Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations.
Document Type
Article
Publication Date
5-1-2020
Abstract
The implementation of radiotherapy in the multimodal treatment of advanced head and neck cancer has greatly improved survival rates. In some patients, however, this benefit comes at the potential expense of the tissue surrounding the primary site of malignancy. Osteoradionecrosis (ORN) of the facial bones, in particular the maxilla, is a debilitating complication of radiation therapy. Exposure to ionizing radiation results in devitalization of underlying bone with necrosis of adjacent soft tissue. Controversy surrounding appropriate early intervention in ORN persists and no consensus for clinical treatment has been established. In the present article, we review the pathophysiology of maxillary ORN and discuss the role of both conservative medical therapy and reconstruction.
Publication Title
Seminars in Plastic Surgery
Recommended Citation
Shokri, Tom; Wang, Weitao; Vincent, Aurora; Cohn, Jason E; Kadakia, Sameep; and Ducic, Yadranko, "Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations." (2020). Otolaryngology (ENT) Resident Research. 60.
https://digitalcommons.pcom.edu/ent_residents/60
PubMed ID
32390778
Comments
This article was published in Seminars in Plastic Surgery, Volume 34, Issue 2, pages 106-113.
The published version is available at https://doi.org/10.1055/s-0040-1709144.
Copyright © 2020 Thieme Medical Publishers.