Differential Expression of Cyclosporine A-Induced Calcineurin Isoform-Specific Matrix Metalloproteinase 9 (MMP-9) in Renal Fibroblasts

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Long-term treatment with the potent immunosuppressive drug cyclosporine A (CsA) results in chronic nephrotoxicity. Its immunosuppressive properties are due to the inhibition of the calcium- and calmodulin-dependent phosphatase protein calcineurin A (CnA) which has three catalytic isoforms. Of those, the CnAα and β isoforms are ubiquitously expressed, particularly in the kidney. Additionally, chronic nephrotoxicity has been associated with an imbalance of extracellular matrix (ECM) synthesis and degradation resulting in an accumulation of ECM molecules. This study evaluates whether the expressions of matrix metalloproteinases (MMP-2 and MMP-9) induced by CsA are calcineurin isoform specific. Wild-type (WT), CnAα knockout (CnAα

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Biochemical and Biophysical Research Communications

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This article was published in Clinical Cancer Research.

The published version is available at https://doi.org/10.1016/j.bbrc.2018.07.014.

Copyright © 2018 Published by Elsevier Inc.

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