Differential Expression of Cyclosporine A-Induced Calcineurin Isoform-Specific Matrix Metalloproteinase 9 (MMP-9) in Renal Fibroblasts
Long-term treatment with the potent immunosuppressive drug cyclosporine A (CsA) results in chronic nephrotoxicity. Its immunosuppressive properties are due to the inhibition of the calcium- and calmodulin-dependent phosphatase protein calcineurin A (CnA) which has three catalytic isoforms. Of those, the CnAα and β isoforms are ubiquitously expressed, particularly in the kidney. Additionally, chronic nephrotoxicity has been associated with an imbalance of extracellular matrix (ECM) synthesis and degradation resulting in an accumulation of ECM molecules. This study evaluates whether the expressions of matrix metalloproteinases (MMP-2 and MMP-9) induced by CsA are calcineurin isoform specific. Wild-type (WT), CnAα knockout (CnAα
Biochemical and Biophysical Research Communications
Francis, Cynthia E. and Bai, Yun, "Differential Expression of Cyclosporine A-Induced Calcineurin Isoform-Specific Matrix Metalloproteinase 9 (MMP-9) in Renal Fibroblasts" (2018). PCOM Scholarly Papers. 1945.