Antioxidant Enzymes and Cancer

Authors

Md. Asaduzzaman Khan, School of Biological Science and Technology, Central South University, Changsha 410013, ChinaFollow
Mousumi Tania, School of Biological Science and Technology, Central South University, Changsha 410013, China
Dianzheng Zhang, Philadelphia College of Osteopathic MedicineFollow
Hanchun Chen, School of Biological Science and Technology, Central South University, Changsha 410013, ChinaFollow

Document Type

Article

Publication Date

6-2010

Abstract

Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components, causing several diseases. Damage in DNA is responsible for cancer formation and progression. However, several enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase etc. act as antioxidants to influence oxidative stress. Polymorphisms in these enzymes are supposed to be associated with DNA damage and subsequently the individual’s risk of cancer susceptibility. This review article aims to further elucidate the relationship between antioxidant enzymes and cancers by summarizing the findings of some of the important study concerning expression levels and genetic polymorphisms of antioxidant enzymes in cancer patients.

Publication Title

Chinese Journal of Cancer Research

Volume

22

Issue

2

First Page

87

Last Page

92

Comments

This article was published in the Chinese Journal of Cancer Research, Volume 22, Issue 2, June 2010, Pages 87-92.

The published version is available at http://dx.doi.org/10.1007/s11670-010-0087-7

Copyright © 2010 Chinese AntiCancer Association and Springer - Verlag

Recommended Citation

Khan, Md. Asaduzzaman; Tania, Mousumi; Zhang, Dianzheng; and Chen, Hanchun, "Antioxidant Enzymes and Cancer" (2010). PCOM Scholarly Papers. 24.
https://digitalcommons.pcom.edu/scholarly_papers/24