Date of Award

2021

Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant

Department

Physician Assistant Studies

Abstract

Objective: The objective of this selective EBM review is to determine whether or not administration of 800 mg IV ibuprofen reduces post-surgical pain within 24-28 hours.

Study Design: A systematic review of three randomized, double blind, placebo-controlled studies.

Data Sources: All studies were published in English during or after the year 2010. All articles were obtained from peer reviewed journals and databases using PubMed and CINAHL Plus. Selection was determined based on the relevance to the clinical question.

Outcomes Measured: All three studies aimed to measure the efficacy of IV ibuprofen on the reduction of post-operative pain at rest and with movement by 24-28 hours. This was done using a visual analog scale (VAS), area under the curve (AUC), and mean difference between groups.

Results: In the randomized control trial (RCT) performed by Singla et al. there was a significant difference (p-value <0.001) in post-operative pain reduction between the experimental and control group. There was a least square mean difference calculated as -269 at rest and -321.1 with movement. Kayhan et al. performed a RCT that found a statistically significant decrease in pain reduction between the experimental and control groups (p-value < 0.001). A mean difference of -4.01 at rest and -10.22 with movement was calculated between groups. The RCT performed by Martinez et al. determined there to be a statistically significant decrease in pain between the experimental and control group. There was a mean difference of 0.08 at rest and 0.24 with movement.

Conclusion: All three studies demonstrated that 800 mg IV ibuprofen provides a statistically significant decrease in severity of post-surgical pain within 24-28 hours.

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