Document Type
Article
Publication Date
12-20-2019
Abstract
Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3
Publication Title
iScience
Volume
22
First Page
353
Last Page
368
PubMed ID
31810000
Recommended Citation
Du, Liang; Wang, Lu; Gan, Jinfeng; Yao, Zhimeng; Lin, Wan; Li, Junkuo; Guo, Yi; Chen, Yuping; Zhou, Fuyou; Jim Yeung, Sai-Ching; Coppes, Robert P; Zhang, Dianzheng; and Zhang, Hao, "MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis" (2019). PCOM Scholarly Papers. 2039.
https://digitalcommons.pcom.edu/scholarly_papers/2039
Comments
This article was published in iScience, Volume 22, pages 353-368.
The published version is available at https://doi.org/10.1016/j.isci.2019.11.009
Copyright © 2019 The Authors. CC BY-NC-ND 4.0