Antifactor Xa Monitoring in Patients on IV Unfractionated Heparin
Although the introduction of newer anticoagulants has revolutionized the treatment of venous thromboembolism, IV unfractionated heparin (UFH) continues to be widely prescribed in hospitalized patients because of its pharmacokinetic profile. The activated partial thromboplastin time (aPTT) test has been used to monitor outcomes in patients receiving UFH, but significant issues, such as varying aPTT reagents, instrumentation procedures, and interpatient variability, are associated with the test. Antifactor Xa monitoring of patients on continuous IV UFH may better correlate with heparin concentrations, determine therapeutic ranges for aPTT, and result in fewer testing procedures for patients and personnel. - See more at: http://www.uspharmacist.com/content/c/53562/#sthash.Pl0cVjLK.dpuf
John, Samuel N.; Lisi, Dusty L.; Greenfield, Nathan; and George, Mary Littleton, "Antifactor Xa Monitoring in Patients on IV Unfractionated Heparin" (2015). PCOM Scholarly Papers. 468.