MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

Authors

Liang Du
Lu Wang
Jinfeng Gan
Zhimeng Yao
Wan Lin
Junkuo Li
Yi Guo
Yuping Chen
Fuyou Zhou
Sai-Ching Jim Yeung
Robert P Coppes
Dianzheng Zhang, Philadelphia College of Osteopathic MedicineFollow
Hao Zhang

Document Type

Article

Publication Date

12-20-2019

Abstract

Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3

Publication Title

iScience

Volume

22

First Page

353

Last Page

368

PubMed ID

31810000

Comments

This article was published in iScience, Volume 22, pages 353-368.

The published version is available at https://doi.org/10.1016/j.isci.2019.11.009

Copyright © 2019 The Authors. CC BY-NC-ND 4.0

Recommended Citation

Du, Liang; Wang, Lu; Gan, Jinfeng; Yao, Zhimeng; Lin, Wan; Li, Junkuo; Guo, Yi; Chen, Yuping; Zhou, Fuyou; Jim Yeung, Sai-Ching; Coppes, Robert P; Zhang, Dianzheng; and Zhang, Hao, "MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis" (2019). PCOM Scholarly Works. 2039.
https://digitalcommons.pcom.edu/scholarly_papers/2039