Analyses of the correlation of HPV vaccination and oropharyngeal cancer/lesion in men: from AllofUs Research Database

Philadelphia, PA

Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. It is most well-known as the leading cause of cervical cancer. However, there is a rising prevalence of HPV-related oropharyngeal cancers, particularly in men from high-income countries. Therefore, it is urgent to advocate prevention. This study aims to understand the correlation between the HPV vaccination and reduced HPV-related oropharyngeal cancer development. Additionally, many factors, such as race, income, risky sexual behavior, smoking, and recreational drugs are worth analyzing to appreciate their role in cancer development. This study was conducted using the AllofUs research database. The keywords included the “male gender” AND “human papillomavirus 9 valent vaccine” OR “human papillomavirus quadrivalent vaccine” OR “human papillomavirus bivalent vaccine” AND “malignant tumor of the oropharynx” OR “disorder of the oropharynx” OR “oropharyngeal lesion” AND “human papillomavirus infection”. First, the cohort for “male gender” was 152,142 subjects. The cohort for “male gender” AND “HPV 9 valent vaccine” was 413 subjects. Second, the cohort for “male gender” AND “oropharyngeal lesion” OR “disorder of the oropharynx” was 4370 subjects. We further added “HPV 9 valent vaccine” to the previously searched keywords; only 36 male subjects with a disorder of the oropharynx or an oropharyngeal lesion received the HPV vaccine. Third, the cohort for “male gender” AND “malignant tumor of the oropharynx” was 356 subjects. We further added “HPV bivalent vaccine” to the previously searched keywords, and only 3 male subjects with malignant tumor of the oropharynx received the HPV vaccine in the database. Lastly, the cohort for “male gender” AND “oropharyngeal lesion” AND “human papillomavirus infection” was 104 subjects. We further added “human papillomavirus quadrivalent vaccine” to the previously searched keywords, and only 2 subjects resulted. Detailed information related to the history of HPV vaccination (e.g., type and the number of doses) and lifestyle-related factors will be further analyzed and compared. The predicted results are that there is significant proof of vaccination prevention for HPV-related oropharyngeal cancer/lesion in men. The study will further acknowledge this public health crisis and highlight the importance of HPV vaccination in attempts at the prevention of oropharyngeal cancer for men.