Location
Moultrie, GA
Start Date
17-4-2026 12:00 PM
End Date
17-4-2026 1:00 PM
Description
Introduction: Metastatic cancer is the spread of cancer from its original site known as the primary tumor to other parts of the body. Metastatic melanoma is more likely to spread and is considered very aggressive, making it common among patients with Melanoma. People are usually initially diagnosed with it locally, however ⅓ of patients eventually will have cancer recurrence or metastasis. One way to obtain a diagnosis of metastatic cancer is from a histological diagnosis involving biopsied tissue and H&E staining.) This cadaveric specimen with confirmed melanoma provided a unique opportunity to evaluate patterns of nodal and visceral metastasis across multiple anatomical sites. Our objective is to document and compare histologic findings of melanoma involvement across multiple lymph node basins and visceral organs in a single cadaveric specimen.
Methods: Formalin-fixed, paraffin-embedded tissue sections were obtained from the right lung, right posterior hepatic lymph node, liver, breast tissue, left axillary lymph node, posterior abdominal wall, left adrenal gland, and tissue adjacent to the superior mesenteric artery. Sections were stained with hematoxylin and eosin (H&E) and examined at 10× and 20× magnification. Histologic evaluation focused on cytologic characteristics of malignant involvement.
Results: Histologic examination of all sampled lymph nodes and visceral tissues demonstrated infiltrating neoplastic cells characterized by marked pleomorphism, enlarged malignant cell morphology, and hyperchromatic nuclei. These cytologic features were consistently observed across the examined anatomical sites.
Discussion: This multiorgan histologic evaluation demonstrates consistent cytologic features of metastatic melanoma across multiple lymphatic and visceral tissues within a single cadaveric specimen. Routine H&E staining was sufficient to identify characteristic malignant morphology across all sampled sites. These findings reinforce the role of standard histopathologic assessment in confirming widespread melanoma involvement.
Embargo Period
5-26-2026
Included in
Multiorgan Histologic Assessment of Metastatic Melanoma in a Cadaveric Specimen
Moultrie, GA
Introduction: Metastatic cancer is the spread of cancer from its original site known as the primary tumor to other parts of the body. Metastatic melanoma is more likely to spread and is considered very aggressive, making it common among patients with Melanoma. People are usually initially diagnosed with it locally, however ⅓ of patients eventually will have cancer recurrence or metastasis. One way to obtain a diagnosis of metastatic cancer is from a histological diagnosis involving biopsied tissue and H&E staining.) This cadaveric specimen with confirmed melanoma provided a unique opportunity to evaluate patterns of nodal and visceral metastasis across multiple anatomical sites. Our objective is to document and compare histologic findings of melanoma involvement across multiple lymph node basins and visceral organs in a single cadaveric specimen.
Methods: Formalin-fixed, paraffin-embedded tissue sections were obtained from the right lung, right posterior hepatic lymph node, liver, breast tissue, left axillary lymph node, posterior abdominal wall, left adrenal gland, and tissue adjacent to the superior mesenteric artery. Sections were stained with hematoxylin and eosin (H&E) and examined at 10× and 20× magnification. Histologic evaluation focused on cytologic characteristics of malignant involvement.
Results: Histologic examination of all sampled lymph nodes and visceral tissues demonstrated infiltrating neoplastic cells characterized by marked pleomorphism, enlarged malignant cell morphology, and hyperchromatic nuclei. These cytologic features were consistently observed across the examined anatomical sites.
Discussion: This multiorgan histologic evaluation demonstrates consistent cytologic features of metastatic melanoma across multiple lymphatic and visceral tissues within a single cadaveric specimen. Routine H&E staining was sufficient to identify characteristic malignant morphology across all sampled sites. These findings reinforce the role of standard histopathologic assessment in confirming widespread melanoma involvement.