The underrecognized epilepsy spectrum: The effects of levetiracetam on neuropsychological functioning in relation to subclinical spike production
The purpose of this prospective, open-label pilot study was to determine whether treatment with levetiracetam improves neuropsychological functioning in children and adolescents who have evidence of subclinical spike production associated with attention and learning difficulties. Six participants (mean age 9.8 years) were treated with levetiracetam up to 40 mg/kg per day and evaluated using neuropsychological (Wide Range Assessment of Memory and Learning, Second Edition), academic (Wechsler Individual Achievement Test, Second Edition, Abbreviated), and electroencephalographic assessments at baseline and after 10 weeks of treatment. Statistically significant improvements on indexes of the Wide Range Assessment of Memory and Learning, Second Edition were observed in 4 participants after 10 weeks. No statistically significant differences were observed for the Wechsler Individual Achievement Test, Second Edition, Abbreviated. Concomitant spike suppression was observed. Levetiracetam was generally well tolerated. A subset of patients exists with attention and learning problems that have associated aberrant cortical electrical activity without clinical seizures and associated neuropsychological deficits that may improve after treatment with levetiracetam.
Journal of child neurology
Mintz, Mark; Legoff, Daniel; Scornaienchi, Jean; Brown, Micah; Levin Allen, Sarah; Mintz, Pnina; and Smith, Cathy, "The underrecognized epilepsy spectrum: The effects of levetiracetam on neuropsychological functioning in relation to subclinical spike production" (2009). PCOM Scholarly Papers. 444.
This article was published in Journal of child neurology, Volume 24, Issue 7, Pages 807-815.
The published version is available at http://dx.doi.org/10.1177/0883073808330762.
Copyright © 2009 The Authors.