Document Type

Article

Publication Date

2006

Abstract

Some forms of hypertrophic cardiomyopathy (HCM) are caused by mutations in cardiac sarcomeric genes, but environmental factors are believed to influence the hypertrophic response. A highly variable but potentially significant environmental factor is diet. Since soy-rich diets have been speculated to confer protection against cardiovascular disease, Stauffer et al. have explored the influence of a soy diet on cardiac growth and function in a transgenic mouse model of HCM (see the related article beginning on page 209). They report that mice fed a soy diet exhibited significantly worse HCM than mice fed a soy-free (milk protein) diet. This study provides the first evidence of an environmental modifier - diet - on the hypertrophic phenotype and has implications for the way in which disease phenotypes are assessed in genetically altered murine models of disease.

Publication Title

Journal of Clinical Investigation

Volume

116

Issue

1

First Page

16

Last Page

19

Comments

This article was published in Journal of Clinical Investigation, Volume 116, Issue 1, Pages 16-19.

The published version is available at http://dx.doi.org/10.1172/JCI27455.

Copyright © 2006 American Society for Clinical Investigation.

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