Document Type
Article
Publication Date
8-19-2025
Abstract
INTRODUCTION: Ethical concerns have been raised by both current and historically controversial neurosurgical interventions for treatment-refractory schizophrenia and schizoaffective disorder (TR-SZ). Considering advances in next-generation deep brain stimulation (DBS), initial success in treating a few cases of TR-SZ, and how challenging trial enrollment is, transparency and disseminating knowledge about DBS is important, as is input from involved groups. Here information was presented about DBS as an experimental treatment option for TR-SZ to stakeholders to gauge enthusiasm after consideration of potential risks and benefits.
METHODS: Stakeholders were presented with information about DBS (total
RESULTS: Most (83%) research participants and presentation audience members agreed that DBS should be an option for TR-SZ and 40% thought the potential benefits outweigh the risks of DBS with at least a 41–60% response rate. Audience approval of DBS was similar for the PD (30%), SZ (52%) and the OCD case with psychosis (56%), but there was a higher rate of approval (77%) for the OCD case whose compulsions involved self-harm. The majority (73–86%) of the audience thought that they would want to try DBS if they had TR-PD, TR-OCD, or TR-SZ.
CONCLUSIONS: Despite difficulty in recruiting patients for DBS clinical trials for TR-SZ, the consensus among 83% of stakeholders was that DBS should be an option for people with severe TR-SZ. Our approach to disseminate general knowledge then gather opinions among diverse stakeholders was to ensure the development of DBS clinical trials for the new indication TR-SZ is a relevant option despite the known difficulties in enrollment. These findings may help prevent disparities in access to advanced DBS therapeutics.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-025-07128-0.
Publication Title
BMC Psychiatry
Volume
25
Issue
1
First Page
796
Last Page
796
PubMed ID
40830450
Recommended Citation
Gault, Judith M; Cascella, Nicola; Moukaddam, Nidal; Lehto, Stephanie; Hosokawa, Patrick; Appelbaum, Paul S; Sawa, Akira; Lippman-Bell, Jocelyn; Anderson, William S; Goodman, Wayne; Sheth, Sameer A; Kramer, Daniel; Thompson, John A; Saks, Elyn R; and Davis, Rachel A, "Ethical considerations of deep brain stimulation for treatment refractory schizophrenia: surveying stakeholders." (2025). PCOM Scholarly Works. 2333.
https://digitalcommons.pcom.edu/scholarly_papers/2333
DOI: https://doi.org/10.1186/s12888-025-07128-0
Comments
This article was published in BMC Psychiatry, Volume 25, Issue 1, page 796.
The published version is available at https://doi.org/10.1186/s12888-025-07128-0.
Copyright © 2025 The Author(s). CC BY-NC-ND 4.0.