Date of Award

2021

Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant

Department

Physician Assistant Studies

Abstract

OBJECTIVE: The objective of this selective EBM review is to determine whether or not is liraglutide effective for weight loss in adults who are overweight or obese compared to placebo.

STUDY DESIGN: Review of three double-blind, randomized controlled trials published after 2010.

DATA SOURCES: All three English language, double-blind, randomized controlled trials were found using PubMed. All three RCT’s were published in peer reviewed journals.

OUTCOMES MEASURED: The outcome measured was loss of 7% or more of body weight from baseline in the study by Sun et al., and loss of greater than 10% of body weight from baseline in the studies by Pi-Sunyer et al. and Davies et al.

RESULTS: The RCT performed by Davies et al. showed 25.2% of subjects in the liraglutide 3.0mg group lost more than 10% of baseline body weight compared to 6.7% in the placebo group (p< 0.001). The RCT performed by Sun et al. showed 54% of subjects in the liraglutide 1.8mg group lost 7% of baseline body weight compared to 4% in the placebo group (p< 0.001). The RCT performed by Pi-Sunyer et al. showed 33.1% of subjects in the liraglutide 3.0mg group lost more than 10% of baseline body weight compared to 10.6% in the placebo group (p< 0.001).

CONCLUSIONS: The results of all three RCT’s included in this review indicate that the use of liraglutide is effective for weight loss in adults. These studies demonstrated that dosages of liraglutide 1.8 mg and 3.0 mg worked in reducing body weight from baseline when compared to placebo. Future studies should include lower dosages of liraglutide to assess the efficacy they have in weight loss.

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