The Effect of Preoperative Tranexamic Acid on Blood Transfusions in Geriatric Hip Fracture Surgery: A Randomized Controlled Trial.

Document Type

Article

Publication Date

3-16-2026

Abstract

OBJECTIVES: To evaluate whether preoperative intravenous tranexamic acid (TXA) reduces postoperative blood transfusion rates in geriatric patients undergoing operative treatment for hip fracture.

METHODS: Design: Prospective, double-blinded, randomized controlled trial terminated early after interim futility analysis.

SETTING: Single-center Level I trauma center.

PATIENT SELECTION CRITERIA: Patients aged ≥65 years who underwent operative treatment for femoral neck (AO/OTA 31-B), intertrochanteric region (AO/OTA 31-A), or subtrochanteric (AO/OTA 32-A/B/C) fractures between June 2019 and June 2022 were included. Procedures included arthroplasty (hemiarthroplasty or total hip arthroplasty), and internal fixation (ORIF) with intramedullary nailing or sliding hip screw fixation. Exclusion criteria were recent thromboembolic events, cancer, hypercoagulable disorders, or TXA allergy.

OUTCOME MEASURES AND COMPARISONS: The primary outcome was postoperative transfusion. Secondary outcomes included hospital length of stay (HLOS), 30-day readmission, and 90-day complications and mortality. Statistical comparisons were performed using odds ratios, chi-squared, and t-tests, with significance thresholds adjusted by O'Brien-Fleming criteria.

RESULTS: 283 patients were analyzed (TXA: 146 (mean age 84 (range 65-100), 71.9% female; Placebo: 137 (mean age 83.1 (range 65-100), 77.2% female). Baseline characteristics, including BMI and procedure type, were comparable (all p> 0.05). 229 patients (80.9%) required no postoperative transfusion (TXA 81%; Placebo: 81%, p=0.97). No significant differences were observed in 30-day readmission (p = 0.729), 90-day complications (p = 0.183), HLOS (p = 0.783), or 90-day mortality (p = 0.655). Subgroup analysis revealed higher transfusion rates in ORIF versus arthroplasty (ORIF 25%, Arthroplasty 8%, p < 0.05), though no difference between TXA and placebo within subgroups (p=0.38).

CONCLUSIONS: Preoperative TXA was not associated with reduced transfusion requirements in geriatric hip fracture surgery. No significant differences were observed in complications, mortality, or hospital stay. Surgical procedure may influence transfusion risk more than TXA use.

LEVEL OF EVIDENCE: Level I.

Comments

This article was published in Journal of Orthopaedic Trauma.

The published version is available at https://doi.org/10.1097/bot.0000000000003172.

Copyright © 2026 Wolters Kluwer Health, Inc. All rights reserved..

Publication Title

Journal of Orthopaedic Trauma

PubMed ID

41837612

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