Date of Award
1-1-2022
Degree Type
Selective Evidence-Based Medicine Review
Degree Name
Master of Science in Health Sciences - Physician Assistant
Department
Physician Assistant Studies
Abstract
OBJECTIVE: The objective of this selective EBM review is to determine, “Does high-flow oxygen therapy decrease the length of hospital stay in pediatric patients with bronchiolitis when compared to standard oxygen therapy?”
STUDY DESIGN: A systematic review of randomized controlled trials (RCTs). All studies were published in the English language after 2014.
DATA SOURCES: All articles were found using PubMed, CINAHL, Alt HealthWatch, AMED. All articles were published in peer-reviewed journals.
OUTCOMES MEASURED: A reduction in length of hospital stay, in terms of the number of days, was the outcome measured in all three studies. This is defined as the initial day of treatment extending to the day the patient was discharged home.
RESULTS: The RCT conducted by Ergul et al. demonstrated a statistically significant difference (p-value <0.001) between high-flow oxygen when compared to standard oxygen. The median length of hospital stay in participants receiving high-flow oxygen was 4 days compared to 5 days in those receiving standard oxygen. The median difference between the two groups was 1 day. The RCT conducted by Frankin et al. demonstrated no statistically significant difference (p-value = 0.19) between the mean length of hospital stay with high-flow oxygen when compared to standard oxygen. The mean length of hospital stay in the high-flow oxygen therapy group was 3.12 ± 2.43 compared to 2.94 ± 2.73 in the standard oxygen therapy group. The mean difference between the two groups was - 0.18. The RCT conducted by Murphy et al. demonstrated no statistically significant difference (p-value = 0.44) between the median length of hospital stay with high-flow oxygen when compared to standard oxygen. The median length of hospital stay of both groups was 8 days. There was no median difference.
CONCLUSIONS: The evidence of effectiveness in high-flow oxygen reducing the length of hospital stay was inconclusive. Ergul et al. was the only study to demonstrate a statistical significance with high-flow oxygen therapy in decreasing the length of hospital stay in patients diagnosed with bronchiolitis. Neither Frankin et al. nor Murphy et al. demonstratedstatistical significance.
Recommended Citation
Tran, Liann N., "Does high-flow oxygen therapy decrease the length of hospital stay in pediatric patients with bronchiolitis when compared to standard oxygen therapy?" (2022). PCOM Physician Assistant Studies Student Scholarship. 640.
https://digitalcommons.pcom.edu/pa_systematic_reviews/640