Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis.
Document Type
Article
Publication Date
9-1-2024
Abstract
Metastasis is the primary culprit behind cancer-related fatalities in multiple cancer types, including prostate cancer. Despite great advances, the precise mechanisms underlying prostate cancer metastasis are far from complete. By using a transgenic mouse prostate cancer model (TRAMP) with and without Phf8 knockout, we have identified a crucial role of PHF8 in prostate cancer metastasis. By complexing with E2F1, PHF8 transcriptionally upregulates SNAI1 in a demethylation-dependent manner. The upregulated SNAI1 subsequently enhances epithelial-to-mesenchymal transition (EMT) and metastasis. Given the role of the abnormally activated PHF8/E2F1-SNAI1 axis in prostate cancer metastasis and poor prognosis, the levels of PHF8 or the activity of this axis could serve as biomarkers for prostate cancer metastasis. Moreover, targeting this axis could become a potential therapeutic strategy for prostate cancer treatment. © 2024 The Pathological Society of Great Britain and Ireland.
Publication Title
Journal of Pathology
Volume
264
Issue
1
First Page
68
Last Page
79
PubMed ID
39022843
Recommended Citation
Wang, Ze; Tang, Peng; Xiao, Haiyang; Peng, Song; Chen, Jian; Wang, Yapeng; Xu, Jing; Yan, Qian; Zhang, Junying; Deng, Jie; Ma, Qiang; Zhu, Hailin; Luo, Weiming; Zhang, Dianzheng; Wang, Luofu; Qin, Jun; Lan, Weihua; Jiang, Jun; and Liu, Qiuli, "Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis." (2024). PCOM Scholarly Works. 2272.
https://digitalcommons.pcom.edu/scholarly_papers/2272
DOI: https://doi.org/10.1002/path.6325
Comments
This article was published in Journal of Pathology, Volume 264, Issue 1, pages 68-79.
The published version is available at https://doi.org/10.1002/path.6325.
Copyright © 2024 The Pathological Society of Great Britain and Ireland.