Transcription factor cascades in congenital heart malformation

Document Type

Article

Publication Date

2003

Abstract

New observations reveal that GATA-4 mutations are one underlying cause of human cardiac septal defects. Recent data has shed light on a potential multiprotein complex formed by GATA-4, TBX5 and NKX2.5, which might act synergistically to transcriptionally regulate other cardiac specific genes. The addition of GATA-4 to the list of genes involved in human congenital heart malformation prompts consideration of how modern molecular genetic advances should be applied to clinical care.

Publication Title

Trends in molecular medicine

Volume

9

Issue

12

First Page

512

Last Page

515

Comments

This article was published in Trends in molecular medicine, Volume 9, Issue 12, Pages 512-515.

The published version is available at http://dx.doi.org/10.1016/j.molmed.2003.10.004.

Copyright © 2003 Elsevier.

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