Location
Moultrie, GA
Start Date
17-4-2026 12:00 PM
End Date
17-4-2026 1:00 PM
Description
Purpose: This work presents a case of clinically established dementia associated with thoracic kyphoscoliosis in an effort to study the relationships between these presentations and cerebrospinal fluid clearance. Given the previously identified relationship between impaired CSF clearance and the development of Alzheimer’s disease, this case study aims to further explore the relationship, using a combination of gross pathological observations and histopathological methods to examine specific brain regions, including the choroid plexus. The observed kyphoscoliosis and its effects on CSF clearance, thereby contributing to the pathogenesis of dementia, are also considered.
Methods: Samples were collected from an 81-year-old male cadaver with grossly observed upper thoracic kyphoscoliosis; his reported cause of death was senile dementia. Histologic samples were collected from the cingulate gyrus, insular lobe, frontal lobe, choroid plexus, occipital lobe, parietal lobe, ventral tegmental area, entorhinal cortex, hippocampus, midbrain, ventral pons, and medulla. The histological slides with H&E stain were reviewed, and sections from the prefrontal cortex (right and left), entorhinal cortex, and cerebellum with silver staining are pending.
Results: The results showed hyperplasia of the ependymal cells and extravascular calcifications in the choroid plexus, indicating significant oxidative stress as well as impaired CSF production and clearance. Granulovacuolar degeneration (GVD), Hirano bodies, and degenerated neurons in the entorhinal cortex indicate neuronal stress and the progression of neurodegenerative disease.
Conclusion: The patient’s history of dementia, along with the upper thoracic kyphoscoliotic curve, confirms the need for follow-up studies to explore the relationship between the two. It is noteworthy that recent advancements in lymphaticovenous anastomosis microsurgery and pharmacological interventions provide a basis for non-invasive adjunctive treatment options for Alzheimer’s disease, including OMT techniques to improve lymphatic drainage, respiratory mechanics, and myofascial somatic dysfunction. As such, evidence-based non-invasive treatment options could improve patient outcomes and quality of life while reducing healthcare costs.
Embargo Period
5-29-2026
Included in
Studying a Case of Dementia Associated with Thoracic Kyphoscoliosis and Potential Implications on CSF Clearance
Moultrie, GA
Purpose: This work presents a case of clinically established dementia associated with thoracic kyphoscoliosis in an effort to study the relationships between these presentations and cerebrospinal fluid clearance. Given the previously identified relationship between impaired CSF clearance and the development of Alzheimer’s disease, this case study aims to further explore the relationship, using a combination of gross pathological observations and histopathological methods to examine specific brain regions, including the choroid plexus. The observed kyphoscoliosis and its effects on CSF clearance, thereby contributing to the pathogenesis of dementia, are also considered.
Methods: Samples were collected from an 81-year-old male cadaver with grossly observed upper thoracic kyphoscoliosis; his reported cause of death was senile dementia. Histologic samples were collected from the cingulate gyrus, insular lobe, frontal lobe, choroid plexus, occipital lobe, parietal lobe, ventral tegmental area, entorhinal cortex, hippocampus, midbrain, ventral pons, and medulla. The histological slides with H&E stain were reviewed, and sections from the prefrontal cortex (right and left), entorhinal cortex, and cerebellum with silver staining are pending.
Results: The results showed hyperplasia of the ependymal cells and extravascular calcifications in the choroid plexus, indicating significant oxidative stress as well as impaired CSF production and clearance. Granulovacuolar degeneration (GVD), Hirano bodies, and degenerated neurons in the entorhinal cortex indicate neuronal stress and the progression of neurodegenerative disease.
Conclusion: The patient’s history of dementia, along with the upper thoracic kyphoscoliotic curve, confirms the need for follow-up studies to explore the relationship between the two. It is noteworthy that recent advancements in lymphaticovenous anastomosis microsurgery and pharmacological interventions provide a basis for non-invasive adjunctive treatment options for Alzheimer’s disease, including OMT techniques to improve lymphatic drainage, respiratory mechanics, and myofascial somatic dysfunction. As such, evidence-based non-invasive treatment options could improve patient outcomes and quality of life while reducing healthcare costs.
Comments
Presented by Sara Roman.