Transcription factor cascades in congenital heart malformation
New observations reveal that GATA-4 mutations are one underlying cause of human cardiac septal defects. Recent data has shed light on a potential multiprotein complex formed by GATA-4, TBX5 and NKX2.5, which might act synergistically to transcriptionally regulate other cardiac specific genes. The addition of GATA-4 to the list of genes involved in human congenital heart malformation prompts consideration of how modern molecular genetic advances should be applied to clinical care.
Trends in molecular medicine
Hatcher, Cathy J.; Diman, Nata; McDermott, Deborah A.; and Basson, Craig T., "Transcription factor cascades in congenital heart malformation" (2003). PCOM Scholarly Papers. 512.