Effect of diaspirin crosslinked and stroma-reduced hemoglobin on mean arterial pressure and endothelin-1 concentration in rats

Document Type

Article

Publication Date

1995

Abstract

The effect of unmodified stroma reduced (SRHb) and modified diaspirin crosslinked (DCLHb™) hemoglobin solutions on the mean arterial pressure and endothelin-1 (ET-1) concentration in blood plasma and various tissues was studied. Infusion of DCLHb or SRHb increased mean arterial blood pressure by 96 % and 39 %, respectively. Heart rate was not significantly affected by DCLHb or SRHb. A significant increase (P < 0.003) in the ET-1 levels in blood plasma after DCLHb and SRHb infusion was observed. The increase in plasma ET-1 concentration was significantly more marked with SRHb (141 %) as compared to DCLHb (78 %) treated rats. The concentration of ET-1 in the heart and brain regions was not altered in DCLHb and SRHb treated rats as compared to control. However, ET-1 concentration was significantly increased in the thoracic aorta (151 %) and renal medulla (272 %) of DCLHb treated rats. SRHb treated rats also showed a significant increase in ET-1 concentration in the thoracic aorta (141 %) and renal medulla (429 %). The effect of SRHb on the renal medulla was found to be significantly greater than that of DCLHb. ET may be one of the factors responsible for the cardiovascular effects of hemoglobin solutions. © 1995.

Publication Title

Life Sciences

Volume

56

Issue

17

First Page

1433

Last Page

1442

Comments

This article was published in Life Sciences, Volume 56, Issue 17, Pages 1433-1442.

The published version is available at http://dx.doi.org/10.1016/0024-3205(95)00095-X.

Copyright © 1995.

This document is currently not available here.

COinS