serum maximal concentration of 0.61 ± 0.42 ng/mL, 1.79 ± 0.72 ng/mL, and 5.51 ± 0.32 ng/mL for ITP, MNs, and combination treatment, respectively. MN treatment alone increased serum concentration 2.5-fold and the combination treatment increased the concentration ninefold as compared with iontophoretic treatment alone. Combination treatment of ITP and MNs resulted in the highest delivery of sCT and therapeutic levels were achieved within 5 min of administration. © 2012 Wiley Periodicals, Inc.

Publication Title

Journal of pharmaceutical sciences

Volume

101

Issue

8

First Page

2861

Last Page

2869

Comments

This article was published in Journal of pharmaceutical sciences, Volume 101, Issue 8, Pages 2861-2869.

The published version is available at http://dx.doi.org/10.1002/jps.23222.

Copyright © 2012 Scopus.

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