The role of Notch and Rho GTPase signaling in the control of dendritic development
Dendritic patterning exerts a profound influence on neuronal connectivity. Recent studies indicate that mammalian Notch receptors are expressed by postmitotic neurons and that Notch signaling has a considerable influence on dendritic growth and branching. Investigations into the intracellular effectors of dendritic development have revealed that dendritic growth and branching are differentially affected by activation of the Rho-family GTPases, RhoA, Rac1, and Cdc42. These observations suggest that the differential activation of Notch receptors and Rho-family GTPases by extracellular signals may be important in the generation of morphological diversity in the developing nervous system.
Current opinion in neurobiology
Hardy, Lori Redmond and Ghosh, Anirvan, "The role of Notch and Rho GTPase signaling in the control of dendritic development" (2001). PCOM Scholarly Papers. 663.