Date of Award
2022
Degree Type
Selective Evidence-Based Medicine Review
Degree Name
Master of Science in Health Sciences - Physician Assistant
Department
Physician Assistant Studies
Abstract
Objective: The objective of this selective EBM review is to determine whether or not “Does lisdexamfetamine dimesylate (Vyvanse) reduce the weekly incidence of binge eating in adults with binge eating disorder?”
Study Design: A systematic review of three double-blind, randomized, placebo-controlled trials published between 2015 and 2017.
Data Sources: All articles were obtained from PubMed and were published in peer-reviewed journals, in the English language. They were selected based on their applicability to the clinical question, credibility, and if the researched outcomes were patient oriented.
Outcomes Measured: The number of binge eating days per week was the outcome measured, with the data compiled from self-reported diaries and clinical interviews. The mean value of binge eating days per week ± standard deviation for both the placebo and intervention group was calculated at two time points, before the trial started and at the end of the trial. The mean change from baseline was then calculated.
Results: The study conducted by McElroy et al. demonstrated a statistically significant reduction (p-value < 0.001) in the number of binge eating days per week with lisdexamfetamine dimesylate 70mg, with a mean change from baseline of 4.1. In the study conducted by Hudson et al., lisdexamfetamine dimesylate 70mg led to a statistically significant reduction (p-value < 0.001) in the number of binge eating days per week, indicated by a mean change from baseline of 4.72. The study conducted by Guerdjikova et al. revealed a statistically significant reduction (p-value = 0.03) in the number of binge eating days per week with lisdexamfetamine dimesylate 70mg, with a mean change from baseline of 3.4.
Conclusion: The results of these three studies demonstrated that the use of lisdexamfetamine dimesylate 70mg led to a statistically significant reduction in the number of binge eating days per week in adults diagnosed with binge eating disorder.
Recommended Citation
Helveston, Krista L., "Does lisdexamfetamine dimesylate (Vyvanse) reduce the weekly incidence of binge eating in adults with binge eating disorder?" (2022). PCOM Physician Assistant Studies Student Scholarship. 619.
https://digitalcommons.pcom.edu/pa_systematic_reviews/619