Regeneration of uterine horn using porcine small intestine submucosa grafts in rabbits
Tubal factor infertility may be reversed using porcine small-intestinal submucosa (SIS). The method uses as a model the New Zealand White rabbit uterine horn. In surgery, SIS grafts were prepared from porcine jejunuml the uterine horn segment was resected and a graft was placed, then the contralateral adnexa was resected. Fecundability was tested with natural mating. Three out of six rabbits became pregnant. Gross and microscopic examination confirmed regeneration of all tissue layers. Thus, this study determined that SIS facilitates successful regeneration of uterine horn morphology in a manner similiar to that observed in other tissues and species.
Journal of Investigative Surgery
Taveau, Jon W.; Tartaglia, Michele; Buchanan, Dana; Smith, Bret; Koenig, George; Thomfohrde, Kevin; Stouch, Bruce; Jeck, Saul; and Greene, Charlotte H., "Regeneration of uterine horn using porcine small intestine submucosa grafts in rabbits" (2004). PCOM Scholarly Papers. 999.