Antioxidant Enzymes and Cancer
Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components, causing several diseases. Damage in DNA is responsible for cancer formation and progression. However, several enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase etc. act as antioxidants to influence oxidative stress. Polymorphisms in these enzymes are supposed to be associated with DNA damage and subsequently the individual’s risk of cancer susceptibility. This review article aims to further elucidate the relationship between antioxidant enzymes and cancers by summarizing the findings of some of the important study concerning expression levels and genetic polymorphisms of antioxidant enzymes in cancer patients.
Chinese Journal of Cancer Research
Khan, Md. Asaduzzaman; Tania, Mousumi; Zhang, Dianzheng; and Chen, Hanchun, "Antioxidant Enzymes and Cancer" (2010). PCOM Scholarly Papers. 24.
This article was published in the Chinese Journal of Cancer Research, Volume 22, Issue 2, June 2010, Pages 87-92.
The published version is available at http://dx.doi.org/10.1007/s11670-010-0087-7
Copyright © 2010 Chinese AntiCancer Association and Springer - Verlag