Tumor necrosis factor alpha (TNF-α) a cytokine has been shown to be the key player during the pathogenesis of several autoimmune inflammatory disorders (presumably sterile inflammation) including rheumatoid arthritis (RA). Several studies have shown that TNF-α is mainly involved in the proinflammatory responses. However recent studies have reported multifunctional role of TNF-α during the development of RA. Therefore, in this article we have highlighted the distinct functions of TNF-α during pathogenesis of RA
Advances in Bioscience and Biotechnology
Ramanjaneya, Mula and Shashidharamurthy, Rangaiah, "Multifacted Role of TNF-α During the Pathogenesis of Rheumatoid Arthritis" (2013). PCOM Scholarly Papers. 288.
This article was published in Advances in Bioscience and Biotechnology, Volume 4, Number 10, 2013.
The published version is available at http://dx.doi.org/10.4236/abb.2013.410123
Copyright 2013 ©Ramanjaneya and Shashidharamurthy