Date of Award
2023
Degree Type
Selective Evidence-Based Medicine Review
Degree Name
Master of Science in Health Sciences - Physician Assistant
Department
Physician Assistant Studies
Abstract
Objective: The objective of this selective EBM review is to determine whether administration of prehospital plasma will improve survival rates in injured adults at risk for hemorrhagic shock.
Study Design: A systematic review of two randomized controlled trials (RCT) and one retrospective cohort study
Data Sources: All three studies were identified using PubMed and selected based on their ability to answer the clinical question while including patient-oriented outcomes (POEMs). All articles were peer-reviewed, published in English, and published on or after 2011.
Outcomes Measured: The outcomes addressed were survival rates, calculated using mortality rates based on if the patient was alive or not at the time of follow up. This includes 30-day, 28-day, and in-hospital mortality rates.
Results: An RCT by Sperry et al. showed improved survival rates of 75.9% in those who received plasma versus 65.9% in those who received standard care (p=0.03). Moore et al. showed a survival rate of 90% in the control group versus 85% in those who received fresh-frozen plasma (p=0.37). Shalifer et al. looked at freeze-dried plasma and found that 91.5% of patients who received it survived versus 93.8% who did not (p=0.17).
Conclusion: Evidence between all three studies was conflicting. Future studies should investigate further the forms of plasma for maximum benefit and logistic ease.
Recommended Citation
Belko, Carly, "Does Administration of Prehospital Plasma Improve Survival Rates in Injured Adults at Risk for Hemorrhagic Shock?" (2023). PCOM Physician Assistant Studies Student Scholarship. 672.
https://digitalcommons.pcom.edu/pa_systematic_reviews/672