Failure to Improve a Thin Endometrium in the Late Proliferative Phase with Uterine Infusion of Granulocyte-Colony Stimulating Factor
PURPOSE: To determine if the treatment with uterine infusion of granulocyte colony-stimulating factor (G-CSF) can improve endometrial thickness in an infertile woman with a double uterus, who consistently showed a thin endometrium in the late proliferative phase either in controlled ovarian hyperstimulation (COH) IVF-ET cycles or with graduated estrogen/sildenafil protocols for frozen embryo transfer (ET).
MATERIALS AND METHODS: A single uterine infusion of G-CSF was performed in the late proliferative phase in a woman who only attained a five-mm thickness despite a high dose vaginal and oral estradiol regimen plus sildenafil.
RESULTS: No increase was found within a couple days.
CONCLUSIONS: A previous four-case study in another center found 100% improvement in the endometrial thickness in women with consistently thin endometria. Perhaps the uterine anomaly in the present case prevented the response of the endometrium.
Clinical and Experimental Obstetrics & Gynecology
Check, Jerome H.; Cohen, Rachael A.; and Choe, J. K., "Failure to Improve a Thin Endometrium in the Late Proliferative Phase with Uterine Infusion of Granulocyte-Colony Stimulating Factor" (2014). PCOM Scholarly Papers. 239.