Enhancement of morphine analgesia by tricyclic antidepressants

Document Type

Article

Publication Date

1979

Abstract

Using a cat tail-flick analgetic testing procedure, enhancement of the antinociceptive action of morphine (0.25 mg/kg s.c.) was detected following pre-treatment (1 hour) with 10 mg/kg s.c. of either amitriptyline or nortriptyline. No analgesia was observed following s.c. administration of either antidepressant or saline alone. Both central (amine re-uptake blockade; anticholinergic) and peripheral (decreased hepatic biotransformation) actions of tricyclic antidepressants may have contributed to augmentation of morphine analgesia. © 1979.

Publication Title

Neuropharmacology

Volume

18

Issue

10

First Page

827

Last Page

829

Comments

This article was published in American Journal of Pharmacy and the Sciences Supporting Public Health, Volume 140, Issue 6, Pages 165-169.

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